Mediación múltiple de la soledad y las afecta negativas en la relación entre la ansiedad social de los adolescentes y los síntomas depresivos.

The current research aims to investigate the multiple mediation of loneliness and negative emotions in the relationship between adolescents’ social anxiety and depressive symptoms. Study participants, selected through convenience sampling, consisted of a total of 263 students, including 155 females (59%) and 108 males (41%), attending various high schools in a city in the mid-Black Sea Region. Participant students’ ages ranged between 14 and 18, with an average age of 15.05 (SD=.90). Data for the current study were collected through the Social Anxiety Scale for Adolescents, UCLA Loneliness Scale – Short Form, Positive and Negative Emotion Scale for Adolescents, Depression Scale for Children, and Personal Information Form. Current research data were analyzed through descriptive statistics, Pearson correlation coefficient, and an approach based on Ordinary Least Squares Regression, and the Bootstrap Method. The current study findings indicated that loneliness and negative emotions, both separately and together, mediated the relationship between social anxiety and depressive symptoms. No significant difference was found in the comparison conducted to reveal the more powerful mediating variable in terms of mediation effect. In addition, it was found that the model overall was significant and it explained 44% of the total variance in depressive symptoms. A discussion about and interpretation of findings obtained in the current study were included along with suggestions for relevant practitioners.La presente investigación tiene como objetivo investigar la mediación múltiple de la soledad y de los afectos negativos en la relación entre la ansiedad social y los síntomas depresivos de los adolescentes. Los participantes del estudio, seleccionados mediante muestreo por conveniencia, fueron un total de 263 estudiantes, incluyendo a 155 mujeres (59%) y 108 hombres (41%), que asistían a varias centros de educación secundaria en una ciudad de la región del Mar Negro. La edad de alumnos participantes osciló entre 14 y 18 años, con una edad promedio de 15.05 (SD = 0.90). Los datos para este estudio fueron recolectados de la Escala de Ansiedad Social para Adolescentes, UCLA Escala de Soledad - Abreviado, Registro de afecto positivo y negativo para Adolescentes, Escala de Depresión para Niños y formulario de información personal. Los datos se analizaron mediante estadística descriptiva, coeficiente de correlación de Pearson, y un enfoque basado en regresión de mínimos cuadrados ordinarios, y el método de Bootstrap. Los hallazgos del estudio indican que la soledad y los afectos negativos, tanto por separado como en conjunto, median en la relación entre la ansiedad social y síntomas depresivos. No se encontraron diferencias significativas en la comparación llevada a cabo para encontrar variables mediadoras más potentes en términos de efecto de la mediación. Además, se encontró que el modelo globalmente fue significativo y explicó el 44% de la varianza total en los síntomas depresivos.  Se incluye una discusión sobre la interpretación de los resultados obtenidos en el presente estudio junto con sugerencias para los profesionales pertinentes

Vías del afecto positivo y negativo a los síntomas depresivos: mediación múltiple de las estrategias de regulación de la emoción

The current study aims to examine the multiple mediations of emotion regulation strategies in the relationship between positive and negative affect and depressive symptoms in adolescents. Participants included 290 students attending middle schools in a mid-size city in Southeastern Anatolian region. Among students, 137 were females (47.2%) and 153 (52.8%) were males. Participants’ ages ranged between 9 and 15 with a mean of 12.12, SD=1.53. Research data were collected through Positive and Negative Affect Schedule for Adolescents, Emotion Regulation Scale for Adolescents, and Depression Scale for Children. Data analysis was conducted through descriptive statistics, Pearson correlation coefficient, an approach based on Ordinary Least Squares Regression, and Bootstrap method. Research findings indicated that the mediation of external dysfunctional emotion regulation, internal dysfunctional emotion regulation, and external functional emotion regulation in the relationships between positive emotions and depressive symptoms was statistically significant. However, the mediation of internal functional emotion regulation was not found to be statistically significant. In the relationship between negative emotions and depressive symptoms, the mediation of internal dysfunctional emotion regulation and external functional emotion regulation was found to be statistically significant. In addition, the mediation of internal functional emotion regulation and external dysfunctional emotion regulation was not found statistically significant. Research findings were discussed based on the relevant literature and some suggestions for researchers were put forward.El presente estudio tiene como objetivo examinar las múltiples mediaciones de las estrategias de regulación de las emociones en la relación entre el afecto positivo y negativo y los síntomas depresivos en los adolescentes. Los participantes fueron 290 estudiantes que asisten a escuelas intermedias en una ciudad de tamaño medio en la región del sudeste de Anatolia. Entre los estudiantes, 137 eran mujeres (47.2%) y 153 (52.8%) eran hombres. Las edades de los participantes variaron entre 9 y 15 con una media de 12.12, DT = 1.53. Los datos de la investigación se recogieron a través del Programa de Afecto Positivo y Negativo para Adolescentes, la Escala de Regulación de la Emoción para Adolescentes y la Escala de Depresión para Niños. El análisis de los datos se realizó mediante estadística descriptiva, coeficiente de correlación de Pearson, un enfoque basado en la regresión de mínimos cuadrados ordinarios y el método de Bootstrap. Los resultados de la investigación indicaron que la mediación de la regulación de la emoción disfuncional externa, la regulación interna de la emoción disfuncional y la regulación externa de la emoción funcional en las relaciones entre las emociones positivas y los síntomas depresivos fue estadísticamente significativa. Sin embargo, la mediación de la regulación de la emoción funcional interna no fue estadísticamente significativa. En la relación entre las emociones negativas y los síntomas depresivos, se encontró que la mediación de la regulación de la emoción interna disfuncional y la regulación de la emoción funcional externa es estadísticamente significativa. Además, la mediación de la regulación de la emoción funcional interna y la regulación de la emoción disfuncional externa no se encontró estadísticamente significativa. Los hallazgos de la investigación se discutieron en base a la literatura relevante y se presentaron algunas sugerencias para los investigadores

