Gene Correction Technology and Its Impact on Viral Research and Therapy

Aim

Evaluation on dry forage yields and nutritional characteristics of introduced herbaceous legumes in Myanmar

The study was carried out to evaluate the forage yields, nutritive values and in vitro fermentation parameters of herbaceous legumes. Five varieties of introduced herbaceous legumes; Stylosanthes guianensis cv. Ubon stylo, Macrotyloma axillare cv. Archer, Centrosema brasilianum cv. Ooloo, Stylosanthes guianensis cv. Stylo 184 and Macroptilum bracteatum cv. Cadarga were evaluated at the research farm, University of Veterinary Science, Yezin, Myanmar. No fertilizer and no irrigation were applied for cultivation to test drought resistance. Dry forage yield, nutritive values and gas production at four harvesting times were measured with 4×5 factorial arrangement (5 legumes and 4 harvesting time) in randomized complete block design. There was no interaction between legumes and harvesting time on forage yield, nutritive values and fermentation parameters but they were affected by the main effects of legume types and harvesting time. Among the legume forages, the highest dry forage yields were found in Ooloo, Ubon stylo, and Stylo 184, and followed by the DM yield of Archer and Cadarga. The DM yield of the second harvest was significantly higher (p<0.05) than those of the first, third and fourth harvest which were not significantly different from each other. As a chemical composition, the DM content of Archer was lower (p<0.05) than those of other varieties. Among the legumes forages, the lower CP content was found in Cadarga. The higher NDF was observed in Ooloo. Ooloo, Ubon stylo and Cadarga showed higher ADF in comparison with the other two varieties. Among the harvesting time, the lowest DM content was found at the first harvest. The highest CP content was found at third harvest. The NDF content was not significantly different. The lowest ADF content was found in fourth harvest. According to the dry forage yield, Ubon stylo and Ooloo had the highest dry forage yield and in term of nutritive values, Stylo 184 and Archer had higher nutritive values. As the main effect of forages, Stylo 184 and Archer had higher gas production in comparison with the other varieties. As the main effect of harvesting time, the fourth harvest had the highest gas production in comparison with other harvesting time. It could be better for cultivation by application of fertilizer and irrigation to get more forage yield and quality. &nbsp

Negotiating and Struggling for a New Life: Stigma, Spirituality, and Coping Strategies of People Living with HIV in Myanmar

Although enacted and internalized stigma is a continuing problem for people living with HIV (PLWH) in Southeast Asia, there is little understanding of how PLWH cope with discrimination, exclusion, and other negative outcomes caused by HIV-related stigmatization. This article aims to bridge this gap by analyzing the lived experiences of HIV-related stigmatization and coping strategies among 30 people with HIV in Myanmar, a country heavily influenced by religion, especially Buddhism. Among the 30 study participants, 20 were female and 10 were male, with ages ranging from 18 to 50 years. Through the lens of Bourdieu's concepts of habitus, field, and capital, this article first elucidates the various forms of stigmatization in family, work, social, and other settings as symbolic violence on people with HIV. The present article shows that spirituality serves as a perceptual and action framework for people with HIV to generate reflexivity toward their HIV infection and related stigmatization and to further engage in agentic responses. More importantly, this article demonstrates how people with HIV draw on spirituality to support peers in reclaiming control over their lives and how they are perceived by society. The findings indicate that the local context, especially cultural and religious resources, should be considered when developing interventions to mitigate HIV-related stigmatization in Southeast Asia

Myanmar migrants living along the Thailand-Myanmar border: Experiences related to pandemic and migration decisions

