Anti-inflammatory Effect of Resveratrol and Polydatinby In Vitro IL-17 Modulation.

Interleukin-17 (IL-17) is a proinflammatory cytokine produced, although not exclusively, by T helper 17 recently identified as a distinct T helper lineage mediating tissue inflammation. IL-17 is known to be involved in a number of chronic disorders although the mechanisms regulating its production in inflammatory disease are still unclear. The beneficial properties of the polyphenolic compound resveratrol including its nti-inflammatory, antioxidant, and antitumor effects, its role in the aging process and in the prevention of heart and neurodegenerative diseases are well-known. In addition, derivatives of resveratrol, including glucosylated molecules as polydatin have been linked to similar beneficial effects. We have investigated the effects of resveratrol and polydatin on the in vitro production of IL-17 in a model of inflammation in vitro. The results obtained by activated human peripheral blood mononuclear cells, stimulated with anti-CD3/anti-CD28 monoclonal antibodies and treated with these polyphenolic compounds at different concentrations show that both decrease IL-17 production in a concentration-dependent manner. This study confirms the anti-inflammatory activity of resveratrol and its derivatives and suggests a potential clinical relevance in the therapy of inflammatory diseases

Anti-apoptotic seminal vesicle protein IV inhibits cell-mediated immunity.

The in vitro effect of seminal vesicle protein IV (SV-IV) on the cytotoxic activity of human natural or acquired cellular immunity has been investigated by standard immunological procedures, a 51Cr-release cytotoxicity assay, and labeled-ligand binding experiments. The data obtained demonstrate that: (1) fluoresceinated or [125I]-labeled SV-IV binds specifically to the surface of human purified non-adherent monuclear cells (NA-MNC); (2)SV-IV suppresses the cytotoxicity of natural killer (NK) cells against K562 target cells, that of IL-2-stimulated NK (LAK) cells against DAUDI target cells, and that of VEL antigen-sensitized cytotoxic T lymphocytes (CTLs) against VEL target cells; (3) treatment of K562 target cells alone with SV-IV decreases their susceptibility to NK-induced lysis. These findings indicate that the protein SV-IV has a marked in vitro inhibitory effect on NK, LAK and CTL cytotoxicity, providing a better understanding of its immune regulatory functions

The immunomodulating activities of resveratrol glucosides in humans

Numerous data are now available on the beneficial properties of the polyphenolic compound resveratrol (3,5,4'- trihydroxy-stilbene) including its anti-inflammatory, antioxidant and antitumor effects, its role in the aging process and in the prevention of heart and neurodegenerative diseases. In addition, derivatives of resveratrol, including glucosylated molecules, have been linked to similar beneficial effects. The immune response is regulated by networks of complex molecular and cellular interactions: the effects of resveratrol and derivatives, as resveratrol glucosides, in this multifaceted immune system are partially unknown. In this paper, we review patents in which resveratrol glucosides are specifically involved in immunological activity in humans. This article highlights recent patents in which a future usage of resveratrol glucosides is envisaged, as therapeutic agents providing a promising immuno-modulatory approach in regulating immunological and inflammatory response

Effects of resveratrol on humane immune cell function.

© 2001 Elsevier Science Inc

Use of extracts fron Spermatophyte plants with immunomodulating activity.

Application number: 01934247.