Antioxidant activity of Piper caninum and Cyclooxygenase-2 inhibition by methoxylated flavones.

Background: This study investigated on antioxidant activity of Piper caninum and cyclooxygenase-2 inhibition by methoxylated flavones.Materials and methods: The present study was carried out to quantify the total phenolic content and free radical scavenging activities of the crude extracts by Folin-Ciocalteu and 1,1-diphenyl-2-picrylhydrazyl free radical scavenging assay respectively.Results: Methanolic extracts of Piper caninum exhibited the highest total phenolic content and free radical scavenging activities. All the pure compounds possessed significant cyclooxygenase-2 inhibition at physiological concentrations.Conclusion: Based on in vitro and molecular docking, we therefore suggest that Piper caninum methoxylated flavones are potent inhibitors of cyclooxygenase-2 at physiological concentrationsKey words: Piper caninum; antioxidant; cyclooxygenase-2.List of abbreviations: COX-2, cyclooxygenase-2; DPPH, 2,2-diphenyl- 1-picrylhydrazyl; PGE2, prostaglandin E2

The effect of industrial and waste fibres on concrete strength and structural behaviour of rc short columns

Concrete is a brittle substance; thus, it is reinforced with rebars and fibers to enhance its ductility. On the other hand, the presence of waste from various industries negatively impacts the environment. The ongoing reconstruction in Iraq has resulted in an abundance of locally produced rebar-connecting wire (RCW) and copper electric wire (CEW) waste. To minimize the environmental impact of these wastes, they can be reused in other industries, such as the concrete industry. Few studies have dealt with concrete's structural and mechanical properties containing these local residues. Therefore, this study included an experimental investigation of concrete columns with and without various types of industrial and waste fibers. Two types of industrial fibers (macro hooked-end; CH, and micro straight; CS) steel fibers and two types of waste fibers (RCW and CEW) were utilized. Six reinforced concrete (RC) columns (150 × 150 × 450 mm3) were cast: one control column without fibers and five columns with fibers. The fiber content within the columns was fixed at 0.75% of the concrete volume. The cracks pattern, load-deflection behavior and concrete strain for RC columns were investigated. Moreover, the mechanical properties in terms of compressive, splitting tensile, and flexural strengths tests were also conducted. The results revealed that all types of fibers used improved the mechanical and structural properties of the concrete. Moreover, although the hybrid synthetic fibers gave the best improvement compared to the reference sample, the waste fibers (especially RCW) showed a significant improvement that reached 30.91% in relation to the ultimate load and (10.1, 10.8 and 14.4%) in relation to the compressive, tensile, and flexural strengths respectively. Konkrit adalah material rapuh; oleh itu ianya dikuatkan dengan besi dan fiber bagi menguatkan kekuatannya. Dalam masa sama, kehadiran bahan buangan dalam pelbagai industri memberi kesan negatif kepada persekitaran. Penstrukturan semula Iraq yang sedang berlangsung memberi kesan kepada kebanjiran bahan buangan seperti besi penghubung litar (RCW) dan litar elektrik tembaga (CEW) buatan tempatan. Bagi mengurangkan kesan pencemaran terhadap alam sekitar, bahan-bahan ini boleh diguna balik dalam industri berbeza, seperti industri konkrit. Terdapat banyak kajian terhadap buangan tempatan yang melibatkan struktur bahan konkrit dan sifat mekanikal.  Oleh itu, kajian ini merupakan kajian eksperimen pasak konkrit dengan atau tanpa pelbagai jenis industri dan fiber buangan. Dua jenis fiber industri iaitu fiber besi (mikro hujung-penyangkut; CH dan mikro lurus; CS) dan dua jenis fiber buangan (RCW dan CEW) dipakai. Enam RC pasak konkrit (150 × 150 × 450 mm3) dihasilkan: satu pasak kawalan tanpa fiber dan lima pasak dengan fiber. Kandungan fiber dalam pasak di tetapkan pada 0.75% isipadu konkrit. Corak rekahan, ciri-ciri kesan beban dan tekanan konkrit pada pasak RC dikaji. Tambahan, kajian terhadap ciri-ciri mekanikal berdasarkan tekanan, rekahan tensil dan kekuatan anjalan telah dijalankan. Dapatan kajian menunjukkan kesemua fiber yang digunakan menambah baik ciri-ciri mekanikal dan struktur konkrit. Tambahan lagi, walaupun fiber sintetik hibrid menunjukkan paling baik berbanding sampel contoh, fiber buangan (terutama RCW) menunjukkan pembaharuan ketara mencapai 30.91% berbanding beban maksimum dan masing-masing menunjukkan 10.1, 10.8 dan 14.4% pada tekanan, rekahan tensil dan kekuatan anjalan

Why is the Winner the Best?

