Simplificar: el ejemplo de Michel Thonet

La rigurosa coherencia formal de toda la producción Thonet demuestra que el uso correcto de los materiales y de las técnicas puede dar lugar a un tipo de estética que no necesita embellecerse con el arte aplicado. (Extraído del libro de Bruno Munari "El arte como oficio" Ed. Labor 5.A., 1994.)Facultad de Arquitectura y Urbanism

Simplificar: el ejemplo de Michel Thonet

La rigurosa coherencia formal de toda la producción Thonet demuestra que el uso correcto de los materiales y de las técnicas puede dar lugar a un tipo de estética que no necesita embellecerse con el arte aplicado. (Extraído del libro de Bruno Munari "El arte como oficio" Ed. Labor 5.A., 1994.)Facultad de Arquitectura y Urbanism

El cuadrado, el círculo

Dos lúcidos textos de este gran artista italiano, Bruno Munari (Italia 1907-1988), permiten acercarnos a su obra y y pensamiento en un justo homenaje.Facultad de Arquitectura y Urbanism

Simplificar: el ejemplo de Michel Thonet

La rigurosa coherencia formal de toda la producción Thonet demuestra que el uso correcto de los materiales y de las técnicas puede dar lugar a un tipo de estética que no necesita embellecerse con el arte aplicado. (Extraído del libro de Bruno Munari "El arte como oficio" Ed. Labor 5.A., 1994.)Facultad de Arquitectura y Urbanism

El cuadrado, el círculo

Dos lúcidos textos de este gran artista italiano, Bruno Munari (Italia 1907-1988), permiten acercarnos a su obra y y pensamiento en un justo homenaje.Facultad de Arquitectura y Urbanism

Discovery of a bipolar and highly variable mass outflow from the symbiotic binary StHa 190

A highly and rapidly variable bipolar mass outflow from StHa 190 has been discovered, the first time in a yellow symbiotic star. Permitted emission lines are flanked by symmetrical jet features and multi-component P-Cyg profiles, with velocities up to 300 km/sec. Given the high orbital inclination of the binary, if the jets leave the system nearly perpendicular to the orbital plane, the de-projected velocity equals or exceeds the escape velocity (1000 km/sec). StHa190 looks quite peculiar in many other respects: the hot component is an O-type sub-dwarf without an accretion disk or a veiling nebular continuum and the cool component is a G7 III star rotating at a spectacular 105 km/sec unseen by a large margin in field G giants.Comment: Letter to the Editor, Astron.Astrophys, in pres

A METHOD TO CALIBRATE THE HIGH-RESOLUTION CATANIA ASTROPHYSICAL OBSERVATORY SPECTROPOLARIMETER

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The roles of different forms of IL-15 in human melanoma progression

BackgroundMelanoma is a lethal skin cancer, and the risk of developing it is increased by exposure to ultraviolet (UV) radiation. The production of cytokines such as interleukin-15 (IL-15), induced by the exposure of skin cells to UV rays, could also promote melanoma development. The aim of this study is to investigate the possible role of Interleukin-15/Interleukin-15 Receptor α (IL-15/IL-15Rα) complexes in melanoma development.MethodsThe expression of IL-15/IL-15Rα complexes by melanoma cells was evaluated both ex vivo and in vitro by tissue microarray, PCR, and flow cytometry. The presence of the soluble complex (sIL-15/IL-15Rα) in the plasma of metastatic melanoma patients was detected using an ELISA assay. Subsequently, we investigated the impact of natural killer (NK) cell activation after rIL-2 starvation followed by exposure to the sIL-15/IL-15Rα complex. Finally, by analyzing public datasets, we studied the correlation between IL-15 and IL-15Rα expressions and melanoma stage, NK and T-cell markers, and overall survival (OS).ResultsAnalysis of a melanoma tissue microarray shows a significant increase in the number of IL-15+ tumor cells from the benign nevi to metastatic melanoma stages. Metastatic melanoma cell lines express a phorbol-12-myristate-13-acetate (PMA)-cleavable membrane-bound IL-15 (mbIL-15), whereas cultures from primary melanomas express a PMA-resistant isoform. Further analysis revealed that 26% of metastatic patients present with consistently high plasmatic levels of sIL-15/IL-15Rα. When the recombinant soluble human IL-15/IL-15Rα complex is added to briefly starved rIL-2-expanded NK cells, these cells exhibit strongly reduced proliferation and levels of cytotoxic activity against K-562 and NALM-18 target cells. The analysis of public gene expression datasets revealed that high IL-15 and IL-15Rα intra-tumoral production correlates with the high levels of expression of CD5+ and NKp46+ (T and NK markers) and significantly correlates with a better OS in stages II and III, but not in stage IV.ConclusionsMembrane-bound and secreted IL-15/IL-15Rα complexes are continuously present during progression in melanoma. It is notable that, although IL-15/IL-15Rα initially promoted the production of cytotoxic T and NK cells, at stage IV promotion of the development of anergic and dysfunctional cytotoxic NK cells was observed. In a subgroup of melanoma metastatic patients, the continuous secretion of high amounts of the soluble complex could represent a novel NK cell immune escape mechanism

Constraining the reflective properties of WASP-178b using Cheops photometry

Multiwavelength photometry of the secondary eclipses of extrasolar planets is able to disentangle the reflected and thermally emitted light radiated from the planetary dayside. This leads to the measurement of the planetary geometric albedo $A_g$, which is an indicator of the presence of clouds in the atmosphere, and the recirculation efficiency $\epsilon$, which quantifies the energy transport within the atmosphere. In this work we aim to measure $A_g$ and $\epsilon$ for the planet WASP-178 b, a highly irradiated giant planet with an estimated equilibrium temperature of 2450 K.} We analyzed archival spectra and the light curves collected by Cheops and Tess to characterize the host WASP-178, refine the ephemeris of the system and measure the eclipse depth in the passbands of the two respective telescopes. We measured a marginally significant eclipse depth of 70$\pm$40 ppm in the Tess passband and statistically significant depth of 70$\pm$20 ppm in the Cheops passband. Combining the eclipse depth measurement in the Cheops (lambda_eff=6300 AA) and Tess (lambda_eff=8000 AA) passbands we constrained the dayside brightness temperature of WASP-178 b in the 2250-2800 K interval. The geometric albedo 0.1<$\rm A_g$<0.35 is in general agreement with the picture of poorly reflective giant planets, while the recirculation efficiency $\epsilon>$0.7 makes WASP-178 b an interesting laboratory to test the current heat recirculation models.Comment: Accepted by Astronomy and Astrophysics on 31/08/202