Searching for the expelled hydrogen envelope in Type I supernovae via late-time H-alpha emission

We report the first results from our long-term observational survey aimed at discovering late-time interaction between the ejecta of hydrogen-poor Type I supernovae and the hydrogen-rich envelope expelled from the progenitor star several decades/centuries before explosion. The expelled envelope, moving with a velocity of ~10 -- 100 km s$^{-1}$, is expected to be caught up by the fast-moving SN ejecta several years/decades after explosion depending on the history of the mass-loss process acting in the progenitor star prior to explosion. The collision between the SN ejecta and the circumstellar envelope results in net emission in the Balmer-lines, especially in H-alpha. We look for signs of late-time H-alpha emission in older Type Ia/Ibc/IIb SNe having hydrogen-poor ejecta, via narrow-band imaging. Continuum-subtracted H-alpha emission has been detected for 13 point sources: 9 SN Ibc, 1 SN IIb and 3 SN Ia events. Thirty-eight SN sites were observed on at least two epochs, from which three objects (SN 1985F, SN 2005kl, SN 2012fh) showed significant temporal variation in the strength of their H-alpha emission in our DIAFI data. This suggests that the variable emission is probably not due to nearby H II regions unassociated with the SN, and hence is an important additional hint that ejecta-CSM interaction may take place in these systems. Moreover, we successfully detected the late-time H-alpha emission from the Type Ib SN 2014C, which was recently discovered as a strongly interacting SN in various (radio, infrared, optical and X-ray) bands.Comment: 8 pages, 7 figures, accepted in Ap

Graduate dress code: How undergraduates are planning to use hair, clothes and make-up to smooth their transition to the workplace

This article explores the relationship between students’ identities, their ideas about professional appearance and their anticipated transition to the world of work. It is based on a series of semi-structured interviews with 13 students from a vocationally-focused university in England. It was found that participants viewed clothing and appearance as an important aspect of their transition to the workplace. They believed that, if carefully handled, their appearance could help them to fit in and satisfy the expectations of employers, although some participants anticipated that this process of fitting in might compromise their identity and values. The article addresses students’ anticipated means of handling the tension between adapting to a new environment and ‘being themselves’. It is argued that the way this process is handled is intertwined with wider facets of identity – most notably those associated with gender.The article is based on research funded by the University of Derby. © 2015 IP Publishing Ltd. ((http://www.ippublishing.com). Reproduced by permission

Long-lived, long-period radial velocity variations in Aldebaran: A planetary companion and stellar activity

We investigate the nature of the long-period radial velocity variations in Alpha Tau first reported over 20 years ago. We analyzed precise stellar radial velocity measurements for Alpha Tau spanning over 30 years. An examination of the Halpha and Ca II 8662 spectral lines, and Hipparcos photometry was also done to help discern the nature of the long-period radial velocity variations. Our radial velocity data show that the long-period, low amplitude radial velocity variations are long-lived and coherent. Furthermore, Halpha equivalent width measurements and Hipparcos photometry show no significant variations with this period. Another investigation of this star established that there was no variability in the spectral line shapes with the radial velocity period. An orbital solution results in a period of P = 628.96 +/- 0.90 d, eccentricity, e = 0.10 +/- 0.05, and a radial velocity amplitude, K = 142.1 +/- 7.2 m/s. Evolutionary tracks yield a stellar mass of 1.13 +/- 0.11 M_sun, which corresponds to a minimum companion mass of 6.47 +/- 0.53 M_Jup with an orbital semi-major axis of a = 1.46 +/- 0.27 AU. After removing the orbital motion of the companion, an additional period of ~ 520 d is found in the radial velocity data, but only in some time spans. A similar period is found in the variations in the equivalent width of Halpha and Ca II. Variations at one-third of this period are also found in the spectral line bisector measurements. The 520 d period is interpreted as the rotation modulation by stellar surface structure. Its presence, however, may not be long-lived, and it only appears in epochs of the radial velocity data separated by $\sim$ 10 years. This might be due to an activity cycle. The data presented here provide further evidence of a planetary companion to Alpha Tau, as well as activity-related radial velocity variations.Comment: 18 pages, 14 figures. Accepted for publication in Astronomy and Astrophysic

Can Streamer Blobs prevent the Buildup of the Interplanetetary Magnetic Field?

