Inspection and repair considerations for downtime assessment of seismically isolated buildings

Data availability: Data will be made available on request.Copyright © 2022 The Authors. This paper investigates the seismic downtime of seismically isolated buildings with steel moment or braced frames designed by the procedures of ASCE/SEI 7–16. The seismic isolation systems considered in this study are comprised of triple or double friction pendulum isolation bearings with and without moat walls. The seismic downtime is calculated from the damage to structural components and non-structural components, demolition and collapse of buildings. The downtime components (repair and inspection) are defined, and mathematical expressions are provided for the computation of downtime fragility curves, expected annual downtime, and economic losses due to the expected annual downtime. The procedure is then implemented using the results of nonlinear response history analysis from previous studies by the first author. The study demonstrates that the expected annual downtime of seismically isolated buildings is less than that of the comparable non-isolated buildings regardless of the seismic isolation systems used. Among the cases of seismically isolated buildings studied in this paper, it is found that the most effective structural system to mitigate long downtime is the seismically isolated building with seismic isolators with enhanced sizes and with braced frames that are designed to be minimally compliant with the seismic design requirements of ASCE/SEI 7–16

Kub5-Hera(RPRD1B) deficiency promotes “BRCAness” and vulnerability to PARP inhibition in BRCA-proficient breast cancers

Purpose: Identification of novel strategies to expand the use of PARP inhibitors beyond BRCA deficiency is of great interest in personalized medicine. Here, we investigated the unannotated role of Kub5-Hera(RPRD1B) (K-H) in homologous recombination (HR) repair and its potential clinical significance in targeted cancer therapy. Experimental Design: Functional characterization of K-H alterations on HR repair of double-strand breaks (DSB) were assessed by targeted gene silencing, plasmid reporter assays, immunofluorescence, and Western blots. Cell survival with PARP inhibitors was evaluated through colony-forming assays and statistically analyzed for correlation with K-H expression in various BRCA1/2 nonmutated breast cancers. Gene expression microarray/qPCR analyses, chromatin immunoprecipitation, and rescue experiments were used to investigate molecular mechanisms of action. Results: K-H expression loss correlates with rucaparib LD50 values in a panel of BRCA1/2 nonmutated breast cancers. Mechanistically, K-H depletion promotes BRCAness, where extensive upregulation of PARP1 activity was required for the survival of breast cancer cells. PARP inhibition in these cells led to synthetic lethality that was rescued by wild-type K-H reexpression, but not by a mutant K-H (p.R106A) that weakly binds RNAPII. K-H mediates HR by facilitating recruitment of RNAPII to the promoter region of a critical DNA damage response and repair effector, cyclin-dependent kinase 1 (CDK1). Conclusions: Cancer cells with low K-H expression may have exploitable BRCAness properties that greatly expand the use of PARP inhibitors beyond BRCA mutations. Our results suggest that aberrant K-H alterations may have vital translational implications in cellular responses/survival to DNA damage, carcinogenesis, and personalized medicine. (C) 2018 AACR

Impacto de un programa de ejercicio sobre la Autoeficacia en mujeres con sobrepeso y obesidad

Introducción: En México la prevalencia combinada de sobrepeso y obesidad en muje- res es de 73%, problema de salud pública que se relaciona con las principales causas de muerte. Las principales estrategias se realizan a través de la práctica de ejercicio y alimentación saludable; sin embargo, no se ha tenido el impacto deseado; es necesario obtener indicadores cognitivos para fortalecer las estrategias de salud.Objetivo: Analizar el impacto de un programa de entrenamiento físico aeróbico gradual sobre el nivel de Autoeficacia (AE) para practicar ejercicio y dieta saludable en mujeres con sobrepeso y obesidad.Material y métodos: Se trató de un experimento en el que se incluyeron mujeres de 18 a 24 años con un IMC≥27. La muestra se conformó por 34 mujeres divididas en los grupos control y experimental (17 mujeres respectivamente), seleccionadas y asignadas median- te muestreo aleatorio. Las mediciones se realizaron mediante un inventario valido y con- fiable que mide la AE en dieta y ejercicio. La dosis de ejercicio fue calculada por la fórmula de Karvonen durante diez semanas de manera gradual y controlada. El estadístico utiliza- do fue un MANOVA de mediciones repetidas, se consideró un nivel de significancia <.05. Resultados: Posterior a la intervención se apreciaron cambios estadísticamente signi- ficativos, AE en ejercicio 40.3±4.0 vs. 35.8±5.4; y AE en dieta 85.8±10.5 vs. 78.8±10.7 (p<.05).Conclusiones: El ejercicio a la dosis establecida mejoró la condición de AE que favoreció la práctica de ejercicio y la dieta saludable en mujeres con sobrepeso y obesidad

