Detection of the United States Neisseria meningitidis urethritis clade in the United Kingdom, August and December 2019 - emergence of multiple antibiotic resistance calls for vigilance.

Since 2015 in the United States (US), the US Neisseria meningitidis urethritis clade (US_NmUC) has caused a large multistate outbreak of urethritis among heterosexual males. Its 'parent' strain caused numerous outbreaks of invasive meningococcal disease among men who have sex with men in Europe and North America. We highlight the arrival and dissemination of US_NmUC in the United Kingdom and the emergence of multiple antibiotic resistance. Surveillance systems should be developed that include anogenital meningococci

Time-Course Analysis of Cyanobacterium Transcriptome: Detecting Oscillatory Genes

The microarray technique allows the simultaneous measurements of the expression levels of thousands of mRNAs. By mining these data one can identify the dynamics of the gene expression time series. The detection of genes that are periodically expressed is an important step that allows us to study the regulatory mechanisms associated with the circadian cycle. The problem of finding periodicity in biological time series poses many challenges. Such challenge occurs due to the fact that the observed time series usually exhibit non-idealities, such as noise, short length, outliers and unevenly sampled time points. Consequently, the method for finding periodicity should preferably be robust against such anomalies in the data. In this paper, we propose a general and robust procedure for identifying genes with a periodic signature at a given significance level. This identification method is based on autoregressive models and the information theory. By using simulated data we show that the suggested method is capable of identifying rhythmic profiles even in the presence of noise and when the number of data points is small. By recourse of our analysis, we uncover the circadian rhythmic patterns underlying the gene expression profiles from Cyanobacterium Synechocystis

Conservation of the Mount Cameron West engraving site

A study of the site and its surroundings indicates that the geochemical environment is such that although the aeolian calcarenite on which the engravings are executed is soft and friable, it is not undergoing appreciable chemical or physical weathering, at least in the short-term. In contrast the site is under considerable threat from coastal erosion. This threat could be reduced, if not eliminated, through the implementation of coastal erosion control measures

The [α/Fe]-[Fe/H] relation in the E-MOSAICS simulations: its connection to the birth place of globular clusters and the fraction of globular cluster field stars in the bulge

The {\alpha}-element abundances of the globular cluster (GC) and field star populations of galaxies encode information about the formation of each of these components. We use the E-MOSAICS cosmological simulations of ~L* galaxies and their GCs to investigate the [{\alpha}/Fe]-[Fe/H] distribution of field stars and GCs in 25 Milky Way-mass galaxies. The [{\alpha}/Fe]-[Fe/H] distribution go GCs largely follows that of the field stars and can also therefore be used as tracers of the [{\alpha}/Fe]-[Fe/H] evolution of the galaxy. Due to the difference in their star formation histories, GCs associated with stellar streams (i.e. which have recently been accreted) have systematically lower [{\alpha}/Fe] at fixed [Fe/H]. Therefore, if a GC is observed to have low [{\alpha}/Fe] for its [Fe/H] there is an increased probability that this GC was accreted recently alongside a dwarf galaxy. There is a wide range of shapes for the field star [{\alpha}/Fe]-[Fe/H] distribution, with a notable subset of galaxies exhibiting bimodal distributions, in which the high [{\alpha}/Fe] sequence is mostly comprised of stars in the bulge, a high fraction of which are from disrupted GCs. We calculate the contribution of disrupted GCs to the bulge component of the 25 simulated galaxies and find values between 0.3-14 per cent, where this fraction correlates with the galaxy's formation time. The upper range of these fractions is compatible with observationally-inferred measurements for the Milky Way, suggesting that in this respect the Milky Way is not typical of L* galaxies, having experienced a phase of unusually rapid growth at early times

Theoretical size distribution of fossil taxa: analysis of a null model

BACKGROUND: This article deals with the theoretical size distribution (of number of sub-taxa) of a fossil taxon arising from a simple null model of macroevolution. MODEL: New species arise through speciations occurring independently and at random at a fixed probability rate, while extinctions either occur independently and at random (background extinctions) or cataclysmically. In addition new genera are assumed to arise through speciations of a very radical nature, again assumed to occur independently and at random at a fixed probability rate. CONCLUSION: The size distributions of the pioneering genus (following a cataclysm) and of derived genera are determined. Also the distribution of the number of genera is considered along with a comparison of the probability of a monospecific genus with that of a monogeneric family

