Cardiac health risk stratification system (CHRiSS): A Bayesian-based decision support system for left ventricular assist device (LVAD) therapy

This study investigated the use of Bayesian Networks (BNs) for left ventricular assist device (LVAD) therapy; a treatment for end-stage heart failure that has been steadily growing in popularity over the past decade. Despite this growth, the number of LVAD implants performed annually remains a small fraction of the estimated population of patients who might benefit from this treatment. We believe that this demonstrates a need for an accurate stratification tool that can help identify LVAD candidates at the most appropriate point in the course of their disease. We derived BNs to predict mortality at five endpoints utilizing the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) database: containing over 12,000 total enrolled patients from 153 hospital sites, collected since 2006 to the present day, and consisting of approximately 230 pre-implant clinical variables. Synthetic minority oversampling technique (SMOTE) was employed to address the uneven proportion of patients with negative outcomes and to improve the performance of the models. The resulting accuracy and area under the ROC curve (%) for predicted mortality were 30 day: 94.9 and 92.5; 90 day: 84.2 and 73.9; 6 month: 78.2 and 70.6; 1 year: 73.1 and 70.6; and 2 years: 71.4 and 70.8. To foster the translation of these models to clinical practice, they have been incorporated into a web-based application, the Cardiac Health Risk Stratification System (CHRiSS). As clinical experience with LVAD therapy continues to grow, and additional data is collected, we aim to continually update these BN models to improve their accuracy and maintain their relevance. Ongoing work also aims to extend the BN models to predict the risk of adverse events post-LVAD implant as additional factors for consideration in decision making

Consequences of temperature and temperature variability on swimming activity, group structure, and predation of endangered delta smelt

The effects of water temperature on individual and group movement behaviour in prey fish can affect ecological interactions such as competition and predation, but how variability in temperature influence fish behaviour is less understood. Of particular concern is how increased warming in tidally fluctuating estuaries may impact the native and endangered delta smelt (Hypomesus transpacificus, Osmeridae). To help address this issue, we tested the effects of increased water temperature (fluctuating [17–21°C] and warm [21°C] acclimated treatments) on juvenile delta smelt individual and group behaviour, response to chemical alarm and predator cues, as well as capacity to evade predation. In addition, predation of delta smelt was tested in the presence of a dominant invasive competitor, Mississippi silversides (Menidia beryllina, Atherinopsidae), as well as comparative predation mortality on Mississippi silversides when isolated. After 7 days of increased temperature treatments, delta smelt in the warm treatment increased swimming velocity, decreased turning angle, and altered group structure with larger inter-individual distances compared to fish in the control (17°C) and fluctuating temperature treatments. Following conspecific and predator chemical alarm cues, delta smelt showed anti-predator responses. Control and fluctuating treatment fish responded to conspecific cues with increased swimming speeds, decreased inter-individual distances and near-neighbour distances, and, after 15 min, fish recovered back to baseline behaviours. In contrast, fish in the warm treatment had not recovered after 15 min, and swimming speeds were maintained at roughly 25 cm/s, close to maximum capabilities. Fish in control and fluctuating treatments showed minimal responses to predator cues, whereas delta smelt exposed to warm conditions significantly increased swimming speeds and decreased turning angle. Predation of delta smelt by largemouth bass (Micropterus salmoides, Centrarchidae) was greatest under the warm treatment, correlating with altered behaviours of delta smelt; however, predation of Mississippi silversides was greater than delta smelt, independent of temperature. This study provides novel insight into the group behaviour of delta smelt, their response to predation, and how prolonged exposure to elevated temperature may induce negative individual and group behaviours causing alterations in predator–prey dynamics. This work highlights the importance of testing ecologically realistic temperature fluctuations in experiments as delta smelt had significantly altered responses to elevated temperature, dependent on variability of warming

Evaluation of Potential Effect of Menthol Solution on Oral Hygiene Status of Dental Students in a University in Iraq

Purpose: To test the effect of menthol extract on the oral hygiene status of dental students of Faculty of Dentistry, Al- Mustansiriya University, Baghdad, Iraq.Methods: A solution (18 mg %) of menthol was prepared by dissolving menthol crystals in absolute ethanol. Chlorhexidine (CHX, 0.2 %) and deionized water were used as positive and negative controls, respectively. Menthol was examined for its toxic effect. Twenty male albino mice were injected intraperitoneally with a low (10 mg/ml) and high dose (50 mg/ml) of the menthol solution, and acute toxicity (LD50) calculated. A double-blind crossover was designed to test plaque re-growth over 5 days. Thirty male dental student volunteers were asked to cease tooth cleaning and then rinse with 10 ml of menthol solution three times daily for 1.5 min, twice daily with CHX and deionized water. Plaque, gingival and bleeding scores were recorded on days 0 and 5. A washout period of 2 weeks was allowed, and then a new test was initiated. The data obtained were analysed statistically.Results: Menthol mouthwash demonstrates a significant reduction in plaque, gingival and bleeding indices of 0.56, 0.45 and 0.03, respectively. CHX induced a greater reduction in these parameters than menthol with indices of 0.14, 0.26, and 0.04, respectively.Conclusion: Menthol mouth rinse (0.018 %) is an antiplaque and anti-gingivitis agent, though less effective than CHX.Keywords: Menthol mouth rinse, Chlorhexidine, Dental plaque, Gingivitis, Oral hygien