Coronal Mass Ejections continuously drag closed magnetic field lines away from the Sun, adding new flux to the interplanetary magnetic field (IMF). We propose that the outward-moving blobs that have been observed in helmet streamers are evidence of ongoing, small-scale reconnection in streamer current sheets, which may play an important role in the prevention of an indefinite buildup of the IMF. Reconnection between two open field lines from both sides of a streamer current sheet creates a new closed field line, which becomes part of the helmet, and a disconnected field line, which moves outward. The blobs are formed by plasma from the streamer that is swept up in the trough of the outward moving field line. We show that this mechanism is supported by observations from SOHO/LASCO. Additionally, we propose a thorough statistical study to quantify the contribution of blob formation to the reduction of the IMF, and indicate how this mechanism may be verified by observations with SOHO/UVCS and the proposed NASA STEREO and ESA Polar Orbiter missions.Comment: 7 pages, 2 figures; accepted by The Astrophysical Journal Letters; uses AASTe

An interdisciplinary framework for measuring and supporting adherence in HIV prevention trials of ARV‐based vaginal rings

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138229/1/jia29158.pd

Gaps in detailed knowledge of human papillomavirus (HPV) and the HPV vaccine among medical students in Scotland

<p>Background: A vaccination programme targeted against human papillomavirus (HPV) types16 and 18 was introduced in the UK in 2008, with the aim of decreasing incidence of cervical disease. Vaccine roll out to 12–13 year old girls with a catch-up programme for girls aged up to 17 years and 364 days was accompanied by a very comprehensive public health information (PHI) campaign which described the role of HPV in the development of cervical cancer.</p> <p>Methods: A brief questionnaire, designed to assess acquisition of knowledge of HPV infection and its association to cervical cancer, was administered to two different cohorts of male and female 1st year medical students (school leavers: 83% in age range 17–20) at a UK university. The study was timed so that the first survey in 2008 immediately followed a summer's intensive PHI campaign and very shortly after vaccine roll-out (150 students). The second survey was exactly one year later over which time there was a sustained PHI campaign (213 students).</p> <p>Results: We addressed three research questions: knowledge about three specific details of HPV infection that could be acquired from PHI, whether length of the PHI campaign and/or vaccination of females had any bearing on HPV knowledge, and knowledge differences between men and women regarding HPV. No female student in the 2008 cohort had completed the three-dose vaccine schedule compared to 58.4% of female students in 2009. Overall, participants’ knowledge regarding the sexually transmitted nature of HPV and its association with cervical cancer was high in both year groups. However, in both years, less than 50% of students correctly identified that HPV causes over 90% of cases of cervical cancer. Males gave fewer correct answers for these two details in 2009. In 2008 only around 50% of students recognised that the current vaccine protects against a limited subset of cervical cancer-causing HPV sub-types, although there was a significant increase in correct response among female students in the 2009 cohort compared to the 2008 cohort.</p> <p>onclusions: This study highlights a lack of understanding regarding the extent of protection against cervical cancer conferred by the HPV vaccine, even among an educated population in the UK who could have a vested interest in acquiring such knowledge. The intensive PHI campaign accompanying the first year of HPV vaccination seemed to have little effect on knowledge over time. This is one of the first studies to assess detailed knowledge of HPV in both males and females. There is scope for continued improvements to PHI regarding the link between HPV infection and cervical cancer.</p&gt

Maintenance treatment of adolescent bipolar disorder: open study of the effectiveness and tolerability of quetiapine

<p>Abstract</p> <p>Background</p> <p>The purpose of the study was to determine the effectiveness and tolerability of quetiapine as a maintenance treatment preventing against relapse or recurrence of acute mood episodes in adolescent patients diagnosed with bipolar disorder.</p> <p>Methods</p> <p>Consenting patients meeting DSM-IV lifetime criteria for a bipolar disorder and clinically appropriate for maintenance treatment were enrolled in a 48-week open prospective study. After being acutely stabilized (CGI-S ≤ 3 for 4 consecutive weeks), patients were started or continued on quetiapine and other medications were weaned off over an 8-week period. Quetiapine monotherapy was continued for 40-weeks and other mood stabilizers or antidepressants were added if clinically indicated. A neurocognitive test battery assessing the most reliable findings in adult patients was administered at fixed time points throughout the study to patients and matched controls.</p> <p>Results</p> <p>Of the 21 enrolled patients, 18 completed the 48-week study. Thirteen patients were able to be maintained without relapse or recurrence in good quality remission on quetiapine monotherapy, while 5 patients required additional medication to treat impairing residual depressive and/or anxiety symptoms. According to symptom ratings and global functioning scores, the quality of remission for all patients was very good.</p> <p>Neurocognitive test performance over treatment was equivalent to that of a matched control group of never ill adolescents. Quetiapine was generally well tolerated with no serious adverse effects.</p> <p>Conclusion</p> <p>This study suggests that a proportion of adolescent patients diagnosed with bipolar disorder can be successfully maintained on quetiapine monotherapy. The good quality of clinical remission and preserved neurocognitive functioning underscores the importance of early diagnosis and effective stabilization.</p> <p>Clinical Trials Registry</p> <p>D1441L00024</p