Effect of Zofenopril on regeneration of sciatic nerve crush injury in a rat model

<p>Abstract</p> <p>Background</p> <p>Zofenopril is an antioxidant agent which has been shown to have beneficial effects in hypertension and heart failure. The aim of this study was to test the effects of Zofenopril on nerve regeneration and scarring in a rat model of peripheral nerve crush injury.</p> <p>Methods</p> <p>Twenty-one adult Sprague-Dawley rats underwent a surgical procedure involving right sciatic nerve crush injury. 15 mg/kg Zofenopril was administered orally to seven rats in group Z for seven days. Seven rats in group S received saline orally for seven days. Seven rats in the control group C received no drug after crush injury. Fourteenth and 42nd days after injury, functional and electromyography assessments of nerves were performed. Functional recovery was analyzed using a walking track assessment, and quantified using the sciatic functional index (SFI). After these evaluations, all rats were sacrificed and microscopic evaluations were performed.</p> <p>Results</p> <p>The Sciatic functional Index (SFI) in group Z on 14^thday is different significantly from group S and group C (p = 0.037). But on 42^ndday there was no difference between groups (p = 0.278). The statistical analyses of electromyelographic (EMG) studies showed that the latency in group Z is significantly different from group S (p = 0.006) and group C (p = 0.045). But on 42^ndday there was no difference between groups like SFI (p = 0.147). The amplitude was evaluated better in group Z than others (p < 0.05). In microscopic evaluation, we observed the highest number of nerve regeneration in the group Z and the lowest in the group C. But it was not significant statistically.</p> <p>Conclusion</p> <p>Our results demonstrate that Zofenopril promotes the regeneration of peripheral nerve injuries in rat models.</p

KONYA YERALTI SUYUNDA KLORLU BENZENLERİN GC/ECD İLE ANALİZİ

Contamination of groundwater with volatile organic compounds such as chlorinated benzenes is an important environmental pollution problem. Therefore monitoring these substances in groundwater is necessary for determination of water contamination. Chlorinated benzenes are found relatively in low concentrations in surface waters compared with ground waters because of their volatility. In this study Bromobenzene and chlorinated benzenes such as 1,3-Diklorobenzen, 1,4-Diklorobenzen, 1,2-Diklorobenzen, 1,2,4-Triklorobenzen, 1,2,3-Triklorobenzene in groundwater were determined by the micro extraction method (EPA method 504). The monitoring of chlorinated benzenes in well and spring water which supply the drinking water for Konya was carried out. In the study, it was determined that chlorinated benzenes was below the concentration limited by EPA and WHOUçucu organik bileşiklerden olan klorlu benzenler tarafından yeraltı suyunun kirlenmesi oldukça önemli bir çevre problemidir. Bu nedenle benzen bileşiklerinden kaynaklanan kirlenmenin tespiti için belirli periyotlarla yeraltı suyunun izlenmesi gereklidir. Klorlu benzen bileşikleri; uçucu olmaları nedeniyle, yeraltı sularında yüzey sularından daha yüksek konsantrasyonlarda bulunmaktadırlar. Bu çalışmada; Bromobenzen ve klorlubenzen bileşiklerinden; 1,3-Diklorobenzen, 1,4-Diklorobenzen, 1,2-Diklorobenzen, 1,2,4-Triklorobenzen, 1,2,3-Triklorobenze’nin yeraltı sularında konsantrasyonlarının tespiti için EPA metod 504. mikro ekstraksiyon yöntemi modifiye edilerek kullanılmıştır. Konya şehrine içme suyu sağlayan kuyu ve memba sularında klorlu benzenler izlenmiştir. Çalışmada klorlu benzenlerin EPA ve WHO tarafından öngörülen limit değerlerin altında olduğu tespit edilmiştir

