HYBRID CLOUD EXPLOITING THE ASSETS OF BUSINESS VALUE

Cloud is kind of centralized database where numerous clients accumulate their data, recover data and possibly adjust data and it is a representation where user is made available services by Cloud Service Provider on the basis of pay per use.  Numerous organizations are now taking most important steps in the direction of cloud computing. A hybrid cloud is a grouping of both public and private clouds which are bound mutually by either harmonized or proprietary knowledge that facilitates data and application portability. Hybrid clouds present the benefits of outlay and scale of public clouds although also offering the security and organizing of private clouds. Hybrid clouds can be measured an intermediary stage as enterprises organize to progress for the most part of their workloads to public clouds. All along with the characteristic security concerns associated through private clouds, there are several additional factors one should regard in a hybrid environment. Hybrid environments entail both on-premise and public cloud providers, several additional infrastructure security considerations come into the view which is normally related with public clouds

Roller Chain Link Plate design Based on FEA

Most of the time conveyor industry uses chain link assembly, the scope of this paper is to find out the areas where we can increase strength of chain, by reducing its stress concentration with reduction in weight. The paper investigates into various manufacturing features for the same. Finally Finite Element Analysis (FEA) has been used to check out the experimental and software outcomes. Later lot of effort has previously been ended in other constituents, in this development the concentration has been tapered down to specific component of chain. Inside the outer link, most dimensions in the manufacturing are parametrically well-defined. In this paper we measure the impact of change in different constraint and manufacturing methods of outer link on the stress in the structure and see if material saving is thinkable or not

Dielectric relaxation properties of aqueous dimethylamine, trimethylamine and ethylamine using time domain reflectometry technique

The complex permittivity spectra of dimethylamine (40 wt. % in water), trimethylamine (30 wt. % in water) and ethylamine (70 wt. % in water) have been obtained at different temperature using time domain reflectometry technique in the frequency range of 10 MHz-50 GHz. The relaxation mechanism for these systems is described by using Cole-Davidson model. The temperature dependant dielectric relaxation parameters such as static dielectric constant (ε0), relaxation time (τ) and distribution parameter (β) have been obtained by using non-linear least square fit method. The extracted static dielectric constant (ε0) and relaxation time (τ) values have been used to calculate thermodynamic parameter and Kirkwood correlation factor (geff). The enthalpy of activation ∆actH suggests that chemical kinetic is exothermic. Entropy of activation ∆actS suggests that the system is less ordered and Gibbs free energy of activation ∆actG reveals the molecular reorientation for all the three systems. Kirkwood factor for DMA40, TMA30 and EA70 is greater than unity which confirms the hydrogen bond interaction and parallel orientation of dipoles in molecules

Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses.

Mesenchymal tumor subpopulations secrete pro-tumorigenic cytokines and promote treatment resistance1-4. This phenomenon has been implicated in chemorefractory small cell lung cancer and resistance to targeted therapies5-8, but remains incompletely defined. Here, we identify a subclass of endogenous retroviruses (ERVs) that engages innate immune signaling in these cells. Stimulated 3 prime antisense retroviral coding sequences (SPARCS) are oriented inversely in 3' untranslated regions of specific genes enriched for regulation by STAT1 and EZH2. Derepression of these loci results in double-stranded RNA generation following IFN-γ exposure due to bi-directional transcription from the STAT1-activated gene promoter and the 5' long terminal repeat of the antisense ERV. Engagement of MAVS and STING activates downstream TBK1, IRF3, and STAT1 signaling, sustaining a positive feedback loop. SPARCS induction in human tumors is tightly associated with major histocompatibility complex class 1 expression, mesenchymal markers, and downregulation of chromatin modifying enzymes, including EZH2. Analysis of cell lines with high inducible SPARCS expression reveals strong association with an AXL/MET-positive mesenchymal cell state. While SPARCS-high tumors are immune infiltrated, they also exhibit multiple features of an immune-suppressed microenviroment. Together, these data unveil a subclass of ERVs whose derepression triggers pathologic innate immune signaling in cancer, with important implications for cancer immunotherapy

Modelling the Effect of Temperature on Respiration Rate of Fresh Cut Papaya (Carica papaya L.) Fruits.

