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Agonist and antagonist effects of diadenosine tetraphosphate, a platelet dense granule constituent, on platelet P2Y1, P2Y12 and P2X1 receptors
INTRODUCTION: Diadenosine 5',5'''-P(1),P(4)- tetraphosphate (Ap(4)A) is stored in platelet dense granules, but its effects on platelet function are not well understood. METHODS AND RESULTS: We examined the effects of Ap(4)A on platelet purinergic receptors P2Y(1), P2Y(12) and P2X(1). Flow cytometry was used to measure the effects of Ap(4)A in the presence or absence of ADP on: a) P2Y(12)-mediated decrease in intraplatelet phosphorylated vasodilator stimulated phosphoprotein (VASP), b) P2Y(1)-mediated increase in platelet cytosolic Ca(2+), and c) P2X(1)-mediated intraplatelet entry of extracellular Ca(2+). ADP-stimulated platelet shape change (P2Y(1)-mediated) and aggregation (P2Y(1)- and P2Y(12)-mediated) were measured optically. Ap(4)A inhibited 3 microM ADP-induced: a) platelet aggregation (IC(50) 9.8+/-2.8 microM), b) P2Y(1)-mediated shape change, c) P2Y(1)-mediated increase in platelet cytosolic Ca(2+) (IC(50) 40.8+/-12.3 microM), and d) P2Y(12)-mediated decrease in VASP phosphorylation (IC(50)>250 microM). In the absence of added ADP, Ap(4)A had agonist effects on platelet P2X(1) and P2Y(12), but not P2Y(1), receptors. CONCLUSION: Ap(4)A, a constituent of platelet dense granules, is a) an antagonist of platelet P2Y(1) and P2Y(12) receptors, where it inhibits the effects of ADP, and b) an agonist of platelet P2X(1) and P2Y(12) receptors
Double-slit interference pattern from single-slit screen and its gravitational analogues
The double slit experiment (DSE) is known as an important cornerstone in the
foundations of physical theories such as Quantum Mechanics and Special
Relativity. A large number of different variants of it were designed and
performed over the years. We perform and discuss here a new verion with the
somewhat unexpected results of obtaining interference pattern from single-slit
screen. This outcome, which shows that the routes of the photons through the
array were changed, leads one to discuss it, using the equivalence principle,
in terms of geodesics mechanics. We show using either the Brill's version of
the canonical formulation of general relativity or the linearized version of it
that one may find corresponding and analogous situations in the framework of
general relativity.Comment: 51 pages, 12 Figures five of them contain two subfigures and thus the
number of figures is 17, 1 Table. Some minor changes introduced, especially,
in the reference
Rapid And Durable Responses With The Syk/Jak Inhibitor Cerdulatinib In A Phase 2 Study In Relapsed/Refractory Follicular Lymphoma—Alone Or In Combination With Rituximab
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149541/1/hon30_2629.pd
Chiral 4d string vacua with D-branes and NSNS and RR fluxes
We discuss type IIB orientifolds with D-branes, and NSNS and RR field
strength fluxes. The D-brane sectors lead to open string spectra with
non-abelian gauge symmetry and charged chiral fermions. The closed string field
strengths generate a scalar potential stabilizing most moduli. We describe the
construction of N=1 supersymmetric models in the context of orientifolds of IIB
theory on T^6/Z_2 x Z_2, containing D9-branes with world-volume magnetic
fluxes, and illustrate model building possibilities with several explicit
examples. We comment on a T-dual picture with D8-branes on non-Calabi-Yau
half-flat geometries, and discuss some of the topological properties of such
configurations. We also explore the construction of models with fluxes and with
D3-branes at singularities and present a non-supersymmetric 3-family SU(5)
model.Comment: latex, 49 pages, 2 figure
Supersymmetric Intersections of M-branes and pp-waves
We study supersymmetric intersections of M2 and M5 branes with different
pp-waves of M-theory. We consider first M-brane probes in the background of
pp-waves and determine under which conditions the embedding is supersymmetric.
We particularize our formalism to the case of pp-waves with 32, 24 and 20
supersymmetries. We also construct supergravity solutions for the brane-wave
system. Generically these solutions are delocalised along some directions
transverse to the brane and preserve the same number of supersymmetries as in
the brane probe approach.Comment: 41 pages, LaTeX; v2 references adde
Flux Compactifications on Calabi-Yau Threefolds
The presence of RR and NS three-form fluxes in type IIB string
compactification on a Calabi-Yau orientifold gives rise to a nontrivial
superpotential W for the dilaton and complex structure moduli. This
superpotential is computable in terms of the period integrals of the Calabi-Yau
manifold. In this paper, we present explicit examples of both supersymmetric
and nonsupersymmetric solutions to the resulting 4d N=1 supersymmetric no-scale
supergravity, including some nonsupersymmetric solutions with relatively small
values of W. Our examples arise on orientifolds of the hypersurfaces in
and . They serve as explicit
illustrations of several of the ingredients which have played a role in the
recent proposals for constructing de Sitter vacua of string theory.Comment: 30 pages, harvmac big; refs and minor comments adde
State sampling dependence of the Hopfield network inference
The fully connected Hopfield network is inferred based on observed
magnetizations and pairwise correlations. We present the system in the glassy
phase with low temperature and high memory load. We find that the inference
error is very sensitive to the form of state sampling. When a single state is
sampled to compute magnetizations and correlations, the inference error is
almost indistinguishable irrespective of the sampled state. However, the error
can be greatly reduced if the data is collected with state transitions. Our
result holds for different disorder samples and accounts for the previously
observed large fluctuations of inference error at low temperatures.Comment: 4 pages, 1 figure, further discussions added and relevant references
adde
Open Strings in Exactly Solvable Model of Curved Spacetime and PP-Wave Limit
In this paper we study the superstring version of the exactly solvable string
model constructed by Russo and Tseytlin. This model represents superstring
theory in a curved spacetime and can be seen as a generalization of the Melvin
background. We investigate D-branes in this model as probes of the background
geometry by constructing the boundary states. We find that spacetime
singularities in the model become smooth at high energy from the viewpoint of
open string. We show that there always exist bulk (movable) D-branes by the
effect of electric flux. The model also includes Nappi-Witten model as the
Penrose limit and supersymmetry is enhanced in the limit. We examine this
phenomenon in the open string spectrum. We also find the similar enhancement of
supersymmetry can be occurred in several coset models.Comment: Latex, 32 pages, typos corrected, references added, to appear in
JHEP, eq.(2.22) correcte
Collective perspective on advances in Dyson-Schwinger Equation QCD
We survey contemporary studies of hadrons and strongly interacting quarks
using QCD's Dyson-Schwinger equations, addressing: aspects of confinement and
dynamical chiral symmetry breaking; the hadron spectrum; hadron elastic and
transition form factors, from small- to large-Q^2; parton distribution
functions; the physics of hadrons containing one or more heavy quarks; and
properties of the quark gluon plasma.Comment: 56 pages. Summary of lectures delivered by the authors at the
"Workshop on AdS/CFT and Novel Approaches to Hadron and Heavy Ion Physics,"
2010-10-11 to 2010-12-03, hosted by the Kavli Institute for Theoretical
Physics, China, at the Chinese Academy of Science