First steps towards the certification of an ARM simulator using Compcert

The simulation of Systems-on-Chip (SoC) is nowadays a hot topic because, beyond providing many debugging facilities, it allows the development of dedicated software before the hardware is available. Low-consumption CPUs such as ARM play a central role in SoC. However, the effectiveness of simulation depends on the faithfulness of the simulator. To this effect, we propose here to prove significant parts of such a simulator, SimSoC. Basically, on one hand, we develop a Coq formal model of the ARM architecture while on the other hand, we consider a version of the simulator including components written in Compcert-C. Then we prove that the simulation of ARM operations, according to Compcert-C formal semantics, conforms to the expected formal model of ARM. Size issues are partly dealt with using automatic generation of significant parts of the Coq model and of SimSoC from the official textual definition of ARM. However, this is still a long-term project. We report here the current stage of our efforts and discuss in particular the use of Compcert-C in this framework.Comment: First International Conference on Certified Programs and Proofs 7086 (2011

A shared mechanism of muscle wasting in cancer and Huntington's disease.

Skeletal muscle loss and dysfunction in aging and chronic diseases is one of the major causes of mortality in patients, and is relevant for a wide variety of diseases such as neurodegeneration and cancer. Muscle loss is accompanied by changes in gene expression and metabolism that lead to contractile impairment and likely affect whole-body metabolism and function. The changes may be caused by inactivity, inflammation, age-related factors or unbalanced nutrition. Although links with skeletal muscle loss have been found in diseases with disparate aetiologies, for example both in Huntingtons disease (HD) and cancer cachexia, the outcome is a similar impairment and mortality. This short commentary aims to summarize recent achievements in the identification of common mechanisms leading to the skeletal muscle wasting syndrome seen in diseases as different as cancer and HD. The latter is the most common hereditary neurodegenerative disorder and muscle wasting is an important component of its pathology. In addition, possible therapeutic strategies for anti-cachectic treatment will be also discussed in the light of their translation into possible therapeutic approaches for HD

Herding cats: observing live coding in the wild

After a momentous decade of live coding activities, this paper seeks to explore the practice with the aim of situating it in the history of contemporary arts and music. The article introduces several key points of investigation in live coding research and discusses some examples of how live coding practitioners engage with these points in their system design and performances. In the light of the extremely diverse manifestations of live coding activities, the problem of defining the practice is discussed, and the question raised whether live coding will actually be necessary as an independent category

Flat Dielectric Grating Reflectors with High Focusing Power

Sub-wavelength dielectric gratings (SWG) have emerged recently as a promising alternative to distributed-Bragg-reflection (DBR) dielectric stacks for broadband, high-reflectivity filtering applications. A SWG structure composed of a single dielectric layer with the appropriate patterning can sometimes perform as well as thirty or forty dielectric DBR layers, while providing new functionalities such as polarization control and near-field amplification. In this paper, we introduce a remarkable property of grating mirrors that cannot be realized by their DBR counterpart: we show that a non-periodic patterning of the grating surface can give full control over the phase front of reflected light while maintaining a high reflectivity. This new feature of dielectric gratings could have a substantial impact on a number of applications that depend on low-cost, compact optical components, from laser cavities to CD/DVD read/write heads.Comment: submitted to Nature Photonic

Electronic band structure of cubic CdSe determined by angle-resolved photoemission: Cd 4d and valence-level states

The valence-band structure of epitaxially grown cubic CdSe along the Γ−K−X direction is determined experimentally using angle-resolved photoelectron spectroscopy on the basis of the free-electron final band model. In the upper valence band the three main branches are determined from normal emission spectra over the range from 15 to 90 eV photon energy, and are found to conform with the general shape expected from this class of materials. The Cd 4d level exhibits considerable dispersion, which is reflected in the spectra. The experimental bands are compared with several calculations based on different schemes, and best agreement with respect to dispersion and binding energies is found for a calculation that takes into account electron self-interaction and relaxation

Antagonism of neuromuscular blockade but not muscle relaxation affects depth of anaesthesia