International benchmarking competitions have become fundamental for the comparative performance assessment of image analysis methods. However, little attention has been given to investigating what can be learnt from these competitions. Do they really generate scientific progress? What are common and successful participation strategies? What makes a solution superior to a competing method? To address this gap in the literature, we performed a multicenter study with all 80 competitions that were conducted in the scope of IEEE ISBI 2021 and MICCAI 2021. Statistical analyses performed based on comprehensive descriptions of the submitted algorithms linked to their rank as well as the underlying participation strategies revealed common characteristics of winning solutions. These typically include the use of multi-task learning (63%) and/or multi-stage pipelines (61%), and a focus on augmentation (100%), image preprocessing (97%), data curation (79%), and post-processing (66%). The “typical” lead of a winning team is a computer scientist with a doctoral degree, five years of experience in biomedical image analysis, and four years of experience in deep learning. Two core general development strategies stood out for highly-ranked teams: the reflection of the metrics in the method design and the focus on analyzing and handling failure cases. According to the organizers, 43% of the winning algorithms exceeded the state of the art but only 11% completely solved the respective domain problem. The insights of our study could help researchers (1) improve algorithm development strategies when approaching new problems, and (2) focus on open research questions revealed by this work

Why is the winner the best?

International benchmarking competitions have become fundamental for the comparative performance assessment of image analysis methods. However, little attention has been given to investigating what can be learnt from these competitions. Do they really generate scientific progress? What are common and successful participation strategies? What makes a solution superior to a competing method? To address this gap in the literature, we performed a multicenter study with all 80 competitions that were conducted in the scope of IEEE ISBI 2021 and MICCAI 2021. Statistical analyses performed based on comprehensive descriptions of the submitted algorithms linked to their rank as well as the underlying participation strategies revealed common characteristics of winning solutions. These typically include the use of multi-task learning (63%) and/or multi-stage pipelines (61%), and a focus on augmentation (100%), image preprocessing (97%), data curation (79%), and post-processing (66%). The 'typical' lead of a winning team is a computer scientist with a doctoral degree, five years of experience in biomedical image analysis, and four years of experience in deep learning. Two core general development strategies stood out for highly-ranked teams: the reflection of the metrics in the method design and the focus on analyzing and handling failure cases. According to the organizers, 43% of the winning algorithms exceeded the state of the art but only 11% completely solved the respective domain problem. The insights of our study could help researchers (1) improve algorithm development strategies when approaching new problems, and (2) focus on open research questions revealed by this work

Prevalence and Knowledge of Respiratory Symptoms Among the General Public in the Southern Area of Najran, Saudi Arabia: A Cross-Sectional Health Survey Study

Mohammad H Alyami,1 Abdallah Y Naser,2 Hamad S Alyami,1 Thamer S Algahtani,1 Abdullah H Alyami,3 Saleh A Alsalem,3 Abdullah H Almansour,3 Hadi S Alswar,3 Ali M Al Alhareth3 1Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, Saudi Arabia; 2Department of Applied Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Isra University, Amman, Jordan; 3Directorate of Health Affairs Najran, Ministry of Health, Najran, Saudi ArabiaCorrespondence: Mohammad H Alyami, Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, 11001, Saudi Arabia, Tel +966 565022774, Email [email protected] Abdallah Y Naser, Department of Applied Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Isra University, Amman, Jordan, Tel +962 795285555, Email [email protected]: To investigate the knowledge, prevalence of chronic respiratory disorders, and utilization of their medications among the adults at Najran region, Saudi Arabia.Methods: An online cross-sectional survey was carried out in Najran region, Saudi Arabia. A self-administered questionnaire was distributed among a random sample of the general population, aged 18 or above between March and December 2022. The survey instrument included questions regarding history and exposure, physician diagnosed-disorders, respiratory symptoms, allergy, use of medications and possible risk-related factors.Results: This research had a total of 712 individuals. Nearly one-third of the participants in the survey (n = 218; 30.6%) said that they or a member of their family suffer from respiratory ailments. The majority of research participants (n = 167; 76.8%) identified asthma as their primary respiratory condition. A total of 32.0% of participants (n = 70) reported dealing with dust or chemicals such as paints, fertilizers, and cleaning products on a daily basis at work or at home. Around 62.0% of the participants (n = 134) said that exposure to gases, fragrances, and other such substances negatively impacts their health. Almost 78.0% (n = 169) of them indicated that summer weather affects their health, whereas 63.0% (n = 138) reported that winter cold affects their health. Participants aged 41– 50 years were 38.0% less likely to have CRDs compared to others (p < 0.05).Conclusion: This study is among the first few studies that explored the knowledge, prevalence of chronic respiratory disorders, and utilization of their medications among the adults at Najran region, Saudi Arabia. In the southern area of Najran, respiratory symptoms are frequent among the inhabitants of Saudi Arabia. More research is required to discover avoidable risk factors and create countermeasures for them. It is recommended that healthcare personnel increase their efforts to educate their patients about respiratory illness prevention methods.Keywords: diseases, respiratory, Saudi Arabia, symptom