IRAS 23385+6053: a candidate protostellar massive object

We present the results of a multi-line and continuum study towards the source IRAS 23385+6053,performed with the IRAM-30m telescope, the Plateau de Bure Interferometer, the Very Large Array Interferometer and the James Clerk Maxwell Telescope. The new results confirm our earlier findings, namely that IRAS 23385+6053 is a good candidate high-mass protostellar object, precursor of an ultracompact H$_{II}$ region. The source is roughly composed of two regions: a molecular core $\sim0.03\div0.04$ pc in size, with a temperature of $\sim40$ K and an H$_{2}$ volume density of the order of 10$^{7}$ cm$^{-3}$, and an extended halo of diameter $\leq$0.4 pc, with an average kinetic temperature of $\sim 15$ K and H$_{2}$ volume density of the order of 10$^{5}$ cm$^{-3}$. The core temperature is much smaller than what is typically found in molecular cores of the same diameter surrounding massive ZAMS stars. We deduce that the core luminosity is between 150 and $1.6\times10^{4}L_{\odot}$, and we believe that the upper limit is near the ``true'' source luminosity. Moreover, by comparing the H$_{2}$ volume density obtained at different radii from the IRAS source, we find that the halo has a density profile of the type $n_{\rm H_{2}}\propto r^{-2.3}$. This suggests that the source is gravitationally unstable. Finally, we demonstrate that the temperature at the core surface is consistent with a core luminosity of $10^3 L_{\odot}$ and conclude that we might be observing a protostar still accreting material from its parental cloud, whose mass at present is $\sim 6 M_{\odot}$.Comment: 18 pages, 20 figure

Detection and characterization of a 500 μm dust emissivity excess in the Galactic plane using Herschel/Hi-GAL observations

Context. Past and recent observations have revealed unexpected variations in the far-infrared – millimeter (FIR-mm) dust emissivity in the interstellar medium. In the Herschel spectral range, those are often referred to as a 500 μm emission excess. Several dust emission models have been developed to interpret astrophysical data in the FIR-mm domain. However, these are commonly unable to fully reconcile theoretical predictions with observations. In contrast, the recently revised two level system (TLS) model, based on the disordered internal structure of amorphous dust grains, seems to provide a promising way of interpreting existing data. Aims. The newly available Herschel infrared GALactic (Hi-GAL) data, which covers most of the inner Milky Way, offers a unique opportunity to investigate possible variations in the dust emission properties both with wavelength and environment. The goal of our analysis is to constrain the internal structure of the largest dust grains on Galactic scales, in the framework of the TLS model. Methods. By combining the IRIS (Improved Reprocessing of the IRAS Survey) 100 μm with the Hi-GAL 160, 250, 350, and 500 μm data, we model the dust emission spectra in each pixel of the Hi-GAL maps, using both the TLS model and, for comparison, a single modified black-body fit. The effect of temperature mixing along the line of sight is investigated to test the robustness of our results. Results. We find a slight decrease in the dust temperature with distance from the Galactic center, confirming previous results. We also report the detection of a significant 500 μm emissivity excess in the peripheral regions of the plane (35° < |l| < 70°) of about 13–15% of the emissivity, which can reach up to 20% in some HII regions. We present the spatial distributions of the best-fit values for the two main parameters of the TLS model, i.e. the charge correlation length, lc, used to characterize the disordered charge distribution (DCD) part of the model, and the amplitude A of the TLS processes with respect to the DCD effect. These distributions illustrate the variations in the dust properties with environment, in particular the plausible existence of an overall gradient with distance to the Galactic center. A comparison with previous findings in the solar neighborhood shows that the local value of the excess is less than expected from the Galactic gradient observed here

Double lenses

The analysis of the shear induced by a single cluster on the images of a large number of background galaxies is all centered around the curl-free character of a well-known vector field that can be derived from the data. Such basic property breaks down when the source galaxies happen to be observed through two clusters at different redshifts, partially aligned along the line of sight. In this paper we address the study of double lenses and obtain five main results. (i) First we generalize the procedure to extract the available information, contained in the observed shear field, from the case of a single lens to that of a double lens. (ii) Then we evaluate the possibility of detecting the signature of double lensing given the known properties of the distribution of clusters of galaxies. (iii) As a different astrophysical application, we demonstrate how the method can be used to detect the presence of a dark cluster that might happen to be partially aligned with a bright cluster studied in terms of statistical lensing. (iv) In addition, we show that the redshift distribution of the source galaxies, which in principle might also contribute to break the curl-free character of the shear field, actually produces systematic effects typically two orders of magnitude smaller than the double lensing effects we are focusing on. (v) Remarkably, a discussion of relevant contributions to the noise of the shear measurement has brought up an intrinsic limitation of weak lensing analyses, since one specific contribution, associated with the presence of a non-vanishing two-galaxy correlation function, turns out not to decrease with the density of source galaxies (and thus with the depth of the observations).Comment: 40 pages, 15 figures. Accepted for publication in ApJ main journa

