9,743 research outputs found
Pickering emulsions responsive to COâ‚‚/Nâ‚‚ and light dual stimuli at ambient temperature
A dual stimulus-responsive n-octane-in-water Pickering emulsion with CO₂/N₂ and light triggers is prepared using negatively charged silica nanoparticles in combination with a trace amount of dual switchable surfactant, 4-butyl-4-(4-N,N-dimethylbutoxyamine) azobenzene bicarbonate (AZO-B₄) as stabilizers. On one hand, the emulsion can be transformed between stable and unstable at ambient temperature rapidly via the N₂/CO₂ trigger, and on the other hand a change in droplet size of the emulsion can occur upon light irradiation/re-homogenization cycles without changing the particle/surfactant concentration. The dual responsiveness thus allows for a precise control of emulsion properties. Compared with emulsions stabilised by specially synthesized stimuli-responsive particles or by stimuli-responsive surfactants, the method reported here is much easier and requires relatively low concentration of surfactant (≈1/10 cmc), which is important for potential applications
Mode stability on the real axis
A generalization of the mode stability result of Whiting (1989) for the
Teukolsky equation is proved for the case of real frequencies. The main result
of the paper states that a separated solution of the Teukolsky equation
governing massless test fields on the Kerr spacetime, which is purely outgoing
at infinity, and purely ingoing at the horizon, must vanish. This has the
consequence, that for real frequencies, there are linearly independent
fundamental solutions of the radial Teukolsky equation which are purely ingoing
at the horizon, and purely outgoing at infinity, respectively. This fact yields
a representation formula for solutions of the inhomogenous Teukolsky equation.Comment: 20 pages, 4 figures. Reference added, revtex4-1 forma
Smart worm-like micelles responsive to COâ‚‚/Nâ‚‚ and light dual stimuli
CO₂/N₂ and light dual stimuli-reponsive worm-like micelles (WLMs) were obtained by addition of a relatively small amount of a switchable surfactant, 4-butyl-4´-(4-N,N-dimethylhexyloxy-amine) azobenzene bicarbonate (AZO-B6-CO₂), sensitive to the same triggers into a binary aqueous solution of cetyltrimethyl ammonium bromide (CTAB) and sodium salycilate (NaSal)
A Study of Gluon Propagator on Coarse Lattice
We study gluon propagator in Landau gauge with lattice QCD, where we use an
improved lattice action. The calculation of gluon propagator is performed on
lattices with the lattice spacing from 0.40 fm to 0.24 fm and with the lattice
volume from to . We try to fit our results by two
different ways, in the first one we interpret the calculated gluon propagators
as a function of the continuum momentum, while in the second we interpret the
propagators as a function of the lattice momentum. In the both we use models
which are the same in continuum limit. A qualitative agreement between two
fittings is found.Comment: Revtex 14pages, 11 figure
Axial vector form factor of nucleons in a light-cone diquark model
The nucleon axial vector form factor is investigated in a light-cone quark
spectator diquark model, in which Melosh rotations are applied to both the
quark and vector diquark. It is found that this model gives a very good
description of available experimental data and the results have very little
dependence on the parameters of the model. The relation between the nucleon
axial constant and the anomalous magnetic moment of nucleons is also discussed.Comment: 8 pages, Revtex4, 1 figure, version to be published in Phys. Rev.
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Utility of 2013 American College of Cardiology/American Heart Association Cholesterol Guidelines in HIV-Infected Adults With Carotid Atherosclerosis.
BackgroundAlthough HIV is associated with increased atherosclerotic cardiovascular disease (CVD) risk, it is unknown whether guidelines can identify HIV-infected adults who may benefit from statins. We compared the 2013 American College of Cardiology/American Heart Association and 2004 Adult Treatment Panel III recommendations in HIV-infected adults and evaluated associations with carotid artery intima-media thickness and plaque.Methods and resultsCarotid artery intima-media thickness was measured at baseline and 3 years later in 352 HIV-infected adults without clinical atherosclerotic CVD and not on statins. Plaque was defined as IMT >1.5 mm in any segment. At baseline, the median age was 43 (interquartile range, 39-49), 85% were men, 74% were on antiretroviral medication, and 50% had plaque. The American College of Cardiology/American Heart Association guidelines were more likely to recommend statins compared with the Adult Treatment Panel III guidelines, both overall (26% versus 14%; P<0.001), in those with plaque (32% versus 17%; P=0.0002), and in those without plaque (16% versus 7%; P=0.025). In multivariable analysis, older age, higher low-density lipoprotein cholesterol, pack per year of smoking, and history of opportunistic infection were associated with baseline plaque. Baseline IMT (hazard ratio, 1.18 per 10% increment; 95% confidence interval, 1.05-1.33; P=0.005) and plaque (hazard ratio, 2.06; 95% confidence interval, 1.02-4.08; P=0.037) were each associated with all-cause mortality, independent of traditional CVD risk factors.ConclusionsAlthough the American College of Cardiology/American Heart Association guidelines recommended statins to a greater number of HIV-infected adults compared with the Adult Treatment Panel III guidelines, both failed to recommend therapy in the majority of HIV-affected adults with carotid plaque. Baseline carotid atherosclerosis but not atherosclerotic CVD risk scores was an independent predictor of mortality. HIV-specific guidelines that include detection of subclinical atherosclerosis may help to identify HIV-infected adults who are at increased atherosclerotic CVD risk and may be considered for statins
HIV and Hepatitis C-Coinfected Patients Have Lower Low-Density Lipoprotein Cholesterol Despite Higher Proprotein Convertase Subtilisin Kexin 9 (PCSK9): An Apparent "PCSK9-Lipid Paradox".
