Inter-regional spillover of China's sulfur dioxide (SO2) pollution across the supply chains

Inter-regional spillover of air pollution can be regarded as a mixture of economic externalities and long-distance transport. To comprehensively reveal this problem, a new consumption-based sulfur dioxide (SO 2) emission inventory in 2010 for 30 provincial regions of China was compiled by introducing source-receptor relationship (SRR) model to integrate the spillover impacts of physical transport from the emitter (producer) region to the receptor region and virtual transfer from the driver (consumer) region to the emitter region. Compared the emissions induced by final regional demand with the emissions received in seven regions of China, Southern (0.59 Mt), Northern (0.25 Mt), Northwestern (0.18 Mt), and Eastern (0.14 Mt) areas outsourced SO 2 pollution in the mass, whereas Central (−0.66 Mt), Northeastern (−0.42 Mt), and Southwestern (−0.08 Mt) areas took excessive environmental burdens in 2010. The four municipalities, Chongqing, Shanghai, Beijing, and Tianjin as well as the most affluent province Guangdong showed significant pollution transfer after an overall assessment of their roles in drivers, emitters and receptors. Shanxi, Inner Mongolia, Guizhou, Henan, and Shandong showed the largest co-benefits of SO 2 emissions control for climate change mitigation. Japan was found to receive more portions of transboundary SO 2 deposition than its market shares in China's export instead of other major trade partners of China. As a mega-city, Beijing induced significant SO 2 emissions for power requirement, food consumption, miscellaneous services, and her vibrant research activities through the sectors of the power industry, coal mining, chemical manufacturing, food-related industries, petroleum processing and coking, but 86% of those emissions were outsourced by Beijing. In total, the spillover of SO 2 emissions induced by Beijing was estimated at 0.20 Mt, 76 times more than its own share as a receptor across the supply chains. This study is competent for an analytic framework of strategic planning for joint prevention and control of air pollution in China and other countries. The results can help reduce pollution transfer, properly tax on drivers, effectively control the emitters, and reasonably compensate the receptors

Mineral Resources: Stocks, Flows, and Prospects

This chapter focuses on metals as they provide the clearest example of the challenges and opportunities that mineral resources present to society, in terms of both primary production and recycling. Basic concepts, information requirements and sources of consumer and industrial resource demand are described as well as the destabilizing effects of volatile resource prices and supply chain disruptions. Challenges facing extraction of in-ground resources and production of secondary resources are discussed and scenarios for the future considered. The results of the scenarios indicate that particularly energy and, as well, water and land requirements could become increasingly constraining factors for metal production. Key research questions are posed and modeling and data priorities discussed, with an emphasis on areas that require novel concepts and analytic tools to help lessen negative environmental impacts associated with minerals. The challenge of sustainability requires collaboration of practitioners and analysts with a multidisciplinary understanding of a broad set of issues, including economics, engineering, geology, ecology, and mathematical modeling, to name a few, as well as policy formulation and implementation.

Life-cycle assessment of domestic and transboundary recycling of post-consumer PET bottles

Abstract Background, aim, and scope In recent years, besides being recycled domestically, a part of Japanese post-consumer polyethylene terephthalate (PET) bottles have been exported to and recycled in mainland China. In this study, life-cycle assessment (LCA) was applied to compare domestic and transboundary recycling scenarios between Japan and China and disposal scenarios from the viewpoints of greenhouse gases (GHG) emission and fossil resource consumption. Methods The following 10 scenarios based on our field surveys were evaluated: Japanese post-consumer PET bottles are (i) recycled into polyester staple in Japan, (ii) recycled into polyester filaments in Japan, (iii) recycled into polyester clothes in Japan, (iv) chemically decomposed and recycled into bottle-grade PET resin in Japan, (v) chemically decomposed and recycled into polyester filaments in Japan, (vi)-(vii) recycled into polyester staple via two different flows in China, (viii) recycled into polyester clothes in China, (ix) incinerated and partly recovered as electricity in Japan, and (x) directly landfilled in Japan. In all the evaluated scenarios, the functional unit is the recycling or disposal of 1 kg of Japanese post-consumer PET bottles. The system boundaries range from waste collection by municipalities to the manufacture of recycled products that can be regarded as substitutes for virgin products, and a credit for the avoided production of equivalent virgin products is given to each scenario. The inventories of both foreground and background processes in Japan were quoted from published reports and databases. The actual conditions of PET bottle recycling that were obtained through field surveys in China were reflected to some inventories of foreground processes in China. The inventories of public electricity supplies in China were based on the national statistics, and the inventories of petroleum products, industrial water supply, and waste treatment are based on our field surveys in China. Other unknown inventories in China were substituted by corresponding inventories in Japan. Results and discussion The results showed that all the domestic and transboundary recycling scenarios had smaller GHG emissions and fossil resource consumptions than the incineration scenario and that the chemical recycling scenarios had larger GHG emissions and fossil resource consumptions than the other recycling scenarios. The landfilling scenario had the largest fossil resource consumption, while it was better than the incineration scenario and slightly better than the chemical recycling scenarios from the viewpoint of GHG emission. The robustness of the results was examined, and it was found that the differences in GHG emission and fossil resource consumption between the domestic and transboundary recycling scenarios, other than the scenarios including cloth-manufacturing processes in system boundaries, were sufficiently large to be robust against the variability of background parameters for electricity supplies. As for the Responsible editor: Shabbir Gheewala Electronic supplementary material The online version of this articl

