A seleção de critérios no zoneamento agroecológico: proposta metodológica.

A seleção de critérios espaciais para um trabalho de zoneamento agroecológico envolve critérios de aptidão, biodiversidade, socioeconomia, recursos hídricos, legais, ambientais, políticas etc. É necessário identificar a questão-chave e traçar diretrizes do zoneamento que representem as orientações do setor. Essas diretrizes são econômicas, estratégicas, empresariais, sociais, técnicas e políticas, obtidas em negociação com representantes de diferentes setores da sociedade e, ao fim, ponderar os diversos critérios segundo a importância de cada um, no contexto em análise. Este trabalho tem por objetivo apresentar uma metodologia de identificação coletiva desses critérios com o aporte de recursos de sistemas de suporte à decisão espacial e de planejamento estratégico territorial. A metodologia apresenta as seguintes etapas: diagnóstico estratégico, identificação de critérios determinantes (não ponderáveis), identificação dos critérios a serem ponderados e uma proposta de fluxo de procedimentos para a seleção de critérios espaciais. Visa subsidiar a formulação de políticas públicas de ordenamento territorial do setor rural. O resultado é composto de um conjunto de procedimentos e de uma lista de perguntas-chave para compor os diagnósticos e selecionar os critérios espaciais que podem ser aplicados em trabalhos de planejamento territorial adicionado a visão estratégica

Exact String Solutions in Nontrivial Backgrounds

We show how the classical string dynamics in $D$-dimensional gravity background can be reduced to the dynamics of a massless particle constrained on a certain surface whenever there exists at least one Killing vector for the background metric. We obtain a number of sufficient conditions, which ensure the existence of exact solutions to the equations of motion and constraints. These results are extended to include the Kalb-Ramond background. The $D1$-brane dynamics is also analyzed and exact solutions are found. Finally, we illustrate our considerations with several examples in different dimensions. All this also applies to the tensionless strings.Comment: 22 pages, LaTeX, no figures; V2:Comments and references added; V3:Discussion on the properties of the obtained solutions extended, a reference and acknowledgment added; V4:The references renumbered, to appear in Phys Rev.

Nonadditivity of critical Casimir forces

In soft condensed matter physics, effective interactions often emerge due to the spatial confinement of fluctuating fields. For instance, microscopic particles dissolved in a binary liquid mixture are subject to critical Casimir forces whenever their surfaces confine the thermal fluctuations of the order parameter of the solvent close to its critical demixing point. These forces are theoretically predicted to be nonadditive on the scale set by the bulk correlation length of the fluctuations. Here we provide direct experimental evidence of this fact by reporting the measurement of the associated many-body forces. We consider three colloidal particles in optical traps and observe that the critical Casimir force exerted on one of them by the other two differs from the sum of the forces they exert separately. This three-body effect depends sensitively on the distance from the critical point and on the chemical functionalisation of the colloid surfaces

Adrenal function recovery after durable oral corticosteroid sparing with benralizumab in the PONENTE study

Background Oral corticosteroid (OCS) dependence among patients with severe eosinophilic asthma can cause adverse outcomes, including adrenal insufficiency. PONENTE's OCS reduction phase showed that, following benralizumab initiation, 91.5% of patients eliminated corticosteroids or achieved a final dosage ≤5 mg·day-1 (median (range) 0.0 (0.0-40.0) mg). Methods The maintenance phase assessed the durability of corticosteroid reduction and further adrenal function recovery. For ~6 months, patients continued benralizumab 30 mg every 8 weeks without corticosteroids or with the final dosage achieved during the reduction phase. Investigators could prescribe corticosteroids for asthma exacerbations or increase daily dosages for asthma control deteriorations. Outcomes included changes in daily OCS dosage, Asthma Control Questionnaire (ACQ)-6 and St George's Respiratory Questionnaire (SGRQ), as well as adrenal status, asthma exacerbations and adverse events. Results 598 patients entered PONENTE; 563 (94.1%) completed the reduction phase and entered the maintenance phase. From the end of reduction to the end of maintenance, the median (range) OCS dosage was unchanged (0.0 (0.0-40.0) mg), 3.2% (n=18/563) of patients experienced daily dosage increases, the mean ACQ-6 score decreased from 1.26 to 1.18 and 84.5% (n=476/563) of patients were exacerbation free. The mean SGRQ improvement (-19.65 points) from baseline to the end of maintenance indicated substantial quality-of-life improvements. Of patients entering the maintenance phase with adrenal insufficiency, 32.4% (n=104/321) demonstrated an improvement in adrenal function. Adverse events were consistent with previous reports. Conclusions Most patients successfully maintained maximal OCS reduction while achieving improved asthma control with few exacerbations and maintaining or recovering adrenal function

Biochemical Characterization and Evaluation of a Brugia malayi Small Heat Shock Protein as a Vaccine against Lymphatic Filariasis

Filarial nematodes enjoy one of the longest life spans of any human pathogen due to effective immune evasion strategies developed by the parasite. Among the various immune evasion strategies exhibited by the parasite, Interleukin 10 (IL-10) productions and IL-10 mediated immune suppression has significant negative impact on the host immune system. Recently, we identified a small heat shock protein expressed by Brugia malayi (BmHsp12.6) that can bind to soluble human IL-10 receptor alpha (IL-10R) and activate IL-10 mediated effects in cell lines. In this study we show that the IL-10R binding region of BmHsp12.6 is localized to its N-terminal region. This region has significant sequence similarity to the receptor binding region of human IL-10. In vitro studies confirm that the N-terminal region of BmHsp12.6 (N-BmHsp12.6) has IL-10 like activity and the region containing the alpha crystalline domain and C-terminus of BmHsp12.6 (BmHsp12.6αc) has no IL-10 like activity. However, BmHsp12.6αc contains B cell, T cell and CTL epitopes. Members of the sHSP families are excellent vaccine candidates. Evaluation of sera samples from putatively immune endemic normal (EN) subjects showed IgG1 and IgG3 antibodies against BmHsp12.6αc and these antibodies were involved in the ADCC mediated protection. Subsequent vaccination trials with BmHsp12.6αc in a mouse model using a heterologous prime boost approach showed that 83% protection can be achieved against B. malayi L3 challenge. Results presented in this study thus show that the N-BmHsp12.6 subunit of BmHsp12.6 has immunoregulatory function, whereas, the BmHsp12.6αc subunit of BmHsp12.6 has significant vaccine potential