Eigenvalue calibration methods for polarimetry

Complex polarisation sensitive systems such as imaging Mueller matrix polarimeters are commonly calibrated using the eigenvalue calibration method. In this paper we present an extensive review of the method and an existing variant. We also introduce two more variants of the method to calibrate imaging polarimeters that use high numerical aperture optics. The calibration methods are tested using a Mueller matrix confocal microscope of high numerical aperture, and the effect of the pinhole size on the polarisation is also assessed experimentally

Further Characterization of the Electrogenicity and pH Sensitivity of the Human Organic Anion-Transporting Polypeptides OATP1B1 and OATP1B3

Organic anion-transporting polypeptides (OATPs) are involved in the liver uptake of many endogenous and xenobiotic compounds, such as bile acids and drugs, respectively. Using Xenopus laevis oocytes and Chinese hamster ovary (CHO) cells expressing rat Oatp1a1, human OATP1B1, or OATP1B3, the sensitivity of these transporters to extracellular/intracellular pH (pHo/pHi) and changes in plasma membrane potential (ΔΨ) was investigated. In X. laevis oocytes, nonspecific plasma membrane permeability increased only at pHo below 4.5. Above this value, both using oocytes and CHO cells, extracellular acidification affected differently the specific transport of taurocholic acid (TCA) and estradiol 17β-d-glucuronide (E217βG) by Oatp1a1 (stimulation), OATP1B1 (inhibition), and OATP1B3 (stimulation). Changes in substrate uptake in the presence of valinomycin (K+-ionophore), carbonyl cyanide 3-chlorophenylhydrazone and nigericin (protonophores), and amiloride (Na+/H+-inhibitor) and cation replacement in the medium were studied with fluorescent probes for measuring substrate uptake (cholylglycyl amidofluorescein) and changes in pHi (SNARF-4F) and ΔΨ [DilC1(5)]. The results suggest that activity of these three carriers is sodium/potassium-independent and affected differently by changes in pHo and ΔΨ: Oatp1a1 was confirmed to be an electroneutral anion exchanger, whereas the function of both OATP1B1 and OATP1B3 was markedly affected by the magnitude of ΔΨ. Moreover, electrophysiological measurements revealed the existence of a net anion influx associated to OATP1B1/OATP1B3-mediated transport of TCA, E217βG, and estrone-3-sulfate. Furthermore, a leakage of Na+ through OATP1B1 and OATP1B3, which is not coupled to substrate transport, was found. In conclusion, these results suggest that OATP1B1 and OATP1B3 are electrogenic transporters whose activity may be strongly affected under circumstances of displacement of local pH

NIKA2: a mm camera for cluster cosmology

Galaxy clusters constitute a major cosmological probe. However, Planck 2015 results have shown a weak tension between CMB-derived and cluster-derived cosmological parameters. This tension might be due to poor knowledge of the cluster mass and observable relationship. As for now, arcmin resolution Sunyaev-Zeldovich (SZ) observations ({\it e.g.} SPT, ACT and Planck) only allowed detailed studies of the intra cluster medium for low redshift clusters ($z0.5$) high resolution and high sensitivity SZ observations are needed. With both a wide field of view (6.5 arcmin) and a high angular resolution (17.7 and 11.2 arcsec at 150 and 260 GHz), the NIKA2 camera installed at the IRAM 30-m telescope (Pico Veleta, Spain) is particularly well adapted for these observations. The NIKA2 SZ observation program will map a large sample of clusters (50) at redshifts between 0.5 and 0.9. As a pilot study for NIKA2, several clusters of galaxies have been observed with the pathfinder, NIKA, at the IRAM 30-m telescope to cover the various configurations and observation conditions expected for NIKA2.

Effectiveness of rosuvastatin plus colchicine, emtricitabine/tenofovir and combinations thereof in hospitalized patients with COVID-19 : a pragmatic, open-label randomized trial

Q1Q1The use of rosuvastatin plus colchicine and emtricitabine/tenofovir in hospitalized patients with SARS- CoV-2 disease (COVID-19) has not been assessed. The objective of this study was to assess the effectiveness and safety of rosuvastatin plus colchicine, emtricitabine/tenofovir, and their combined use in these patients.Revista Internacional - Indexad

Effective Phone Calls

“Effective Phone Calls” is a practical and accessible course specifically designed to develop students` essential communication and language skills. It is divided into six units, which contain face-to-face with teacher and self-study materials. The course aims to develop both competence and confi-dence in a variety of situations, so that by the end of the period of study students will have acquired the necessary skills to handle almost any kind of call in business setting

Mapping the hot gas temperature in galaxy clusters using X-ray and Sunyaev-Zel'dovich imaging

We propose a method to map the temperature distribution of the hot gas in galaxy clusters that uses resolved images of the ther- mal Sunyaev-Zel’dovich (tSZ) effect in combination with X-ray data. Application to images from the New IRAM KIDs Array (NIKA) and XMM-Newton allows us to measure and determine the spatial distribution of the gas temperature in the merging cluster MACS J0717.5+3745, at z = 0.55. Despite the complexity of the target object, we find a good morphological agreement between the temperature maps derived from X-ray spectroscopy only – using XMM-Newton (TXMM) and Chandra (TCXO) – and the new gas-mass-weighted tSZ+X-ray imaging method (TSZX). We correlate the temperatures from tSZ+X-ray imaging and those from X-ray spectroscopy alone and find that TSZX is higher than TXMM and lower than TCXO by ∼10% in both cases. Our results are limited by uncertainties in the geometry of the cluster gas, contamination from kinetic SZ (∼10%), and the absolute calibration of the tSZ map (7%). Investigation using a larger sample of clusters would help minimise these effects

