A Ten-microRNA Expression Signature Predicts Survival in Glioblastoma

Glioblastoma (GBM) is the most common and aggressive primary brain tumor with very poor patient median survival. To identify a microRNA (miRNA) expression signature that can predict GBM patient survival, we analyzed the miRNA expression data of GBM patients (n = 222) derived from The Cancer Genome Atlas (TCGA) dataset. We divided the patients randomly into training and testing sets with equal number in each group. We identified 10 significant miRNAs using Cox regression analysis on the training set and formulated a risk score based on the expression signature of these miRNAs that segregated the patients into high and low risk groups with significantly different survival times (hazard ratio [HR] = 2.4; 95% CI = 1.4–3.8; p<0.0001). Of these 10 miRNAs, 7 were found to be risky miRNAs and 3 were found to be protective. This signature was independently validated in the testing set (HR = 1.7; 95% CI = 1.1–2.8; p = 0.002). GBM patients with high risk scores had overall poor survival compared to the patients with low risk scores. Overall survival among the entire patient set was 35.0% at 2 years, 21.5% at 3 years, 18.5% at 4 years and 11.8% at 5 years in the low risk group, versus 11.0%, 5.5%, 0.0 and 0.0% respectively in the high risk group (HR = 2.0; 95% CI = 1.4–2.8; p<0.0001). Cox multivariate analysis with patient age as a covariate on the entire patient set identified risk score based on the 10 miRNA expression signature to be an independent predictor of patient survival (HR = 1.120; 95% CI = 1.04–1.20; p = 0.003). Thus we have identified a miRNA expression signature that can predict GBM patient survival. These findings may have implications in the understanding of gliomagenesis, development of targeted therapy and selection of high risk cancer patients for adjuvant therapy

Ë,x »‰ÊÏk ‡Ç~‰Ö Ë,xÌ€ ‘ »i)Ï€ Effective use of Multimedia for Teaching Languages to Adult Illiterates: A Case Study in Tamil

One of the big challenges for India at the turn of this century is illiteracy. India has about 150 to 200 million Indian illiterate adults, as per the 2001 census, and this number is growing every year! Further, the increase in literacy levels between 1991 and 2001 is less than 13 per cent. The National Literacy Mission (NLM) is making all-out efforts to tackle the problem by constituting Adult Literacy programs and Continuing Education programs across the country. The conventional methods used in such programs take anywhere between six and 18 months to convert an adult from an illiterate to a functional literate. Moreover, the whole process is highly dependent on trained teachers who are in short supply. Tamilnadu, for example, has a literacy rate of around 73 % and efforts to raise it call for a faster and more cost-effective methodology. This paper describes the approach of a successful Computer Based Functional Literacy (CBFL) Programme, pioneered by TCS, in imparting reading skills in Tamil to illiterates, both as a pilot as well as over large numbers across the state. The key success factor has been the effective use of multimedia technology. The &amp;quot;success &amp;quot; factor involves the following: a) &amp;quot;Luring &amp;quot; the illiterates to attend the entire program, through compelling and excitin

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Not AvailableConservation agriculture (CA) including reduced or no-tillage and crop residue retention, is known to be a self–sustainable system as well as an alternative to residue burning. The present study evaluated the effect of reduced tillage coupled with residue retention under different cropping systems on soil properties and crop yields in a Vertisol of a semiarid region of central India. Two tillage systems – conventional tillage (CT) with residue removed, and reduced tillage (RT) with residue retained – and six major cropping systems of this region were examined after 3 years of experimentation. Results demonstrated that soil moisture content, mean weight diameter, percent water stable aggregates (>0.25mm) for the 0–15cm soil layer were significantly (Pmoderately labile>less labile. At the 0–15cm depth, the contributions of moderately labile, less labile and non-labile C fractions to total organic C were 39.3%, 10.3% and 50.4% respectively in RT and corresponding values for CT were 38.9%, 11.7% and 49.4%. Significant differences in different C fractions were observed between RT and CT. Soil microbial biomass C concentration was significantly higher in RT than CT at 0–15cm depth. The maize–chickpea cropping system had significantly (P<0.05) higher soybean grain equivalent yield of 4.65 t ha–1 followed by soybean+pigeon pea (2:1) intercropping (3.50 t ha–1) and soybean–wheat cropping systems (2.97 t ha–1). Thus, CA practices could be sustainable management practices for improving soil health and crop yields of rainfed Vertisols in these semiarid regionsNot Availabl

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Not AvailableConservation agriculture (CA) including reduced or no-tillage and crop residue retention, is known to be a self–sustainable system as well as an alternative to residue burning. The present study evaluated the effect of reduced tillage coupled with residue retention under different cropping systems on soil properties and crop yields in a Vertisol of a semiarid region of central India. Two tillage systems – conventional tillage (CT) with residue removed, and reduced tillage (RT) with residue retained – and six major cropping systems of this region were examined after 3 years of experimentation. Results demonstrated that soil moisture content, mean weight diameter, percent water stable aggregates (>0.25mm) for the 0–15cm soil layer were significantly (Pmoderately labile>less labile. At the 0–15cm depth, the contributions of moderately labile, less labile and non-labile C fractions to total organic C were 39.3%, 10.3% and 50.4% respectively in RT and corresponding values for CT were 38.9%, 11.7% and 49.4%. Significant differences in different C fractions were observed between RT and CT. Soil microbial biomass C concentration was significantly higher in RT than CT at 0–15cm depth. The maize–chickpea cropping system had significantly (P<0.05) higher soybean grain equivalent yield of 4.65 t ha–1 followed by soybean+pigeon pea (2:1) intercropping (3.50 t ha–1) and soybean–wheat cropping systems (2.97 t ha–1). Thus, CA practices could be sustainable management practices for improving soil health and crop yields of rainfed Vertisols in these semiarid regionsNot Availabl

Not Available

Not AvailableConservation agriculture (CA) including reduced or no-tillage and crop residue retention, is known to be a self–sustainable system as well as an alternative to residue burning. The present study evaluated the effect of reduced tillage coupled with residue retention under different cropping systems on soil properties and crop yields in a Vertisol of a semiarid region of central India. Two tillage systems – conventional tillage (CT) with residue removed, and reduced tillage (RT) with residue retained – and six major cropping systems of this region were examined after 3 years of experimentation. Results demonstrated that soil moisture content, mean weight diameter, percent water stable aggregates (>0.25mm) for the 0–15cm soil layer were significantly (Pmoderately labile>less labile. At the 0–15cm depth, the contributions of moderately labile, less labile and non-labile C fractions to total organic C were 39.3%, 10.3% and 50.4% respectively in RT and corresponding values for CT were 38.9%, 11.7% and 49.4%. Significant differences in different C fractions were observed between RT and CT. Soil microbial biomass C concentration was significantly higher in RT than CT at 0–15cm depth. The maize–chickpea cropping system had significantly (P<0.05) higher soybean grain equivalent yield of 4.65 t ha–1 followed by soybean+pigeon pea (2:1) intercropping (3.50 t ha–1) and soybean–wheat cropping systems (2.97 t ha–1). Thus, CA practices could be sustainable management practices for improving soil health and crop yields of rainfed Vertisols in these semiarid regionsNot Availabl