Dasar Program Perencanaan Dan Perancangan Arsitektur (DP3A) Perencanaan Kawasan Publik Space Di Lahan Bekas Terminal Bus Kartasura

Perencanaan Kawasan Public Space Di Lahan Bekas Terminal Bus Kartasura adalah menata atau membangun kembali Terminal Kartasura lama yang sudah tidak terpakai untuk digunakan kembali sebagai ruang public space yang berfungsi untuk mewadahi kegiatan masyarakat Sukoharjo khususnya dan masayarakat Surakarta secara umum sbagai tempat refreshing atau penyegaran yang dapat diakses oleh semua orang tanpa dipungut biaya contohnya untuk tempat jalan-jalan di sore hari, jogging pagi hari, bersepeda, bermain skate board atau hanya sekedar tempat bersantai untuk melepas lelah bagi pengguna jalan yang sedang melintas melewati Kartasura. Merancang kembali bangunan Terminal Kartasura lama menjadi uang public yang mampu mewadahi segala aktifitas semua warga masyarakat dari kalangan usiasebagai tempat penyegaran dan bersantai dari hiruk pikuk pekerjaan sehari-hari, dengan penekanan pada konsep desain arsitektur lansekap dan vegetasi, disertai bangunan-bangunan penunjang aktifitas segala kegiatan pada area tersebut. Menggunakan bahan material pilihan penutup tanah atau lantai yang bersifat soft atau lembut, sehingga para pengunjung tetap merasa nyaman dan sejuk walaupun berada di tempat yang jauh dari vegetasi dan dalam keadaan cuaca yang panas

Pengembangan Digital Book Berbasis Android Materi Perpindahan Kalor Di Sekolah Menengah Atas

ABSTRACT - This research aims to develop Android-based digital book on the material of heat transfer is valid, practical and effective. The background of this research with the learning process less attractive, the interaction process is not running optimally and visualization learning is not maximized. This type of research is the development research. Instruments used in this research is to test the validity of the expert review and test one to one to determine the practicality and field test to determine keefaktifan android-based digital book. Based on the results of pretest performed at the first meeting showed that the average value achieved by students in the pretest was 56.0 with enough categories. Then in the second meeting, after the learning process carried out, held postest gained an average of 81.9 by category Very Good. This represents an increase of 20.31 learning outcomes. Additionally obtained N-Gain of 0.60 indicating that learning by using Digital book android based on the material in this heat transfer effectiveness on student learning outcomes. Then are suggested for further research in order to create a digital book based on android which meets the criteria Stand alone (stand alone) that is not dependent on teaching materials / other media, or should not be used together teaching materials / other media means digital book still uses matter because the sheets can not be incorporated into the test questions interactive digital book. Keyword: Development, Digital book, Heat Transfer ABSTRAK - Penelitian ini bertujuan untuk mengembangkan digital book berbasis android pada materi perpindahan kalor yang valid, praktis dan efektif. Penelitian ini dilatar belakangi dengan proses pembelajaran yang kurang begitu menarik, proses interaksi tidak berjalan maksimal dan visualisasi pembelajaran yang belum maksimal. Jenis penelitian ini adalah penelitian pengembangan (Research Development). Instrumen yang digunakan dalam penelitian ini adalah expert review untuk menguji kevalidan dan uji one to one untuk mengetahui kepraktisan serta field test untuk mengetahui keefaktifan digital book berbasis android. Berdasarkan hasil pretest yang dilakukan pada pertemuan pertama menunjukkan nilai rata-rata yang dicapai siswa pada pretest adalah 56,0 dengan kategori cukup. Kemudian pada pertemuan kedua, setelah proses pembelajaran dilaksanakan, diadakan postest yang didapat rata-rata sebesar 82,2 dengan kategori Sangat Baik. Hal ini memperlihatkan peningkatan hasil belajar sebesar 20,31. Selain itu didapat N-Gain sebesar 0,60 yang menunjukkan bahwa pembelajaran dengan menggunakan Digital book berbasis android pada materi perpindahan kalor ini memiliki keefektifan terhadap hasil belajar siswa. Kemudian di sarankan untuk peneliti selanjutnya agar dapat membuat digital book berbasis android yang memenuhi kriteria Stand alone (berdiri sendiri) yakni tidak tergantung pada bahan ajar/media lain, atau tidak harus digunakan bersama-sama bahan ajar/media lain maksudnya digital book ini masih menggunaan lembaran soal karena belum dapat di padukannya soal test interaktif kedalam digital book. Kata Kunci: Pengembangan, Digital book, Perpindahan Kalo

Quality control and beam test of GEM detectors for future upgrades of the CMS muon high rate region at the LHC

Gas Electron Multipliers (GEM) are a proven position sensitive gas detector technology which nowadays is becoming more widely used in High Energy Physics. GEMs offer an excellent spatial resolution and a high particle rate capability, with a close to 100% detection efficiency. In view of the high luminosity phase of the CERN Large Hadron Collider, these aforementioned features make GEMs suitable candidates for the future upgrades of the Compact Muon Solenoid (CMS) detector. In particular, the CMS GEM Collaboration proposes to cover the high-eta region of the muon system with large-area triple-GEM detectors, which have the ability to provide robust and redundant tracking and triggering functions. In this contribution, after a general introduction and overview of the project, the construction of full-size trapezoidal triple-GEM prototypes will be described in more detail. The procedures for the quality control of the GEM foils, including gain uniformity measurements with an x-ray source will be presented. In the past few years, several CMS triple-GEM prototype detectors were operated with test beams at the CERN SPS. The results of these test beam campaigns will be summarised

