Supervised Typing of Big Graphs using Semantic Embeddings

We propose a supervised algorithm for generating type embeddings in the same semantic vector space as a given set of entity embeddings. The algorithm is agnostic to the derivation of the underlying entity embeddings. It does not require any manual feature engineering, generalizes well to hundreds of types and achieves near-linear scaling on Big Graphs containing many millions of triples and instances by virtue of an incremental execution. We demonstrate the utility of the embeddings on a type recommendation task, outperforming a non-parametric feature-agnostic baseline while achieving 15x speedup and near-constant memory usage on a full partition of DBpedia. Using state-of-the-art visualization, we illustrate the agreement of our extensionally derived DBpedia type embeddings with the manually curated domain ontology. Finally, we use the embeddings to probabilistically cluster about 4 million DBpedia instances into 415 types in the DBpedia ontology.Comment: 6 pages, to be published in Semantic Big Data Workshop at ACM, SIGMOD 2017; extended version in preparation for Open Journal of Semantic Web (OJSW

Shot Noise Suppression in Avalanche Photodiodes

We identify a new shot noise suppression mechanism in a thin (~100 nm) heterostructure avalanche photodiode. In the low-gain regime the shot noise is suppressed due to temporal correlations within amplified current pulses. We demonstrate in a Monte Carlo simulation that the effective excess noise factors can be <1, and reconcile the apparent conflict between theory and experiments. This shot noise suppression mechanism is independent of known mechanisms such as Coulomb interaction, or reflection at heterojunction interfaces.Comment: Phys. Rev. Lett., accepted for publicatio

Quasi-periodic X-ray brightness fluctuations in an accreting millisecond pulsar

The relativistic plasma flows onto neutron stars that are accreting material from stellar companions can be used to probe strong-field gravity as well as the physical conditions in the supranuclear-density interiors of neutron stars. Plasma inhomogeneities orbiting a few kilometres above the stars are observable as X-ray brightness fluctuations on the millisecond dynamical timescale of the flows. Two frequencies in the kilohertz range dominate these fluctuations: the twin kilohertz quasi-periodic oscillations (kHz QPOs). Competing models for the origins of these oscillations (based on orbital motions) all predict that they should be related to the stellar spin frequency, but tests have been difficult because the spins were not unambiguously known. Here we report the detection of kHz QPOs from a pulsar whose spin frequency is known. Our measurements establish a clear link between kHz QPOs and stellar spin, but one not predicted by any current model. A new approach to understanding kHz QPOs is now required. We suggest that a resonance between the spin and general relativistic orbital and epicyclic frequencies could provide the observed relation between QPOs and spin.Comment: Published in the 2003 July 3 issue of Natur

Effect of pyramiding Bt and CpTI genes on resistance of cotton to Helicoverpa armigera (Lepidoptera: Noctuidae) under laboratory and field conditions

Transgenic cotton (Gossypium hirsutum L.) varieties, adapted to China, have been bred that express two genes for resistance to insects. the Cry1Ac gene from Bacillus thuringiensis (Berliner) (Bt), and a trypsin inhibitor gene from cowpea (CpTI). Effectiveness of the double gene modification in conferring resistance to cotton bollworm, Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae), was studied in laboratory and field experiments. In each experiment, performance of Bt+CpTI cotton was compared with Bt cotton and to a conventional nontransgenic variety. Larval survival was lower on both types of transgenic variety, compared with the conventional cotton. Survival of first-, second-, and third-stage larvae was lower on Bt+CpTI cotton than on Bt cotton. Plant structures differed in level of resistance, and these differences were similar on Bt and Bt+CpTI cotton. Likewise, seasonal trends in level of resistance in different plant structures were similar in Bt and Bt+CpTI cotton. Both types of transgenic cotton interfered with development of sixth-stage larvae to adults, and no offspring was produced by H. armigera that fed on Bt or Bt+CpTI cotton from the sixth stage onward. First-, second-, and third-stage larvae spent significantly less time feeding on transgenic cotton than on conventional cotton, and the reduction in feeding time was significantly greater on Bt+CpTI cotton than on Bt cotton. Food conversion efficiency was lower on transgenic varieties than on conventional cotton, but there was no significant difference between Bt and Bt+CpTI cotton. In 3-yr field experimentation, bollworm densities were greatly suppressed on transgenic as compared with conventional cotton, but no significant differences between Bt and Bt+CpTI cotton were found. Overall, the results from laboratory work indicate that introduction of the CpTI gene in Bt cotton raises some components of resistance in cotton against H. armigera, but enhanced control of H. armigera under field conditions, due to expression of the CpTI gene, was not demonstrate

An integrated 80V 45W class-D power amplifier with optimal-efficiency-tracking switching frequency regulation

Piezoelectric actuators are widely used in smart materials for vibration and noise control, precision actuators, etc. [1]. These actuators are largely capacitive and the reactive power applied on them can go to several tens of Watts. Highvoltage, high-power class-D amplifiers [2]-[5] are ideal drivers for such loads, because of their high power efficiency. Preferably, efficiency should be high both at maximum power and at average output power. Obtaining high power efficiency over the full output power range of a class-D amplifier is the main focus of this work

Design and analysis of a high-efficiencyv high-voltage class-D power output stage

