An Investigation of Occupation-based Practice in Upper Extremity Intervention - A Pilot Study

The primary purpose of this study was to explore the extent to which therapists focused on functional occupation-based performance in both assessments and goals, and whether this was related to client satisfaction and perceived self-efficacy. Researchers found that while most therapists demonstrated inconsistent occupation-based practices, therapists were most occupation-focused during goal writing and in their clinical reasoning. Results also suggest that clients responded well to client-centered practices

The Importance of Effective Listening Skills: Implications for the Workplace and Dealing with Difficult People

A survey of University of Southern Maine (USM) employees was conducted to identify the importance of the leadership skill, effective listening, in supervisors and supervisees, and to evaluate its implications in the workplace, specifically when dealing with difficult people in everyday interactions. USM employees were asked their opinions about the importance of effective listening skills, their perceptions of their own effective listening skills as well as those of their coworkers, experiences of dealing with difficult people in the workplace, and the importance of training regarding these skills for leadership and general work performance. Results of the qualitative and quantitative survey data indicated that both supervisors and supervised employees felt effective listening skills in the workplace was important, not specifically for supervisors, but for all employees, and training on such would be beneficial to all. Most perceived themselves and their coworkers to possess effective listening skills, and they all found themselves in difficult situations, at one time or another. Difficult situations ranged from simply involving people with bad attitudes to those more serious involving the police

Rabies Surveillance Identifies Potential Risk Corridors and Enables Management Evaluation

Intensive efforts are being made to eliminate the raccoon variant of rabies virus (RABV) from the eastern United States and Canada. The United States Department of Agriculture (USDA) Wildlife Services National Rabies Management Program has implemented enhanced rabies surveillance (ERS) to improve case detection across the extent of the raccoon oral rabies vaccination (ORV) management area. We evaluated ERS and public health surveillance data from 2006 to 2017 in three northeastern USA states using a dynamic occupancy modeling approach. Our objectives were to examine potential risk corridors for RABV incursion from the U.S. into Canada, evaluate the effectiveness of ORV management strategies, and identify surveillance gaps. ORV management has resulted in a decrease in RABV cases over time within vaccination zones (from occupancy (ψ) of 0.60 standard error (SE) = 0.03 in the spring of 2006 to ψ of 0.33 SE = 0.10 in the spring 2017). RABV cases also reduced in the enzootic area (from ψ of 0.60 SE = 0.03 in the spring of 2006 to ψ of 0.45 SE = 0.05 in the spring 2017). Although RABV occurrence was related to habitat type, greater impacts were associated with ORV and trap–vaccinate–release (TVR) campaigns, in addition to seasonal and yearly trends. Reductions in RABV occupancy were more pronounced in areas treated with Ontario Rabies Vaccine Bait (ONRAB) compared to RABORAL V-RG®. Our approach tracked changes in RABV occurrence across space and time, identified risk corridors for potential incursions into Canada, and highlighted surveillance gaps, while evaluating the impacts of management actions. Using this approach, we are able to provide guidance for future RABV management

Properties and Macromolecular Structure of Unacetylated and Acetylated Nata de Coco

This study aims to gain more insight into the supramolecular structure of the cellulose in nata de coco, and to compare its ability to be modified with the known types of cellulose. The investigations were done using IR spectroscopy and thennal analysis. The IR spectra of microcrystalline cellulose were identical to cellulose spectra. However, those of dried nata de coco cellulose showed additional peaks that indicated a loss of inter- and intra-sheet hydrogen bonding, usually extensive in other cellulose forms where sheets are the prevalent secondary structures. This kind of structure would be consistent with the necessary framework for gel formation. Details in the fingerprint region further supported a different macromolecular structure from the microcrystalline cellulose. Acetylation of the fresh and pressed-and-dried nata de coco yielded only partial acetylation, as indicated by the C=O stretching as well as the remaining broad OR-stretch. Acetylated samples showed reduced water retention capacities, and were more prone to variable water retention characteristics during pH changes. The DSC and TGA behavi or of microcrystalline cellulose, acetylated and unacetylated forms of nata de coco showed differences in the macromolecular structures, as well as in stability of the material

MCTP is an ER-resident calcium sensor that stabilizes synaptic transmission and homeostatic plasticity.

