Inverse semigroup actions as groupoid actions

To an inverse semigroup, we associate an \'etale groupoid such that its actions on topological spaces are equivalent to actions of the inverse semigroup. Both the object and the arrow space of this groupoid are non-Hausdorff. We show that this construction provides an adjoint functor to the functor that maps a groupoid to its inverse semigroup of bisections, where we turn \'etale groupoids into a category using algebraic morphisms. We also discuss how to recover a groupoid from this inverse semigroup.Comment: Corrected a typo in Lemma 2.14 in the published versio

Decoupling Transport from Economic Growth

This paper reports on a research project that aimed to identify and assess measures which could be used to reduce travel demand while maintaining economic growth and enhancing environmental quality. The research methodology involved a detailed review of past research; contact with over 600 experts from around Europe and elsewhere for ideas on potential measures; detailed questionnaires from over 100 of these experts; and a series of three panel sessions held in different parts of Europe, each of which involved around 16 experts debating the merits of different measures and identifying case study evidence of their effectiveness. The end result was a shortlist of 13 measures, indicative of broad types, which are considered to be effective, and an indication of their effectiveness if applied across the European Union. Seven illustrative measures are discussed which stand out from the results as having proven potential (though not necessarily at a European scale) to influence transport intensity and/or unit environmental load whilst not having large detrimental effects on GDP. These are the areas where it is felt that European transport policy could most usefully be focussed in terms of decoupling of transport demand and economic growth

Mass segregation in star clusters is not energy equipartition

Mass segregation in star clusters is often thought to indicate the onset of energy equipartition, where the most massive stars impart kinetic energy to the lower-mass stars and brown dwarfs/free floating planets. The predicted net result of this is that the centrally concentrated massive stars should have significantly lower velocities than fast-moving low-mass objects on the periphery of the cluster. We search for energy equipartition in initially spatially and kinematically substructured N-body simulations of star clusters with N = 1500 stars, evolved for 100 Myr. In clusters that show significant mass segregation we find no differences in the proper motions or radial velocities as a function of mass. The kinetic energies of all stars decrease as the clusters relax, but the kinetic energies of the most massive stars do not decrease faster than those of lower-mass stars. These results suggest that dynamical mass segregation -- which is observed in many star clusters -- is not a signature of energy equipartition from two-body relaxation

Social informatics of data norms

Big data has been widely promoted across disciplines and sectors for its potential to enhance lives and promote knowledge discovery. However, challenges arise at all stages of the data lifecycle due to the complexity of interactions between data and the contexts within which they are collected and managed, which has implications for interpretations of this data and eventual use of information and the creation of knowledge products from these data. Starting from the perspective of social informatics, this panel will discuss: the reciprocal relationships between data and context; specific challenges in distinct stages of data generation, data repository implementation, data curation, data use, and data reproducibility; and the implications of these challenges and their potential solutions for both social informatics research and society in general

Quantitative profiling of feruloylated arabinoxylan side-chains from graminaceous cell walls

Graminaceous arabinoxylans are distinguished by decoration with feruloylated monosaccharidic and oligosaccharidic side-chains. Although it is hypothesized that structural complexity and abundance of these feruloylated arabinoxylan side-chains may contribute, among other factors, to resistance of plant cell walls to enzymatic degradation, quantitative profiling approaches for these structural units in plant cell wall materials have not been described yet. Here we report the development and application of a rapid and robust method enabling the quantitative comparison of feruloylated side-chain profiles in cell wall materials following mildly acidic hydrolysis, C18-solid phase extraction (SPE), reduction under aprotic conditions, and liquid chromatography with diode array detection/mass spectrometry (LC-DAD/MS) separation and detection. The method was applied to the insoluble fiber/cell wall materials isolated from 12 whole grains: wild rice (Zizania aquatica L.), long-grain brown rice (Oryza sativa L.), rye (Secale cereale L.), kamut (Triticum turanicum Jakubz.), wheat (Triticum aestivum L.), spelt (Triticum spelta L.), intermediate wheatgrass (Thinopyrum intermedium), maize (Zea mays L.), popcorn (Zea mays L. var. everta), oat (Avena sativa L.) (dehulled), barley (Hordeum vulgare L.) (dehulled), and proso millet (Panicum miliaceum L.). Between 51 and 96% of the total esterified monomeric ferulates were represented in the quantified compounds captured in the feruloylated side-chain profiles, which confirms the significance of these structures to the global arabinoxylan structure in terms of quantity. The method provided new structural insights into cereal grain arabinoxylans, in particular, that the structural moiety α-L-galactopyranosyl (1→2)-β-D-xylopyranosyl-(1→2)-5-O-trans-feruloyl-L-arabinofuranose (FAXG), which had previously only been described in maize, is ubiquitous to cereal grains. © 2016 Schendel, Meyer and Bunzel