Acceleration of hemiacetal cleavage through hydrogen bonding : a new synthetic catalyst with balanced conformational flexibility and preorganization

Hemiacetal cleavage catalyst 1 was designed, synthesized, and shown to be effective in promoting glycolaldehyde dimer dissociation and tetramethylglucose mutarotation

Two massive star-forming regions at early evolutionary stages

We report sensitive ATCA radio-continuum observations toward IRAS 15596-5301 and 16272-4837, two luminous objects (> 2x10^4 Lsun) thought to represent massive star-forming regions in early stages of evolution (due to previously undetected radio emission at the 1-sigma level of 2 mJy per beam). Also reported are 1.2-millimeter continuum and a series of molecular-line observations made with the SEST telescope. For IRAS 15596-5301, the observations reveal the presence of three distinct compact radio-continuum sources associated with a dense molecular core. We suggest that this core contains a cluster of B stars which are exciting compact HII regions that are in pressure equilibrium with the dense molecular surroundings. No radio continuum emission was detected from IRAS 16272-4837 (3-sigma limit of 0.2 mJy). However, a dense molecular core has been detected. The high luminosity and lack of radio emission from this massive core suggests that it hosts an embedded young massive protostar that is still undergoing an intense accretion phase. This scenario is supported by the observed characteristics of the line profiles and the presence of a bipolar outflow detected from observations of the SiO emission. We suggest that IRAS 16272-4837 is a bona fide massive star- forming region in a very early evolutionary stage, being the precursor of an ultra compact HII region.Comment: 25 pages, 9 figures, accepted for publication in The Astrophysical Journa

Star Formation in the Milky Way. The Infrared View

I present a brief review of some of the most recent and active topics of star formation process in the Milky Way using mid and far infrared observations, and motivated by the research being carried out by our science group using data gathered by the Spitzer and Herschel space telescopes. These topics include bringing together the scaling relationships found in extragalactic systems with that of the local nearby molecular clouds, the synthetic modeling of the Milky Way and estimates of its star formation rate.Comment: 12 pages, 9 figures. To apper in "Cosmic-ray induced phenomenology in star-forming environments: Proceedings of the 2nd Session of the Sant Cugat Forum of Astrophysics" (April 16-19, 2012), Olaf Reimer and Diego F. Torres (eds.

Direct Estimate of Cirrus Noise in Herschel Hi-GAL Images

In Herschel images of the Galactic plane and many star forming regions, a major factor limiting our ability to extract faint compact sources is cirrus confusion noise, operationally defined as the "statistical error to be expected in photometric measurements due to confusion in a background of fluctuating surface brightness". The histogram of the flux densities of extracted sources shows a distinctive faint-end cutoff below which the catalog suffers from incompleteness and the flux densities become unreliable. This empirical cutoff should be closely related to the estimated cirrus noise and we show that this is the case. We compute the cirrus noise directly, both on Herschel images from which the bright sources have been removed and on simulated images of cirrus with statistically similar fluctuations. We connect these direct estimates with those from power spectrum analysis, which has been used extensively to predict the cirrus noise and provides insight into how it depends on various statistical properties and photometric operational parameters. We report multi-wavelength power spectra of diffuse Galactic dust emission from Hi-GAL observations at 70 to 500 microns within Galactic plane fields at l= 30 degrees and l= 59 degrees. We find that the exponent of the power spectrum is about -3. At 250 microns, the amplitude of the power spectrum increases roughly as the square of the median brightness of the map and so the expected cirrus noise scales linearly with the median brightness. Generally, the confusion noise will be a worse problem at longer wavelengths, because of the combination of lower angular resolution and the rising power spectrum of cirrus toward lower spatial frequencies, but the photometric signal to noise will also depend on the relative spectral energy distribution of the source compared to the cirrus.Comment: 4 pages (in journal), 3 figures, Astronomy and Astrophysics, accepted for publication 13 May 201

