A Common Biomarker Signature for Tolerated Allografts and Self Tissues

SCOPUS: no.jinfo:eu-repo/semantics/publishe

Location of the Energy Levels of the Rare-Earth Ion in BaF2 and CdF2

The location of the energy levels of rare-earth (RE) elements in the energy band diagram of BaF2 and CdF2 crystals is determined. The role of RE3+ and RE2+ ions in the capture of charge carriers, luminescence, and the formation of radiation defects is evaluated. It is shown that the substantial difference in the luminescence properties of BaF2:RE and CdF2:RE is associated with the location of the excited energy levels in the band diagram of the crystals

Evaluation of onset, cessation and seasonal precipitation of the Southeast Asia rainy season in CMIP5 regional climate models and HighResMIP global climate models

Representing the rainy season of the maritime continent is a challenge for global and regional climate models. Here, we compare regional climate models (RCMs) based on the coupled model intercomparison project phase 5 (CMIP5) model generation with high-resolution global climate models with a comparable spatial resolution from the HighResMIP experiment. The onset and the total precipitation of the rainy season for both model experiments are compared against observational datasets for Southeast Asia. A realistic representation of the monsoon rainfall is essential for agriculture in Southeast Asia as a delayed onset jeopardizes the possibility of having three annual crops. In general, the coupled historical runs (Hist-1950) and the historical force atmosphere run (HighresSST) of the high-resolution model intercomparison project (HighResMIP) suite were consistently closer to the observations than the RCM of CMIP5 used in this study. We find that for the whole of Southeast Asia, the HighResMIP models simulate the onset date and the total precipitation of the rainy season over the region closer to the observations than the other model sets used in this study. High-resolution models in the HighresSST experiment showed a similar performance to their low-resolution equivalents in simulating the monsoon characteristics. The HighresSST experiment simulated the anomaly of the onset date and the total precipitation for different El Niño-southern oscillation conditions best, although the magnitude of the onset date anomaly was underestimated. © 2021 The Authors. International Journal of Climatology published by John Wiley Sons Ltd on behalf of Royal Meteorological Society

Prognostic evaluation in patients with advanced cancer in the last months of life:ESMO Clinical Practice Guideline

: • This ESMO Clinical Practice Guideline provides key recommendations for using prognostic estimates in advanced cancer. • The guideline covers recommendations for patients with cancer and an expected survival of months or less. • An algorithm for use of clinical predictions, prognostic factors and multivariable risk prediction models is presented. • The author group encompasses a multidisciplinary group of experts from different institutions in Europe, USA and Asia. • Recommendations are based on available scientific data and the authors’ collective expert opinion

Impact of increased resolution on long-standing biases in HighResMIP-PRIMAVERA climate models

We examine the influence of increased resolution on four long-standing biases using five different climate models developed within the PRIMAVERA project. The biases are the warm eastern tropical oceans, the double Intertropical Convergence Zone (ITCZ), the warm Southern Ocean, and the cold North Atlantic. Atmosphere resolution increases from ∼100–200 to ∼25–50 km, and ocean resolution increases from (eddy-parametrized) to (eddy-present). For one model, ocean resolution also reaches ∘ (eddy-rich). The ensemble mean and individual fully coupled general circulation models and their atmosphere-only versions are compared with satellite observations and the ERA5 reanalysis over the period 1980–2014. The four studied biases appear in all the low-resolution coupled models to some extent, although the Southern Ocean warm bias is the least persistent across individual models. In the ensemble mean, increased resolution reduces the surface warm bias and the associated cloud cover and precipitation biases over the eastern tropical oceans, particularly over the tropical South Atlantic. Linked to this and to the improvement in the precipitation distribution over the western tropical Pacific, the double-ITCZ bias is also reduced with increased resolution. The Southern Ocean warm bias increases or remains unchanged at higher resolution, with small reductions in the regional cloud cover and net cloud radiative effect biases. The North Atlantic cold bias is also reduced at higher resolution, albeit at the expense of a new warm bias that emerges in the Labrador Sea related to excessive ocean deep mixing in the region, especially in the ORCA025 ocean model. Overall, the impact of increased resolution on the surface temperature biases is model-dependent in the coupled models. In the atmosphere-only models, increased resolution leads to very modest or no reduction in the studied biases. Thus, both the coupled and atmosphere-only models still show large biases in tropical precipitation and cloud cover, and in midlatitude zonal winds at higher resolutions, with little change in their global biases for temperature, precipitation, cloud cover, and net cloud radiative effect. Our analysis finds no clear reductions in the studied biases due to the increase in atmosphere resolution up to 25–50 km, in ocean resolution up to 0.25∘, or in both. Our study thus adds to evidence that further improved model physics, tuning, and even finer resolutions might be necessary

