167 research outputs found
Site structure analysis and optimization
The article contains information about
current situation of site development, reasons why
sites are so essential for activity of organizations and
why researches of their structure improvement are so
important. Short analysis of previous researches is
provided, with their negative features and ways for
further researches being exposed. Several ways to
formulate recommendations and requirements for site
structure are suggested, as well as methods for its
optimization. A method for implementation of
research results as software product is proposed. The
information about an example of such software which
performs analysis of sites of educational institution is
provided too
До питання фольклоризму та фольклоризації творчості трудових мігрантів
The topicality of the research is caused by the lack of study of creative activities of the Ukrainians who are hunting for a job abroad. Prose, poetry, small genres are not the object of the thorough research yet. At the same time folkloristic processes flow lively among this group of people. This thought is proved by author’s own fieldwork. Dramatic peculiarities of migrants’ creativity (homesickness, loneliness, nostalgia) help laborers to bear their lives. Some of the bright examples of migrant folklore (poems, jokes, and a vocabulary) are given in the article as well
YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration
Tissue regeneration requires dynamic cellular adaptation to the wound environment. It is currently unclear how this is orchestrated at the cellular level and how cell fate is affected by severe tissue damage. Here we dissect cell fate transitions during colonic regeneration in a mouse dextran sulfate sodium (DSS) colitis model, and we demonstrate that the epithelium is transiently reprogrammed into a primitive state. This is characterized by de novo expression of fetal markers as well as suppression of markers for adult stem and differentiated cells. The fate change is orchestrated by remodeling the extracellular matrix (ECM), increased FAK/Src signaling, and ultimately YAP/TAZ activation. In a defined cell culture system recapitulating the extracellular matrix remodeling observed in vivo, we show that a collagen 3D matrix supplemented with Wnt ligands is sufficient to sustain endogenous YAP/TAZ and induce conversion of cell fate. This provides a simple model for tissue regeneration, implicating cellular reprogramming as an essential element
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