High-Speed, Photon Counting CCD Cameras for Astronomy

The design of electron multiplying CCD cameras require a very different approach from that appropriate for slow scan CCD operation. This paper describes the main problems in using electron multiplying CCDs for high-speed, photon counting applications in astronomy and how these may be substantially overcome. With careful design it is possible to operate the E2V Technologies L3CCDs at rates well in excess of that claimed by the manufacturer, and that levels of clock induced charge dramatically lower than those experienced with commercial cameras that need to operate at unity gain. Measurements of the performance of the E2V Technologies CCD201 operating at 26 MHz will be presented together with a guide to the effective reduction of clock induced charge levels. Examples of astronomical results obtained with our cameras are presented.Comment: 11 pages, 5 figure

High-resolution imaging and spectroscopy in the visible from large ground-based telescopes with natural guide stars

Near-diffraction limited imaging and spectroscopy in the visible on large (8-10 meter) class telescopes has proved to be beyond the capabilities of current adaptive optics technologies, even when using laser guide stars. The need for high resolution visible imaging in any part of the sky suggests that a rather different approach is needed. This paper describes the results of simulations, experiments and astronomical observations that show that a combination of low order adaptive optic correction using a 4-field curvature sensor and fast Lucky Imaging strategies with a photon counting CCD camera systems should deliver 20-25 milliarcsecond resolution in the visible with reference stars as faint as 18.5 magnitude in I band on large telescopes. Such an instrument may be used to feed an integral field spectrograph efficiently using configurations that will also be described.Comment: 8 pages, 3 figure

Infrared observations of gravitational lensing in Abell 2219 with CIRSI

We present the first detection of a gravitational depletion signal at near-infrared wavelengths, based on deep panoramic images of the cluster Abell 2219 (z=0.22) taken with the Cambridge Infrared Survey Instrument (CIRSI) at the prime focus of the 4.2-m William Herschel Telescope. Infrared studies of gravitational depletion offer a number of advantages over similar techniques applied at optical wavelengths, and can provide reliable total masses for intermediate-redshift clusters. Using the maximum-likelihood technique developed by Schneider, King & Erben, we detect the gravitational depletion at the 3σ confidence level. By modelling the mass distribution as a singular isothermal sphere and ignoring the uncertainty in the unlensed number counts, we find an Einstein radius of θ_E ≃ 13.7^(+3.9)_(-4.2) arcsec (66 per cent confidence limit). This corresponds to a projected velocity dispersion of σᵥ∼800 km s⁻¹, in agreement with constraints from strongly lensed features. For a Navarro, Frenk & White mass model, the radial dependence observed indicates a best-fitting halo scalelength of 125h⁻¹ kpc. We investigate the uncertainties arising from the observed fluctuations in the unlensed number counts, and show that clustering is the dominant source of error. We extend the maximum-likelihood method to include the effect of incompleteness, and discuss the prospects of further systematic studies of lensing in the near-infrared band

Accommodating 'others'?: housing dispersed, forced migrants in the UK

Utilising insights from a qualitative study in the city of Leeds (UK), this paper considers issues related to the housing of dispersed forced migrants. The term 'dispersed forced migrants' is used here as a general label to include four groups of international migrants (i.e. refugees, asylum seekers, those with humanitarian protection status and failed asylum seekers) who have previously been dispersed, on a no choice basis, to a variety of locations across the UK under the requirements of the Immigration and Asylum Act (1999). The tiering of housing entitlement that exists within the generic population of dispersed forced migrants (a consequence of the particular socio-legal status assigned to individuals), and its role in rendering migrants susceptible to homelessness is outlined. The adequacy/standard of accommodation made available to forced migrants is also discussed. It is concluded that current arrangements fail to meet the basic housing needs of many forced migrants. Any future improvement in this situation will require a significant shift in government policy

Rates, causes and predictors of all-cause and avoidable mortality in 163 686 children and young people with and without intellectual disabilities:A record linkage national cohort study

Objectives: To investigate mortality rates and associated factors, and avoidable mortality in children/young people with intellectual disabilities. Design: Retrospective cohort; individual record-linked data between Scotland’s 2011 Census and 9.5 years of National Records for Scotland death certification data. Setting: General community. Participants: Children and young people with intellectual disabilities living in Scotland aged 5–24 years, and an age-matched comparison group. Main outcome measures: Deaths up to 2020: age of death, age-standardised mortality ratios (age-SMRs); causes of death including cause-specific age-SMRs/sex-SMRs; and avoidable deaths. Results: Death occurred in 260/7247 (3.6%) children/young people with intellectual disabilities (crude mortality rate=388/100 000 person-years) and 528/156 439 (0.3%) children/young people without intellectual disabilities (crude mortality rate=36/100 000 person-years). SMRs for children/young people with versus those without intellectual disabilities were 10.7 for all causes (95% CI 9.47 to 12.1), 5.17 for avoidable death (95% CI 4.19 to 6.37), 2.3 for preventable death (95% CI 1.6 to 3.2) and 16.1 for treatable death (95% CI 12.5 to 20.8). SMRs were highest for children (27.4, 95% CI 20.6 to 36.3) aged 5–9 years, and lowest for young people (6.6, 95% CI 5.1 to 8.6) aged 20–24 years. SMRs were higher in more affluent neighbourhoods. Crude mortality incidences were higher for the children/young people with intellectual disabilities for most International Statistical Classification of Diseases and Related Health Problems, 10th Revision chapters. The most common underlying avoidable causes of mortality for children/young people with intellectual disabilities were epilepsy, aspiration/reflux/choking and respiratory infection, and for children/young people without intellectual disabilities were suicide, accidental drug-related deaths and car accidents. Conclusion: Children with intellectual disabilities had significantly higher rates of all-cause, avoidable, treatable and preventable mortality than their peers. The largest differences were for treatable mortality, particularly at ages 5–9 years. Interventions to improve healthcare to reduce treatable mortality should be a priority for children/young people with intellectual disabilities. Examples include improved epilepsy management and risk assessments, and coordinated multidisciplinary actions to reduce aspiration/reflux/choking and respiratory infection. This is necessary across all neighbourhoods