Impacto de un programa de ejercicio sobre la Autoeficacia en mujeres con sobrepeso y obesidad

Introducción: En México la prevalencia combinada de sobrepeso y obesidad en muje- res es de 73%, problema de salud pública que se relaciona con las principales causas de muerte. Las principales estrategias se realizan a través de la práctica de ejercicio y alimentación saludable; sin embargo, no se ha tenido el impacto deseado; es necesario obtener indicadores cognitivos para fortalecer las estrategias de salud.Objetivo: Analizar el impacto de un programa de entrenamiento físico aeróbico gradual sobre el nivel de Autoeficacia (AE) para practicar ejercicio y dieta saludable en mujeres con sobrepeso y obesidad.Material y métodos: Se trató de un experimento en el que se incluyeron mujeres de 18 a 24 años con un IMC≥27. La muestra se conformó por 34 mujeres divididas en los grupos control y experimental (17 mujeres respectivamente), seleccionadas y asignadas median- te muestreo aleatorio. Las mediciones se realizaron mediante un inventario valido y con- fiable que mide la AE en dieta y ejercicio. La dosis de ejercicio fue calculada por la fórmula de Karvonen durante diez semanas de manera gradual y controlada. El estadístico utiliza- do fue un MANOVA de mediciones repetidas, se consideró un nivel de significancia <.05. Resultados: Posterior a la intervención se apreciaron cambios estadísticamente signi- ficativos, AE en ejercicio 40.3±4.0 vs. 35.8±5.4; y AE en dieta 85.8±10.5 vs. 78.8±10.7 (p<.05).Conclusiones: El ejercicio a la dosis establecida mejoró la condición de AE que favoreció la práctica de ejercicio y la dieta saludable en mujeres con sobrepeso y obesidad

Simonsenia aveniformis sp nov (Bacillariophyceae), molecular phylogeny and systematics of the genus, and a new type of canal raphe system

The genus Simonsenia is reviewed and S. aveniformis described as new for science by light and electron microscopy. The new species originated from estuarine environments in southern Iberia (Atlantic coast) and was isolated into culture. In LM, Simonsenia resembles Nitzschia, with bridges (fibulae) beneath the raphe, which is marginal. It is only electron microscope (EM) examination that reveals the true structure of the raphe system, which consists of a raphe canal raised on a keel (wing), supported by rib like braces (fenestral bars) and tube-like portulae; between the portulae the keel is perforated by open windows (fenestrae). Based on the presence of portulae and a fenestrated keel, Simonsenia has been proposed to be intermediate between Bacillariaceae and Surirellaceae. However, an rbcL phylogeny revealed that Simonsenia belongs firmly in the Bacillariaceae, with which it shares a similar chloroplast arrangement, rather than in the Surirellaceae. Lack of homology between the surirelloid and simonsenioid keels is reflected in subtle differences in the morphology and ontogeny of the portulae and fenestrae. The diversity of Simonsenia has probably been underestimated, particularly in the marine environment.Polish National Science Centre in Cracow within the Maestro program [N 2012/04/A/ST10/00544]; Sciences and Technologies Foundation-FCT (Portugal) [SFRH/BD/62405/2009]info:eu-repo/semantics/publishedVersio

An RxLR effector from phytophthora infestans prevents re-localisation of two plant NAC transcription factors from the endoplasmic reticulum to the nucleus

