Gravitational detection of a low-mass dark satellite at cosmological distance

The mass-function of dwarf satellite galaxies that are observed around Local Group galaxies substantially differs from simulations based on cold dark matter: the simulations predict many more dwarf galaxies than are seen. The Local Group, however, may be anomalous in this regard. A massive dark satellite in an early-type lens galaxy at z = 0.222 was recently found using a new method based on gravitational lensing, suggesting that the mass fraction contained in substructure could be higher than is predicted from simulations. The lack of very low mass detections, however, prohibited any constraint on their mass function. Here we report the presence of a 1.9 +/- 0.1 x 10^8 M_sun dark satellite in the Einstein-ring system JVAS B1938+666 at z = 0.881, where M_sun denotes solar mass. This satellite galaxy has a mass similar to the Sagittarius galaxy, which is a satellite of the Milky Way. We determine the logarithmic slope of the mass function for substructure beyond the local Universe to be alpha = 1.1^+0.6_-0.4, with an average mass-fraction of f = 3.3^+3.6_-1.8 %, by combining data on both of these recently discovered galaxies. Our results are consistent with the predictions from cold dark matter simulations at the 95 per cent confidence level, and therefore agree with the view that galaxies formed hierarchically in a Universe composed of cold dark matter.Comment: 25 pages, 7 figures, accepted for publication in Nature (19 January 2012

Ethanol‐Lock Therapy for the Prevention of Central Venous Access Device Infections in Pediatric Patients With Intestinal Failure

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141158/1/jpen0067.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/141158/2/jpen0067-sup-0001.pd

The luxS mutation causes loosely-bound biofilms in Shewanella oneidensis

<p>Abstract</p> <p>Background</p> <p>The <it>luxS </it>gene in <it>Shewanella oneidensis </it>was shown to encode an autoinducer-2 (AI-2)-like molecule, the postulated universal bacterial signal, but the impaired biofilm growth of a <it>luxS </it>deficient mutant could not be restored by AI-2, indicating it might not have a signalling role in this organism.</p> <p>Findings</p> <p>Here, we provide further evidence regarding the metabolic role of a <it>luxS </it>mutation in <it>S. oneidensis</it>. We constructed a <it>luxS </it>mutant and compared its phenotype to a wild type control with respect to its ability to remove AI-2 from the medium, expression of secreted proteins and biofilm formation. We show that <it>S. oneidensis </it>has a cell-dependent mechanism by which AI-2 is depleted from the medium by uptake or degradation at the end of the exponential growth phase. As AI-2 depletion is equally active in the <it>luxS </it>mutant and thus does not require AI-2 as an inducer, it appears to be an unspecific mechanism suggesting that AI-2 for <it>S. oneidensis </it>is a metabolite which is imported under nutrient limitation. Secreted proteins were studied by iTraq labelling and liquid chromatography mass spectrometry (LC-MS) detection. Differences between wild type and mutant were small. Proteins related to flagellar and twitching motility were slightly up-regulated in the <it>luxS </it>mutant, in accordance with its loose biofilm structure. An enzyme related to cysteine metabolism was also up-regulated, probably compensating for the lack of the LuxS enzyme. The <it>luxS </it>mutant developed an undifferentiated, loosely-connected biofilm which covered the glass surface more homogenously than the wild type control, which formed compact aggregates with large voids in between.</p> <p>Conclusions</p> <p>The data confirm the role of the LuxS enzyme for biofilm growth in <it>S. oneidensis </it>and make it unlikely that AI-2 has a signalling role in this organism.</p