ImportanceIn Myanmar, amid political and civil unrest, droves of Burmese are displaced to neighboring countries including Thailand. Since the COVID-19 pandemic, little is known about the available healthcare services and health and well-being among refugees and migrant workers within resettlement areas along the Myanmar-Thailand border.ObjectiveTo explore the unmet needs of migrants along the Thailand-Myanmar border during the COVID-19 pandemic and their reasons for leaving Myanmar.DesignA qualitative study that used focus groups with migrant schoolteachers and school masters was undertaken. An interpretative analysis approach was used to analyze the data from the focus group sessions. The study followed the COREQ (COnsolidated criteria for REporting Qualitative) checklist.SettingIn July 2022, community stakeholders from migrant schools located in the vicinity of Mae Sot, Thailand were referred to the study team.ParticipantsA purposive sample of 17 adult participants was recruited from 4 migrant schools. The participants were schoolteachers and schoolmasters who had traveled from Myanmar to Thailand 1 to 20 years ago.Main outcomes and measuresThematic analysis was used to scrutinize qualitative data for the outcomes of health and well-being, barriers, and reasons for migration.ResultsThree main themes were identified: "issues related to the pandemic", "teenage marriage and pregnancies" and "migration decisions". The issues related to the pandemic included behavior changes in children, a diminished quality of education, and barriers to receiving COVID-19 vaccines and accessing other health care. There were more dropouts due to teenage pregnancy/marriage during the shelter in place mandate. Migration decisions were affected by concerns over health, civil unrest, and military harassment.Conclusions and relevanceThis study presented the difficulties experienced by Myanmar migrants currently living along the Thailand-Myanmar border. The reasons for leaving Myanmar included health and safety. Suspending education during the pandemic caused more school dropouts due to teenage pregnancy/marriage. Additionally, behavioral changes in children, a diminished quality of education, barriers to receiving COVID-19 vaccines and access to other health care services were reported. Future studies should focus on how migration stress and access to mental health care impact the migrant population

Longitudinal trends in malaria testing rates in the face of elimination in eastern Myanmar: a 7-year observational study

Background: Providing at-risk communities with uninterrupted access to early diagnosis and treatment is a key component in reducing malaria transmission and achieving elimination. As programmes approach malaria elimination targets it is critical that each case is tested and treated early, which may present a challenge when the burden of malaria is reduced. In this paper we investigate whether malaria testing rates decline over time and assess the impacts of integrating malaria and non-malaria services on testing rates in the malaria elimination task force (METF) programme in the Kayin state of Myanmar. Methods: A retrospective analysis was conducted using weekly collected data on testing rates from a network of more than 1200 malaria posts during the period from 2014 to 2020. To determine whether monthly testing rates changed over the years of programme operations, and whether integrating malaria and non-malaria services impacted these testing rates, we fitted negative binomial mixed-effects regression models to aggregate monthly data, accounting for malaria seasonal variation. Results: In the first year of malaria post operation, testing rates declined, correlating with a decline in attendance by people from outside the malaria post catchment area, but then remained fairly constant (the Rate Ratio (RR) for 2nd versus 1st year open ranged from 0.68 to 0.84 across the four townships included in the analysis, the RR for 3rd to 6th year versus 1st year open were similar, ranging from 0.59–0.78). The implementation of a training programme, which was intended to expand the role of the malaria post workers, had minimal impact on testing rates up to 24 months after training was delivered (RR for integrated versus malaria-only services ranged from 1.00 to 1.07 across METF townships). Conclusion: Despite the decline in malaria incidence from 2014 to 2020, there has been no decline in the malaria testing rate in the METF programme after the establishment of the complete malaria post network in 2016. While the integration of malaria posts with other health services provides benefits to the population, our evaluation questions the necessity of integrated services in maintaining malaria testing rates in areas approaching elimination of malaria

Surveillance to achieve malaria elimination in eastern Myanmar: a 7-year observational study

Background The collection and utilization of surveillance data is essential in monitoring progress towards achieving malaria elimination, in the timely response to increases in malaria case numbers and in the assessment of programme functioning. This paper describes the surveillance activities used by the malaria elimination task force (METF) programme which operates in eastern Myanmar, and provides an analysis of data collected from weekly surveillance, case investigations, and monitoring and evaluation of programme performance. Methods This retrospective analysis was conducted using data collected from a network of 1250 malaria posts operational between 2014 and 2021. To investigate changes in data completeness, malaria post performance, malaria case numbers, and the demographic details of malaria cases, summary statistics were used to compare data collected over space and time. Results In the first 3 years of the METF programme, improvements in data transmission routes resulted in a 18.9% reduction in late reporting, allowing for near real-time analysis of data collected at the malaria posts. In 2020, travel restrictions were in place across Karen State in response to COVID-19, and from February 2021 the military coup in Myanmar resulted in widescale population displacement. However, over that period there has been no decline in malaria post attendance, and the majority of consultations continue to occur within 48 h of fever onset. Case investigations found that 43.8% of cases travelled away from their resident village in the 3 weeks prior to diagnosis and 36.3% reported never using a bed net whilst sleeping in their resident village, which increased to 72.2% when sleeping away from their resident village. Malaria post assessments performed in 82.3% of the METF malaria posts found malaria posts generally performed to a high standard. Conclusions Surveillance data collected by the METF programme demonstrate that despite significant changes in the context in which the programme operates, malaria posts have remained accessible and continue to provide early diagnosis and treatment contributing to an 89.3% decrease in Plasmodium falciparum incidence between 2014 and 2021

