Barriers in the HCV treatment cascade after confirmed diagnosis

Background: Hepatitis C (HCV) is the most common blood-borne viral infection in the United States with an estimated prevalence of 2.4 million people[1]. Oklahoma has an estimated 54,000 chronic cases of hepatitis C and has the highest exposure rate of all 50 states[2]. Even with increased screening and access to medications, gaps exist in the cascade of care for patients with hepatitis C with approximately 40% of diagnosed patients not having been prescribed antiviral treatment[3]. Treatment of hepatitis C has been associated with a reduction in liver failure, a reduction in hepatocellular carcinoma, and a reduction in all-cause mortality.Aim: With increased access to curative medications and better treatment options for hepatitis C, our goal is to determine the barriers to treatment for those who have been diagnosed with hepatitis C. By removing barriers to hepatitis C treatment, we can decrease the incidence and prevalence of this disease. Furthermore, by decreasing the disease burden of hepatitis C, we can decrease rates of liver disease, cirrhosis, hepatocellular carcinoma, and associated morbidity and mortality.Method: We conducted a retrospective review of lab data from the electronic health record for patients seen by the OSU Family Medicine department. Patients who had a detectable HCV viral load lab drawn between January 1, 2018 to March 31, 2019 was generated. From this list we identified those patients who were not actively being treated for HCV. Our intervention was contacting these patients to assess any barriers which may have delayed treatment, and evaluate how effective this phone call is in connecting patients with the proper resources to proceed to the next step in work up and treatment

Radiative corrections to W-boson hadroproduction: higher-order electroweak and supersymmetric effects

The high accuracy envisaged for future measurements of W-boson production at hadron colliders has to be matched by precise theoretical predictions. We study the impact of electroweak radiative corrections on W-boson production cross sections and differential distributions at the Tevatron and at the LHC. In particular, we include photon-induced processes, which contribute at O(alpha), and leading radiative corrections beyond O(alpha) in the high-energy Sudakov regime and from multi-photon final-state radiation. We furthermore present the calculation of the complete supersymmetric next-to-leading-order electroweak and QCD corrections to W-boson hadroproduction within the MSSM. The supersymmetric corrections turn out to be negligible in the vicinity of the W resonance in general, reaching the percent level only at high lepton transverse momentum and for specific choices of the supersymmetric parameters.Comment: 30 pages, 10 figures, 2 new sections, including a comparison with previous results on multi-photon radiation; version published in PR

Testing the effect of individual scent compounds on pollinator attraction in nature using quasi-isogenic Capsella lines

Premise Floral scent, usually consisting of multiple compounds, is a complex trait, and its role in pollinator attraction has received increasing attention. However, disentangling the effect of individual floral scent compounds is difficult due to the complexity of isolating the effect of single compounds by traditional methods. Methods Using available quasi-isogenic lines (qILs) that were generated as part of the original mapping of the floral scent volatile-related loci CNL1 (benzaldehyde) and TPS2 (β-ocimene) in Capsella, we generated four genotypes that should only differ in these two compounds. Plants of the four genotypes were introduced into a common garden outside the natural range of C. rubella or C. grandiflora, with individuals of a self-compatible C. grandiflora line as pollen donors, whose different genetic background facilitates the detection of outcrossing events. Visitors to flowers of all five genotypes were compared, and the seeds set during the common-garden period were collected for high-throughput amplicon-based sequencing to estimate their outcrossing rates. Results Benzaldehyde and β-ocimene emissions were detected in the floral scent of corresponding genotypes. While some pollinator groups showed specific visitation preferences depending on scent compounds, the outcrossing rates in seeds did not vary among the four scent-manipulated genotypes. Conclusions The scent-manipulated Capsella materials constructed using qILs provide a powerful system to study the ecological effects of individual floral scent compounds under largely natural environments. In Capsella, individual benzaldehyde and β-ocimene emission may act as attractants for different types of pollinators

Long-term field and laboratory leaching tests of cemented radioactive wastes

Experiments with real and simulated radioactive cementitious wasteforms were set up to compare the leaching behaviour of cementitious wasteforms containing nuclear power plant operational waste in field and laboratory test conditions. Experiments revealed that the average annual Cs-137 leach rate in deionised water was about thirty-five times greater compared with the measured average value for the 1st year of the field test. Cumulative leached fraction of Cs-137 for 1st year (3.74%) was close to values reported in literature for similar laboratory experiments in deionised water, however more than two orders of magnitude higher than the 1st year leached fraction of Cs-137 in the repository test (0.01%). Therefore, to compare field and laboratory test results, a scaling factor is required in order to account for surface to volume factor difference, multiplied by a temperature factor and a leach rate decrease coefficient related to the ground water composition. (C) 2011 Elsevier B.V. All rights reserved

Fruit shape diversity in the Brassicaceae is generated by varying patterns of anisotropy