Organized B cell sites in cartilaginous fishes reveal the evolutionary foundation of germinal centers

The absence of germinal centers (GCs) in cartilaginous fishes lies at odds with data showing that nurse sharks can produce robust antigen-specific responses and affinity mature their B cell repertoires. To investigate this apparent incongruity, we performed RNA sequencing on single nuclei, allowing us to characterize the cell types present in the nurse shark spleen, and RNAscope to provide in situ cellular resolution of key marker gene expression following immunization with R-phycoerythrin (PE). We tracked PE to the splenic follicles where it co-localizes with CXCR5high centrocyte-like B cells and a population of putative T follicular helper (Tfh) cells, surrounded by a peripheral ring of Ki67+ AID+ CXCR4+ centroblast-like B cells. Further, we reveal selection of mutations in B cell clones dissected from these follicles. We propose that the B cell sites iden tified here represent the evolutionary foundation of GCs, dating back to the jawed vertebrate ancestor

A novel method for the analysis of clinical biomarkers to investigate the effect of diet on health in a rat model

Experiments into the relationship between diet and health have been an area of high interest for a long time. In this study, we investigate the application of multivariate data analysis to differentiate between rat populations fed on two different diets: normal rat diet (control) and Western affluent diet (WAD). Two sets of data were acquired and analysed: one from a biochemical clinical analyser, taking measurements of blood-based biochemical markers; the other from the analysis of the volatile organic compounds (VOCs) emitted from faecal samples from the same animals using selected ion flow tube mass spectrometry (SIFT-MS). Five classes were considered: weanlings, 12 month controls, 12 month WADs, 18 month controls, and 18 month WADs. Data from the biochemical analyser, weanlings and 18 month WAD fed rats showed significant differences from the other measurement classes. This was shown in both the exploratory analysis and through multivariate classification. Classification of control diet versus WAD diets suggested there are differences between classes with 92% accuracy for the 12 month classes and 91% for the 18 month classes. Cholesterol markers, especially as low density lipoprotein-cholesterol (LDL), were the main factor in influencing WAD samples. The data from the SIFT-MS analysis also produced very good classification accuracies. Classification of control diet versus WAD diets using the H3O+ precursor ion data suggested there are differences between classes with 71% accuracy for the 12 month classes and 100% for the 18 month classes. These findings confirm that total cholesterol and LDL-cholesterol are elevated in the 18 month WAD-fed rats. We therefore suggest that the analysis of VOCs from faecal samples in conjunction with multivariate data analysis may be a useful alternative to blood analysis for the detection of parameters of health

The Hobby-Eberly Telescope Dark Energy Experiment (HETDEX): Description and Early Pilot Survey Results

The Hobby-Eberly Telescope Dark Energy Experiment (HETDEX) will outfit the 10 m HET with a new wide field and an array of 150 integral-field spectrographs to survey a 420 sq. deg. area in the north Galactic cap. Each fiber-coupled unit spectrograph will cover 350-550 nm, simultaneously. This instrument, called VIRUS, will produce ~34,000 spectra per exposure, and will open up the emission-line universe to large surveys for the first time. The survey will detect 0.8 million Lyman-alpha emitting (LAE) galaxies with 1.9<z<3.5 and more than a million [OII] emitting galaxies with z<0.5. The 3-D map of LAE galaxies in 9 cubic Gpc volume will be used to measure the expansion history at this early epoch using baryonic acoustic oscillations and the shape of the power spectrum. The aim of HETDEX is to provide a direct detection of dark energy at z~3. The measurement will constrain the evolution of dark energy and will also provide 0.1%-level accuracy on the curvature of the Universe, ten times better than current. The prototype of the VIRUS unit spectrograph (VIRUS-P) is a powerful instrument in its own right. Used on the McDonald 2.7 m, it covers the largest area of any integral field spectrograph, and reaches wavelengths down to 340 nm. VIRUS-P is being used for a pilot survey to better measure the properties of LAE galaxies in support of HETDEX. We report initial results from this survey.Comment: 4 pages, 1 Postscript figure. Paper presented at conference "Panoramic Views of the Universe", Hayama, Japan, December 2007 (ASP Conference Series, in press