BackgroundProprotein convertase subtilisin kexin 9 (PCSK9) inhibitors reduce low-density lipoprotein cholesterol (LDL-C) and improve outcomes in the general population. HIV-infected individuals are at increased risk for cardiovascular events and have high rates of dyslipidemia and hepatitis C virus (HCV) coinfection, making PCSK9 inhibition a potentially attractive therapy.Methods and resultsWe studied 567 participants from a clinic-based cohort to compare PCSK9 levels in patients with HIV/HCV coinfection (n=110) with those with HIV infection alone (n=385) and with uninfected controls (n=72). The mean age was 49 years, and the median LDL-C level was 100 mg/dL (IQR 77-124 mg/dL); 21% were taking statins. The 3 groups had similar rates of traditional risk factors. Total cholesterol, LDL-C, and high-density lipoprotein cholesterol levels were lower in coinfected patients compared with controls (P<0.001). PCSK9 was 21% higher in HIV/HCV-coinfected patients versus controls (95% CI 9-34%, P<0.001) and 11% higher in coinfected individuals versus those with HIV infection alone (95% CI 3-20%, P=0.008). After adjustment for cardiovascular risk factors, HIV/HCV coinfection remained significantly associated with 20% higher PCSK9 levels versus controls (95% CI 8-33%, P=0.001). Interleukin-6 levels increased in a stepwise fashion from controls (lowest) to HIV-infected to HIV/HCV-coinfected individuals (highest) and correlated with PCSK9 (r=0.11, P=0.018).ConclusionsDespite having lower LDL-C, circulating PCSK9 levels were increased in patients coinfected with HIV and HCV in parallel with elevations in the inflammatory, proatherogenic cytokine interleukin-6. Clinical trials should be conducted to determine the efficacy of targeted PCSK9 inhibition in the setting of HIV/HCV coinfection
Sevoflurane Pre-conditioning Ameliorates Diabetic Myocardial Ischemia/Reperfusion Injury Via Differential Regulation of p38 and ERK.
Diabetes mellitus (DM) significantly increases myocardial ischemia/reperfusion (MI/R) injury. During DM, cardioprotection induced by conventional pre-conditioning (PreCon) is decreased due to impaired AMP-activated protein kinase (AMPK) signaling. The current study investigated whether PreCon with inhaled anesthetic sevoflurane (SF-PreCon) remains cardioprotective during DM, and identified the involved mechanisms. Normal diet (ND) and high-fat diet (HFD)-induced DM mice were randomized into control and SF-PreCon (3 cycles of 15-minute period exposures to 2% sevoflurane) groups before MI/R. SF-PreCon markedly reduced MI/R injury in DM mice, as evidenced by improved cardiac function (increased LVEF and ±Dp/dt), decreased infarct size, and decreased apoptosis. To determine the relevant role of AMPK, the effect of SF-PreCon was determined in cardiac-specific AMPKα2 dominant negative expressing mice (AMPK-DN). SF-PreCon decreased MI/R injury in AMPK-DN mice. To explore the molecular mechanisms responsible for SF-PreCon mediated cardioprotection in DM mice, cell survival molecules were screened. Interestingly, in ND mice, SF-PreCon significantly reduced MI/R-induced activation of p38, a pro-death MAPK, without altering ERK and JNK. In DM and AMPK-DN mice, the inhibitory effect of SF-PreCon upon p38 activation was significantly blunted. However, SF-PreCon significantly increased phosphorylation of ERK1/2, a pro-survival MAPK in DM and AMPK-DN mice. We demonstrate that SF-PreCon protects the heart via AMPK-dependent inhibition of pro-death MAPK in ND mice. However, SF-PreCon exerts cardioprotective action via AMPK-independent activation of a pro-survival MAPK member in DM mice. SF-PreCon may be beneficial compared to conventional PreCon in diabetes or clinical scenarios in which AMPK signaling is impaired
The Four-Fermi Model in Three Dimensions at Non-Zero Density and Temperature
The Four Fermi model with discrete chiral symmetry is studied in three
dimensions at non-zero chemical potential and temperature using the Hybrid
Monte Carlo algorithm. The number of fermion flavors is chosen large
to compare with analytic results. A first order chiral symmetry restoring
transition is found at zero temperature with a critical chemical potential
in good agreement with the large calculations. The critical index
of the correlation length is measured in good agreement with analytic
calculations. The two dimensional phase diagram (chemical potential vs.
temperature) is mapped out quantitatively. Finite size effects on relatively
small lattices and non-zero fermion mass effects are seen to smooth out the
chiral transition dramatically.Comment: 21 pages, sorry, no figure
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