The art of video MashUp: supporting creative users with an innovative and smart application

In this paper, we describe the development of a new and innovative tool of video mashup. This application is an easy to use tool of video editing integrated in a cross-media platform; it works taking the information from a repository of videos and puts into action a process of semi-automatic editing supporting users in the production of video mashup. Doing so it gives vent to their creative side without them being forced to learn how to use a complicated and unlikely new technology. The users will be further helped in building their own editing by the intelligent system working behind the tool: it combines semantic annotation (tags and comments by users), low level features (gradient of color, texture and movements) and high level features (general data distinguishing a movie: actors, director, year of production, etc.) to furnish a pre-elaborated editing users can modify in a very simple way

Coupled climate response to Atlantic Multidecadal Variability in a multi-model multi-resolution ensemble

North Atlantic sea surface temperatures (SSTs) underwent pronounced multidecadal variability during the twentieth and early twenty-first century. We examine the impacts of this Atlantic Multidecadal Variability (AMV), also referred to as the Atlantic Multidecadal Oscillation (AMO), on climate in an ensemble of five coupled climate models at both low and high spatial resolution. We use a SST nudging scheme specified by the Coupled Model Intercomparision Project’s Decadal Climate Prediction Project Component C (CMIP6 DCPP-C) to impose a persistent positive/negative phase of the AMV in the North Atlantic in coupled model simulations; SSTs are free to evolve outside this region. The large-scale seasonal mean response to the positive AMV involves widespread warming over Eurasia and the Americas, with a pattern of cooling over the Pacific Ocean similar to the Pacific Decadal Oscillation (PDO), together with a northward displacement of the inter-tropical convergence zone (ITCZ). The accompanying changes in global atmospheric circulation lead to widespread changes in precipitation. We use Analysis of Variance (ANOVA) to demonstrate that this large-scale climate response is accompanied by significant differences between models in how they respond to the common AMV forcing, particularly in the tropics. These differences may arise from variations in North Atlantic air-sea heat fluxes between models despite a common North Atlantic SST forcing pattern. We cannot detect a widespread effect of increased model horizontal resolution in this climate response, with the exception of the ITCZ, which shifts further northwards in the positive phase of the AMV in the higher resolution configuratio

Deep mixed ocean volume in the Labrador Sea in HighResMIP models

Simulations from seven global coupled climate models performed at high and standard resolution as part of the high resolution model intercomparison project (HighResMIP) are analyzed to study deep ocean mixing in the Labrador Sea and the impact of increased horizontal resolution. The representation of convection varies strongly among models. Compared to observations from ARGO-floats and the EN4 data set, most models substantially overestimate deep convection in the Labrador Sea. In four out of five models, all four using the NEMO-ocean model, increasing the ocean resolution from 1° to 1/4° leads to increased deep mixing in the Labrador Sea. Increasing the atmospheric resolution has a smaller effect than increasing the ocean resolution. Simulated convection in the Labrador Sea is mainly governed by the release of heat from the ocean to the atmosphere and by the vertical stratification of the water masses in the Labrador Sea in late autumn. Models with stronger sub-polar gyre circulation have generally higher surface salinity in the Labrador Sea and a deeper convection. While the high-resolution models show more realistic ocean stratification in the Labrador Sea than the standard resolution models, they generally overestimate the convection. The results indicate that the representation of sub-grid scale mixing processes might be imperfect in the models and contribute to the biases in deep convection. Since in more than half of the models, the Labrador Sea convection is important for the Atlantic Meridional Overturning Circulation (AMOC), this raises questions about the future behavior of the AMOC in the models