Why the whole is more than the sum of its parts: salience-driven overestimation in aggregated tactile sensations

Experimental psychology often studies perception analytically, reducing its focus to minimal sensory units, such as thresholds or just noticeable differences in a single stimulus. Here, in contrast, we examine a synthetic aspect: how multiple inputs to a sensory system are aggregated into an overall percept. Participants in three experiments judged the total stimulus intensity for simultaneous electrical shocks to two digits. We tested whether the integration of component somatosensory stimuli into a total percept occurs automatically, or rather depends on the ability to consciously perceive discrepancy among components (Experiment 1), whether the discrepancy among these components influences sensitivity or/and perceptual bias in judging totals (Experiment 2), and whether the salience of each individual component stimulus affects perception of total intensity (Experiment 3). Perceptual aggregation of two simultaneous component events occurred both when participants could perceptually discriminate the two intensities, and also when they could not. Further, the actual discrepancy between the stimuli modulated both participants’ sensitivity and perceptual bias: increasing discrepancies produced a systematic and progressive overestimation of total intensity. The degree of this bias depended primarily on the salience of the stronger stimulus in the pair. Overall, our results suggest that important nonlinear mechanisms contribute to sensory aggregation. The mind aggregates component inputs into a coherent and synthetic perceptual experience in a salience-weighted fashion that is not based on simple summation of inputs

The AOLI low-order non-linear curvature wavefront sensor: a method for high sensitivity wavefront reconstruction

The Adaptive Optics Lucky Imager (AOLI) is a new instrument under development to demonstrate near diffraction limited imaging in the visible on large ground-based telescopes. We present the adaptive optics system being designed for the instrument comprising a large stroke deformable mirror, fixed component non-linear curvature wavefront sensor and photon-counting EMCCD detectors. We describe the optical design of the wavefront sensor where two photoncounting CCDs provide a total of four reference images. Simulations of the optical characteristics of the system are discussed, with their relevance to low and high order AO systems. The development and optimisation of high-speed wavefront reconstruction algorithms are presented. Finally we discuss the results of simulations to demonstrate the sensitivity of the system.Comment: 10 pages. To be published in Proc SPIE 8447: Adaptive Optics Systems II

Investigating the brain’s neurochemical profile at midlife in relation to dementia risk factors

Changes in the brain’s physiology in Alzheimer’s disease are thought to occur early in the disease’s trajectory. In this study our aim was to investigate the brain’s neurochemical profile in a midlife cohort in relation to risk factors for future dementia using single voxel proton magnetic resonance spectroscopy. Participants in the multi-site PREVENT-Dementia study (age range 40–59 year old) underwent 3T magnetic resonance spectroscopy with the spectroscopy voxel placed in the posterior cingulate/precuneus region. Using LCModel, we quantified the absolute concentrations of myo-inositol, total N-acetylaspartate, total creatine, choline, glutathione and glutamate-glutamine for 406 participants (mean age 51.1; 65.3% female). Underlying partial volume effects were accounted for by applying a correction for the presence of cerebrospinal fluid in the magnetic resonance spectroscopy voxel. We investigated how metabolite concentrations related to apolipoprotein ɛ4 genotype, dementia family history, a risk score (Cardiovascular Risk Factors, Aging and Incidence of Dementia -CAIDE) for future dementia including non-modifiable and potentially-modifiable factors and dietary patterns (adherence to Mediterranean diet). Dementia family history was associated with decreased total N-acetylaspartate and no differences were found between apolipoprotein ɛ4 carriers and non-carriers. A higher Cardiovascular Risk Factors, Aging, and Incidence of Dementia score related to higher myo-inositol, choline, total creatine and glutamate-glutamine, an effect which was mainly driven by older age and a higher body mass index. Greater adherence to the Mediterranean diet was associated with lower choline, myo-inositol and total creatine; these effects did not survive correction for multiple comparisons. The observed associations suggest that at midlife the brain demonstrates subtle neurochemical changes in relation to both inherited and potentially modifiable risk factors for future dementia