Elucidation of the metabolites of the novel psychoactive substance 4-methyl-N-ethyl-cathinone (4-MEC) in human urine and pooled liver microsomes by GC-MS & LC-HR-MS/MS techniques and of its detectability by GC-MS or LC-MS(n) standard screening approaches

4-methyl-N-ethcathinone (4-MEC), the N-ethyl homologue of mephedrone, is a novel psychoactive substance of the beta-keto amphetamine (cathinone) group. The aim of the present work was to study the phase I and phase II metabolism of 4-MEC in human urine as well as in pooled human liver microsome (pHLM) incubations. The urine samples were worked up with and without enzymatic cleavage, the pHLM incubations by simple deproteinization. The metabolites were separated and identified by gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-high resolution-tandem mass spectrometry (LC-HR-MS/MS). Based on the metabolites identified in urine and/or pHLM, the following metabolic pathways could be proposed: reduction of the keto group, N-deethylation, hydroxylation of the 4-methyl group followed by further oxidation to the corresponding 4-carboxy metabolite, and combinations of these steps. Glucuronidation could only be observed for the hydroxy metabolite. These pathways were similar to those described for the N-methyl homologue mephedrone and other related drugs. In pHLM, all phase I metabolites with the exception of the N-deethyl-dihydro isomers and the 4-carboxy-dihydro metabolite could be confirmed. Glucuronides could not be formed under the applied conditions. Although the taken dose was not clear, an intake of 4-MEC should be detectable in urine by the GC-MS and LC-MS(n) standard urine screening approaches at least after overdose

Expanding the expressive power of Monadic Second-Order logic on restricted graph classes

We combine integer linear programming and recent advances in Monadic Second-Order model checking to obtain two new algorithmic meta-theorems for graphs of bounded vertex-cover. The first shows that cardMSO1, an extension of the well-known Monadic Second-Order logic by the addition of cardinality constraints, can be solved in FPT time parameterized by vertex cover. The second meta-theorem shows that the MSO partitioning problems introduced by Rao can also be solved in FPT time with the same parameter. The significance of our contribution stems from the fact that these formalisms can describe problems which are W[1]-hard and even NP-hard on graphs of bounded tree-width. Additionally, our algorithms have only an elementary dependence on the parameter and formula. We also show that both results are easily extended from vertex cover to neighborhood diversity.Comment: Accepted for IWOCA 201

Osteogenic tumour in Australopithecus sediba: Earliest hominin evidence for neoplastic disease

We describe the earliest evidence for neoplastic disease in the hominin lineage. This is reported from the type specimen of the extinct hominin Australopithecus sediba from Malapa, South Africa, dated to 1.98 million years ago. The affected individual was male and developmentally equivalent to a human child of 12 to 13 years of age. A penetrating lytic lesion affected the sixth thoracic vertebra. The lesion was macroscopically evaluated and internally imaged through phase-contrast X-ray synchrotron microtomography. A comprehensive differential diagnosis was undertaken based on gross- and micro-morphology of the lesion, leading to a probable diagnosis of osteoid osteoma. These neoplasms are solitary, benign, osteoid and bone-forming tumours, formed from well-vascularised connective tissue within which there is active production of osteoid and woven bone. Tumours of any kind are rare in archaeological populations, and are all but unknown in the hominin record, highlighting the importance of this discovery. The presence of this disease at Malapa predates the earliest evidence of malignant neoplasia in the hominin fossil record by perhaps 200 000 years.NCS201

Biotransformation and detectability of the designer drug 2,5-dimethoxy-4-propylphenethylamine (2C-P) studied in urine by GC-MS, LC-MS(n), and LC-high-resolution-MS(n)

2,5-Dimethoxy-4-propylphenethylamine (2C-P) is a hallucinogenic designer drug of the phenethylamine class, the so-called 2Cs, named according to the ethyl spacer between the nitrogen and the aromatic ring. The aims of the present work were to identify the phases I and II metabolites of 2C-P. In addition, the detectability of 2C-P and its metabolites in urine as proof of an intake in clinical or forensic cases was tested. According to the identified metabolites, the following pathways were proposed: N-acetylation; deamination followed by reduction to the corresponding alcohol and oxidation to carbonic acid; mono- and bis-hydroxylation at different positions; mono- and bis-O-demethylation, followed by glucuronidation, sulfation, or both; and combination of these steps. Proof of an intake of a common user\u27s dose of 2C-P was possible by both standard urine screening approaches, the GC-MS as well as the LC-MS(n) approach