Multipurpose silicon photonics signal processor core

[EN] Integrated photonics changes the scaling laws of information and communication systems offering architectural choices that combine photonics with electronics to optimize performance, power, footprint, and cost. Application-specific photonic integrated circuits, where particular circuits/chips are designed to optimally perform particular functionalities, require a considerable number of design and fabrication iterations leading to long development times. A different approach inspired by electronic Field Programmable Gate Arrays is the programmable photonic processor, where a common hardware implemented by a two-dimensional photonic waveguide mesh realizes different functionalities through programming. Here, we report the demonstration of such reconfigurable waveguide mesh in silicon. We demonstrate over 20 different functionalities with a simple seven hexagonal cell structure, which can be applied to different fields including communications, chemical and biomedical sensing, signal processing, multiprocessor networks, and quantum information systems. Our work is an important step toward this paradigm.J.C. acknowledges funding from the ERC Advanced Grant ERC-ADG-2016-741415 UMWP-Chip, I.G. acknowledges the funding through the Spanish MINECO Ramon y Cajal program. D.P. acknowledges financial support from the UPV through the FPI predoctoral funding scheme. D.J.T. acknowledges funding from the Royal Society for his University Research Fellowship.Pérez-López, D.; Gasulla Mestre, I.; Crudgington, L.; Thomson, DJ.; Khokhar, AZ.; Li, K.; Cao, W.... (2017). Multipurpose silicon photonics signal processor core. Nature Communications. 8(1925):1-9. https://doi.org/10.1038/s41467-017-00714-1S1981925Doerr, C. R. & Okamoto, K. Advances in silica planar lightwave circuits. J. Lightw. Technol. 24, 4763–4789 (2006).Coldren, L. A. et al. High performance InP-based photonic ICs—A tutorial. J. Lightw. Technol 29, 554–570 (2011).Soref, R. The past, present, and future of silicon photonics. IEEE J. Sel. Top. Quantum Electron. 12, 1678–1687 (2006).Bogaerts, W. Design challenges in silicon photonics. IEEE J. Sel. Top. Quantum Electron. 20, 8202008 (2014).Bogaerts, W. et al. Nanophotonic waveguides in silicon-on-insulator fabricated with CMOS technology. J. Lightw. Technol. 23, 401–412 (2005).Smit, M. K. et al. An introduction to InP-based generic integration technology. Semicond. Sci. Technol. 29, 083001 (2014).Leinse, A. et al. TriPleX waveguide platform: low-loss technology over a wide wavelength range. Proc. SPIE 8767, 87670E (2013).Kish, F. et al. From visible light-emitting diodes to large-scale III–V photonic integrated circuits. Proc. IEEE 101, 2255–2270 (2013).Heck, M. J. R. et al. Hybrid silicon photonic integrated circuit technology. IEEE J. Sel. Top. Quantum Electron. 19, 6100117 (2013).Sacher, W. et al. Multilayer silicon nitride-on-silicon integrated photonic platforms and devices. J. Lightw. Technol. 33, 901–910 (2015).Asghari, M. Silicon photonics: A low cost integration platform for datacom and telecom applications. In OFC/NFOEC 2008 – 2008 Conference on Optical Fiber Communication/National Fiber Optic Engineers Conference 1–10 (San Diego, USA, 2008).Melati, D. et al. Integrated all-optical MIMO demultiplexer for mode- and wavelength-division-multiplexed transmission. Opt. Lett. 42, 342–345 (2017).Waterhouse, R. & Novak, D. Realizing 5G: microwave photonics for 5G mobile wireless systems. IEEE Microw. Mag. 16, 84–92 (2015).Marpaung, D. et al. Integrated microwave photonics. Laser Photon. Rev. 7, 506–538 (2013).Iezekiel, S., Burla, M., Klamkin, J., Marpaung, D. & Capmany, J. RF engineering meets optoelectronics: Progress in integrated microwave photonics. IEEE Microw. Mag. 16, 28–45 (2015).Technology focus on microwave photonics. Nat. Photon. 5, 723 (2011).Ghelfi, P. et al. A fully photonics-based coherent radar system. Nature 507, 341–345 (2014).Heideman, R. G. TriPleX™-based integrated optical ring resonators for lab-ona-chip-and environmental detection. IEEE J. Sel. Top. Quantum Electron. 18, 1583–1596 (2012).Estevez, M. C., Alvarez, M. & Lechuga, L. Integrated optical devices for lab-on-a-chip biosensing applications. Laser Photon. Rev. 6, 463–487 (2012).Almeida, V. R., Barrios, C. A., Panepucci, R. & Lipson, M. All-optical control of light on a silicon chip. Nature 431, 1081–1084 (2004).Norberg, E. J., Guzzon, R. S., Parker, J. S., Johansson, L. A. & Coldren, L. A. Programmable photonic microwave filters monolithically integrated in InP/InGaAsP. J. Lightw. Technol. 