Time-Efficient resource allocation algorithm over HSDPA in femtocell networks

This paper presents a time-efficient optimal resource allocation algorithm aiming to maximize the system throughput of the single-user High Speed Downlink Packet Access (HSDPA) deployed in femtocell base station. The system throughput maximization with constrained total power is rst formulated as a constrained integer programming problem. We rst prove that a two-group bit and energy allocation provides the global optimum solution in the system without multipath. We then focus on the use of the two-group allocation method over frequency selective channels. A pre-processing method was used to systematically cluster and remove channels to stop using energies over severely degraded channels with the two-group allocation approach. This improves the system throughput whilst greatly reducing the computation complexity. The proposed twogroup approach with channel removal is suitable for femtocell base station with limited signal processing capability.Accepted versio

EASY AND EFFICIENT SPLIT-ROOT METHOD TO STUDY MORPHOLOGY AND ANATOMY OF RICE (Oryza sativa L.)

ABSTRACT: Objective: This study was intended to investigate the efficacy of PVC pipe method for split-root experiment in rice (Oryza sativa L.) using soil medium at all the growth stages of rice.Methods: Rice seeds were sown in small PVC pipes and allowed to grow for one month, which were then transferred to split-root setup by equally splitting the roots of these seedlings into two halves and were allowed to grow for different time periods of their growth stages to analyze their health and stability.Results: We report an easy split-root study for rice grown in soil. Unlike the field grown plants, the efficient PVC tube method enables simple and systematic growth and harvesting for proper analysis of the plant samples without damaging the tissue. In our experiments, although the rice plants were transferred to the split-root setup by splitting their roots, they were healthy and stable after 7days, 15 days, 70 days and even at 120 days (maturity) of growth in split-root condition.Conclusion: Morphology and anatomy of plants can be easily and efficiently studied at any growth stage using PVC tube method as opposed to field method where sample harvesting requires inconvenient process of uprooting the plant while losing and damaging the tissue

Sugar alcohols-induced oxidative metabolism in cotton callus culture

Sugar alcohols (mannitol and sorbitol) may cause oxidative damage in plants if used in higher concentration. Our present experiment was undertaken to study physiological and metabolic responses in cotton (Gossypium hirsutum L.) callus against mannitol and sorbitol higher doses. Both markedly declined mean values of relative fresh weight growth rates with the increase in their concentration intensities. The overall protein and malonaldehyde (MDA) contents increased in the stressed-shocked cells. Also, the mean values of various antioxidants such as superoxide dismutase (SOD), peroxidase (POD), ascorbate peroxidase (APX) and calalase (CAT) quantitatively improved over their respective controls. As a whole, MDA contents were higher in magnitude than that of different antioxidant enzymes. Also values of relative increase in case of POD were higher as compared to SOD showing the ability of cotton callus culture to scavenge H2O2 produced as a result of the activity of SOD. Our results show that both agents caused greater damage to the membranous structure in comparison to less activation of the antioxidants. As a whole, the overall change regarding fresh weight growth rates was less after 14-day stress regime, while the mean values of the antioxidant enzymes activities were lower after the 28-day stress period. Such decrease conveys the message that less reactive oxygen species (ROS) might have been produced.Keywords: Antioxidants, callus culture, Gossypium hirsutum L., osmotic stress, sugar alcoholsAfrican Journal of Biotechnology Vol. 12(17), pp. 2191-220

GEAR: A GPU-Centric Experience Replay System for Large Reinforcement Learning Models