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

Accuracy of drug advertisements in medical journals under new law regulating the marketing of pharmaceutical products in Switzerland

<p>Abstract</p> <p>Background</p> <p>New legal regulations for the marketing of pharmaceutical products were introduced in 2002 in Switzerland. We investigated whether claims in drug advertisements citing published scientific studies were justified by these studies after the introduction of these new regulations.</p> <p>Methods</p> <p>In this cross-sectional study, two independent reviewers screened all issues of six major Swiss medical journals published in the year 2005 to identify all drug advertisements for analgesic, gastrointestinal and psychopharmacologic drugs and evaluated all drug advertisements referring to at least one publication. The pharmaceutical claim was rated as being supported, being based on a potentially biased study or not to be supported by the cited study according to pre-specified criteria. We also explored factors likely to be associated with supported advertisement claims.</p> <p>Results</p> <p>Of 2068 advertisements 577 (28%) promoted analgesic, psychopharmacologic or gastrointestinal drugs. Among them were 323 (56%) advertisements citing at least one reference. After excluding multiple publications of the same drug advertisement and advertisements with non-informative references, there remained 29 unique advertisements with at least one reference to a scientific study. These 29 advertisements contained 78 distinct pairs of claims of analgesic, gastrointestinal and psychopharmacologic drugs and referenced studies. Thirty-seven (47%) claims were supported, 16 (21%) claims were not supported by the corresponding reference, and 25 (32%) claims were based on potentially biased evidence, with no relevant differences between drug groups. Studies with conflict of interest and studies stating industry funding were more likely to support the corresponding claim (RR 1.52, 95% CI 1.07–2.17 and RR 1.50, 95% CI 0.98–2.28) than studies without identified conflict of interest and studies without information on type of funding.</p> <p>Conclusion</p> <p>Following the introduction of new regulations for drug advertisement in Switzerland, 53% of all assessed pharmaceutical claims published in major medical journals are not supported by the cited referenced studies or based on potentially biased study information. In light of the discrepancy between the new legislation and the endorsement of these regulations, physicians should not trust drug advertisement claims even when they seem to refer to scientific studies.</p

Evaluation of bacteriophage as an adjunct therapy for treatment of peri-prosthetic joint infection caused by Staphylococcus aureus

Phage therapy offers a potential alternate strategy for the treatment of peri-prosthetic joint infection (PJI), particularly where limited effective antibiotics are available. We undertook preclinical trials to investigate the therapeutic efficacy of a phage cocktail, alone and in combination with vancomycin, to reduce bacterial numbers within the infected joint using a clinically-relevant model of Staphylococcus aureus-induced PJI. Infected animals were randomised to 4 treatment groups, with treatment commencing 21-days post-surgery: bacteriophage alone, vancomycin alone, bacteriophage and vancomycin, and sham. At day 28 post-surgery, animals were euthanised for microbiological and immunological assessment of implanted joints. Treatment with phage alone or vancomycin alone, led to 5-fold and 6.2-fold reductions, respectively in bacterial load within peri-implant tissue compared to shamtreated animals. Compared to sham-treated animals, a 22.5-fold reduction in S. aureus burden was observed within joint tissue of animals that were administered phage in combination with vancomycin, corresponding with decreased swelling in the implanted knee. Microbiological data were supported by evidence of decreased inflammation within the joints of animals administered phage in combination with vancomycin, compared to sham-treated animals. Our findings provide further support for phage therapy as a tolerable and effective adjunct treatment for PJI

Holocene dynamics of the Southern Hemisphere westerly winds and possible links to CO2 outgassing

The Southern Hemisphere westerly winds (SHW) play an important role in regulating the capacity of the Southern Ocean carbon sink. They modulate upwelling of carbon-rich deep water and, with sea ice, determine the ocean surface area available for air–sea gas exchange. Some models indicate that the current strengthening and poleward shift of these winds will weaken the carbon sink. If correct, centennial- to millennial-scale reconstructions of the SHW intensity should be linked with past changes in atmospheric CO2, temperature and sea ice. Here we present a 12,300-year reconstruction of wind strength based on three independent proxies that track inputs of sea-salt aerosols and minerogenic particles accumulating in lake sediments on sub-Antarctic Macquarie Island. Between about 12.1 thousand years ago (ka) and 11.2 ka, and since about 7 ka, the wind intensities were above their long-term mean and corresponded with increasing atmospheric CO2. Conversely, from about 11.2 to 7.2 ka, the wind intensities were below their long-term mean and corresponded with decreasing atmospheric CO2. These observations are consistent with model inferences of enhanced SHW contributing to the long-term outgassing of CO2 from the Southern Ocean

The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms

The upcoming 5th edition of the World Health Organization (WHO) Classification of Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers arising in various organ systems within a single relational database. This paper summarizes the new WHO classification scheme for myeloid and histiocytic/dendritic neoplasms and provides an overview of the principles and rationale underpinning changes from the prior edition. The definition and diagnosis of disease types continues to be based on multiple clinicopathologic parameters, but with refinement of diagnostic criteria and emphasis on therapeutically and/or prognostically actionable biomarkers. While a genetic basis for defining diseases is sought where possible, the classification strives to keep practical worldwide applicability in perspective. The result is an enhanced, contemporary, evidence-based classification of myeloid and histiocytic/dendritic neoplasms, rooted in molecular biology and an organizational structure that permits future scalability as new discoveries continue to inexorably inform future editions