A philosophical context for methods to estimate origin-destination trip matrices using link counts.

This paper creates a philosophical structure for classifying methods which estimate origin-destination matrices using link counts. It is claimed that the motivation for doing so is to help real-life transport planners use matrix estimation methods effectively, especially in terms of trading-off observational data with prior subjective input (typically referred to as 'professional judgement'). The paper lists a number of applications that require such methods, differentiating between relatively simple and highly complex applications. It is argued that a sound philosophical perspective is particularly important for estimating trip matrices in the latter type of application. As a result of this argument, a classification structure is built up through using concepts of realism, subjectivity, empiricism and rationalism. Emphasis is put on the fact that, in typical transport planning applications, none of these concepts is useful in its extreme form. The structure is then used to make a review of methods for estimating trip matrices using link counts, covering material published over the past 30 years. The paper concludes by making recommendations, both philosophical and methodological, concerning both practical applications and further research

High ON/OFF ratio and multimode transport in silicon nanochains field effect transistors

We have observed multimode transport and high ON/OFF ratio in silicon nanochain devices. Silicon nanochains grown by thermal evaporation of SiO solid sources consisted of chains of silicon nanocrystals ~10 nm in diameter, separated by SiO2 regions. The devices were fabricated using electron beam lithography on SiO2 thermally grown on silicon substrate. These devices exhibited high ON/OFF current ratio up to 104. The inverse subthreshold slope as small as ~500 mV/decade was observed in these devices. Therefore, we believe silicon nanochains hold great potential to be used in field effect transistors

Charge injection and trapping in TiO2 nanoparticles decorated silicon nanowires arrays

We investigate carrier transport properties of silicon nanowire (SiNW) arrays decorated with TiO2 nanoparticles (NPs). Ohmic conduction was dominant at lower voltages and space charge limited current with and without traps was observed at higher voltages. Mott’s 3D variable range hoping mechanism was found to be dominant at lower temperatures. The minimum hopping distance (Rmin) for n and p-SiNWs/TiO2 NPs devices was 1.5 nm and 0.68 nm, respectively, at 77 K. The decrease in the value of Rmin can be attributed to higher carrier mobility in p-SiNWs/TiO2 NPs than that of n-SiNWs/TiO2 NPs hybrid device

Defining Plasmodium falciparum Treatment in South West Asia: A Randomized Trial Comparing Artesunate or Primaquine Combined with Chloroquine or SP

INTRODUCTION: Antimalarial resistance has led to a global policy of artemisinin-based combination therapy. Despite growing resistance chloroquine (CQ) remained until recently the official first-line treatment for falciparum malaria in Pakistan, with sulfadoxine-pyrimethamine (SP) second-line. Co-treatment with the gametocytocidal primaquine (PQ) is recommended for transmission control in South Asia. The relative effect of artesunate (AS) or primaquine, as partner drugs, on clinical outcomes and gametocyte carriage in this setting were unknown. METHODS: A single-blinded, randomized trial among Afghan refugees in Pakistan compared six treatment arms: CQ; CQ+(single-dose)PQ; CQ+(3 d)AS; SP; SP+(single-dose)PQ, and SP+(3 d)AS. The objectives were to compare treatment failure rates and effect on gametocyte carriage, of CQ or SP monotherapy against the respective combinations (PQ or AS). Outcomes included trophozoite and gametocyte clearance (read by light microscopy), and clinical and parasitological failure. FINDINGS: A total of 308 (87%) patients completed the trial. Failure rates by day 28 were: CQ 55/68 (81%); CQ+AS 19/67 (28%), SP 4/41 (9.8%), SP+AS 1/41 (2.4%). The addition of PQ to CQ or SP did not affect failure rates (CQ+PQ 49/67 (73%) failed; SP+PQ 5/33 (16%) failed). AS was superior to PQ at clearing gametocytes; gametocytes were seen on d7 in 85% of CQ, 40% of CQ+PQ, 21% of CQ+AS, 91% of SP, 76% of SP+PQ and 23% of SP+AS treated patients. PQ was more effective at clearing older gametocyte infections whereas AS was more effective at preventing emergence of mature gametocytes, except in cases that recrudesced. CONCLUSIONS: CQ is no longer appropriate by itself or in combination. These findings influenced the replacement of CQ with SP+AS for first-line treatment of uncomplicated falciparum malaria in the WHO Eastern Mediterranean Region. The threat of SP resistance remains as SP monotherapy is still common. Three day AS was superior to single-dose PQ for reducing gametocyte carriage. TRIAL REGISTRATION: ClinicalTrials.gov NCT00959517