This paper introduces a distributed, GPU-centric experience replay system, GEAR, designed to perform scalable reinforcement learning (RL) with large sequence models (such as transformers). With such models, existing systems such as Reverb face considerable bottlenecks in memory, computation, and communication. GEAR, however, optimizes memory efficiency by enabling the memory resources on GPU servers (including host memory and device memory) to manage trajectory data. Furthermore, it facilitates decentralized GPU devices to expedite various trajectory selection strategies, circumventing computational bottlenecks. GEAR is equipped with GPU kernels capable of collecting trajectories using zero-copy access to host memory, along with remote-directed-memory access over InfiniBand, improving communication efficiency. Cluster experiments have shown that GEAR can achieve performance levels up to 6× greater than Reverb when training state-of-the-art large RL models. GEAR is open-sourced at https://github.com/bigrl-team/gear

Eurasian Arctic greening reveals teleconnections and the potential for novel ecosystems

Arctic warming has been linked to observed increases in tundra shrub cover and growth in recent decades on the basis of significant relationships between deciduous shrub growth/biomass and temperature. These vegetation trends have been linked to Arctic sea ice decline and thus to the sea ice/albedo feedback known as Arctic amplification. However, the interactions between climate, sea ice and tundra vegetation remain poorly understood. Here we reveal a 50- year growth response over a >100,000 km2 area to a rise in summer temperature for alder (Alnus) and willow (Salix), the most abundant shrub genera respectively at and north of the continental treeline. We demonstrate that whereas plant productivity is related to sea ice in late spring, the growing season peak responds to persistent synoptic-scale air masses over West Siberia associated with Fennoscandian weather systems through the Rossby wave train. Substrate is important for biomass accumulation, yet a strong correlation between growth and temperature encompasses all observed soil types. Vegetation is especially responsive to temperature in early summer. These results have significant implications for modelling present and future Low Arctic vegetation responses to climate change, and emphasize the potential for structurally novel ecosystems to emerge fromwithin the tundra zone.Vertaisarviointia edeltävä käsikirjoitu

Should We Learn Probabilistic Models for Model Checking? A New Approach and An Empirical Study

Many automated system analysis techniques (e.g., model checking, model-based testing) rely on first obtaining a model of the system under analysis. System modeling is often done manually, which is often considered as a hindrance to adopt model-based system analysis and development techniques. To overcome this problem, researchers have proposed to automatically "learn" models based on sample system executions and shown that the learned models can be useful sometimes. There are however many questions to be answered. For instance, how much shall we generalize from the observed samples and how fast would learning converge? Or, would the analysis result based on the learned model be more accurate than the estimation we could have obtained by sampling many system executions within the same amount of time? In this work, we investigate existing algorithms for learning probabilistic models for model checking, propose an evolution-based approach for better controlling the degree of generalization and conduct an empirical study in order to answer the questions. One of our findings is that the effectiveness of learning may sometimes be limited.Comment: 15 pages, plus 2 reference pages, accepted by FASE 2017 in ETAP

Chemico-calorimetric analysis of amorphous granules manufactured via continuous granulation process

The current study explores the first case of the implementation of solution calorimetry (SolCal) in order to determine the amorphous content of crystalline benzoyl-methoxy-methylindol-acetic acid (BMA)—a model poorly soluble drug, in the amorphous granules prepared via single-step continuous twin-screw dry granulations (TSG). Amorphous magnesium aluminometasilicate (Neusilin®) (US2) was used as a novel inorganic carrier via a TwinLab 10 mm twin-screw extruder. The BMA/US2 blends were processed at 180 °C and varying drug: carrier ratios of 1:4, 1:2.5 and 1:1 (w/w). Physico-chemical characterisation conducted via SEM, DSC and XRPD showed amorphous state of the drug in all granulated formulations. Reverse optical microscopy revealed a meso-porous structure of US2 in which the drug particles are adsorbed and/or entrapped within the porous network of the carrier. This phenomenon can be the underlying reason for the increase of the amorphous content in the extruded granules. Solution calorimetry (SolCal) study revealed amorphous content of the drug in all formulations quite precisely, whereas the dynamic vapour sorption (DVS) analysis complemented the results from SolCal. Furthermore, an attempt has been made for the first time to interrelate the findings from the SolCal to that of the release of the drug from the amorphous granules. It can be concluded that SolCal can be used as a novel technique to precisely quantify and interrelate the amorphous content to its physico-chemical performances such as drug release from the granulated formulations processed via TS

Perceptions, Barriers, and Enablers on Salt Reduction in the Out-of-Home Sectors in Malaysia (MySaltOH) from the Perspective of Street Food Vendors, Caterers, and Consumers.

