1,308 research outputs found
Beam Orientation Optimization for Intensity Modulated Radiation Therapy using Adaptive l1 Minimization
Beam orientation optimization (BOO) is a key component in the process of IMRT
treatment planning. It determines to what degree one can achieve a good
treatment plan quality in the subsequent plan optimization process. In this
paper, we have developed a BOO algorithm via adaptive l_1 minimization.
Specifically, we introduce a sparsity energy function term into our model which
contains weighting factors for each beam angle adaptively adjusted during the
optimization process. Such an energy term favors small number of beam angles.
By optimizing a total energy function containing a dosimetric term and the
sparsity term, we are able to identify the unimportant beam angles and
gradually remove them without largely sacrificing the dosimetric objective. In
one typical prostate case, the convergence property of our algorithm, as well
as the how the beam angles are selected during the optimization process, is
demonstrated. Fluence map optimization (FMO) is then performed based on the
optimized beam angles. The resulted plan quality is presented and found to be
better than that obtained from unoptimized (equiangular) beam orientations. We
have further systematically validated our algorithm in the contexts of 5-9
coplanar beams for 5 prostate cases and 1 head and neck case. For each case,
the final FMO objective function value is used to compare the optimized beam
orientations and the equiangular ones. It is found that, our BOO algorithm can
lead to beam configurations which attain lower FMO objective function values
than corresponding equiangular cases, indicating the effectiveness of our BOO
algorithm.Comment: 19 pages, 2 tables, and 5 figure
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The association between sleep patterns and obesity in older adults.
BackgroundReduced sleep duration has been increasingly reported to predict obesity. However, timing and regularity of sleep may also be important. In this study, the cross-sectional association between objectively measured sleep patterns and obesity was assessed in two large cohorts of older individuals.MethodsWrist actigraphy was performed in 3053 men (mean age: 76.4 years) participating in the Osteoporotic Fractures in Men Study and 2985 women (mean age: 83.5 years) participating in the Study of Osteoporotic Fractures. Timing and regularity of sleep patterns were assessed across nights, as well as daytime napping.ResultsGreater night-to-night variability in sleep duration and daytime napping were associated with obesity independent of mean nocturnal sleep duration in both men and women. Each 1 h increase in the standard deviation of nocturnal sleep duration increased the odds of obesity 1.63-fold (95% confidence interval: 1.31-2.02) among men and 1.22-fold (95% confidence interval: 1.01-1.47) among women. Each 1 h increase in napping increased the odds of obesity 1.23-fold (95% confidence interval: 1.12-1.37) in men and 1.29-fold (95% confidence interval: 1.17-1.41) in women. In contrast, associations between later sleep timing and night-to-night variability in sleep timing with obesity were less consistent.ConclusionsIn both older men and women, variability in nightly sleep duration and daytime napping were associated with obesity, independent of mean sleep duration. These findings suggest that characteristics of sleep beyond mean sleep duration may have a role in weight homeostasis, highlighting the complex relationship between sleep and metabolism
Comparative study of dimer vacancies and dimer-vacancy lines on Si(001) and Ge(001)
Although the clean Si(001) and Ge(001) surfaces are very similar, experiments
to date have shown that dimer-vacancy (DV) defects self-organize into vacancy
lines (VLs) on Si(001), but not on Ge(001). In this paper, we perform
empirical-potential calculations aimed at understanding the differences between
the vacancies on Si(001) and Ge(001). We identify three energetic parameters
that characterize the DVs on the two surfaces: the formation energy of a single
DV, the attraction between two DVs in adjacent dimer rows, and the strain
sensitivity of the formation energy of DVs and VLs. At the empirical level of
treatment of the atomic interactions (Tersoff potentials), all three parameters
are favorable for the self-assembly of DVs on the Si(001) surface rather than
on Ge(001). The most significant difference between the defects on Si(001) and
on Ge(001) concerns the formation energy of single DVs, which is three times
larger in the latter case. By calculating the strain-dependent formation
energies of DVs and VLs, we propose that the experimental observation of
self-assembly of vacancies on clean Ge(001) could be achieved by applying
compressive strains of the order of 2%.Comment: 3 tables, 4 figures, to appear in Surface Scienc
Mechanisms of enhanced heterogeneous nucleation during solidification in binary Al-Mg alloys
This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2012 ElsevierThe mechanisms involved in the grain refinement of Al–Mg alloys through varying the Mg content and applying intensive melt shearing were investigated. It was found that the oxide formed in Al–Mg alloys under normal melting conditions is MgAl2O4, which displays an equiaxed and faceted morphology with {1 1 1} planes exposed as its natural surfaces. Depending on the Mg content, MgAl2O4 particles exist either as oxide films in dilute Al–Mg alloys (Mg 1 wt.%). Such MgAl2O4 particles can act as potent sites for nucleation of α-Al grains, which is evidenced by the well-defined cube-on-cube orientation relationship between MgAl2O4 and α-Al. Enhanced heterogeneous nucleation in Al–Mg alloys can be attributed to the high potency of MgAl2O4 particles with a lattice misfit of 1.4% and the increased number density of MgAl2O4 particles due to either natural dispersion by the increased Mg content or forced dispersion through intensive melt shearing. It was also found that intensive melt shearing leads to significant grain refinement of dilute Al–Mg alloys by effective dispersion of the MgAl2O4 particles entrapped in oxide films, but it has marginal effect on the grain refinement of concentrated Al–Mg alloys, where MgAl2O4 particles have been naturally dispersed into individual particles by the increased Mg content.This study is funded from the EPSRC Grant EP/H026177/1
Effect of long-term fluorination on surface electrical performance of ethylene propylene rubber
