1,508 research outputs found
Termómetros Clínicos
Na prática clínica, várias decisões relacionadas com o diagnóstico e tratamento resultam da análise
dos valores da temperatura corporal, sendo a medição deste parâmetro habitualmente realizada
com instrumentos de medição, designados por termómetros clínicos.
A correta medição da temperatura corporal assume relevância na prática diária dos cuidados de
saúde, sendo um parâmetro regularmente avaliado no diagnóstico e monitorização do estado de
saúde de um indivíduo.info:eu-repo/semantics/publishedVersio
Instrumentos de Medição da Pressão Arterial
No setor da saúde, as medições e os instrumentos de medição desempenham um papel fundamental
no quotidiano dos cidadãos. Variadíssimas decisões clínicas são fundamentadas por resultados de
medições, e suportadas na evidência dos mesmos. Por razões de diversa índole, os resultados
obtidos a partir de sistemas de medição podem apresentar variabilidade que conduzem a erros de
diagnóstico e de tratamento, comprometendo o rigor da medição e os recursos disponíveis.
Neste contexto, o presente trabalho tem como finalidade divulgar conceitos gerais e específicos,
aplicados a instrumentos e sistemas de medição, apresentando-se como um documento de consulta
e um guia para a implementação de boas práticas no âmbito da Metrologia na Saúde.info:eu-repo/semantics/publishedVersio
Vacuum Stability, Perturbativity, and Scalar Singlet Dark Matter
We analyze the one-loop vacuum stability and perturbativity bounds on a
singlet extension of the Standard Model (SM) scalar sector containing a scalar
dark matter candidate. We show that the presence of the singlet-doublet quartic
interaction relaxes the vacuum stability lower bound on the SM Higgs mass as a
function of the cutoff and lowers the corresponding upper bound based on
perturbativity considerations. We also find that vacuum stability requirements
may place a lower bound on the singlet dark matter mass for given singlet
quartic self coupling, leading to restrictions on the parameter space
consistent with the observed relic density. We argue that discovery of a light
singlet scalar dark matter particle could provide indirect information on the
singlet quartic self-coupling.Comment: 25 pages, 10 figures; v2 - fixed minor typos; v3 - added to text
discussions of other references, changed coloring of figures for easier black
and white viewin
Trinucleotide repeats in 202 families with ataxia: a small expanded (CAG)n allele at the SCA17 locus
BACKGROUND: Ten neurodegenerative disorders characterized by spinocerebellar ataxia (SCA) are known to be caused by trinucleotide repeat (TNR) expansions. However, in some instances the molecular diagnosis is considered indeterminate because of the overlap between normal and affected allele ranges. In addition, the mechanism that generates expanded alleles is not completely understood. OBJECTIVE: To examine the clinical and molecular characteristics of a large group of Portuguese and Brazilian families with ataxia to improve knowledge of the molecular diagnosis of SCA. PATIENTS AND METHODS: We have (1) assessed repeat sizes at all known TNR loci implicated in SCA; (2) determined frequency distributions of normal alleles and expansions; and (3) looked at genotype-phenotype correlations in 202 unrelated Portuguese and Brazilian patients with SCA. Molecular analysis of TNR expansions was performed using polymerase chain reaction amplification. RESULTS: Patients from 110 unrelated families with SCA showed TNR expansions at 1 of the loci studied. Dominantly transmitted cases had (CAG)(n) expansions at the Machado-Joseph disease gene (MJD1) (63%), at SCA2 (3%), the gene for dentatorubropallidoluysian atrophy (DRPLA) (2%), SCA6 (1%), or SCA7 (1%) loci, or (CTG)(n) expansions at the SCA8 (2%) gene, whereas (GAA)(n) expansions in the Freidreich ataxia gene (FRDA) were found in 64% of families with recessive ataxia. Isolated patients also had TNR expansions at the MJD1 (6%), SCA8 (6%), or FRDA (8%) genes; in addition, an expanded allele at the TATA-binding protein gene (TBP), with 43 CAGs, was present in a patient with ataxia and mental deterioration. Associations between frequencies of SCA2 and SCA6 and a frequency of large normal alleles were found in Portuguese and Brazilian individuals, respectively. Interestingly, no association between the frequencies of DRPLA and large normal alleles was found in the Portuguese group. CONCLUSIONS: Our results show that (1) a significant number of isolated cases of ataxia are due to TNR expansions; (2) expanded DRPLA alleles in Portuguese families may have evolved from an ancestral haplotype; and (3) small (CAG)(n) expansions at the TBP gene may cause SCA17
Validação conceitual das características definidoras de diagnósticos de enfermagem respiratórios em neonatos
OBJECTIVE:To develop and validate conceptual and operational definitions for the defining characteristics of the respiratory nursing diagnoses, ineffective breathing pattern, impaired gas exchange and impaired spontaneous ventilation, in newborns.METHODS:This was a methodological study of conceptual validation of the defining characteristics of three respiratory nursing diagnoses, by consensus analysis of a committee of five specialist nurses, and then a group of five non-nursing professionals, using the Delphi technique.RESULTS:After two rounds of evaluation, consensus was obtained that was equal to or greater than 80% on all of the definitions, which were then considered validated.CONCLUSION:The definitions developed for the defining characteristics of three nursing diagnoses were validated with a high level of consensus.OBJETIVO:Elaborar e validar definições conceituais e operacionais para as características definidoras dos diagnósticos de enfermagem respiratórios, Padrão Respiratório Ineficaz, Troca de Gases Prejudicada e Ventilação Espontânea Prejudicada em recém-nascidos.MÉTODOS:Estudo metodológico, de validação conceitual das características definidoras dos três diagnósticos de enfermagem respiratórios por meio da análise de consenso de um comitê de cinco enfermeiras especialistas e de cinco profissionais não enfermeiros, utilizando a técnica Delphi.RESULTADOS:Após duas rodadas de avaliação, obteve-se consenso igual ou superior a 80% na totalidade das definições, sendo consideradas validadas.CONCLUSÃO:As definições elaboradas para as características definidoras dos três diagnósticos de enfermagem foram validadas com elevado grau de consenso.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de EnfermagemUNIFESP, EPESciEL
Murine model for Fusarium oxysporum invasive fusariosis reveals organ-specific structures for dissemination and long-term persistence
Peer reviewedPublisher PD
Diagnósticos de enfermagem respiratórios para crianças com infecção respiratória aguda
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