Influence of Various Factors on Deterioration of Repaired Concrete Structures (3) : Influence of Exposure Conditions of Reinforced Concrete

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Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

Estimation of Heat Flow in Certain Exploration Wells in Offshore Areas of Malaysia

As a part of studies on the thermal state of the crust under shallow seas where heat flow data is rare, we estimated the heat flow in the offshore areas of Malaysia, based on the existing thermal gradient data and newly measured thermal conductivity of 152 core samples from exploration wells. The results show that the regional heat flow is anomalously high in the Malay Basin which is located on a now stable continental shelf. In contrast, the heat flow off the shore of Saban is subnormal to normal.浅海底下の地殻熱流量測定計画の一環として,マレーシア沿海の石油会社による探査孔のコア試料の熱伝導率測定を行い既に公表済の地温勾配データを用いて熱流量を求めた.得られた熱流量値は,マレー堆積盆では現在安定な地域であるにもかかわらず異常に高く,サバの沖では普通又はやや低い値にある

Some Magnetic Anomalies Accompanied with Topographic Irregularities of Subducting Plate and Their Tectonic Implications

From the detailed aeromagnetic survey data and seismicity data on the area around the Japan arc, it was found that several magnetic anomalies with relatively short wave-lengths are accompanied with high seismic activity. Based on the results of model analysis, geological data and crustal structures inferred from seismic studies, we propose a possible interpretation that irregularities on the underthrusting plate such as seamounts or local bathymetric highs cause the magnetic anomalies, earthquakes and certain other surface geological features.日本列島周辺の詳細な空中磁気探査及び地震活動データから,比較的短波長の地磁気異常のいくつかが,高い地震活動を伴うことが判明した.モデル解析,地質学的データ及び地震学的に推定される地殻構造などに基づき,海山や局地的な隆起地形のような,沈みこむプレート上の凹凸が,地磁気異常,地震,表層地質の特徴などの原因をなすという解釈を提唱する