Non-invasive determination of cardiovascular indices in thalassaemia major patients

78 p.Thalassaemia is the haematological genetic disorder due to impaired haemoglobin synthesis. Although they depend on multiple blood transfusions for their survival, one side effect called iron induced cardiomyopathy due to multiple blood transfusions leads to life-threatening complications. The contractile function of heart is decreased with the increasing cardiac iron deposition status. Although cardiomyopathy is a reversible complication if treated with iron-chelating therapy, the diagnosis of detecting the heart iron overloading is usually very late. Life expectancy of thalassaemia patients can be extended and the prognosis is good if iron overloading status can be measured accurately in its early development and subsequently treated properly.Master of Science (Biomedical Engineering

Indoor environmental quality sensor station

As the world is developing at a fast pace, every technology must improve to meet the higher standard of human needs and be convenient to users. In the past, sensors and programming devices are physically connected to laptop, desktops or work stations to read/write data and upload/download the programming codes. The problem arises when there is a need for users to make changes to the program, user must be physically at the location of the programming devices and connect it to laptop before making any changes. It is very inconvenient for users especially if the programming devices are installed at inaccessible areas. It is also very cumbersome for the users to visit each sensor stations to make minor programming modifications, if the different sensors and programming devices are located throughout the buildings or production plants. This project aims to design and build the portable sensor station which is low-power, light-weight and log sensor data for users. This portable sensor will measure temperature and humidity from surrounding and hence, it is also known as, IEQMS, Indoor Environmental Quality Monitoring Station. This sensor station will be connected wirelessly to the server and will send data wirelessly as well. By using this portable IEQMS station, users can make changes to program and monitor data remotely via wireless network.Bachelor of Engineerin

Web Page Encryption using PKCS

A lot of system has been developed with security feature. This paper describes the cryptography techniques in Web Page. The browser will interpret by HTML commands and tags for display Web Page. In this paper, Web Page encryption system using is purposed.The system provides for a client user to security and privacy in which to safety downloads and send to other user. Web page can take to secure and protect for the bug guys that are transform it into a bunch of number known as ciphertext in a particular cryptography and to disguise of their Web Page.Web Page Encryption a batch process software to encrypt and protect HTML files, web pages, web site. This is a useful tool for web Developers, Author, Designer, Web site Programmer to guard and protect their new html techniques and resources or any part of the web pages, defend unauthorized web copy, protect unique and professional web site page style, html manner; Pass web content Filter.In this paper, independent and support of Microsoft Internet Explorer and then the program source code of HTML structure encrypts using PKCS of NTRU Algorithm

A Study of the Urban Informal Sector in Yangon : Case Study in Street Vendors

The urban informal sector is a sub-set of the total informal sector as well as of the total urban sector. In the context of Myanmar, the urban informal sector is described as livelihood activities. In this sector, street-based activities are more distinct than other activities. In this thesis, it has studied what factors involve to push into street-based activities and the public views on it in Yangon. This study used descriptive method base on both primary and secondary data. Activities of street vendors in Yangon include selling food and goods, and providing services in prescribed or unprescribed markets or areas, such as streets, roadsides, in front of supermarkets and at bus stops. These activities are owned by one or two persons , a family or by group of people. The street vendors activities are boosted by a continuous stream of rural to urban migration because of no work opportunity in rural areas. Most of the people who engaged the street vending are reasonably educated; a few even highly educated (graduates) and they are clearly not recent migrants . The control is not properly implemented to the vendors ' activities. The predominant feeling among the general public toward the urban street vendors ' activities is more negative than positive