Production of doubly heavy baryons via Higgs boson decays

We systematically analyzed the production of semi-inclusive doubly heavy baryons ($\Xi_{cc}$, $\Xi_{bc}$ and $\Xi_{bb}$) for the process $H^0 \rightarrow \Xi_{QQ'}+ \bar {Q'} + \bar {Q}$ through four main Higgs decay channels within the framework of non-relativistic QCD. The contributions from the intermediate diquark states, $\langle cc\rangle[^{1}S_{0}]_{\mathbf{6}}$, $\langle cc\rangle[^{3}S_{1}]_{\mathbf{\bar 3}}$, $\langle bc\rangle[^{3}S_{1}]_{\mathbf{\bar 3}/ \mathbf{6}}$, $\langle bc\rangle[^{1}S_{0}]_{\mathbf{\bar 3}/ \mathbf{6}}$, $\langle bb\rangle[^{1}S_{0}]_{\mathbf{6}}$ and $\langle bb\rangle[^{3}S_{1}]_{\mathbf{\bar 3}}$, have been taken into consideration. The differential distributions and three main sources of the theoretical uncertainties have been discussed. At the High Luminosity Large Hadron Collider, there will be about 0.43$\times10^4$ events of $\Xi_{cc}$, 6.32$\times10^4$ events of $\Xi_{bc}$ and 0.28$\times10^4$ events of $\Xi_{bb}$ produced per year. There are fewer events produced at the Circular Electron Positron Collider and the International Linear Collider, about $0.26\times 10^{2}$ events of $\Xi_{cc}$, $3.83\times 10^{2}$ events of $\Xi_{bc}$ and $0.17\times 10^{2}$ events of $\Xi_{bb}$ in operation.Comment: 15 pages, 3 figures, 7 table

Ethyl 1-[(4-acetyl-2-methoxy­phen­oxy)meth­yl]cyclo­propane-1-carboxyl­ate

In the title compound, C16H20O5, the dihedral angle between the planar rings, viz. benzene and cyclo­propane, is 52.1 (2)°. Mol­ecules are connected in the crystal via weak inter­molecular C—H⋯O hydrogen bonds, forming chains in the [001] direction

HoxA9 binds and represses the Cebpa +8 kb enhancer

C/EBPα plays a key role in specifying myeloid lineage development. HoxA9 is expressed in myeloid progenitors, with its level diminishing during myeloid maturation, and HOXA9 is over-expressed in a majority of acute myeloid leukemia cases, including those expressing NUP98-HOXD13. The objective of this study was to determine whether HoxA9 directly represses Cebpa gene expression. We find 4-fold increased HoxA9 and 5-fold reduced Cebpa in marrow common myeloid and LSK progenitors from Vav-NUP98-HOXD13 transgenic mice. Conversely, HoxA9 decreases 5-fold while Cebpa increases during granulocytic differentiation of 32Dcl3 myeloid cells. Activation of exogenous HoxA9-ER in 32Dcl3 cells reduces Cebpa mRNA even in the presence of cycloheximide, suggesting direct repression. Cebpa transcription in murine myeloid cells is regulated by a hematopoietic-specific +37 kb enhancer and by a more widely active +8 kb enhancer. ChIP-Seq analysis of primary myeloid progenitor cells expressing exogenous HoxA9 or HoxA9-ER demonstrates that HoxA9 localizes to both the +8 kb and +37 kb Cebpa enhancers. Gel shift analysis demonstrates HoxA9 binding to three consensus sites in the +8 kb enhancer, but no affinity for the single near-consensus site present in the +37 kb enhancer. Activity of a Cebpa +8 kb enhancer/promoter-luciferase reporter in 32Dcl3 or MOLM14 myeloid cells is increased ~2-fold by mutation of its three HOXA9-binding sites, suggesting that endogenous HoxA9 represses +8 kb Cebpa enhancer activity. In contrast, mutation of five C/EBPα-binding sites in the +8 kb enhancer reduces activity 3-fold. Finally, expression of a +37 kb enhancer/promoter-hCD4 transgene reporter is reduced ~2-fold in marrow common myeloid progenitors when the Vav-NUP98-HOXD13 transgene is introduced. Overall, these data support the conclusion that HoxA9 represses Cebpa expression, at least in part via inhibition of its +8 kb enhancer, potentially allowing normal myeloid progenitors to maintain immaturity and contributing to the pathogenesis of acute myeloid leukemia associated with increased HOXA9