29, 1611–1619 (2011).Wang, J. et al. Reconfigurable radio-frequency arbitrary waveforms synthesized in a silicon photonic chip. Nat. Commun. 6, 5957 (2015).Hill, M. T. et al. A fast low power optical memory based on coupled micro-ring lasers. Nature 432, 206–209 (2004).Slavík, R. et al. Photonic temporal integrator for all-optical computing. Opt. Express 16, 18202–18214 (2008).Sun, C. et al. A monolithically-integrated chip-to-chip optical link in bulk CMOS. IEEE J. Solid-State Circ. 50, 828–844 (2015).Sun, C. et al. Single-chip microprocessor that communicates directly using light. Nature 528, 534–538 (2015).Assefa, S. et al. in Optical Fibre Communication Conference OMM6, https://www.osapublishing.org/abstract.cfm?uri=OFC-2011-OMM6 (Optical Society of America, 2011).Peruzzo, A. et al. Multimode quantum interference of photons in multiport integrated devices. Nat. Commun. 2, 224 (2011).Bonneau, D. et al. Quantum interference and manipulation of entanglement in silicon wire waveguide quantum circuits. N. J. Phys. 14, 045003 (2012).Metcalf, B. J. et al. Multiphoton quantum interference in a multiport integrated photonic device. Nat. Commun. 4, 1356 (2013).Muñoz, P. et al. in 16th International Conference on Transparent Optical Networks (ICTON), 1–4 (Graz, 2014).Ribeiro, A. et al. Demonstration of a 4×4-port universal linear circuit. Optica 3, 1348–1357 (2016).Liu, W. et al. A fully reconfigurable photonic integrated signal processor. Nat. Photon 10, 190–195 (2016).Graydon, O. Birth of the programmable optical chip. Nat. Photon 10, 1 (2016).Pérez, D., Gasulla, I. & Capmany, J. Software-defined reconfigurable microwave photonics processor. Opt. Express 23, 14640–14654 (2015).Miller, D. A. B. Self-configuring universal linear optical component. Photon. Res. 1, 1–15 (2013).Miller, D. A. B. Self-aligning universal beam coupler. Opt. Express 21, 6360–6370 (2013).Clements, W. R. et al. Optimal design for universal multiport interferometers. Optica 3, 1460–1465 (2016).Zhuang, L., Roeloffzen, C. G. H., Hoekman, M., Boller, K.-J. & Lowery, A. J. Programmable photonic signal processor chip for radiofrequency applications. Optica 2, 854–859 (2015).Capmany, J., Gasulla, I. & Pérez, D. Microwave photonics: The programmable processor. Nat. Photon. 10, 6–8 (2016).Pérez, D., Gasulla., Capmany, J. & Soref, R. A. Reconfigurable lattice mesh designs for programmable photonic processors. Opt. Express 24, 12093–12106 (2016).Madsen, C. K. & Zhao, J. H. Optical Filter Design and Analysis: A Signal Processing Approach. 1st edn. (Wiley, 1999).Jinguji, K. Synthesis of coherent two-port lattice-form optical delay-line circuit. J. Lightw. Technol. 13, 73–82 (1995).Jinguji, K. Synthesis of coherent two-port Optical delay-line circuit with ring waveguides. J. Lightw. Technol. 14, 1882–1898 (1996).Madsen, C. K. General IIR optical filter design for WDM applications using all-pass filters. J. Lightw. Technol. 18, 860–868 (2000).Burla, M. et al. On-chip CMOS compatible reconfigurable optical delay line with separate carrier tuning for microwave photonic signal processing. Opt. Express 19, 21475–21484 (2011).Yariv, A. et al. Coupled resonator optical waveguides: a proposal and analysis. Opt. Lett. 24, 711–713 (1999).Hebner, J. E. et al. Distributed and localized feedback in microresonator sequences for linear and nonlinear optics. J. Opt. Soc. Am. B. 21, 1665–1673 (2004).Fandiño, J. S. et al. A monolithic integrated photonic microwave filter. Nat. Photon. 11, 124–129 (2017).Miller, D. A. B. All linear optical devices are mode converters. Opt. Express 20, 23985–23993 (2012).Reck, M. et al. Experimental realization of any discrete unitary operator. Phys. Rev. Lett. 73, 58–61 (1994).Carolan, J. et al. Universal linear optics. Science 349, 711 (2015).Nielsen, M. A. & Chuang, I. L. Quantum Computation and Quantum Information. 1st edn. (Cambridge University Press, 2001).Miller, D. A. B. Perfect optics with imperfect components. Optica 2, 747–750 (2015).Grillanda, S. et al. Non-invasive monitoring and control in silicon photonics using CMOS integrated electronics. Optica 1, 129–136 (2014)