Fruits exhibit a vast array of different 3D shapes, from simple spheres and cylinders to more complex curved forms; however, the mechanism by which growth is oriented and coordinated to generate this diversity of forms is unclear. Here, we compare the growth patterns and orientations for two very different fruit shapes in the Brassicaceae: the heart-shaped Capsella rubella silicle and the near-cylindrical Arabidopsis thaliana silique. We show, through a combination of clonal and morphological analyses, that the different shapes involve different patterns of anisotropic growth during three phases. These experimental data can be accounted for by a tissue-level model in which specified growth rates vary in space and time and are oriented by a proximodistal polarity field. The resulting tissue conflicts lead to deformation of the tissue as it grows. The model allows us to identify tissue-specific and temporally specific activities required to obtain the individual shapes. One such activity may be provided by the valve-identity gene FRUITFULL, which we show through comparative mutant analysis to modulate fruit shape during post-fertilisation growth of both species. Simple modulations of the model presented here can also broadly account for the variety of shapes in other Brassicaceae species, thus providing a simplified framework for fruit development and shape diversity

Symplectic degenerate flag varieties

Let \SF^a_\lambda be the degenerate symplectic flag variety. These are projective singular irreducible \bG_a^M degenerations of the classical flag varieties for symplectic group $Sp_{2n}$. We give an explicit construction for the varieties \SF^a_\lambda and construct their desingularizations, similar to the Bott-Samelson resolutions in the classical case. We prove that \SF^a_\la are normal locally complete intersections with terminal and rational singularities. We also show that these varieties are Frobenius split. Using the above mentioned results, we prove an analogue of the Borel-Weil-Bott theorem and obtain a $q$-character formula for the characters of irreducible $Sp_{2n}$-modules via the Atiyah-Bott-Lefschetz fixed points formula.Comment: 32 page

BENCH-SCALE STEAM REFORMING OF ACTUAL TANK 48H WASTE

Fluidized Bed Steam Reforming (FBSR) has been demonstrated to be a viable technology to remove >99% of the organics from Tank 48H simulant, to remove >99% of the nitrate/nitrite from Tank 48H simulant, and to form a solid product that is primarily carbonate based. The technology was demonstrated in October of 2006 in the Engineering Scale Test Demonstration Fluidized Bed Steam Reformer1 (ESTD FBSR) at the Hazen Research Inc. (HRI) facility in Golden, CO. The purpose of the Bench-scale Steam Reformer (BSR) testing was to demonstrate that the same reactions occur and the same product is formed when steam reforming actual radioactive Tank 48H waste. The approach used in the current study was to test the BSR with the same Tank 48H simulant and same Erwin coal as was used at the ESTD FBSR under the same operating conditions. This comparison would allow verification that the same chemical reactions occur in both the BSR and ESTD FBSR. Then, actual radioactive Tank 48H material would be steam reformed in the BSR to verify that the actual tank 48H sample reacts the same way chemically as the simulant Tank 48H material. The conclusions from the BSR study and comparison to the ESTD FBSR are the following: (1) A Bench-scale Steam Reforming (BSR) unit was successfully designed and built that: (a) Emulated the chemistry of the ESTD FBSR Denitration Mineralization Reformer (DMR) and Carbon Reduction Reformer (CRR) known collectively as the dual reformer flowsheet. (b) Measured and controlled the off-gas stream. (c) Processed real (radioactive) Tank 48H waste. (d) Met the standards and specifications for radiological testing in the Savannah River National Laboratory (SRNL) Shielded Cells Facility (SCF). (2) Three runs with radioactive Tank 48H material were performed. (3) The Tetraphenylborate (TPB) was destroyed to > 99% for all radioactive Bench-scale tests. (4) The feed nitrate/nitrite was destroyed to >99% for all radioactive BSR tests the same as the ESTD FBSR. (5) The radioactive Tank 48H DMR product was primarily made up of soluble carbonates. The three most abundant species were thermonatrite, [Na{sub 2}CO{sub 3} {center_dot} H{sub 2}O], sodium carbonate, [Na{sub 2}CO{sub 3}], and trona, [Na{sub 3}H(CO{sub 3}){sub 2} {center_dot} 2H{sub 2}O] the same as the ESTD FBSR. (6) Insoluble solids analyzed by X-Ray Diffraction (XRD) did not detect insoluble carbonate species. However, they still may be present at levels below 2 wt%, the sensitivity of the XRD methodology. Insoluble solids XRD characterization indicated that various Fe/Ni/Cr/Mn phases are present. These crystalline phases are associated with the insoluble sludge components of Tank 48H slurry and impurities in the Erwin coal ash. The percent insoluble solids, which mainly consist of un-burnt coal and coal ash, in the products were 4 to 11 wt% for the radioactive runs. (7) The Fe{sup +2}/Fe{sub total} REDOX measurements ranged from 0.58 to 1 for the three radioactive Bench-scale tests. REDOX measurements > 0.5 showed a reducing atmosphere was maintained in the DMR indicating that pyrolysis was occurring. (8) Greater than 90% of the radioactivity was captured in the product for all three runs. (9) The collective results from the FBSR simulant tests and the BSR simulant tests indicate that the same chemistry occurs in the two reactors. (10) The collective results from the BSR simulant runs and the BSR radioactive waste runs indicates that the same chemistry occurs in the simulant as in the real waste. The FBSR technology has been proven to destroy the organics and nitrates in the Tank 48H waste and form the anticipated solid carbonate phases as expected