Exploiting NIKA2/ XMM-Newton imaging synergy for intermediate-mass high- z galaxy clusters within the NIKA2 SZ large program: Observations of ACT-CL J0215.4+0030 at z ∼0.9

High-resolution mapping of the intracluster medium (ICM) up to high redshift and down to low masses is crucial to derive accurate mass estimates of the galaxy cluster and to understand the systematic eects aecting cosmological studies based on galaxy clusters. We present a spatially resolved Sunyaev-Zel'dovich (SZ)/X-ray analysis of ACT-CL J0215.4+0030, a high-redshift (z = 0:865) galaxy cluster of intermediate mass (M500 ' 3:5 1014 M) observed as part of the ongoing NIKA2 SZ large program, which is a follow-up of a representative sample of objects at 0:5 z 0:9. In addition to the faintness and small angular size induced by its mass and redshift, the cluster is contaminated by point sources that significantly aect the SZ signal. This is therefore an interesting case study for the most challenging sources of the NIKA2 cluster sample. We present the NIKA2 observations of this cluster and the resulting data.We identified the point sources that aect the NIKA2 maps of the cluster as submillimeter galaxies with counterparts in catalogs of sources constructed by the SPIRE instrument on board the Herschel observatory. We reconstructed the ICM pressure profile by performing a joint analysis of the SZ signal and of the point-source component in the NIKA2 150 GHz map. This cluster is a very weak source that lies below the selection limit of the Planck catalog. Nonetheless, we obtained high-quality estimates of the ICM thermodynamical properties with NIKA2. We compared the pressure profile extracted from the NIKA2 map to the pressure profile obtained from X-ray data alone by deprojecting the public XMM-Newton observations of the cluster.We combined the NIKA2 pressure profile with the X-ray deprojected density to extract detailed information on the ICM. The radial distribution of its thermodynamic properties (the pressure, temperature and entropy) indicate that the cluster has a highly disturbed core. We also computed the hydrostatic mass of the cluster, which is compatible with estimations from SZ and X-ray scaling relations. We conclude that the NIKA2 SZ large program can deliver quality information on the thermodynamics of the ICM even for one of its faintest clusters after a careful treatment of the contamination by point sources

NIKA2: a mm camera for cluster cosmology

Galaxy clusters constitute a major cosmological probe. However, Planck 2015 results have shown a weak tension between CMB-derived and cluster-derived cosmological parameters. This tension might be due to poor knowledge of the cluster mass and observable relationship. As for now, arcmin resolution Sunyaev-Zeldovich (SZ) observations (e.g. SPT, ACT and Planck) only allowed detailed studies of the intra cluster medium for low redshift clusters (z < 0:2). For high redshift clusters ( z > 0:5) high resolution and high sensitivity SZ observations are needed. With both a wide field of view (6.5 arcmin) and a high angular resolution (17.7 and 11.2 arcsec at 150 and 260 GHz), the NIKA2 camera installed at the IRAM 30-m telescope (Pico Veleta, Spain) is particularly well adapted for these observations. The NIKA2 SZ observation program will map a large sample of clusters (50) at redshifts between 0.5 and 0.9. As a pilot study for NIKA2, several clusters of galaxies have been observed with the pathfinder, NIKA, at the IRAM 30-m telescope to cover the various configurations and observation conditions expected for NIKA2

Mapping the kinetic Sunyaev-Zel'dovich effect toward MACS J0717.5+3745 with NIKA

Measurement of the gas velocity distribution in galaxy clusters provides insight into the physics of mergers, through which large scale structures form in the Universe. Velocity estimates within the intracluster medium (ICM) can be obtained via the Sunyaev-Zel’dovich (SZ) effect, but its observation is challenging both in term of sensitivity requirement and control of systematic effects, including the removal of contaminants. In this paper we report resolved observations, at 150 and 260 GHz, of the SZ effect toward the triple merger MACS J0717.5+3745 (z = 0.55), using data obtained with the NIKA camera at the IRAM 30 m telescope. Assuming that the SZ signal is the sum of a thermal (tSZ) and a kinetic (kSZ) component and by combining the two NIKA bands, we extract for the first time a resolved map of the kSZ signal in a cluster. The kSZ signal is dominated by a dipolar structure that peaks at −5.1 and +3.4σ, corresponding to two subclusters moving respectively away and toward us and coincident with the cold dense X-ray core and a hot region undergoing a major merging event. We model the gas electron density and line-of-sight velocity of MACS J0717.5+3745 as four subclusters. Combining NIKA data with X-ray observations from XMM-Newton and Chandra, we fit this model to constrain the gas line-of-sight velocity of each component, and we also derive, for the first time, a velocity map from kSZ data (i.e. that is model- dependent). Our results are consistent with previous constraints on the merger velocities, and thanks to the high angular resolution of our data, we are able to resolve the structure of the gas velocity. Finally, we investigate possible contamination and systematic effects with a special care given to radio and submillimeter galaxies. Among the sources that we detect with NIKA, we find one which is likely to be a high redshift lensed submillimeter galaxy