The analysis and design of a highly-efficient 80 V class-D power stage design in a 0.14 μm SOI-based BCD process is described. It features immunity to the on-chip supply bounce, realized by internally regulated floating supplies, variable driving strength for the gate driver, and an efficient 2-step level shifter design. Fast switching transition and low switching loss are achieved with 94% peak efficiency for the complete class-D power stage in the realized chip

Performance analysis of a parallel, multi-node pipeline for DNA sequencing

Post-sequencing DNA analysis typically consists of read mapping followed by variant calling and is very time-consuming, even on a multi-core machine. Recently, we proposed Halvade, a parallel, multi-node implementation of a DNA sequencing pipeline according to the GATK Best Practices recommendations. The MapReduce programming model is used to distribute the workload among different workers. In this paper, we study the impact of different hardware configurations on the performance of Halvade. Benchmarks indicate that especially the lack of good multithreading capabilities in the existing tools (BWA, SAMtools, Picard, GATK) cause suboptimal scaling behavior. We demonstrate that it is possible to circumvent this bottleneck by using multiprocessing on high-memory machines rather than using multithreading. Using a 15-node cluster with 360 CPU cores in total, this results in a runtime of 1 h 31 min. Compared to a single-threaded runtime of similar to 12 days, this corresponds to an overall parallel efficiency of 53%

Discovery of Quasi-Periodic Oscillations in the Recurrent Burst Emission from SGR 1806-20

We present evidence for Quasi-Periodic Oscillations (QPOs) in the recurrent outburst emission from the soft gamma repeater SGR 1806-20 using NASA's Rossi X-ray Timing Explorer (RXTE) observations. By searching a sample of 30 bursts for timing signals at the frequencies of the QPOs discovered in the 2004 December 27 giant flare from the source, we find three QPOs at 84, 103, and 648 Hz in three different bursts. The first two QPOs lie within $\sim$ 1$\: \sigma$ from the 92 Hz QPO detected in the giant flare. The third QPO lie within $\sim$ 9$\: \sigma$ from the 625 Hz QPO also detected in the same flare. The detected QPOs are found in bursts with different durations, morphologies, and brightness, and are vindicated by Monte Carlo simulations, which set a lower limit confidence interval $\geq 4.3 \sigma$. We also find evidence for candidate QPOs at higher frequencies in other bursts with lower statistical significance. The fact that we can find evidence for QPOs in the recurrent bursts at frequencies relatively close to those found in the giant flare is intriguing and can offer insight about the origin of the oscillations. We confront our finding against the available theoretical models and discuss the connection between the QPOs we report and those detected in the giant flares. The implications to the neutron star properties are also discussed.Comment: 5 pages, 2 figures, Accepted for publication in the Astrophysical Journal Letters (ApJL

Changes in chlamydia control activities in Europe between 2007 and 2012: a cross-national survey

BACKGROUND: In 2012, the levels of chlamydia control activities including primary prevention, effective case management with partner management and surveillance were assessed in 2012 across countries in the European Union and European Economic Area (EU/EEA), on initiative of the European Centre for Disease Control (ECDC) survey, and the findings were compared with those from a similar survey in 2007. METHODS: Experts in the 30 EU/EEA countries were invited to respond to an online questionnaire; 28 countries responded, of which 25 participated in both the 2007 and 2012 surveys. Analyses focused on 13 indicators of chlamydia prevention and control activities; countries were assigned to one of five categories of chlamydia control. RESULTS: In 2012, more countries than in 2007 reported availability of national chlamydia case management guidelines (80% vs. 68%), opportunistic chlamydia testing (68% vs. 44%) and consistent use of nucleic acid amplification tests (64% vs. 36%). The number of countries reporting having a national sexually transmitted infection control strategy or a surveillance system for chlamydia did not change notably. In 2012, most countries (18/25, 72%) had implemented primary prevention activities and case management guidelines addressing partner management, compared with 44% (11/25) of countries in 2007. CONCLUSION: Overall, chlamydia control activities in EU/EEA countries strengthened between 2007 and 2012. Several countries still need to develop essential chlamydia control activities, whereas others may strengthen implementation and monitoring of existing activities

Heisenberg models and a particular isotropic model

The Heisenberg model, a quantum mechanical analogue of the Ising model, has a large ground state degeneracy, due to the symmetry generated by the total spin. This symmetry is also responsible for degeneracies in the rest of the spectrum. We discuss the global structure of the spectrum of Heisenberg models with arbitrary couplings, using group theoretical methods. The Hilbert space breaks up in blocks characterized by the quantum numbers of the total spin, $S$ and $M$, and each block is shown to constitute the representation space of an explicitly given irreducible representation of the symmetric group $S_N$, consisting of permutations of the $N$ spins in the system. In the second part of the paper we consider, as a concrete application, the model where each spin is coupled to all the other spins with equal strength. Its partition function is written as a single integral, elucidating its $N$-dependence. This provides a useful framework for studying finite size effects. We give explicit results for the heat capacity, revealing interesting behavior just around the phase transition.Comment: 16 pages LaTeX, one of the 2 figures included as a postscript file. Oxford preprint OUTP-93-18S, to be published in Phys. Rev.