Ten years after the FDA black box warning for antidepressant drugs: a critical narrative review

Background The United States Food and Drug Administration (FDA) has warned about the increased suicidality risk associated with the use of selective serotonin reuptake inhibitors (SSRI) and venlafaxine in children and adolescents. Objectives To critically appraise the available evidence supporting the FDA Black box warning concerning to the use of antidepressants in child and adolescents. Methods A critical review of articles in Medline/PubMed and SciELO databases regarding the FDA Black box warning for antidepressants, and the impact of FDA warnings on antidepressant prescriptions and suicide rates. Results The warning was based on surveys that did not report either cases of suicide nor a significant difference supporting an increased suicidality rate. The concept was defined in an ambiguous way and there is currently more available evidence to support such definition. The use of SSRI and venlafaxine has been associated to lower suicidality rates, but the prescription fall due to the warning increased suicide rates. Discussion Suicidality is an inherent feature of depressive disorders so it would be desirable to consider how much of the phenomenon may be attributed to antidepressants per se. It would be appropriate to consider that suicide rates might increase also as a consequence of the warning

Validation of a new reference values’s database for semiquantification of 123I‐FP‐CIT SPECT scans in one nuclear medicine department

The DatScanTM and its Semiquantification (SQ) can provide advantages in the diagnosis of Parkinsonian Syndromes (PS). To improve the SQ is recommended the creation of adapted database (DB) with reference values for the Nuclear Medicine Departments. Previously to this work was created a adapted database (DBRV) to Nuclear Medicine Department's protocol and population of Infanta Cristina's Hospital located in Badajoz, for patients between the ages of 60 and 75, and reference values of the SQ were calculated. Aim: To evaluate the discrimination capacity of a department's adapted DB reference's values of healthy controls for DatScanTM

Mapping Chilean clinical research : A protocol for a scoping review and multiple evidence gap maps

Introduction Clinical research broadly aims to influence decision-making in order to promote appropriate healthcare. Funding agencies should prioritise research projects according to needed research topics, methodological and cost-effectiveness considerations, and expected social value. In Chile, there is no local diagnosis regarding recent clinical research that might inform prioritisation for future research funding. This research aims to comprehensively identify and classify Chilean health research studies, elaborating evidence gap maps for the most burdensome local conditions. Methods and analysis We will search in electronic databases (MEDLINE, Embase, PsycINFO, CINAHL, LILACS and WoS) and perform hand searches to retrieve, identify and classify health research studies conducted in Chile or by authors whose affiliations are based in Chile, from 2000 onwards. We will elaborate evidence matrices for the 20 conditions with the highest burden in Chile (according to the Global Burden of Disease 2019) selected from those defined under the General Regime of the Health Guarantees Act. To elaborate the evidence gap maps, we will consider prioritised interventions and core outcome sets. To identify knowledge gaps and estimate redundant research, we will contrast these gap maps with the available international evidence of high or moderate certainty of evidence, for each specific clinical question. For this purpose, we will search systematic reviews using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. Ethics and dissemination No ethical approval is required to conduct this project. We will submit our results in both peer-reviewed journals and scientific conferences. We will aim to disseminate our findings through different academic platforms, social media, local press, among others. The final results will be communicated to local funding agencies and government stakeholders. Discussion We aim to provide an accurate and up-to-date picture of the research gaps - to be filled by new future findings - and the identification of redundant research, which will constitute relevant information for local decision-makers

Clinical classification versus semiquantification with adapted reference values for 123I-FP-CIT SPECT in a nuclear medicine department

Semi quantification (SQ) in DaTScan® studies is broadly used in clinic daily basis, however there is a suspicious about its discriminative capability, and concordance with the diagnostic classification performed by the physician. Aim: Evaluate the discriminate capability of an adapted database and reference's values of healthy controls for the Dopamine Transporters (DAT) with 123I–FP-IT named DBRV adapted to Nuclear Medicine Department's protocol and population of Infanta Cristina's Hospital, and its concordance with the physician classification

Efficiency of marker-assisted selection in detection of ascochyta blight resistance in Tunisian chickpea breeding lines

