But You are the God of the Lowly, Helper of the Oppressed: God in the Prayer of Judith (Jdt. 9:1–14)

The early chapters of the Book of Judith record the boast of “Nebuchadnezzar, king of the Assyrians … the Great King, the lord of the whole earth” (2:4–5), that he would “accomplish by [his] own hand” (2:12) the destruction and plunder of the lands of those who had refused to join in the war against [the unknown] KingArphaxad “in the great plain that is on the borders of Ragau” (1:5)

Laboratory capture, isolation and analysis of microparticles in aerogel: Preparation for the return of Stardust

We present observations from the laboratory capture of particles in aerogel. The paper focuses on a possible extraction technique and the bulk mineral characterization of the captured material using non-destructive analytical techniques

Phonons and specific heat of linear dense phases of atoms physisorbed in the grooves of carbon nanotube bundles

The vibrational properties (phonons) of a one-dimensional periodic phase of atoms physisorbed in the external groove of the carbon nanotube bundle are studied. Analytical expressions for the phonon dispersion relations are derived. The derived expressions are applied to Xe, Kr and Ar adsorbates. The specific heat pertaining to dense phases of these adsorbates is calculated.Comment: 4 PS figure

Numerical Solutions of Matrix Differential Models using Cubic Matrix Splines II

This paper presents the non-linear generalization of a previous work on matrix differential models. It focusses on the construction of approximate solutions of first-order matrix differential equations Y'(x)=f(x,Y(x)) using matrix-cubic splines. An estimation of the approximation error, an algorithm for its implementation and illustrative examples for Sylvester and Riccati matrix differential equations are given.Comment: 14 pages; submitted to Math. Comp. Modellin

Vibrations of a chain of Xe atoms in a groove of carbon nanotube bundle

We present a lattice dynamics study of the vibrations of a linear chain of Xe adsorbates in groove positions of a bundle of carbon nanotubes. The characteristic phonon frequencies are calculated and the adsorbate polarization vectors discussed. Comparison of the present results with the ones previously published shows that the adsorbate vibrations cannot be treated as completely decoupled from the vibrations of carbon nanotubes and that a significant hybridization between the adsorbate and the tube modes occurs for phonons of large wavelengths.Comment: 3 PS figure

Sequential SNARE disassembly and GATE-16–GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion

Characterization of mammalian NSF (G274E) and Drosophila NSF (comatose) mutants revealed an evolutionarily conserved NSF activity distinct from ATPase-dependent SNARE disassembly that was essential for Golgi membrane fusion. Analysis of mammalian NSF function during cell-free assembly of Golgi cisternae from mitotic Golgi fragments revealed that NSF disassembles Golgi SNAREs during mitotic Golgi fragmentation. A subsequent ATPase-independent NSF activity restricted to the reassembly phase is essential for membrane fusion. NSF/α-SNAP catalyze the binding of GATE-16 to GOS-28, a Golgi v-SNARE, in a manner that requires ATP but not ATP hydrolysis. GATE-16 is essential for NSF-driven Golgi reassembly and precludes GOS-28 from binding to its cognate t-SNARE, syntaxin-5. We suggest that this occurs at the inception of Golgi reassembly to protect the v-SNARE and regulate SNARE function

Cost Utility of Omalizumab Compared with Standard of Care for the Treatment of Chronic Spontaneous Urticaria.

BACKGROUND: Chronic spontaneous urticaria (CSU) negatively impacts patient quality of life and productivity and is associated with considerable indirect costs to society. OBJECTIVE: The aim of this study was to assess the cost utility of add-on omalizumab treatment compared with standard of care (SOC) in moderate or severe CSU patients with inadequate response to SOC, from the UK societal perspective. METHODS: A Markov model was developed, consisting of health states based on Urticaria Activity Score over 7 days (UAS7) and additional states for relapse, spontaneous remission and death. Model cycle length was 4 weeks, and total model time horizon was 20 years in the base case. The model considered early discontinuation of non-responders (response: UAS7 ≤6) and retreatment upon relapse (relapse: UAS7 ≥16) for responders. Clinical and cost inputs were derived from omalizumab trials and published sources, and cost utility was expressed as incremental cost-effectiveness ratios (ICERs). Scenario analyses included no early discontinuation of non-responders and an altered definition of response (UAS7 <16). RESULTS: With a deterministic ICER of £3183 in the base case, omalizumab was associated with increased costs and benefits relative to SOC. Probabilistic sensitivity analysis supported this result. Productivity inputs were key model drivers, and individual scenarios without early discontinuation of non-responders and adjusted response definitions had little impact on results. ICERs were generally robust to changes in key model parameters and inputs. CONCLUSIONS: In this, the first economic evaluation of omalizumab in CSU from a UK societal perspective, omalizumab consistently represented a treatment option with societal benefit for CSU in the UK across a range of scenarios

Quantum Computing with NMR

A review of progress in NMR quantum computing and a brief survey of the literatureComment: Commissioned by Progress in NMR Spectroscopy (95 pages, no figures

Convexity in partial cubes: the hull number

We prove that the combinatorial optimization problem of determining the hull number of a partial cube is NP-complete. This makes partial cubes the minimal graph class for which NP-completeness of this problem is known and improves some earlier results in the literature. On the other hand we provide a polynomial-time algorithm to determine the hull number of planar partial cube quadrangulations. Instances of the hull number problem for partial cubes described include poset dimension and hitting sets for interiors of curves in the plane. To obtain the above results, we investigate convexity in partial cubes and characterize these graphs in terms of their lattice of convex subgraphs, improving a theorem of Handa. Furthermore we provide a topological representation theorem for planar partial cubes, generalizing a result of Fukuda and Handa about rank three oriented matroids.Comment: 19 pages, 4 figure

Analysis of the spatio-temporal pattern of Southern blue whiting (Micromesistius australis australis) abundance in the bottom-trawl fisheries in the southwest Atlantic using GIS techniques

Southern blue whiting (Micromesistius australis australis ) inhabits the waters of the Southern Hemisphere, and in the south-west Atlantic Ocean. It is distributed over an area next to the Falkland/Malvinas Islands, where it is commonly the most abundant commercial finfish species. This fish migrates to the outer Falkland shelf and aggregates in dense schools to spawn in August-September in the south-western part of the islands. Feeding concentrations of Southern blue whiting are targeted by specialized surimi vessels until the following March. Southern blue whiting is also taken as an occasional bycatch by finfish trawlers. Fishery and biological information collected by scientific observers aboard commercial Spanish trawlers between 1988 and 2003 were analysed in relation to physical and environmental factors to establish the spatio-temporal pattern of the species. The data included 26 168 commercial hauls of which 4 797 positive (including effort, catches and discards, as well as biological and environmental information). CPUE (Catch Per Unit Effort, kg⋅hr-1) was used as abundance index. The analysis of the general spatio-temporal pattern of fish abundance, and the influence of environmental factors, such as SST, SBT and depth on fish abundance and distribution, was based on correlation, variograms, and time-series maps created using GIS. Mature individuals and more specifically spawning females were recorded mainly in the waters south and south-west of the Islands, between 100 and 200 m isobaths