OBJECTIVE: To explore the perspectives, barriers, and enablers on salt reduction in out-of-home sectors in Malaysia among street food vendors, caterers, and consumers. DESIGN: A qualitative study involving 22 focus group discussions and six in-depth interviews was conducted, recorded and transcribed verbatim. An inductive thematic analysis approach was employed to analyze the data. SETTING: Two in-depth interviews and 22 focus group discussions were conducted face-to-face. Four in-depth interviews were conducted online. PARTICIPANTS: Focus group discussions were conducted among 23 street food vendors, 21 caterers, and 76 consumers of various eateries. In-depth interviews were conducted among two street food vendors, and four caterers, individually. RESULTS: Consumers and food operators perceived a high salt intake within Malaysia's out-of-home food sectors. Food operators emphasized the necessity for a comprehensive salt reduction policy in the out-of-home sector involving all stakeholders. Consumers faced limited awareness and knowledge, counterproductive practices among food operators, and challenges in accessing affordable low-sodium food products; whereas food operators faced the lack of standardized guidelines and effective enforcement mechanisms, and uncooperative consumer practices. Both groups expressed that food quality and price of salt were also the barriers, and they advocated for awareness promotion, enhanced regulation of manufactured food products, and stricter enforcement targeting vendors. Consumers also suggested promoting and recognizing health-conscious food premises; whereas food operators suggested on knowledge enhancement tailored to them, strategies for gaining consumers acceptance, and maintaining food quality. CONCLUSIONS: These findings provide valuable insights that serve as foundational evidence for developing and implementing salt reduction policies within Malaysia's out-of-home sectors

Protein crystals in adenovirus type 5-infected cells: requirements for intranuclear crystallogenesis, structural and functional analysis

Intranuclear crystalline inclusions have been observed in the nucleus of epithelial cells infected with Adenovirus serotype 5 (Ad5) at late steps of the virus life cycle. Using immuno-electron microscopy and confocal microscopy of cells infected with various Ad5 recombinants modified in their penton base or fiber domains, we found that these inclusions represented crystals of penton capsomers, the heteromeric capsid protein formed of penton base and fiber subunits. The occurrence of protein crystals within the nucleus of infected cells required the integrity of the fiber knob and part of the shaft domain. In the knob domain, the region overlapping residues 489–492 in the FG loop was found to be essential for crystal formation. In the shaft, a large deletion of repeats 4 to 16 had no detrimental effect on crystal inclusions, whereas deletion of repeats 8 to 21 abolished crystal formation without altering the level of fiber protein expression. This suggested a crucial role of the five penultimate repeats in the crystallisation process. Chimeric pentons made of Ad5 penton base and fiber domains from different serotypes were analyzed with respect to crystal formation. No crystal was found when fiber consisted of shaft (S) from Ad5 and knob (K) from Ad3 (heterotypic S5-K3 fiber), but occurred with homotypic S3K3 fiber. However, less regular crystals were observed with homotypic S35-K35 fiber. TB5, a monoclonal antibody directed against the Ad5 fiber knob was found by immunofluorescence microscopy to react with high efficiency with the intranuclear protein crystals in situ. Data obtained with Ad fiber mutants indicated that the absence of crystalline inclusions correlated with a lower infectivity and/or lower yields of virus progeny, suggesting that the protein crystals might be involved in virion assembly. Thus, we propose that TB5 staining of Ad-infected 293 cells can be used as a prognostic assay for the viability and productivity of fiber-modified Ad5 vectors