To investigate the effect of fluorination on surface electrical performance of ethylene propylene rubber (EPR), four pieces of EPR specimens are prepared and fluorinated for different duration ranging from 120 min to 480 min. The surface morphology and element compositions of experimental specimens are tested. The surface potential decay and complex permittivity are measured. The tracking discharge property and the erosion properties after tracking test are investigated. The surface charge transport and electrical property tailoring mechanism are discussed. The results show that when the fluorination duration is from 120 min to 360 min, the surface morphology gradually becomes flat and compact with time, and the surface resistance to electrical tracking is improved. While an excessive fluorination with the duration of 480 min leads to a significant increase in surface conductivity and a weakening in the resistance to electrical tracking, which is mainly due to a change in surface morphology. The recommended fluorination duration for an optimised surface property is between 240 and 360 min for EPR specimen
Orbit optimization for ASTROD-GW and its time delay interferometry with two arms using CGC ephemeris
ASTROD-GW (ASTROD [Astrodynamical Space Test of Relativity using Optical
Devices] optimized for Gravitation Wave detection) is an optimization of ASTROD
to focus on the goal of detection of gravitation waves. The detection
sensitivity is shifted 52 times toward larger wavelength compared to that of
LISA. The mission orbits of the 3 spacecraft forming a nearly equilateral
triangular array are chosen to be near the Sun-Earth Lagrange points L3, L4 and
L5. The 3 spacecraft range interferometrically with one another with arm length
about 260 million kilometers. In order to attain the requisite sensitivity for
ASTROD-GW, laser frequency noise must be suppressed below the secondary noises
such as the optical path noise, acceleration noise etc. For suppressing laser
frequency noise, we need to use time delay interferometry (TDI) to match the
two different optical paths (times of travel). Since planets and other
solar-system bodies perturb the orbits of ASTROD-GW spacecraft and affect the
(TDI), we simulate the time delay numerically using CGC 2.7 ephemeris
framework. To conform to the ASTROD-GW planning, we work out a set of 20-year
optimized mission orbits of ASTROD-GW spacecraft starting at June 21, 2028, and
calculate the residual optical path differences in the first and second
generation TDI for one-detector case. In our optimized mission orbits for 20
years, changes of arm length are less than 0.0003 AU; the relative Doppler
velocities are less than 3m/s. All the second generation TDI for one-detector
case satisfies the ASTROD-GW requirement.Comment: 17 pages, 7 figures, 1 tabl
Regional Variation in Physician Adoption of Antipsychotics: Impact on US Medicare expenditures
Background—Regional variation in US Medicare prescription drug spending is driven by higher prescribing of costly brand-name drugs in some regions. This variation likely arises from differences in the speed of diffusion of newly-approved medications. Second-generation
antipsychotics were widely adopted for treatment of severe mental illness and for several off-label uses. Rapid diffusion of new psychiatric drugs likely increases drug spending but its relationship to non-drug spending is unclear. The impact of antipsychotic diffusion on drug and medical
spending is of great interest to public payers like Medicare, which finance a majority of mental health spending in the U.S.National Institute of Mental Health (U.S.) (R01 MH093359
Numerical simulation of time delay interferometry for eLISA/NGO
eLISA/NGO is a new gravitational wave detection proposal with arm length of
10^6 km and one interferometer down-scaled from LISA. Just like LISA and
ASTROD-GW, in order to attain the requisite sensitivity for eLISA/NGO, laser
frequency noise must be suppressed to below the secondary noises such as the
optical path noise, acceleration noise etc. In previous papers, we have
performed the numerical simulation of the time delay interferometry (TDI) for
LISA and ASTROD-GW with one arm dysfunctional by using the CGC 2.7 ephemeris.
The results are well below their respective limits which the laser frequency
noise is required to be suppressed. In this paper, we follow the same procedure
to simulate the time delay interferometry numerically. To do this, we work out
a set of 1000-day optimized mission orbits of the eLISA/NGO spacecraft starting
at January 1st, 2021 using the CGC 2.7 ephemeris framework. We then use the
numerical method to calculate the residual optical path differences in the
second-generation TDI solutions as in our previous papers. The maximum path
length difference, for all configurations calculated, is below 13 mm (43 ps).
It is well below the limit which the laser frequency noise is required to be
suppressed for eLISA/NGO. We compare and discuss the resulting differences due
to the different arm lengths for various mission proposals -- eLISA/NGO, an
NGO-LISA-type mission with a nominal arm length of 2 x 10^6 km, LISA and
ASTROD-GW.Comment: 17 pages, 13 figures, 3 tables, minor changes in description to match
the accepted version of Classical and Quantum Gravity. arXiv admin note: text
overlap with arXiv:1102.496
Limits of Earthquake Early Warning Accuracy and Best Alerting Strategy
We explore how accurate earthquake early warning (EEW) can be, given our limited ability to forecast expected shaking even if the earthquake source is known. Because of the strong variability of ground motion metrics, such as peak ground acceleration (PGA) and peak ground velocity (PGV), we find that correct alerts (i.e., alerts that accurately estimate the ground motion will be above a predetermined damage threshold) are not expected to be the most common EEW outcome even when the earthquake magnitude and location are accurately determined. Infrequently, ground motion variability results in a user receiving a false alert because the ground motion turned out to be significantly smaller than the system expected. More commonly, users will experience missed alerts when the system does not issue an alert but the user experiences potentially damaging shaking. Despite these inherit limitations, EEW can significantly mitigate earthquake losses for false-alert-tolerant users who choose to receive alerts for expected ground motions much smaller than the level that could cause damage. Although this results in many false alerts (unnecessary alerts for earthquakes that do not produce damaging ground shaking), it minimizes the number of missed alerts and produces overall optimal performance
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