Ilha de santiago (Cabo Verde) - Notas Florísticas e Fitogeográficas

Dez taya (Achyranthes aspera var.pubescens, Andropogon/astigiatus, Anthephora cristata, Cenchrus bgorus, Chamaecrista mimosoides, Commelina d~@sa subsp. d$iia, Forsskaolea viridis, Tephrosia linearis, Tolpis/arinulosa e Stylosanthes humilis) sãom encionadopse lap rimeirav ez paraS antiagoE. stacitacáo constitui também,p ara4 deles,a suap rimeirar eferencia para o arquipélagod e CaboV erde. A ~orrkcia de espéciese ndémicasc,u ja presentan estai lha não era verificada desdeh á longa data, é ylientada. Pelo valor dasc omunidadevse getaisq uen eleso correm, sãor eferidosa lgunslo caisp articti+nente importantes.biJorus, Chamaecrista mimosoides, Commelina dl@ia subsp. d@úsa, Forsskaolea viridis, Tephrosia finearis, To~pisfürinulosa and Stylosanthes humilis) are quoted for the first time to Santiago, being ‘four of them unknown in the Cape Verde archipelago. It is remarked the observation of endemic species which :presente, although known in this island, where not seen for a long time. In reasori of its interesting plant communities,it is referred somei mportants ites

Efeito de práticas parentais de controlo alimentar na ingestão de hortofrutícolas em crianças em idade pré-escolar

[resumo][abstract

Nystagmus in a newborn: a manifestation of Joubert syndrome in the neonatal period.

Joubert syndrome is a rare disorder, usually autosomal recessive, with a prevalence of 1:80 000 to 1:100 000. This disease presents most commonly as breathing irregularities, although the two major clinical criteria are hypotonia and developmental delay, sometimes associated with ocular movement abnormalities. The severity of the presentation varies, ranging from mild cases with normal intelligence to severe developmental delays associated with early death. We report a case of a newborn who presented to the emergency department for absent ocular fixation and torsional nystagmus without other neurological abnormalities. Her cranial MR showed cerebellar vermis agenesis and a molar tooth sign. Her laboratory evaluation, and renal and abdominal ultrasound were normal. An electroretinogram showed mixed retinal dystrophy and an AHI1 homozygous missense c.1981T>C mutation was identified (parents are carriers). Throughout infancy, she has shown mild developmental delay and hypotonia, but no respiratory abnormalities. Owing to variable expressivity, a high level of suspicion is required

Flora das Culturas Agrícolas da Ilha de Santiago (cabo Verde)

Com o objectivo de caracterizar as comunidades vegetais que acompanham as culturas agrícolas de sequeiro e de regadio praticadas em Santiago e, particularmente, no vale da ribeira Seca, efectuaram-se 16 levantamentos titoecológicos ao longo deste curso de água e encostas sobranceiras. A inventaria@0 floristica revelou a presenta de 118 taro pertencenteas 3 3 familias. Analisaram-sea, inda,6 2 levantamentorse alizadose m diversosp ontosd a ilha, tendo sido identificados1 72t axa pertencenteas 42 familiasG. ramineae. Leguminosae e Compositue sao as famílias melhor representadasA. flora inventariadaC comparadac om a referida em trabalhos precedentesr,e alizadosp or outrosa utores,r evelandolao correnciad e, pelo menos,1 82t axa na flora infestante. Os levantamentos da ribeira Seca foram analisadosa travt5sd o programad e análise numérica TWINSPAN, que indicou a presentad e 4 agrupamentosv egetais distintos, cuja interpretacao,a tendendoà s característicase dáticas,c limáticase topográticasd os locais onde ocorrem,s ugeriua disponibilidadeh idrica comoo factorm aisd eterminantde as uac omposicáo. Palavras-chavefl:o ra, adventiciasd asc ulturasT, WINSPAN, ilhasd eC aboV erde, Santiago. In order to identify and to characterizeth e plant communitiesp resenat t the irrigated and dry cropso f ribeira Secav alley, it were established16 s amplep lots. The tloristic inventory has revealedt he presenteo f 118 tara belongingt o 33 families.I n addition,m ore 62 samplep lots,were establishedth roughoutt he island,w hich permittedt he identifkation of 172t ara from 42 families.G ramineae, CompQsitae &ndL eguminosae weret he mostr epresentativeosn es.T his flora is comparedw ith that referred in precedingw orksf rom othersa uthors,r evealingt he occurrence of, at least, 182 tma in the weed flora. The application of the TWINSPAN numerical analysis, to the plots in the ribeira Seca vallcy. has revealed the presente of 4 distinct plant communities, which were related with edaphic,c limatic and topographicf actors.T his analysiss uggestetdh at the water availability wa.s the mainf actor affecting the speciesc ompositionof the communities. Key-words:f lora weedsT, WINSPAN, CapeV erdei slandsS, antiago

Evolution of Drug Resistance: Insight on TEM β-Lactamases Structure and Activity and β-Lactam Antibiotics

Since the discovery of the first penicillin bacterial resistance to β-lactam antibiotics has spread and evolved promoting new resistances to pathogens. The most common mechanism of resistance is the production of β-lactamases that have spread thorough nature and evolve to complex phenotypes like CMT type enzymes. New antibiotics have been introduced in clinical practice, and therefore it becomes necessary a concise summary about their molecular targets, specific use and other properties. β-lactamases are still a major medical concern and they have been extensively studied and described in the scientific literature. Several authors agree that Glu166 should be the general base and Ser70 should perform the nucleophilic attack to the carbon of the carbonyl group of the β-lactam ring. Nevertheless there still is controversy on their catalytic mechanism. TEMs evolve at incredible pace presenting more complex phenotypes due to their tolerance to mutations. These mutations lead to an increasing need of novel, stronger and more specific and stable antibiotics. The present review summarizes key structural, molecular and functional aspects of ESBL, IRT and CMT TEM β-lactamases properties and up to date diagrams of the TEM variants with defined phenotype. The activity and structural characteristics of several available TEMs in the NCBI-PDB are presented, as well as the relation of the various mutated residues and their specific properties and some previously proposed catalytic mechanisms