Mapping the column density and dust temperature structure of IRDCs with Herschel

Infrared dark clouds (IRDCs) are cold and dense reservoirs of gas potentially available to form stars. Many of these clouds are likely to be pristine structures representing the initial conditions for star formation. The study presented here aims to construct and analyze accurate column density and dust temperature maps of IRDCs by using the first Herschel data from the Hi-GAL galactic plane survey. These fundamental quantities, are essential for understanding processes such as fragmentation in the early stages of the formation of stars in molecular clouds. We have developed a simple pixel-by-pixel SED fitting method, which accounts for the background emission. By fitting a grey-body function at each position, we recover the spatial variations in both the dust column density and temperature within the IRDCs. This method is applied to a sample of 22 IRDCs exhibiting a range of angular sizes and peak column densities. Our analysis shows that the dust temperature decreases significantly within IRDCs, from background temperatures of 20-30 K to minimum temperatures of 8-15 K within the clouds, showing that dense molecular clouds are not isothermal. Temperature gradients have most likely an important impact on the fragmentation of IRDCs. Local temperature minima are strongly correlated with column density peaks, which in a few cases reach NH2 = 1 x 10^{23} cm^{-2}, identifying these clouds as candidate massive prestellar cores. Applying this technique to the full Hi-GAL data set will provide important constraints on the fragmentation and thermal properties of IRDCs, and help identify hundreds of massive prestellar core candidates.Comment: Accepted for publication in A&A Herschel special issu

HST NICMOS Images of the HH 7/11 Outflow in NGC1333

We present near infrared images in H2 at 2.12um of the HH 7/11 outflow and its driving source SVS 13 taken with HST NICMOS 2 camera, as well as archival Ha and [SII] optical images obtained with the WFPC2 camera. The NICMOS high angular resolution observations confirm the nature of a small scale jet arising from SVS 13, and resolve a structure in the HH 7 working surface that could correspond to Mach disk H2 emission. The H2 jet has a length of 430 AU (at a distance of 350 pc), an aspect ratio of 2.2 and morphologically resembles the well known DG Tau optical micro-jet. The kinematical age of the jet (approx. 10 yr) coincides with the time since the last outburst from SVS 13. If we interpret the observed H2 flux density with molecular shock models of 20-30 km/s, then the jet has a density as high as 1.e+5 cc. The presence of this small jet warns that contamination by H2 emission from an outflow in studies searching for H2 in circumstellar disks is possible. At the working surface, the smooth H2 morphology of the HH 7 bowshock indicates that the magnetic field is strong, playing a major role in stabilizing this structure. The H2 flux density of the Mach disk, when compared with that of the bowshock, suggests that its emission is produced by molecular shocks of less than 20 km/s. The WFPC2 optical images display several of the global features already inferred from groundbased observations, like the filamentary structure in HH 8 and HH 10, which suggests a strong interaction of the outflow with its cavity. The H2 jet is not detected in {SII] or Ha, however, there is a small clump at approx. 5'' NE of SVS 13 that could be depicting the presence either of a different outburst event or the north edge of the outflow cavity.Comment: 13 pages, 5 figures (JPEGs

Hepatic arterial infusion of chemotherapy for advanced hepatobiliary cancers: State of the art

Liver functional failure is one of the leading causes of cancer-related death. Primary liver tumors grow up mainly in the liver, and thus happens for liver metastases deriving from other organs having a lower burden of disease at the primary site. Systemic chemotherapy usually offers a modest benefit in terms of disease control rate, progression-free survival, and overall survival at the cost of a significant percentage of adverse events. Liver malignancies are mostly perfused by the hepatic artery while the normal liver parenchyma by the portal vein network. On these bases, the therapeutic strategy consisting of hepatic arterial infusion (HAI) of chemotherapy takes place. In literature, HAI chemotherapy was applied for the treatment of advanced hepatobiliary cancers with encouraging results. Different chemotherapeutic agents were used such as Oxaliplatin, Cisplatin, Gemcitabine, Floxuridine, 5-Fluorouracil, Epirubicin, individually or in combination. However, the efficacy of this treatment strategy remains controversial. Therefore, this review aims to summarize the current knowledge on this approach from different points of view, such as techniques, drugs pharmacology and pharmacokinetics, and clinical outcomes for advanced hepatobiliary cancers