Two-temperature coronal flow above a thin disk

We extended the disk corona model (Meyer & Meyer-Hofmeister 1994; Meyer, Liu, & Meyer-Hofmeister 2000a) to the inner region of galactic nuclei by including different temperatures in ions and electrons as well as Compton cooling. We found that the mass evaporation rate and hence the fraction of accretion energy released in the corona depend strongly on the rate of incoming mass flow from outer edge of the disk, a larger rate leading to more Compton cooling, less efficient evaporation and a weaker corona. We also found a strong dependence on the viscosity, higher viscosity leading to an enhanced mass flow in the corona and therefore more evaporation of gas from the disk below. If we take accretion rates in units of the Eddington rate our results become independent on the mass of the central black hole. The model predicts weaker contributions to the hard X-rays for objects with higher accretion rate like narrow-line Seyfert 1 galaxies (NLS1s), in agreement with observations. For luminous active galactic nuclei (AGN) strong Compton cooling in the innermost corona is so efficient that a large amount of additional heating is required to maintain the corona above the thin disk.Comment: 17 pages, 6 figures. ApJ accepte

Dust detection by the wave instrument on STEREO: nanoparticles picked up by the solar wind?

The STEREO/WAVES instrument has detected a very large number of intense voltage pulses. We suggest that these events are produced by impact ionisation of nanoparticles striking the spacecraft at a velocity of the order of magnitude of the solar wind speed. Nanoparticles, which are half-way between micron-sized dust and atomic ions, have such a large charge-to-mass ratio that the electric field induced by the solar wind magnetic field accelerates them very efficiently. Since the voltage produced by dust impacts increases very fast with speed, such nanoparticles produce signals as high as do much larger grains of smaller speeds. The flux of 10-nm radius grains inferred in this way is compatible with the interplanetary dust flux model. The present results may represent the first detection of fast nanoparticles in interplanetary space near Earth orbit.Comment: In press in Solar Physics, 13 pages, 5 figure

Rubber friction on wet and dry road surfaces: the sealing effect

Rubber friction on wet rough substrates at low velocities is typically 20-30% smaller than for the corresponding dry surfaces. We show that this cannot be due to hydrodynamics and propose a novel explanation based on a sealing effect exerted by rubber on substrate "pools" filled with water. Water effectively smoothens the substrate, reducing the major friction contribution due to induced viscoelastic deformations of the rubber by surface asperities. The theory is illustrated with applications related to tire-road friction.Comment: Format Revtex 4; 8 pages, 11 figures (no color); Published on Phys. Rev. B (http://link.aps.org/abstract/PRB/v71/e035428); previous work on the same topic: cond-mat/041204

Holographic (De)confinement Transitions in Cosmological Backgrounds

For type IIB supergravity with a running axio-dilaton, we construct bulk solutions which admit a cosmological background metric of Friedmann-Robertson-Walker type. These solutions include both a dark radiation term in the bulk as well as a four-dimensional (boundary) cosmological constant, while gravity at the boundary remains non-dynamical. We holographically calculate the stress-energy tensor, showing that it consists of two contributions: The first one, generated by the dark radiation term, leads to the thermal fluid of N = 4 SYM theory, while the second, the conformal anomaly, originates from the boundary cosmological constant. Conservation of the boundary stress tensor implies that the boundary cosmological constant is time-independent, such that there is no exchange between the two stress-tensor contributions. We then study (de)confinement by evaluating the Wilson loop in these backgrounds. While the dark radiation term favours deconfinement, a negative cosmological constant drives the system into a confined phase. When both contributions are present, we find an oscillating universe with negative cosmological constant which undergoes periodic (de)confinement transitions as the scale of three space expands and re-contracts.Comment: 31 pages, 5 figures, v2: Reference adde

A Note on Bimodal Accretion Disks

The existence of bimodal disks is investigated. Following a simple argument based on energetic considerations we show that stationary, bimodal accretion disk models in which a Shakura--Sunyaev disk (SSD) at large radii matches an advection dominated accretion flow (ADAF) at smaller radii are never possible using the standard slim disk approach, unless some extra energy flux is present. The same argument, however, predicts the possibility of a transition from an outer Shapiro--Lightman--Eardley (SLE) disk to an ADAF, and from a SLE disk to a SSD. Both types of solutions have been found.Comment: 9 pages including 9 figures, accepted for publication in The Astrophysical Journa

Targeting tumor multicellular aggregation through IGPR-1 inhibits colon cancer growth and improves chemotherapy

Adhesion to extracellular matrix (ECM) is crucially important for survival of normal epithelial cells as detachment from ECM triggers specific apoptosis known as anoikis. As tumor cells lose the requirement for anchorage to ECM, they rely on cell-cell adhesion 'multicellular aggregation' for survival. Multicellular aggregation of tumor cells also significantly determines the sensitivity of tumor cells to the cytotoxic effects of chemotherapeutics. In this report, we demonstrate that expression of immunoglobulin containing and proline-rich receptor-1 (IGPR-1) is upregulated in human primary colon cancer. Our study demonstrates that IGPR-1 promotes tumor multicellular aggregation, and interfering with its adhesive function inhibits multicellular aggregation and, increases cell death. IGPR-1 supports colon carcinoma tumor xenograft growth in mouse, and inhibiting its activity by shRNA or blocking antibody inhibits tumor growth. More importantly, IGPR-1 regulates sensitivity of tumor cells to the chemotherapeutic agent, doxorubicin/adriamycin by a mechanism that involves doxorubicin-induced AKT activation and phosphorylation of IGPR-1 at Ser220. Our findings offer novel insight into IGPR-1's role in colorectal tumor growth, tumor chemosensitivity, and as a possible novel anti-cancer target.Grant support from: R01 CA175382/CA/NCI NIH HHS/United States, R21 CA191970/CA/NCI NIH HHS/United States, and R21 CA193958/CA/NCI NIH HHS/United State

Acid-Labile Traceless Click Linker for Protein Transduction

Intracellular delivery of active proteins presents an interesting approach in research and therapy. We created a protein transduction shuttle based on a new traceless click linker that combines the advantages of click reactions with implementation of reversible pH-sensitive bonds. The azidomethyl-methylmaleic anhydride (AzMMMan) linker was found compatible with different click chemistries, demonstrated in bioreversible protein modification with dyes, polyethylene glycol, or a transduction carrier. Linkages were stable at physiological pH but reversible at the mild acidic pH of endosomes or lysosomes. We show that pH-reversible attachment of a defined endosome-destabilizing three-arm oligo(ethane amino)amide carrier generates an effective shuttle for protein delivery. The cargo protein nlsEGFP, when coupled via the traceless AzMMMan linker, experiences efficient cellular uptake and endosomal escape into the cytosol, followed by import into the nucleus. In contrast, irreversible linkage to the same shuttle hampers nuclear delivery of nlsEGFP which after uptake remains trapped in the cytosol. Successful intracellular delivery of bioactive ß-galactosidase as a model enzyme was also demonstrated using the pH-controlled shuttle system