The plant immune system is activated following the perception of exposed, essential and invariant microbial molecules that are recognised as non-self. A major component of plant immunity is the transcriptional induction of genes involved in a wide array of defence responses. In turn, adapted pathogens deliver effector proteins that act either inside or outside plant cells to manipulate host processes, often through their direct action on plant protein targets. To date, few effectors have been shown to directly manipulate transcriptional regulators of plant defence. Moreover, little is known generally about the modes of action of effectors from filamentous (fungal and oomycete) plant pathogens. We describe an effector, called Pi03192, from the late blight pathogen Phytophthora infestans, which interacts with a pair of host transcription factors at the endoplasmic reticulum (ER) inside plant cells. We show that these transcription factors are released from the ER to enter the nucleus, following pathogen perception, and are important in restricting disease. Pi03192 prevents the plant transcription factors from accumulating in the host nucleus, revealing a novel means of enhancing host susceptibility

Physical and Electrical Performance of Vapor–Solid Grown ZnO Straight Nanowires

Physical and electrical properties of wurtzitic ZnO straight nanowires grown via a vapor–solid mechanism were investigated. Raman spectrum shows four first-order phonon frequencies and a second-order Raman frequency of the ZnO nanowires. Electrical and photoconductive performance of individual ZnO straight nanowire devices was studied. The results indicate that the nanowires reported here are n-type semi-conductors and UV light sensitive, and a desirable candidate for fabricating UV light nanosensors and other applications

Primary Language and Receipt of Recommended Health Care Among Hispanics in the United States

BackgroundDisparities in health care services between Hispanics and whites in the United States are well documented.ObjectiveThe objective of the study was to determine whether language spoken at home identifies Hispanics at risk for not receiving recommended health care services.DesignThe design of the study was cross-sectional, nationally representative survey of households.PatientsThe patients were non-Hispanic white and Hispanic adults participating in the 2003 Medical Expenditure Panel Survey.MeasurementsWe compared receipt of ten recommended health care services by ethnicity and primary language adjusting for demographic and socioeconomic characteristics, health status, and access to care.ResultsThe sample included 12,706 whites and 5,500 Hispanics. In bivariate comparisons, 57.0% of whites received all eligible health care services compared to 53.6% for Hispanics who spoke English at home, 44.9% for Hispanics who did not speak English at home but who were comfortable speaking English, and 35.0% for Hispanics who did not speak English at home and were uncomfortable speaking English (p < .001). In multivariate logistic models, compared to non-Hispanic whites, Hispanics who did not speak English at home were less likely to receive all eligible health care services, whether they were comfortable speaking English (risk ratio [RR] 0.88, 95% confidence interval [CI] 0.74-0.97) or not (RR 0.84, 95% CI 0.68-0.95).ConclusionsSpeaking a language other than English at home identified Hispanics at risk for not receiving recommended health care services, whether they were comfortable in speaking English or not. Identifying the mechanism for disparities by language usage may lead to interventions to reduce ethnic disparities

Consumption of single cigarettes and quitting behavior: A longitudinal analysis of Mexican smokers

<p>Abstract</p> <p>Background</p> <p>Previous cross-sectional research has suggested single cigarettes could either promote or inhibit consumption. The present study aimed to assess the effects of single cigarette availability and consumption on downstream quit behavior.</p> <p>Methods</p> <p>We analyzed population-based, longitudinal data from adult smokers who participated in the 2008 and 2010 administrations of the International Tobacco Control Policy Evaluation Survey in Mexico.</p> <p>Results</p> <p>At baseline, 30% of smokers saw single cigarettes for sale on a daily basis, 17% bought singles at their last purchase, and 7% bought singles daily. Smokers who most frequently purchased singles, both in general and specifically to control their consumption, were no more likely to attempt to quit over the 14 month follow-up period than those who did not purchase singles. Frequency of buying singles to reduce consumption had a non-monotonic association with being quit at followup. The odds of being quit was only statistically significant when comparing those who had not bought singles to reduce consumption with those who had done so on a more irregular basis (AOR = 2.30; 95% CI 1.19, 4.45), whereas those who did so more regularly were no more likely to be quit at followup. Frequency of self-reported urges to smoke upon seeing singles for sale was unassociated with either quit attempts or being quit at followup.</p> <p>Conclusions</p> <p>These results suggest that the relationship between singles consumption and quit behavior is complex, with no clear evidence that singles either promote or inhibit downstream quit behavior.</p