Presynaptic homeostatic plasticity (PHP) controls synaptic transmission in organisms from Drosophila to human and is hypothesized to be relevant to the cause of human disease. However, the underlying molecular mechanisms of PHP are just emerging and direct disease associations remain obscure. In a forward genetic screen for mutations that block PHP we identified mctp (Multiple C2 Domain Proteins with Two Transmembrane Regions). Here we show that MCTP localizes to the membranes of the endoplasmic reticulum (ER) that elaborate throughout the soma, dendrites, axon and presynaptic terminal. Then, we demonstrate that MCTP functions downstream of presynaptic calcium influx with separable activities to stabilize baseline transmission, short-term release dynamics and PHP. Notably, PHP specifically requires the calcium coordinating residues in each of the three C2 domains of MCTP. Thus, we propose MCTP as a novel, ER-localized calcium sensor and a source of calcium-dependent feedback for the homeostatic stabilization of neurotransmission

Relationships Among Occupation/Activity Patterns, Health and Stress Perceptions, and Life Orientation in Well Adults

Background: This study examined the relationships among activity choices, perceived health, stress, and life orientation (optimism-pessimism) in a general population of 675 healthy adults ranging in age from 18-91 years. The objective was to examine assumptions that occupational scientists and practitioners hold regarding the relationships among health factors and engagement in activities/occupations. Method: The study used four self-report measures, including a customized activity card sort that asked participants about both healthy and unhealthy activity patterns. Responses were then compared with the participants’ perceptions of overall health, stress levels, and degrees of optimism and pessimism (life orientation). Results: Major findings confirmed that being engaged in more activities overall is aligned with more optimally perceived health, positive life orientation, and lower stress. However, participation in unhealthy activities negatively affected overall health, stress perception, and life orientation. The study also confirmed that women tend to have higher perceived stress than men and that caring for others is associated with more positive health ratings. Conclusion: The amount and type of activity participation appears to matter for even healthy individuals in terms of overall health, stress perception, and life orientation. This study confirms the importance of participating in a wide repertoire of activities and underscores the need for practitioners to ask clients about engagement in unhealthy activities as well as healthy ones

MEMS411: We ROCK n’ ROVERIN\u27

The goal of this project is to create a remotely-controlled rover that can reliably collect dice. The customer, Chiamaka Asinugo, requires a device that meets the needs of a potential challenge that the WURocketry Team might face in future “NASA Student Launch” competitions. These needs include the rover being able to fit into a theoretical payload cylinder that is 5.36 in diameter and 8.5 long and the rover weighing less than 3.5 lbs

A Potenial Benefit of Albinism in Astyanax Cavefish: Downregulation of the oca2 Gene Increases Tyrosine and Catecholamine Levels as an Alternative to Melanin Synthesis

Albinism, the loss of melanin pigmentation, has evolved in a diverse variety of cave animals but the responsible evolutionary mechanisms are unknown. In Astyanax mexicanus, which has a pigmented surface dwelling form (surface fish) and several albino cave-dwelling forms (cavefish), albinism is caused by loss of function mutations in the oca2 gene, which operates during the first step of the melanin synthesis pathway. In addition to albinism, cavefish have evolved differences in behavior, including feeding and sleep, which are under the control of the catecholamine system. The catecholamine and melanin synthesis pathways diverge after beginning with the same substrate, L-tyrosine. Here we describe a novel relationship between the catecholamine and melanin synthesis pathways in Astyanax. Our results show significant increases in L-tyrosine, dopamine, and norepinephrine in pre-feeding larvae and adult brains of Pachón cavefish relative to surface fish. In addition, norepinephrine is elevated in cavefish adult kidneys, which contain the teleost homologs of catecholamine synthesizing adrenal cells. We further show that the oca2 gene is expressed during surface fish development but is downregulated in cavefish embryos. A key finding was that knockdown of oca2 expression in surface fish embryos delays the development of pigmented melanophores and simultaneously increases L-tyrosine and dopamine. We conclude that a potential evolutionary benefit of albinism in Astyanax cavefish may be to provide surplus L-tyrosine as a precursor of the elevated catecholamine synthesis pathway, which could be important for adaptation to the challenging cave environment