Curl-free positive definite form of time-harmonic Maxwells equations well-suitable for iterative numerical solving

A new form of time-harmonic Maxwells equations is developed and proposed for numerical modeling. It is written for the magnetic field strength, electric displacement, vector potential and the scalar potential. There are several attractive features of this form. The first one is that the differential operator acting on these quantities is positive. The second is absence of curl operators among the leading order differential operators. The Laplacian stands for the leading order operator in the equations for the magnetic field strength, vector potential and the scalar potential, while the gradient of divergence stands for the electric displacement. The third feature is absence of space varied coefficients in the leading order differential operators that provides diagonal domination of the resulting matrix of the discretized equations. A simple example is given to demonstrate the applicability of this new form of time-harmonic Maxwells equations.Comment: Invited talk for 47th Annual EPS Plasma Conferenc

Медикаментозная коррекция хронической сердечной недостаточности с учетом лабораторных маркеров дисфункции эндотелия

СЕРДЕЧНАЯ НЕДОСТАТОЧНОСТЬ ЗАСТОЙНАЯ /ЛЕК ТЕРСЕРДЦА БОЛЕЗНИЭНДОТЕЛИЙ /ПОВРЕЖДЭПИТЕЛИЙ /ПОВРЕЖДБИОЛОГИЧЕСКИЕ МАРКЕРЫБИОЛОГИЧЕСКИЕ ФАКТОР

Study of the Processes of Complex Processing of Lignite in Order to Extract Rare Elements

Стратегическим вопросом для предприятий редкометаллической промышленности является наличие собственной сырьевой базы. Особое внимание привлекают новые, ранее неиспользовавшиеся ресурсы, к которым можно отнести лигниты, выявленные в среднем течении р. Енисей. Проведены исследования процессов комплексной переработки лигнита, обеспечивающей образование возгонов, обогащенных германием до 1,8 мас.%, и золы, содержащей ~1,2 мас.% суммы редкоземельных металлов. Изучены закономерности выщелачивания РЗМ из золы с получением растворов для их выделения на селективных сорбентахThe strategic issue for rare metals manufacturers is availability of the own raw material base. Previously unused resources which include the lignites located at central watershed of the Yenisei river are becoming important due to depletion of traditional sources of raw materials. The comprehensive approach to the processing of the lignite which ensures the formation of sublimates germanium-enriched to 1,8 wt.% and ash rare earth metals-enriched to 1,2 wt.% was proposed. The regularities of rare earth metals leaching from ash residue with obtaining rich solutions suitable for further processing using selective sorbents have been studie

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

First experiments on plasma production using field-aligned ICRF fast wave antennas in the large helical device

The results of the first experimental series to produce a plasma using the ion cyclotron range of frequency (ICRF) in the large helical device (LHD) within the minority scenario developed at Uragan-2M (U-2M) are presented. The motivation of this study is to provide plasma creation in conditions when an electron cyclotron resonance heating start-up is not possible, and in this way widen the operational frame of helical machines. The major constraint of the experiments is the low RF power to reduce the possibility of arcing. No dangerous voltage increase at the radio-frequency (RF) system elements and no arcing has been detected. As a result, a low plasma density is obtained and the antenna-plasma coupling is not optimal. However, such plasmas are sufficient to be used as targets for further neutral beam injection (NBI) heating. This will open possibilities to explore new regimes of operation at LHD and Wendelstein 7-X (W7-X) stellarator. The successful RF plasma production in LHD in this experimental series stimulates the planning of further studies of ICRF plasma production aimed at increasing plasma density and temperature within the ICRF minority scenario as well as investigating the plasma prolongation by NBI heating

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment

Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types

Protein ubiquitination is a dynamic and reversibleprocess of adding single ubiquitin molecules orvarious ubiquitin chains to target proteins. Here,using multidimensional omic data of 9,125 tumorsamples across 33 cancer types from The CancerGenome Atlas, we perform comprehensive molecu-lar characterization of 929 ubiquitin-related genesand 95 deubiquitinase genes. Among them, we sys-tematically identify top somatic driver candidates,including mutatedFBXW7with cancer-type-specificpatterns and amplifiedMDM2showing a mutuallyexclusive pattern withBRAFmutations. Ubiquitinpathway genes tend to be upregulated in cancermediated by diverse mechanisms. By integratingpan-cancer multiomic data, we identify a group oftumor samples that exhibit worse prognosis. Thesesamples are consistently associated with the upre-gulation of cell-cycle and DNA repair pathways, char-acterized by mutatedTP53,MYC/TERTamplifica-tion, andAPC/PTENdeletion. Our analysishighlights the importance of the ubiquitin pathwayin cancer development and lays a foundation fordeveloping relevant therapeutic strategies