Ascochyta blight (AB) resistance reactions were studied in 23 chickpea cultivars, mainly advanced lines and Tunisian varieties from the Tunisian chickpea breeding program, growing both at two locations and under controlled conditions. Two co-dominant markers both associated with AB resistance were also used in this study; the CaETR marker tightly linked to QTLAR1 in combination with the SCAR SCY17590 marker linked to QTLAR2 to explore their usefulness in discriminating between resistant and susceptible chickpea genotypes. These two markers contribute efficiently in the selection of new chickpea varieties with better combinations of alleles to ensure durable resistance to AB. The advanced line V10 presenting the resistance allele for CaETR, but being still heterozygous for the SCAR17590 was characterized as resistant to moderately resistant in field studies and under controlled conditions. This line could be very useful for developing a new variety that is fixed for both resistance alleles and expresses good levels of resistance to AB in different chickpea cropping environments. These markers are very useful in assisting chickpea breeding programs, especially thanks to their robustness, their co-dominance and their utility across different genetic backgrounds

Incremento de las habilidades sociales a través de la expresión corporal: la experiencia en clases de iniciación al baile

El contexto multicultural que diariamente convivimos, invita a pensar que en pleno siglo XXI debemos abrir nuestras concepciones sobre los bienes culturales que transmitimos y contribuimos a reproducir, a la vez que transformar. Sin duda existen modos diferenciados de abordar el movimiento corporal, sean formales o no-formales, sistemáticos o espontáneos y entre estos modos el danzar y el bailar, forma parte de una de las actividades corporales más practicadas por todas las culturas del mundo. Pues no olvidemos que una de las experiencias vinculadas al movimiento que se legitimó desde el origen de la educación física, fueron las danzas nativas

Phase 2 Trial (POLA Study) of Lurbinectedin plus Olaparib in Patients with Advanced Solid Tumors: Results of Efficacy, Tolerability, and the Translational Study

Endometrial cancer; Genomic instability; OlaparibCáncer endometrial; Inestabilidad genómica; OlaparibCàncer d'endometri; Inestabilitat genòmica; OlaparibWe hypothesized that the combination of olaparib and lurbinectedin maximizes DNA damage, thus increasing its efficacy. The POLA phase 1 trial established the recommended phase 2 dose of lurbinectedin as being 1.5 mg (day 1) and that of olaparib as being 250 mg/12 h (days 1–5) for a 21-day cycle. In phase 2, we explore the efficacy of the combination in terms of clinical response and its correlation with mutations in the HRR genes and the genomic instability (GI) parameters. Results: A total of 73 patients with high-grade ovarian (n = 46), endometrial (n = 26), and triple-negative breast cancer (n = 1) were treated with lurbinectedin and olaparib. Most patients (62%) received ≥3 lines of prior therapy. The overall response rate (ORR) and disease control rate (DCR) were 9.6% and 72.6%, respectively. The median progression-free survival (PFS) was 4.54 months (95% CI 3.0–5.2). Twelve (16.4%) patients were considered long-term responders (LTR), with a median PFS of 13.3 months. No clinical benefit was observed for cases with HRR gene mutation. In ovarian LTRs, although a direct association with GI and a total loss of heterozygosity (LOH) events was observed, the association did not reach statistical significance (p = 0.055). Globally, the total number of LOHs might be associated with the ORR (p =0.074). The most common grade 3–4 toxicities were anemia and thrombocytopenia, in 6 (8.2%) and 3 (4.1%) patients, respectively. Conclusion: The POLA study provides evidence that the administration of lurbinectedin and olaparib is feasible and tolerable, with a DCR of 72.6%. Different GI parameters showed associations with better responses.This trial was sponsored by AstraZeneca and PharmaMar, including supply of the drugs used in this study

Diseño de un plan de marketing estratégico que contribuya a generar el incremento de turistas al Centro Recreativo Jaguar de Piedra en el municipio de Quelepa, Departamento de San Miguel, durante el año 2010

