656 research outputs found
A meta-analysis of pharmacotherapy for social anxiety disorder: an examination of efficacy, moderators, and mediators
INTRODUCTION: Social anxiety disorder (SAD) is among the most prevalent mental disorders, associated with impaired functioning and poor quality of life. Pharmacotherapy is the most widely utilized treatment option. The current study provides an updated meta-analytic review of the efficacy of pharmacotherapy and examines moderators and mediators of treatment efficacy. Areas Covered: A comprehensive search of the current literature yielded 52 randomized, pill placebo-controlled trials of pharmacotherapy for adults diagnosed with SAD. Data on potential mediators of treatment outcome were collected, as well as data necessary to calculate pooled correlation matrices to compute indirect effects. Expert Opinion: The overall effect size of pharmacotherapy for SAD is small to medium (Hedges' g = 0.41). Effect sizes were not moderated by age, sex, length of treatment, initial severity, risk of study bias, or publication year. Furthermore, reductions in symptoms mediated pharmacotherapy's effect on quality of life. Support was found for reverse mediation. Future directions may include sustained efforts to examine treatment mechanisms of pharmacotherapy using rigorous longitudinal methodology to better establish temporal precedence
A Dynamic Model of Interactions of Ca^(2+), Calmodulin, and Catalytic Subunits of Ca^(2+)/Calmodulin-Dependent Protein Kinase II
During the acquisition of memories, influx of Ca^(2+) into the postsynaptic spine through the pores of activated N-methyl-D-aspartate-type glutamate receptors triggers processes that change the strength of excitatory synapses. The pattern of Ca^(2+) influx during the first few seconds of activity is interpreted within the Ca^(2+)-dependent signaling network such that synaptic strength is eventually either potentiated or depressed. Many of the critical signaling enzymes that control synaptic plasticity, including Ca^(2+)/calmodulin-dependent protein kinase II (CaMKII), are regulated by calmodulin, a small protein that can bind up to 4 Ca^(2+) ions. As a first step toward clarifying how the Ca^(2+)-signaling network decides between potentiation or depression, we have created a kinetic model of the interactions of Ca^(2+), calmodulin, and CaMKII that represents our best understanding of the dynamics of these interactions under conditions that resemble those in a postsynaptic spine. We constrained parameters of the model from data in the literature, or from our own measurements, and then predicted time courses of activation and autophosphorylation of CaMKII under a variety of conditions. Simulations showed that species of calmodulin with fewer than four bound Ca^(2+) play a significant role in activation of CaMKII in the physiological regime, supporting the notion that processing ofCa^(2+) signals in a spine involves competition among target enzymes for binding to unsaturated species of CaM in an environment in which the concentration of Ca^(2+) is fluctuating rapidly. Indeed, we showed that dependence of activation on the frequency of Ca^(2+) transients arises from the kinetics of interaction of fluctuating Ca^(2+) with calmodulin/CaMKII complexes. We used parameter sensitivity analysis to identify which parameters will be most beneficial to measure more carefully to improve the accuracy of predictions. This model provides a quantitative base from which to build more complex dynamic models of postsynaptic signal transduction during learning
Light-cone-like spreading of correlations in a quantum many-body system
How fast can correlations spread in a quantum many-body system? Based on the
seminal work by Lieb and Robinson, it has recently been shown that several
interacting many-body systems exhibit an effective light cone that bounds the
propagation speed of correlations. The existence of such a "speed of light" has
profound implications for condensed matter physics and quantum information, but
has never been observed experimentally. Here we report on the time-resolved
detection of propagating correlations in an interacting quantum many-body
system. By quenching a one-dimensional quantum gas in an optical lattice, we
reveal how quasiparticle pairs transport correlations with a finite velocity
across the system, resulting in an effective light cone for the quantum
dynamics. Our results open important perspectives for understanding relaxation
of closed quantum systems far from equilibrium as well as for engineering
efficient quantum channels necessary for fast quantum computations.Comment: 7 pages, 5 figures, 2 table
Probabilistic Clustering of Time-Evolving Distance Data
We present a novel probabilistic clustering model for objects that are
represented via pairwise distances and observed at different time points. The
proposed method utilizes the information given by adjacent time points to find
the underlying cluster structure and obtain a smooth cluster evolution. This
approach allows the number of objects and clusters to differ at every time
point, and no identification on the identities of the objects is needed.
Further, the model does not require the number of clusters being specified in
advance -- they are instead determined automatically using a Dirichlet process
prior. We validate our model on synthetic data showing that the proposed method
is more accurate than state-of-the-art clustering methods. Finally, we use our
dynamic clustering model to analyze and illustrate the evolution of brain
cancer patients over time
Rapidly Decaying Supernova 2010X: A Candidate ".Ia" Explosion
We present the discovery, photometric and spectroscopic follow-up
observations of SN 2010X (PTF 10bhp). This supernova decays exponentially with
tau_d=5 days, and rivals the current recordholder in speed, SN 2002bj. SN 2010X
peaks at M_r=-17mag and has mean velocities of 10,000 km/s. Our light curve
modeling suggests a radioactivity powered event and an ejecta mass of 0.16
Msun. If powered by Nickel, we show that the Nickel mass must be very small
(0.02 Msun) and that the supernova quickly becomes optically thin to
gamma-rays. Our spectral modeling suggests that SN 2010X and SN 2002bj have
similar chemical compositions and that one of Aluminum or Helium is present. If
Aluminum is present, we speculate that this may be an accretion induced
collapse of an O-Ne-Mg white dwarf. If Helium is present, all observables of SN
2010X are consistent with being a thermonuclear Helium shell detonation on a
white dwarf, a ".Ia" explosion. With the 1-day dynamic-cadence experiment on
the Palomar Transient Factory, we expect to annually discover a few such
events.Comment: 6 pages, 5 figures; Minor Changes; Note correction in Fig 4 caption;
published by ApJ
A comprehensive evaluation of colonic mucosal isolates of Sutterella wadsworthensis from inflammatory bowel disease
Peer reviewedPublisher PD
Service provision and barriers to care for homeless people with mental health problems across 14 European capital cities
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Rapid Diagnostic Algorithms as a Screening Tool for Tuberculosis: An Assessor Blinded Cross-Sectional Study
Background: A major obstacle to effectively treat and control tuberculosis is the absence of an accurate, rapid, and low-cost diagnostic tool. A new approach for the screening of patients for tuberculosis is the use of rapid diagnostic classification algorithms.
Methods: We tested a previously published diagnostic algorithm based on four biomarkers as a screening tool for
tuberculosis in a Central European patient population using an assessor-blinded cross-sectional study design. In addition, we developed an improved diagnostic classification algorithm based on a study population at a tertiary hospital in Vienna, Austria, by supervised computational statistics.
Results: The diagnostic accuracy of the previously published diagnostic algorithm for our patient population consisting of 206 patients was 54% (CI: 47%–61%). An improved model was constructed using inflammation parameters and clinical information. A diagnostic accuracy of 86% (CI: 80%–90%) was demonstrated by 10-fold cross validation. An alternative model relying solely on clinical parameters exhibited a diagnostic accuracy of 85% (CI: 79%–89%).
Conclusion: Here we show that a rapid diagnostic algorithm based on clinical parameters is only slightly improved by
inclusion of inflammation markers in our cohort. Our results also emphasize the need for validation of new diagnostic algorithms in different settings and patient populations
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