Heavy quarkonium production through the top quark rare decays via the channels involving flavor changing neutral currents

In the paper, we discuss the possibility of observation of heavy quarkoniums via the processes involving flavor changing neutral currents (FCNC). More explicitly, we systematically calculate the production of heavy charmonium and $(c\bar{b})$-quarkonium through the top quark semi-exclusive rare FCNC decays in the framework of the non-relativistic QCD (NRQCD) factorization theory. Our results show that the total decay widths $\Gamma_{t\to \eta_c} =1.20^{+1.04+1.14}_{-0.51-0.45}\times 10^{-16}$ GeV, $\Gamma_{t\to J/\psi} =1.37^{+1.03+1.30}_{-0.51-0.51}\times 10^{-16}$ GeV, $\Gamma_{t\to B_c}=2.06^{+0.17+0.91}_{-0.17-0.54}\times 10^{-18}$ GeV, and $\Gamma_{t\to B^*_c}=6.27^{+0.63+2.78}_{-0.62-1.64}\times 10^{-18}$ GeV, where the uncertainties are from variation of quark masses and renormalization scales. Even though the decay widths are small, it is important to make a systematic study on the production of charmonium and $(c\bar{b})$-quarkonium through the top-quark decays via FCNC in the Standard Model, which will provide useful guidance for future new physics research from the heavy quarkonium involved processes.Comment: 17 pages, 8 figures and 6 tables, to be published in European Physical Journal C. arXiv admin note: text overlap with arXiv:1304.1303 by other author

Combined analysis of mRNA expression of ERCC1, BAG-1, BRCA1, RRM1 and TUBB3 to predict prognosis in patients with non-small cell lung cancer who received adjuvant chemotherapy

<p>Abstract</p> <p>Background</p> <p>The aim of this study was to investigate prognostic value of excision repair cross-complementing 1 (ERCC1), BCL2-associated athanogene (BAG-1), the breast and ovarian cancer susceptibility gene 1 (BRCA1), ribonucleotide reductase subunit M1 (RRM1) and class III β-tubulin (TUBB3) in patients with non-small cell lung cancer (NSCLC) who received platinum- based adjuvant chemotherapy.</p> <p>Methods</p> <p>Messenger RNA expressions of these genes were examined in 85 tumor tissues and 34 adjacent tissue samples using semi-quantitative RT-PCR. The expressions of these five genes were analyzed in relation to chemotherapy and progression-free survival (PFS) and overall survival (OS). Seventy-four patients were enrolled into chemotherapy.</p> <p>Results</p> <p>Patients with ERCC1 or BAG-1 negative expression had a significantly longer PFS (<it>P </it>= 0.001 and <it>P </it>= 0.001) and OS (<it>P </it>= 0.001 and <it>P </it>= 0.001) than those with positive expression. Patients with negative ERCC1 and BAG-1 expression benefited more from platinum regimen (<it>P </it>= 0.001 and <it>P </it>= 0.002). Patients with BRCA1 negative expression might have a longer OS (<it>P </it>= 0.052), but not PFS (<it>P </it>= 0.088) than those with BRCA1 positive expression. A significant relationship was observed between the mRNA expression of ERCC1 and BAG-1 (<it>P </it>= 0.042). In multivariate analysis, ERCC1 and BAG-1 were significantly favorable factors for PFS (<it>P </it>= 0.018 and <it>P </it>= 0.017) and OS (<it>P </it>= 0.027 and <it>P </it>= 0.022).</p> <p>Conclusions</p> <p>ERCC1 and BAG-1 are determinants of survival after surgical treatment of NSCLC, and its mRNA expression in tumor tissues could be used to predict the prognosis of NSCLC treated by platinum.</p

Shear response behavior of STF/kevlar composite fabric in picture frame test

The picture frame test was applied to compare Kevlar neat and STF/Kevlar composite fabrics. The digital image correlation markers method was applied to measure the shear deformation behavior of the fabric in real-time under three loading rates: 100, 500, and 1000 mm/min. A theoretical model was applied to evaluate the effect of STF on the shear deformation stiffness of the fabric and cells and on the energy absorption during shear deformation. The results show that the STF/Kevlar composite fabric has a larger load-carrying capacity than the neat fabric in the picture frame test, and has obvious loading rate dependence. The yarn cell of the fabric undergoes slip deformation and reaches a shear-locked state; the shear modulus and the cell spring torsion coefficient of the STF/Kevlar composite fabric are significantly higher than those of neat fabric. The shear thickening behavior of STF occurs at higher loading rates, and the composite fabric has the highest shear deformation stiffness and shear energy absorption level