Esta investigación tiene por objetivo diseñar un plan de marketing estratégico en el Centro Recreativo Jaguar de Piedra que contribuya a generar el incremento de turistas en el Municipio de Quelepa,Departamento de San Miguel. Para desarrollar la investigación se aplicaron diferentes tipos de estudio, dentro de los cuales tenemos: la investigación exploratoria y descriptiva, que a continuación se detallan. Conclusiones: El centro recreativo Jaguar de Piedra, actualmente no cuenta con una planificación estratégica que le permita su desarrollo; y a pesar de poseer los recursos naturales propicios para una actividad turística placentera e incursionar en un rubro atractivo, la ausencia de una buena planificación dificulta obtener la rentabilidad deseada. El centro recreativo Jaguar de Piedra es conocido por muy pocas personas, sin embargo los turistas están en la disposición de visitar dicho lugar ya que les llama la atención conocer un nuevo lugar donde se pueda disfrutar en familia y amigos un momento agradable. Actualmente el tipo de turista que visita el centro son los grupos familiares y los grupos religiosos, según los empleados las personas religiosas utilizan las piscinas para realizar los bautismos o cualquier otro tipo de evento. Debido a la situación económica que se vive actualmente los turistas están dispuestos a cancelar el menor precio posible para ingresar a los lugares turísticos y la municipalidad de Quelepa apoya la sana diversión a precios bajos que es la estrategia utilizada por el Centro Recreativo Jaguar de Piedra aunque con los ingresos percibidos no se logran cubrir todos los gastos de dicho lugar. En el centro no se ofrecen promociones a los turistas pero consideran que es importante por lo tanto dan descuentos pero solo a los grupos religiosos; sin embargo, los visitantes desean que se ofrezcan distintos tipos de promociones para todas las personas. Los empleados consideran que la publicidad es importante para dar a conocer el centro y según el alcalde se da a conocer por medio de la televisión, pero los turista

Motivación en la elección de carrera del grupo bilingüe

[SPA] El objetivo principal de este trabajo es analizar si existen diferentes motivaciones en la elección de la carrera universitaria entre estudiantes de los grupos bilingüe y no bilingüe del grado en Administración y Dirección de Empresas de la Universidad Politécnica de Cartagena. Para llevar a cabo dicho estudio, se elaboró un cuestionario en el que se preguntaba al alumnado de ambos grupos sobre sus motivaciones para elegir la carrera, basándose en la escala propuesta por Gámez y Marrero (2003). Los resultados del análisis factorial exploratorio muestran que, tras identificar en el alumnado hasta seis tipos de motivaciones, no existen diferencias significativas entre estudiantes de ambos grupos (bilingüe y no bilingüe) para cada uno de los tipos de motivación. Dichos resultados tienen implicaciones tanto en el ámbito de los docentes de secundaria y bachillerato, como en el de la gestión universitaria. [ENG] The main objective of this work is to analyze the existence of different motivations in he decision of starting a bachelor degree, between the students of both the bilingual and non-bilingual group of Business Administration at Technical University of Cartagena. To carry out this study, a survey was developed in which motivations to choose the degree were requested to the students, according to the scale proposed by Gámez & Marrero (2003). The results of the exploratory factorial analysis show that, after identifying six types of motivations, there are not significant differences between both groups (bilingual and non-bilingual) for each type of motivation. These results have implications at secondary school and at University

Evaluating the Functional Properties of Spray-Dried Porcine Plasma in Gilthead Seabream (Sparus aurata) Fed Low Fish Meal Diets

Blood by-products are an untapped source of high-quality ingredients for aquafeeds, containing a broad variety of cytokines, hormones, growth factors, proteins, bioactive peptides, and amino acids. The effects of the spray-dried porcine plasma (SDPP), a type of processed animal protein on several immune parameters, were evaluated in sea bream using ex vivo and in vitro assays. In this study, fish were fed with two isoproteic, isolipidic, and isoenergetic diets: control diet (7% fish meal, FM) and SDPP diet (2% FM and 5% SDPP). At the end of the 92-days trial, those fed the SDPP diet were larger in body weight (p 0.05). The ex vivo immune stimulation of splenocytes indicated that SDPP had a beneficial effect in promoting systemic immunity, since the surface cell marker (cd4), pro- (il-1β), and anti-inflammatory (tgf-β1) cytokines, and genes involved in humoral immunity (IgM) were up-regulated. The co-culture assays of skin mucus corroborated that SDPP enhanced the antibacterial capacity of mucus against V. anguillarum. In addition, main mucus biomarkers did not show significant differences, except for cortisol levels which were lower in the SDPP diet. The present study indicated that SDPP may be considered a functional ingredient in aquafeeds formulated with low FM levels.info:eu-repo/semantics/publishedVersio