A respiration rate (RR) model based on Peleg’s equation was developed for predicting RRs of fresh cut papaya. Respiration data for fresh cut papaya at 3/4 maturity were generated at temperatures 5, 10, 15, 20, 25 and 30°C using a closed system. RRs was found to be significantly influenced by storage temperature and increased from 0.021 to 0.289 mL[O2]/kg·h and 0.063 to 0.393 mL[CO2]/kg·h as a function of O2 and CO2 gas concentrations, respectively. Peleg’s constant K 1 and K 2 were obtained from linear regression analysis using GraphPad Prism 5.0 software and regression coefficients have good fit with values close to unity. The model was verified to assess the capability of its predictability of the RRs over the temperatures. There was good agreement with the experimentally estimated RRs. Information derived from the model can contribute in the design of successful modified atmospheric systems for storage of fresh cut papaya

Biomimetic Synthesis of Gelatin Polypeptide-Assisted Noble-Metal Nanoparticles and Their Interaction Study

Herein, the generation of gold, silver, and silver–gold (Ag–Au) bimetallic nanoparticles was carried out in collagen (gelatin) solution. It first showed that the major ingredient in gelatin polypeptide, glutamic acid, acted as reducing agent to biomimetically synthesize noble metal nanoparticles at 80°C. The size of nanoparticles can be controlled not only by the mass ratio of gelatin to gold ion but also by pH of gelatin solution. Interaction between noble-metal nanoparticles and polypeptide has been investigated by TEM, UV–visible, fluorescence spectroscopy, and HNMR. This study testified that the degradation of gelatin protein could not alter the morphology of nanoparticles, but it made nanoparticles aggregated clusters array (opposing three-dimensional α-helix folding structure) into isolated nanoparticles stabilized by gelatin residues. This is a promising merit of gelatin to apply in the synthesis of nanoparticles. Therefore, gelatin protein is an excellent template for biomimetic synthesis of noble metal/bimetallic nanoparticle growth to form nanometer-sized device

Hand disease in scleroderma: a clinical correlate for chronic hand transplant rejection

Chronic rejection remains a potential long-term consequence of hand composite tissue allotransplantation (CTA). Scleroderma has already been proposed as a model for chronic facial allograft rejection based on potential parallels of observed progression of disease and pathophysiology course. This study proposes a similar model for how chronic rejection may manifest itself in the context of hand CTA through the functional and psychological assessment of patients with scleroderma, should it occur

A review of the distribution of particulate trace elements in urban terrestrial environments and its application to considerations of risk

We review the evolution, state of the art and future lines of research on the sources, transport pathways, and sinks of particulate trace elements in urban terrestrial environments to include the atmosphere, soils, and street and indoor dusts. Such studies reveal reductions in the emissions of some elements of historical concern such as Pb, with interest consequently focusing on other toxic trace elements such as As, Cd, Hg, Zn, and Cu. While establishment of levels of these elements is important in assessing the potential impacts of human society on the urban environment, it is also necessary to apply this knowledge in conjunction with information on the toxicity of those trace elements and the degree of exposure of human receptors to an assessment of whether such contamination represents a real risk to the city’s inhabitants and therefore how this risk can be addressed

Suicide in Sri Lanka 1975-2012:age, period and cohort analysis of police and hospital data

BACKGROUND: Sri Lanka has experienced major changes in its suicide rates since the 1970s, and in 1995 it had one of the highest rates in the world. Subsequent reductions in Sri Lanka’s suicide rates have been attributed to the introduction of restrictions on the availability of highly toxic pesticides. We investigate these changes in suicide rates in relation to age, gender, method specific trends and birth-cohort and period effects, with the aim of informing preventative strategies. METHODS: Secular trends of suicide in relation to age, sex, method, birth-cohort and period effects were investigated graphically using police data (1975–2012). Poisoning case-fatality was investigated using national hospital admission data (2004–2010). RESULTS: There were marked changes to the age-, gender- and method-specific incidence of suicide over the study period. Year on year declines in rates began in 17–25 year olds in the early 1980s. Reduction in older age groups followed and falls in all age groups occurred after all class I (the most toxic) pesticides were banned. Distinct changes in the age/gender pattern of suicide are observed: in the 1980s suicide rates were highest in 21–35 year old men; by the 2000s, this pattern had reversed with a stepwise increase in male rates with increasing age. Throughout the study period female rates were highest in 17–25 year olds. There has been a rise in suicide by hanging, though this rise is relatively small in relation to the marked decline in self-poisoning deaths. The patterns of suicides are more consistent with a period rather than birth-cohort effect. CONCLUSIONS: The epidemiology of suicide in Sri Lanka has changed noticeably in the last 30 years. The introduction of pesticide regulations in Sri Lanka coincides with a reduction in suicide rates, with evidence of limited method substitution. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1471-2458-14-839) contains supplementary material, which is available to authorized users