Age-Related Skeletal Dynamics and Decrease in Bone Strength in DNA Repair Deficient Male Trichothiodystrophy Mice

Accumulation of DNA damage caused by oxidative stress is thought to be one of the main contributors of human tissue aging. Trichothiodystrophy (TTD) mice have a mutation in the Ercc2 DNA repair gene, resulting in accumulation of DNA damage and several features of segmental accelerated aging. We used male TTD mice to study the impact of DNA repair on bone metabolism with age. Analysis of bone parameters, measured by micro-computed tomography, displayed an earlier decrease in trabecular and cortical bone as well as a loss of periosteal apposition and a reduction in bone strength in TTD mice with age compared to wild type mice. Ex vivo analysis of bone marrow differentiation potential showed an accelerated reduction in the number of osteogenic and osteoprogenitor cells with unaltered differentiation capacity. Adipocyte differentiation was normal. Early in life, osteoclast number tended to be increased while at 78 weeks it was significantly lower in TTD mice. Our findings reveal the importance of genome stability and proper DNA repair for skeletal homeostasis with age and support the idea that accumulation of damage interferes with normal skeletal maintenance, causing reduction in the number of osteoblast precursors that are required for normal bone remodeling leading to a loss of bone structure and strength

Human-Mediated Emergence as a Weed and Invasive Radiation in the Wild of the CD Genome Allotetraploid Rice Species (Oryza, Poaceae) in the Neotropics

BACKGROUND: The genus Oryza is being used as a model in plant genomic studies although there are several issues still to be resolved regarding the spatio-temporal evolution of this ancient genus. Particularly contentious is whether undated transoceanic natural dispersal or recent human interference has been the principal agent determining its present distribution and differentiation. In this context, we studied the origin and distribution history of the allotetraploid CD rice genome. It is endemic to the Neotropics but the genus is thought to have originated in the Paleotropics, and there is relatively little genetic divergence between some orthologous sequences of the C genome component and their Old World counterparts. METHODOLOGY/PRINCIPAL FINDINGS: Because of its allotetraploidy, there are several potential pitfalls in trying to date the formation of the CD genome using molecular data and this could lead to erroneous estimates. Therefore, we rather chose to rely on historical evidence to determine whether or not the CD genome was present in the Neotropics before the arrival of Columbus. We searched early collections of herbarium specimens and studied the reports of explorers of the tropical Americas for references to rice. In spite of numerous collectors traveling inland and collecting Oryza, plants determined as CD genome species were not observed away from cultivated rice fields until 1869. Various arguments suggest that they only consisted of weedy forms until that time. CONCLUSIONS/SIGNIFICANCE: The spatio-temporal distribution of herbarium collections fits a simple biogeographical scenario for the emergence in cultivated rice fields followed by radiation in the wild of the CD genome in the Neotropics during the last four centuries. This probably occurred from species introduced to the Americas by humans and we found no evidence that the CD genome pre-existed in the Old World. We therefore propose a new evolutionary hypothesis for such a recent origin of the CD genome. Moreover, we exemplify how an historical approach can provide potentially important information and help to disentangle the timing of evolutionary events in the history of the Oryza genomes