Background. Conflicting effects of neuromuscular blocking drugs and anticholinesterases on depth of anaesthesia have been reported. Therefore we evaluated the effect of atracurium and neostigmine on bispectral index (BIS) and middle-latency auditory evoked potentials (AAI). Methods. We studied 40 patients (ASA I-II) aged 18-69 yr. General anaesthesia consisted of propofol and remifentanil by target-controlled infusion and neuromuscular function was monitored by electromyography. When BIS reached stable values, patients were randomly assigned to one of two groups. Group 1 received atracurium 0.4 mg kg−1 and, 5 min later, the same volume of NaCl 0.9%; group 2 received saline first and then atracurium. When the first twitch of a train of four reached 10% of control intensity, patients were again randomized: one group (N) received neostigmine 0.04 mg kg−1 and glycopyrrolate 0.01 mg kg−1, and the control group (G) received only glycopyrrolate. Results. Injection of atracurium or NaCl 0.9% had no effect on BIS or AAI. After neostigmine-glycopyrrolate, BIS and AAI increased significantly (mean maximal change of BIS 7.1 [sd 7.5], P<0.001; mean maximal change of AAI 9.7 [10.5], P<0.001). When glycopyrrolate was injected alone BIS and AAI also increased (mean maximal change of BIS 2.2 [3.4], P=0.008; mean maximal change of AAI 3.5 [5.7], P=0.012), but this increase was significantly less than in group N (P=0.012 for BIS; P=0.027 for AAI). Conclusion. These data suggest that neostigmine alters the state of propofol-remifentanil anaesthesia and may enhance recover

The rating reliability calculator

BACKGROUND: Rating scales form an important means of gathering evaluation data. Since important decisions are often based on these evaluations, determining the reliability of rating data can be critical. Most commonly used methods of estimating reliability require a complete set of ratings i.e. every subject being rated must be rated by each judge. Over fifty years ago Ebel described an algorithm for estimating the reliability of ratings based on incomplete data. While his article has been widely cited over the years, software based on the algorithm is not readily available. This paper describes an easy-to-use Web-based utility for estimating the reliability of ratings based on incomplete data using Ebel's algorithm. METHODS: The program is available public use on our server and the source code is freely available under GNU General Public License. The utility is written in PHP, a common open source imbedded scripting language. The rating data can be entered in a convenient format on the user's personal computer that the program will upload to the server for calculating the reliability and other statistics describing the ratings. RESULTS: When the program is run it displays the reliability, number of subject rated, harmonic mean number of judges rating each subject, the mean and standard deviation of the averaged ratings per subject. The program also displays the mean, standard deviation and number of ratings for each subject rated. Additionally the program will estimate the reliability of an average of a number of ratings for each subject via the Spearman-Brown prophecy formula. CONCLUSION: This simple web-based program provides a convenient means of estimating the reliability of rating data without the need to conduct special studies in order to provide complete rating data. I would welcome other researchers revising and enhancing the program

Memory and superposition in a spin glass

Non-equilibrium dynamics in a Ag(Mn) spin glass are investigated by measurements of the temperature dependence of the remanent magnetisation. Using specific cooling protocols before recording the thermo- or isothermal remanent magnetisations on re-heating, it is found that the measured curves effectively disclose non-equilibrium spin glass characteristics such as ageing and memory phenomena as well as an extended validity of the superposition principle for the relaxation. The usefulness of this "simple" dc-method is discussed, as well as its applicability to other disordered magnetic systems.Comment: REVTeX style; 8 pages, 4 figure

Relaxation of the field-cooled magnetization of an Ising spin glass

The time and temperature dependence of the field-cooled magnetization of a three dimensional Ising spin glass, Fe_{0.5}Mn_{0.5}TiO_{3}, has been investigated. The temperature and cooling rate dependence is found to exhibit memory phenomena that can be related to the memory behavior of the low frequency ac-susceptibility. The results add some further understanding on how to model the three dimensional Ising spin glass in real space.Comment: 8 pages RevTEX, 5 figure