Acute effects of cardiac resynchronization therapy on arterial distensibility and serum norepinephrine levels in advanced heart failure

Background: Cardiac resynchronization therapy (CRT) has become an accepted method fortreating refractory heart failure (HF). Arterial distensibility is an index of arterial stiffnessand a surrogate marker for atherosclerosis. The present study aims to assess the acute effects of ventricular resynchronization therapy with biventricular stimulation on arterial distensibility, echocardiographic parameters and serum norepinephrine levels in patients with drugrefractory HF.Methods: Fourteen cardiac HF patients (53.6 ± 9.1; 39–67 years, 7 woman) were enrolled for CRT. Patients had an advanced cardiac HF (NYHA III–IV functional class) due to non-ischemic dilated cardiomyopathy, with a left ventricular ejection fraction (LVEF) &lt; 35% and QRS duration ≥ 120 ms. Blood samples for norepinephrine and B-type natriuretic peptidewere collected before 24 h biventricular implantation and after 48 h of CRT. Transthoracic echocardiography was used to evaluate arterial distensibility and cardiovascular condition.Results: Although systolic blood pressure, diastolic blood pressure, LV end-diastolic diameter, LV end-systolic diameter, serum B-type natriuretic peptide, and serum norepinephrine levels significantly decreased after CRT implantation; EF and aortic distensibility significantly increased (p &lt; 0.05). There was no significance in the hemodynamic and echocardiographic values, norepinephrine and B-type natriuretic peptide levels in pre- and post-CRT between man and woman.Conclusions: The major findings of this study are that in patients with cardiac HF in acute period, after implantation of CRT serum norepinephrine levels decrease and the arterial distensibility improves

Evaluation of the Oxidative Effect of Long-Term Repetitive Hyperbaric Oxygen Exposures on Different Brain Regions of Rats

Hyperbaric oxygen (HBO2) exposure affects both oxidative and antioxidant systems. This effect is positively correlated with the exposure time and duration of the treatment. The present study aims enlightening the relation of HBO2 with oxidative/antioxidant systems when administered in a prolonged and repetitive manner in brain tissues of rats. Sixty rats were divided into 6 study (n = 8 for each) and 1 control (n = 12) group. Rats in the study groups were daily exposed 90-min HBO2 sessions at 2.8 ATA for 5, 10, 15, 20, 30 and 40 days. One day after the last session, animals were sacrificed; their whole brain tissue was harvested and dissected into three different regions as the outer grey matter (cortex), the inner white matter and cerebellum. Levels of lipid peroxidation and protein oxidation and activities of superoxide dismutase and glutathione peroxidase were measured in these tissues. Malondialdehyde, carbonylated protein and glutathione peroxidase levels were found to be insignificantly increased at different time-points in the cerebral cortex, inner white matter and cerebellum, respectively. These comparable results provide evidence for the safety of HBO treatments and/or successful adaptive mechanisms at least in the brain tissue of rats, even when administered for longer periods

Gastroenterology Cases of Cutaneous Leukocytoclastic Vasculitis

Rarely, leukocytoclastic vasculitis can result from ischemic colitis, inflammatory bowel disease, and cryoglobulinemia. There is no established standard for the treatment of leukocytoclastic vasculitis associated with gastroenterologic diseases. This paper presents three cases of leukoytoclastic vasculitis, each of which is associated with a different gastroenterologic condition: ischemic colitis, Crohn’s disease, and chronic hepatitis C. Each condition went into remission by treatment of leukocytoclastic vasculitis, regardless of the underlying disease

Live Cell Imaging of Bone Marrow Stromal Cells on Nano-pitted and Polished Titanium Surfaces: A Micro-Incubator in vitro Approach

Current orthopedic implants are not conducive for optimal integration of the biomaterial with newly-formed tissue (osseointegration) inside a patient’s body. In this study, medical-rade Ti-6Al-4V was used as a substrate due to its biocompatibility and ability to facilitate cellular adhesion and proliferation. Live cell imaging was conducted on bone marrow stromal cells, genetically modified to express the green fluorescent protein (GFP), from the 24-96 hours growth period, with the first 24 hours of growth being held inside a lab-scale incubator. Periodic images were recorded on nanopitted anodized and polished Ti-6Al-4V substrates to study how substratestiffness influences adhesion and proliferation. Collected images were analyzed for mitosis, adhesion, and filopodia-stretchability using ImageJ, an image processing program. Images were enhanced in order to perform cell counts at 24, 48, 72, and 96 hours of growth. Continuous recordings were produced to account for the number of mitosis occurrences and cellular migration on each of the substrates. Based on the conducted experiments, it appears that polished Ti-6Al-4V has a higher cell adherence than “nanopitted” anodized surface and an improved rate of proliferation which may be because the cells once adhered on the nano-pitted surface have less ability to detach in-order to undergo mitosis.https://engagedscholarship.csuohio.edu/u_poster_2014/1004/thumbnail.jp