Nutritional value OF Bottle Gourd (Lagenaria siceraria) Seeds

Whole seeds, dehulled seeds and seed coats of bottle gourd seed (Lagenaria siceraria) were analysed for their proximate, amino acids and mineral compositions. The results of the analysis showed that, whole seed has highest content of moisture (17.5  0.21%) and ash (5.80  0.83%) while dehulled had highest amount of crude protein (35.0  0.48%) and crude lipid (39.22  1.48%) and seed coat contain highest amount of crude fiber (59.05  0.98%). The study showed a profile of seventeen amino acids (isoleucine, leucine, lysine, methionine, cysteine, phenylalanine, tyrosine, threonine, valine, alanine, arginine, aspartic acid, glutamic acid, glycine, histidine, proline and serine) with glutamic acid, leucine and aspartic acid being the predominant amino acid. The percentages (%) of essential and non-essential amino acids in dehulled seeds, whole seeds and seed coats were 44 vs 56, 41 vs 59 and 51 vs 49 respectively. The dehulled seeds contained essential amino acids that were found to be higher than WHO/FAO/UNU requirement. In whole seeds, threonine, lysine and lysine were found to be the most limiting amino acids. Seed coats were deficient in all the essential amino acids except for valine. Generally, the mineral composition of the seed was found to be relatively high, indicating the seed to be a good source of dietary elements, except for Ca, Zn, Co and Cr where very low values were obtained. Finally, the results of the study indicate that, bottle gourd seed is a potential source of protein, lipid, micro and macronutrients, and if properly utilised, could contribute in solving the problem of malnutrition and also serve as raw material for agro-based industries Keywords: Bottle gourd seeds, seed coat, proximate analysis, minerals and Amino acid composition.Global Journal of Pure and Applied Sciences Vol. 14 (3) 2008: pp. 301-30

PNe abundances: Galactic bulge versus the disc

We compare the abundances of He, N, O, Ar, S, and Ne, determined in a similar way, for a sample of Galactic bulge and disc planetary nebulae (PNe). We find that in all aspects – average abundances and dispersion, distribution functions, abundance relationships, and the ratio of N/O – the bulge and disc PNe are indistinguishable. The nebular distribution of [O/H] is different to the stellar

Lax pair and first integrals for two of nonlinear coupled oscillators

The system of two nonlinear coupled oscillators is studied. As partial case this system of equation is reduced to the Duffing oscillator which has many applications for describing physical processes. It is well known that the inverse scattering transform is one of the most powerful methods for solving the Cauchy problems of partial differential equations. To solve the Cauchy problem for nonlinear differential equations we can use the Lax pair corresponding to this equation. The Lax pair for ordinary differential or systems or for system ordinary differential equations allows us to find the first integrals, which also allow us to solve the question of integrability for differential equations. In this report we present the Lax pair for the system of coupled oscillators. Using the Lax pair we get two first integrals for the system of equations. The considered system of equations can be also reduced to the fourth-order ordinary differential equation and the Lax pair can be used for the ordinary differential equation of fourth order. Some special cases of the system of equations are considered.Comment: 9 page

Improving healthcare system usability without real users: A semi-parallel design approach

Copyright © 2015 IGI Global. This paper describes an early stage usability study conducted on a prototype system designed to capture and analyse Patient Reported Outcome Measures (PROMs) activities. The system - PROMS 2.0, was developed by Bluespier for the trauma and orthopaedic department in Trafford Hospital, Manchester, United Kingdom (UK). The Centre for Health and Social Care Informatics (CHaSCI), Liverpool John Moores University (LJMU) examined the system without real users, identified potential usability issues and suggested possible solutions for improvements before final release by Bluespier. Three different approaches were adopted for evaluating user interface (UI) design without users. The first approach is the Cognitive Walkthrough (CW), a task-oriented technique capable of identifying issues through action sequence required to perform a task. The second approach is action analysis which predicts the time a skilled user would need to perform a task. The third approach is heuristic evaluation which tends to identify problems based on recognised standards. Results support the argument from relevant cognitive psychology theories and user-centric design principles that UI evaluation without real users is a useful tool in yielding rapid output for subsequent enhancement. It is concluded that semi-parallel design concept could be the key to timely delivery of software design projects

Collaborative Computation in Self-Organizing Particle Systems

Many forms of programmable matter have been proposed for various tasks. We use an abstract model of self-organizing particle systems for programmable matter which could be used for a variety of applications, including smart paint and coating materials for engineering or programmable cells for medical uses. Previous research using this model has focused on shape formation and other spatial configuration problems (e.g., coating and compression). In this work we study foundational computational tasks that exceed the capabilities of the individual constant size memory of a particle, such as implementing a counter and matrix-vector multiplication. These tasks represent new ways to use these self-organizing systems, which, in conjunction with previous shape and configuration work, make the systems useful for a wider variety of tasks. They can also leverage the distributed and dynamic nature of the self-organizing system to be more efficient and adaptable than on traditional linear computing hardware. Finally, we demonstrate applications of similar types of computations with self-organizing systems to image processing, with implementations of image color transformation and edge detection algorithms