Fully integrated InGaAs/InP single-photon detector module with gigahertz sine wave gating

InGaAs/InP single-photon avalanche diodes (SPADs) working in the regime of GHz clock rates are crucial components for the high-speed quantum key distribution (QKD). We have developed for the first time a compact, stable and user-friendly tabletop InGaAs/InP single-photon detector system operating at a 1.25 GHz gate rate that fully integrates functions for controlling and optimizing SPAD performance. We characterize the key parameters of the detector system and test the long-term stability of the system for continuous operation of 75 hours. The detector system can substantially enhance QKD performance and our present work paves the way for practical high-speed QKD applications.Comment: 11 pages, 6 figures. Accepted for publication in Review of Scientific Instrument

Association between tea drinking and disability levels in older Chinese adults: a longitudinal analysis

ObjectiveAs the global population ages, disability among the elderly presents unprecedented challenges for healthcare systems. However, limited research has examined whether dietary interventions like tea consumption may alleviate and prevent disability in older adults. As an important dietary therapy, the health benefits of tea drinking have gained recognition across research disciplines. Therefore, this study aimed to investigate the association between tea drinking habits and disability levels in the elderly Chinese population.MethodsLeveraging data from the 2008 to 2018 waves of the Chinese Longitudinal Healthy Longevity Survey, we disaggregated tea drinking frequency and activities of daily living (ADL) measures and deployed fixed-effect ordered logit models to examine the tea-disability association for the first time. We statistically adjusted for potential confounders and conducted stratified analyses to assess heterogeneity across subpopulations.ResultsMultivariable fixed-effect ordered logistic regression suggested tea drinking has protective effects against ADL disability. However, only daily tea drinking was associated with lower risks of basic activities of daily living (BADL) disability [odds ratio (OR) = 0.61; 95% confidence interval (CI), 0.41–0.92] and lower levels of instrumental activities of daily living (IADL) disability (OR = 0.78; 95% CI, 0.64–0.95). Stratified analyses indicated heterogeneous effects across age and income groups. Daily tea drinking protected against BADL (OR = 0.26 and OR = 0.28) and IADL disability (OR = 0.48 and OR = 0.45) for adults over 83 years old and high-income households, respectively.ConclusionWe found that drinking tea almost daily was protective against disability in elderly people, warranting further research into optimal dosages. Future studies should utilize more rigorous causal inference methods and control for confounders

Substrate specificity provides insights into the sugar donor recognition mechanism of O-GlcNAc transferase (OGT).

O-Linked β-N-acetylglucosaminyl transferase (OGT) plays an important role in the glycosylation of proteins, which is involved in various cellular events. In human, three isoforms of OGT (short OGT [sOGT]; mitochondrial OGT [mOGT]; and nucleocytoplasmic OGT [ncOGT]) share the same catalytic domain, implying that they might adopt a similar catalytic mechanism, including sugar donor recognition. In this work, the sugar-nucleotide tolerance of sOGT was investigated. Among a series of uridine 5'-diphosphate-N-acetylglucosamine (UDP-GlcNAc) analogs tested using the casein kinase II (CKII) peptide as the sugar acceptor, four compounds could be used by sOGT, including UDP-6-deoxy-GlcNAc, UDP-GlcNPr, UDP-6-deoxy-GalNAc and UDP-4-deoxy-GlcNAc. Determined values of Km showed that the substitution of the N-acyl group, deoxy modification of C6/C4-OH or epimerization of C4-OH of the GlcNAc in UDP-GlcNAc decreased its affinity to sOGT. A molecular docking study combined with site-directed mutagenesis indicated that the backbone carbonyl oxygen of Leu653 and the hydroxyl group of Thr560 in sOGT contributed to the recognition of the sugar moiety via hydrogen bonds. The close vicinity between Met501 and the N-acyl group of GlcNPr, as well as the hydrophobic environment near Met501, were responsible for the selective binding of UDP-GlcNPr. These findings illustrate the interaction of OGT and sugar nucleotide donor, providing insights into the OGT catalytic mechanism