Gravitational Lensing in Astronomy

Deflection of light by gravity was predicted by General Relativity and observationaly confirmed in 1919. In the following decades various aspects of the gravitational lens effect were explored theoretically, among them the possibility of multiple or ring-like images of background sources, the use of lensing as a gravitational telescope on very faint and distant objects, and the possibility to determine Hubble's constant with lensing. Only relatively recently gravitational lensing became an observational science after the discovery of the first doubly imaged quasar in 1979. Today lensing is a booming part of astrophysics. In addition to multiply-imaged quasars, a number of other aspects of lensing have been discovered since, e.g. giant luminous arcs, quasar microlensing, Einstein rings, galactic microlensing events, arclets, or weak gravitational lensing. By now literally hundreds of individual gravitational lens phenomena are known. Although still in its childhood, lensing has established itself as a very useful astrophysical tool with some remarkable successes. It has contributed significant new results in areas as different as the cosmological distance scale, the large scale matter distribution in the universe, mass and mass distribution of galaxy clusters, physics of quasars, dark matter in galaxy halos, or galaxy structure.Comment: Review article for "Living Reviews in Relativity", see http://www.livingreviews.org . 41 pages, latex, 22 figures (partly in GIF format due to size constraints). High quality postscript files can be obtained electronically at http://www.aip.de:8080/~jkw/review_figures.htm

Honey, a Gift from Nature to Health and Beauty: A Review

Benefits of honey are contributed by the composition of its elements such as glucose, fructose, glucose oxidase, vitamins and phenolic compounds. For health, honey can be used to treat wounds due to the antibacterial activity conferred by the hydrogen peroxide produced by glucose oxidase in honey. Anti-inflammatory, anti-oxidant, deodorizing and tissue regeneration activities in honey also help in the wound healing process. It can also be an alternative sweetener for diabetic patients to ensure compliance to a healthy diet. Moreover, honey exerts several effects such as lowering low density lipids and increasing high density lipids, thus reducing risk of atherosclerosis. In terms of beauty, honey can be used on skin and hair. It moisturizes skin through its natural humectant properties contributed by high contents of fructose and glucose. Honey treats acne on the skin due to its antibacterial activity, anti-inflammatory action and tissue repair. The hair can benefit from honey in such a way that the hair has abundance, and becomes easier to comb. However, there have not been as many studies regarding the use of honey in skin in comparison to its use for health. Therefore, future studies on honey could research its use, action and benefits in both cosmetics and dermatology

Clostridium difficile infection.

Infection of the colon with the Gram-positive bacterium Clostridium difficile is potentially life threatening, especially in elderly people and in patients who have dysbiosis of the gut microbiota following antimicrobial drug exposure. C. difficile is the leading cause of health-care-associated infective diarrhoea. The life cycle of C. difficile is influenced by antimicrobial agents, the host immune system, and the host microbiota and its associated metabolites. The primary mediators of inflammation in C. difficile infection (CDI) are large clostridial toxins, toxin A (TcdA) and toxin B (TcdB), and, in some bacterial strains, the binary toxin CDT. The toxins trigger a complex cascade of host cellular responses to cause diarrhoea, inflammation and tissue necrosis - the major symptoms of CDI. The factors responsible for the epidemic of some C. difficile strains are poorly understood. Recurrent infections are common and can be debilitating. Toxin detection for diagnosis is important for accurate epidemiological study, and for optimal management and prevention strategies. Infections are commonly treated with specific antimicrobial agents, but faecal microbiota transplants have shown promise for recurrent infections. Future biotherapies for C. difficile infections are likely to involve defined combinations of key gut microbiota