Decreased activity in the reward network of chronic insomnia patients

In modern society, many people have insomnia. Chronic insomnia has been noted as a risk factor for depression. However, there are few functional imaging studies of the brain on affective functions in chronic insomnia. This study aimed to investigate brain activities induced by emotional stimuli in chronic insomnia patients. Fifteen patients with primary insomnia and 30 age and gender matched healthy controls participated in this study. Both groups were presented images of fearful, happy, and neutral expressions consciously and non-consciously while undergoing MRI to compare the activity in regions of the brain responsible for emotions. Conscious presentation of the Happy-Neutral contrast showed significantly lower activation in the right orbitofrontal cortex of patients compared to healthy controls. The Happy-Neutral contrast presented in a non-conscious manner resulted in significantly lower activation of the ventral striatum, right insula, putamen, orbitofrontal cortex and ventral tegmental area in patients compared to healthy controls. Our findings revealed that responsiveness to positive emotional stimuli were decreased in insomniac patients. Specifically, brain networks associated with rewards and processing positive emotions showed decreased responsiveness to happy emotions especially for non-conscious image. The magnitude of activity in these areas also correlated with severity of insomnia, even after controlling for depression scale scores. These findings suggest that insomnia induces an affective functional disorder through an underlying mechanism of decreased sensitivity in the regions of the brain responsible for emotions and rewards to positive emotional stimuli

STRAD Project for Systematic Treatments of Radioactive Liquid Wastes Generated in Nuclear Facilities

A new collaborative research project for systematic treatments of radioactive liquid wastes containing various reagents generating in nuclear facilities was started from 2018 initiated by Japan Atomic Energy Agency. The project was named as STRAD (Systematic Treatments of RAdioactive liquid wastes for Decommissioning) project. Tentative targets to be studied under the project are aqueous and organic liquid wastes which have been generated by experiments and analyses in a reprocessing experimental laboratory of JAEA. Currently fundamental studies for treatments of the liquid wastes with complicated compositions are underway. In the STRAD project, process flow for treatment of ammonium ion involved in aqueous waste was designed though the inactive experiments, and decomposition of ammonium ion using catalysis will be carried out soon. Adsorbents for recovery of U and Pu from spent solvent were also developed. Demonstration experiments on genuine spent solvent is under planning

Genetic and clinical landscape of breast cancers with germline BRCA1/2 variants

遺伝性乳癌の遺伝学的・臨床学的特徴を解明 --BRCA1/2 変異乳癌は両アレルの不活化の有無により異なった特徴を持つ--. 京都大学プレスリリース. 2020-10-26.The genetic and clinical characteristics of breast tumors with germline variants, including their association with biallelic inactivation through loss-of-heterozygosity (LOH) and second somatic mutations, remain elusive. We analyzed germline variants of 11 breast cancer susceptibility genes for 1, 995 Japanese breast cancer patients, and identified 101 (5.1%) pathogenic variants, including 62 BRCA2 and 15 BRCA1 mutations. Genetic analysis of 64 BRCA1/2-mutated tumors including TCGA dataset tumors, revealed an association of biallelic inactivation with more extensive deletions, copy neutral LOH, gain with LOH and younger onset. Strikingly, TP53 and RB1 mutations were frequently observed in BRCA1- (94%) and BRCA2- (9.7%) mutated tumors with biallelic inactivation. Inactivation of TP53 and RB1 together with BRCA1 and BRCA2, respectively, involved LOH of chromosomes 17 and 13. Notably, BRCA1/2 tumors without biallelic inactivation were indistinguishable from those without germline variants. Our study highlights the heterogeneity and unique clonal selection pattern in breast cancers with germline variants

Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.

Reactive aldehydes arise as by-products of metabolism and are normally cleared by multiple families of enzymes. We find that mice lacking two aldehyde detoxifying enzymes, mitochondrial ALDH2 and cytoplasmic ADH5, have greatly shortened lifespans and develop leukemia. Hematopoiesis is disrupted profoundly, with a reduction of hematopoietic stem cells and common lymphoid progenitors causing a severely depleted acquired immune system. We show that formaldehyde is a common substrate of ALDH2 and ADH5 and establish methods to quantify elevated blood formaldehyde and formaldehyde-DNA adducts in tissues. Bone-marrow-derived progenitors actively engage DNA repair but also imprint a formaldehyde-driven mutation signature similar to aging-associated human cancer mutation signatures. Furthermore, we identify analogous genetic defects in children causing a previously uncharacterized inherited bone marrow failure and pre-leukemic syndrome. Endogenous formaldehyde clearance alone is therefore critical for hematopoiesis and in limiting mutagenesis in somatic tissues