Characterization of high-current pulsed arcs ranging from 100--250 kA peak

In this paper, we present the laboratory study on three experimental setups that produce a free arc channel subjected to the transient phase of a lightning current waveform. This work extends the high-current pulsed arc characterization performed in previous studies for peak levels up to 100 kA. Eleven high-current waveforms with peak value ranging from 100--250 kA with different growth rates and action integrals are studied, allowing the comparison of different test benches. These waveforms correspond to standard lightning ones used in aircraft certification processes. Hydrodynamic properties such as arc channel evolution and shock-wave propagation are determined by high-speed video imaging and the background-oriented Schlieren method. The arc diameter reaches around 90mm at 50 $\mu$s for a current of 250 kA peak. Space- and time-resolved measurements of temperature, electron density and pressure are assessed by optical emission spectroscopy associated with the radiative transfer equation. It is solved across the arc column and takes into account the assumption of non-optically thin plasma at local thermodynamic equilibrium. For a 250 kA waveform, temperatures up to 43000K are found, with pressures in the order of 50 bar. The influence of current waveform parameters on the arc properties are analyzed and discussed

Treatment of Bouveret Syndrome With Electrohydraulic Lithotripsy

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The speciation of Noctua atlantica (Lepidoptera, Noctuidae) occurred in the Azores as supported by a molecular clock based on mitochondrial COI sequences

The complete sequence of the cytochrome c oxidase subunit I (COI) gene of Noctua atlantica (Warren, 1905) has been determined and deposited in the NCBI GenBank under the Accession number AY600452. Complete and partial COI sequences of other Lepidoptera have been collected and used to reconstruct a phylogeny with both the Neighbor-Joining and the Maximum Likelihood methods. A molecular clock calibrated for our models indicate a divergence time between Noctua atlantica and Noctua pronuba of 4.7-5.9 Million years, consistent with the geological age of the Azores and suggesting that the speciation process of N. atlantica occurred in this archipelago

Gastrointestinal Tuberculosis Mimicking Crohn’s Disease

We present the case of a 24-year-old woman with complaints of abdominal pain, bloody diarrhea, and weight loss for 3 months. An outpatient colonoscopy revealed scattered ulcers, suggestive of Crohn's disease (CD). Histopathology also favored the diagnosis of CD. However, after admission to our hospital for further investigation, a chest radiograph revealed pulmonary cavitations. A computed tomography scan suggested the diagnosis of active pulmonary tuberculosis (TB). Therefore, a bronchofibroscopy, a total colonoscopy with ileoscopy, and an upper endoscopy were performed. Not only were acid-fast bacilli present in both bronchoalveolar lavage fluid and gastric juice, but also in colonic biopsies. A complete resolution of gastrointestinal symptoms was achieved 2 weeks after starting anti-TB drugs.info:eu-repo/semantics/publishedVersio

Risk factors for the emergence of multidrug-resistant organisms in liver cirrhosis

Comunicação oral premiada a nível europeu durante a United Gastroenterology Week 2018, com a NationalScholar Award, prémio destinado a jovens investigadores com < 35 anosinfo:eu-repo/semantics/publishedVersio

Headspace solid-phase microextraction procedure for gas-chromatography analysis of toluene in urine

Toluene is widely used in industrial and laboratory applications and in many countries is related with social problems of abuse. Unaltered urinary toluene was introduced as a bioindicator of occupational exposure to the solvent, but its analysis presents difficulties due to the low levels of the compound excreted in urine. A gas-chromatography/flame ionization method for toluene in urine is described using headspace solid-phase microextraction and establishing the better conditions for two different extracting phases: polydimethylsiloxane (PDMS) and carboxen-PDMS. The carboxen-PDMS fiber showed lower quantifying limit (12.5 ng mL-1), better extraction efficiency (up to 28.1%) and repeatability (CV < 4.9%) than PDMS coating. The method was applied to analysis of toluene in urine of workers from car repair shops exposed to low solvent levels

Dipeptidyl Peptidase IV Inhibition Exerts Renoprotective Effects in Rats with Established Heart Failure