Wolbachia in the flesh: symbiont intensities in germ-line and somatic tissues challenge the conventional view of Wolbachia transmission routes

Symbionts can substantially affect the evolution and ecology of their hosts. The investigation of the tissue-specific distribution of symbionts (tissue tropism) can provide important insight into host-symbiont interactions. Among other things, it can help to discern the importance of specific transmission routes and potential phenotypic effects. The intracellular bacterial symbiont Wolbachia has been described as the greatest ever panzootic, due to the wide array of arthropods that it infects. Being primarily vertically transmitted, it is expected that the transmission of Wolbachia would be enhanced by focusing infection in the reproductive tissues. In social insect hosts, this tropism would logically extend to reproductive rather than sterile castes, since the latter constitute a dead-end for vertically transmission. Here, we show that Wolbachia are not focused on reproductive tissues of eusocial insects, and that non-reproductive tissues of queens and workers of the ant Acromyrmex echinatior, harbour substantial infections. In particular, the comparatively high intensities of Wolbachia in the haemolymph, fat body, and faeces, suggest potential for horizontal transmission via parasitoids and the faecal-oral route, or a role for Wolbachia modulating the immune response of this host. It may be that somatic tissues and castes are not the evolutionary dead-end for Wolbachia that is commonly thought

Where did the globular clusters of the Milky Way form? Insights from the E-MOSAICS simulations

Globular clusters (GCs) are typically old, with most having formed at z >~ 2. This makes understanding their birth environments difficult, as they are typically too distant to observe with sufficient angular resolution to resolve GC birth sites. Using 25 cosmological zoom-in simulations of Milky Way-like galaxies from the E-MOSAICS project, with physically-motivated models for star formation, feedback, and the formation, evolution, and disruption of GCs, we identify the birth environments of present-day GCs. We find roughly half of GCs in these galaxies formed in-situ (52.0 +/- 1.0 per cent) between z ~ 2 - 4, in turbulent, high-pressure discs fed by gas that was accreted without ever being strongly heated through a virial shock or feedback. A minority of GCs form during mergers (12.6 +/- 0.6 per cent in major mergers, and 7.2 +/- 0.5 per cent in minor mergers), but we find that mergers are important for preserving the GCs seen today by ejecting them from their natal, high density interstellar medium (ISM), where proto-GCs are rapidly destroyed due to tidal shocks from ISM substructure. This chaotic history of hierarchical galaxy assembly acts to mix the spatial and kinematic distribution of GCs formed through different channels, making it difficult to use observable GC properties to distinguish GCs formed in mergers from ones formed by smooth accretion, and similarly GCs formed in-situ from those formed ex-situ. These results suggest a simple picture of GC formation, in which GCs are a natural outcome of normal star formation in the typical, gas-rich galaxies that are the progenitors of present-day galaxies

Social, environmental and psychological factors associated with objective physical activity levels in the over 65s

Objective: To assess physical activity levels objectively using accelerometers in community dwelling over 65 s and to examine associations with health, social, environmental and psychological factors. Design: Cross sectional survey. Setting: 17 general practices in Scotland, United Kingdom. Participants: Random sampling of over 65 s registered with the practices in four strata young-old (65–80 years), old-old (over 80 years), more affluent and less affluent groups. Main Outcome Measures: Accelerometry counts of activity per day. Associations between activity and Theory of Planned Behaviour variables, the physical environment, health, wellbeing and demographic variables were examined with multiple regression analysis and multilevel modelling. Results: 547 older people (mean (SD) age 79(8) years, 54% female) were analysed representing 94% of those surveyed. Accelerometry counts were highest in the affluent younger group, followed by the deprived younger group, with lowest levels in the deprived over 80 s group. Multiple regression analysis showed that lower age, higher perceived behavioural control, the physical function subscale of SF-36, and having someone nearby to turn to were all independently associated with higher physical activity levels (R2 = 0.32). In addition, hours of sunshine were independently significantly associated with greater physical activity in a multilevel model. Conclusions: Other than age and hours of sunlight, the variables identified are modifiable, and provide a strong basis for the future development of novel multidimensional interventions aimed at increasing activity participation in later life.Publisher PDFPeer reviewe