Association of urinary bisphenols and triclosan with thyroid function during early pregnancy

© 2019 The Authors. Background Bisphenols and triclosan are considered as potential thyroid disruptors. While mild alterations in maternal thyroid function can result in adverse pregnancy and child developmental outcomes, there is still uncertainty whether bisphenols or triclosan can interfere with thyroid function during pregnancy. Objectives We aimed to investigate the association of urinary bisphenol A (BPA), bisphenol S (BPS), bisphenol F (BPF) and triclosan with early pregnancy thyroid function. Methods This study was embedded in the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy study (SELMA), a population-based prospective pregnancy cohort. In total, 1996 participants were included in the current study. Maternal urinary concentrations of three bisphenols and triclosan, collected at median (95% range) 10 (6–14) weeks of pregnancy as well as serum concentrations of thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), total thyroxine (TT4), and total triiodothyronine (TT3) were measured. Results Higher BPA levels were associated with lower TT4 concentrations (non-monotonic, P = 0.03), a lower FT4/FT3 ratio (β [SE] -0.02 [0.01], P = 0.03) and a lower TT4/TT3 ratio (β [SE] -0.73 [0.27], P = 0.008). Higher BPF levels were associated with a higher FT3 (β [SE] 0.01 [0.007], P = 0.04). There were no associations between other bisphenols or triclosan and absolute TSH, (F)T4 or (F)T3 concentrations. The association of BPA with thyroid function differed with gestational age. The negative association of BPA with FT4/FT3 and TT4/TT3 ratios was only apparent in early but not late gestation (P for interaction: 0.003, 0.008, respectively). Conclusion These human data during pregnancy substantiate experimental findings suggesting that BPA could potentially affect thyroid function and deiodinase activities in early gestation.European Union of Medical Specialists; European Union's Horizon 2020 Programme for research; echnological development and demonstration; Swedish Research Council; County Council of Värmland, Swede

A patologização do sedentarismo

A identifica????o do sedentarismo como fator de risco para doen??as cr??nico-degenerativas influenciou significativamente nas recomenda????es de sa??de p??blica em defesa de estilos de vida fisicamente ativos. O artigo estuda o processo de patologiza????o do sedentarismo e seus desdobramentos para o campo da sa??de p??blica. Num primeiro momento, discutimos de que maneira o modelo biom??dico serve de base para a transposi????o de aspectos da conduta humana como ???fator de risco??? e, a seguir, como patologia, tal qual no caso espec??fico da ???S??ndrome da Morte Sedent??ria???, assim classificada por alguns autores. Em seguida, analisamos como essa vis??o vem sendo difundida no campo da sa??de, tomando por base um programa institucional que, ao mesmo tempo em que transforma o sedentarismo em doen??a, apresenta a atividade f??sica como um rem??dio cujos resultados podem se estender a todas as esferas da vida. Nessa linha de racioc??nio, em que os mal-estares de nossa civiliza????o s??o medicalizados e tornados mercadoria ao serem transformados em riscos e patologias, a atividade f??sica torna-se vacina para o corpo social.The identification of physical inactivity as a risk factor for chronic degenerative diseases has significantly influenced public health recommendations in support of physically active lifestyles. This study analyzes the pathologization of sedentariness and its implications in the public health field. First we discuss how the biomedical model serves as a basis to transform aspects of human behavior into ???risk factors??? and subsequently into pathologies such as the ???Sedentary Death Syndrome???, as some authors classify it. Second, we analyze how this view is being spread in the health field; our analysis is based on an institutional program which transforms sedentariness into illness while presents physical activity as a medicine whose results can reach all aspects of life. According to this rationale, in which the discomforts of our civilization are medicalized and made into commodities as they are transformed into risks and pathologies, physical activity becomes a vaccine to be applied to the social body

First Sagittarius A* Event Horizon Telescope results. I. The shadow of the supermassive black hole in the center of the Milky Way

Galaxie

First Sagittarius A* event horizon telescope results. II. EHT and multiwavelength observations, data processing, and calibration

Instrumentatio