459 research outputs found

    Representaciones sobre clima creativo: una perspectiva de alumnos y profesores de educación primaria en escuelas públicas y privadas de Portugal

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    A criatividade é assumida como conceito relevante no contexto educativo. Este estudo analisou diferenças nas representações em professores de escolas públicas e privadas sobre condições favoráveis e desfavoráveis à criatividade no seu ambiente de trabalho, assim como nas representações de clima criativo em sala de aula pelos alunos desses tipos de escola. Participaram 202 alunos portugueses dos 3º e 4º anos do ensino básico e 72 professores. Os dados dos alunos foram recolhidos por meio da Escala sobre o Clima para a Criatividade em Sala de Aula e usou-se, para os professores, o Questionário Indicadores de Clima para a Criatividade no Ambiente de Trabalho. Os resultados revelam, para os alunos, diferenças significativas em alguns fatores, apresentando o ensino público valores superiores. Em relação aos professores, emergiram diferenças significativas em dois fatores, havendo superioridade do ensino privado nas condições favoráveis à criatividade e do ensino público nos bloqueios a esta.Creativity is assumed as a relevant concept in education. This study analyses differences in the representations of favorable and unfavorable conditions for creativity in the workplace by teachers from Portuguese public and private schools, and differences in representations of creative climate in the classroom of the 3rd and 4th grades of basic school, as well as 72 teachers. Data was collected through Scale Environment for Creativity in the Classroom in the case of students; in the case of teachers, we utilized the Questionnaire Indicators of Climate for Creativity in the Workplace. For the students, results show significant differences in several dimensions, presenting public schools higher values. In the case of teachers, emerged significant differences considering favorable conditions for creativity (higher values from private schools) and obstructions to creativity (higher values from public schools).La creatividad es asumida como un concepto relevante en el contexto educativo. Este estudio examinó diferencias en las representaciones en profesores de escuelas públicas y privadas sobre condiciones favorables y desfavorables a la creatividad en su ambiente de trabajo, así como en las representaciones de clima creativo en el aula por los alumnos de esos tipos de escuela. Participaron 202 alumnos portugueses del 3 º y 4 º año de enseñanza primaria y 72 profesores. Los datos de los estudiantes fueron recogidos a través de la Escala sobre el Clima de Creatividad en el Aula y se utilizó para los profesores el Cuestionario de Indicadores del Clima para la Creatividad en el Ambiente de Trabajo. Los resultados muestran, para los alumnos, diferencias significativas en algunos factores, presentando la enseñanza pública valores más altos. En los profesores, surgieron diferencias significativas en los dos factores, habiendo superioridad de la enseñanza privada en las condiciones favorables a la creatividad y de la enseñanza pública en los bloqueos a ésta.info:eu-repo/semantics/publishedVersio

    Comparative Cr, As and CCA induced Cytostaticity in mice kidney: a contribution to assess CCA toxicity

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    CCA (Chromium Copper Arsenate) treated wood, widely used in outdoor residential structures and playgrounds, poses considerable dangers of leaching of its components to the environment. In this study, mouse kidney samples were used to evaluate the effects of CCA, chromium trioxide (CrO3) and arsenic pentoxide (As2O5) on cell pathophysiology by flow cytometry. Samples were collected after 14, 24, 48 and 96 h of animal exposure. While Cr had no statistically significant cytostatic effects, As2O5 induced a S-phase delay in animals exposed for 24 h, and over time a G0/G1 phase blockage. The effects of CCA in S-phase were similar, but more severe than those of As2O5. Since environmental and public health hazards due to the long durability of CCA-treated wood products, these data confirm that CCA has profoundly toxic effects on cell cycle, distinct from the compounds themselves. These cytostatic effects support cell cycle dynamics as a valuable endpoint to assess the toxicity of remaining CCA-treated infrastructures, and the expected increased waste stream over the coming decades.publishe

    Antiparasitic Activity of Natural and Semi-Synthetic Tirucallane Triterpenoids from Schinus terebinthifolius (Anacardiaceae): Structure/Activity Relationships

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    Leishmaniasis and Chagas are diseases caused by parasitic protozoans that affect the poorest population in the World, causing a high mortality and morbidity. As a result of highly toxic and long-term treatments, the discovery of novel, safe and more efficacious drugs is essential. in this work, the in vitro antiparasitic activity and mammalian cytotoxicity of three natural tirucallane triterpenoids, isolated from leaves of Schinus terebinthifolius (Anacardiaceae), and nine semi-synthetic derivatives were investigated against Leishmania (L.) infantum and Trypanosoma cruzi. Trypomastigotes of T. cruzi were the most susceptible parasites and seven compounds demonstrated a trypanocidal activity with IC50 values in the range between 15 and 58 mu g/mL. Four compounds demonstrated selectivity towards the intracellular amastigotes of Leishmania, with IC50 values in the range between 28 and 97 mu g/mL. the complete characterization of triterpenoids was afforded after thorough analysis of nuclear magnetic resonance (NMR) data as well as electrospray ionization mass spectrometry (ESI-MS). Additionally, structure-activity relationships were performed using Decision Trees.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)Universidade Federal de São Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Diadema, SP, BrazilAdolfo Lutz Inst, Ctr Parasitol, BR-01246902 São Paulo, BrazilUniv Fed Paraiba, Ctr Ciencias Aplicadas & Educ, BR-58297000 Rio Tinto, BrazilUniv Fed Uberlandia, Inst Quim, BR-38400902 Uberlandia, MG, BrazilUniversidade Federal de São Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Diadema, SP, BrazilCNPq: 300546/2012-2CNPq: 471458/2012-0FAPESP: 2011/51739-0FAPESP: 2012/18756-1FAPESP: 2013/16320-4Web of Scienc
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