Circulating dipeptidyl peptidase IV (DPPIV) activity is associated with worse cardiovascular outcomes in humans and experimental heart failure (HF) models, suggesting that DPPIV may play a role in the pathophysiology of this syndrome. Renal dysfunction is one of the key features of HF, but it remains to be determined whether DPPIV inhibitors are capable of improving cardiorenal function after the onset of HF. Therefore, the present study aimed to test the hypothesis that DPPIV inhibition by vildagliptin improves renal water and salt handling and exerts anti-proteinuric effects in rats with established HF. To this end, male Wistar rats were subjected to left ventricle (LV) radiofrequency ablation or sham operation. Six weeks after surgery, radiofrequency-ablated rats who developed HF were randomly divided into two groups and treated for 4 weeks with vildagliptin (120 mg/kg/day) or vehicle by oral gavage. Echocardiography was performed before (pretreatment) and at the end of treatment (post-treatment) to evaluate cardiac function. The fractional area change (FAC) increased (34 +/- 5 vs. 45 +/- 3%, p < 0.05), and the isovolumic relaxation time decreased (33 +/- 2 vs. 27 +/- 1 msp < 0.05) in HF rats treated with vildagliptin (post-treatment vs. pretreatment). On the other hand, cardiac dysfunction deteriorated further in vehicle-treated HF rats. Renal function was impaired in vehicle-treated HF rats as evidenced by fluid retention, low glomerular filtration rate (GFR) and high levels of urinary protein excretion. Vildagliptin treatment restored urinary flow. GFR, urinary sodium and urinary protein excretion to sham levels. Restoration of renal function in HF rats by DPPIV inhibition was associated with increased active glucagon-like peptide-1 (GLP-1) serum concentration, reduced DPPIV activity and increased activity of protein kinase A in the renal cortex. Furthermore, the anti-proteinuric effect of vildagliptin treatment in rats with established HF was associated with upregulation of the apical proximal tubule endocytic receptor megalin and of the podocyte main slit diaphragm proteins nephrin and podocin. Collectively, these findings demonstrate that DPPIV inhibition exerts renoprotective effects and ameliorates cardiorenal function in rats with established HF. Long-term studies with DPPIV inhibitors are needed to ascertain whether these effects ultimately translate into improved clinical outcomes.Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)Univ Sao Paulo, Sch Med, Heart Inst InCor, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Med, Div Cardiol, Sao Paulo, BrazilUniv Fed Espirito Santo, Dept Physiol Sci, Vitoria, BrazilUniv Fed Sao Paulo, Dept Med, Div Cardiol, Sao Paulo, BrazilFAPESP: 2013/10619-8Web of Scienc

Associations between movement behaviours and obesity markers among preschoolers compliant and non-compliant with sleep duration:A latent profile analysis

This study identifies physical activity (PA) and sedentary behaviour (SB) clusters in preschoolers compliant (C) or non-compliant (NC) with sleep recommendations; and associates these clusters with obesity markers. PA and SB were objectively assessed (Actigraph WGT3-X) in 272 preschoolers (4.4 ± 0.7 years old). Sleep duration was parent-reported, and preschoolers were classified as C (3–4 years old: 600–780 min/day; 5 years old: 540–660 min/day) or NC with sleep recommendations. Body mass index (BMI) and waist circumference (WC) were assessed according to international protocols. Moderate to vigorous physical activity (MVPA) and light physical activity (LPA) were categorized as low/high (60 min/day or <180 min/180 min/day, respectively). SB was defined according to mean values between clusters. Latent profile analysis was performed. Associations between the observed clusters and obesity markers were determined using linear regression (RStudio; 1.3.1073). Four cluster solutions for C and NC preschoolers were identified. A negative association between C/Low MVPA cluster and BMI, and a positive association between NC/Low MVPA and BMI (β = −0.8, 95%CI = −1.6;−0.1, and β = 0.9, 95%CI = 0.1;1.7, respectively) were observed. No association was seen for SB clusters. Adequate sleep duration may have a protective role for preschoolers’ BMI, even if the children do not comply with MVPA recommendations