38 research outputs found
Lonely adatoms in space
There is a close relation between the problems of second layer nucleation in
epitaxial crystal growth and chemical surface reactions, such as hydrogen
recombination, on interstellar dust grains. In both cases standard rate
equation analysis has been found to fail because the process takes place in a
confined geometry. Using scaling arguments developed in the context of second
layer nucleation, I present a simple derivation of the hydrogen recombination
rate for small and large grains. I clarify the reasons for the failure of rate
equations for small grains, and point out a logarithmic correction to the
reaction rate when the reaction is limited by the desorption of hydrogen atoms
(the second order reaction regime)
Schwinger boson theory of anisotropic ferromagnetic ultrathin films
Ferromagnetic thin films with magnetic single-ion anisotropies are studied
within the framework of Schwinger bosonization of a quantum Heisenberg model.
Two alternative bosonizations are discussed. We show that qualitatively correct
results are obtained even at the mean-field level of the theory, similar to
Schwinger boson results for other magnetic systems. In particular, the
Mermin-Wagner theorem is satisfied: a spontaneous magnetization at finite
temperatures is not found if the ground state of the anisotropic system
exhibits a continuous degeneracy. We calculate the magnetization and effective
anisotropies as functions of exchange interaction, magnetic anisotropies,
external magnetic field, and temperature for arbitrary values of the spin
quantum number. Magnetic reorientation transitions and effective anisotropies
are discussed. The results obtained by Schwinger boson mean-field theory are
compared with the many-body Green's function technique.Comment: 14 pages, including 7 EPS figures, minor changes, final version as
publishe
Isoscaling in dissipative projectile breakup
Dynamical breakup of projectile-like fragments (PLF) following dissipative reactions of Ca-48 projectiles with Sn-112 and Sn-124 is shown to exhibit "isoscaling" regularities that can be understood in terms of phase space governed by ground state masses. Ambiguities in isoscaling parameters obscure information on nuclear symmetry energy at subnormal densities
DLG4-related synaptopathy: a new rare brain disorder
PURPOSE: Postsynaptic density protein-95 (PSD-95), encoded by DLG4, regulates excitatory synaptic function in the brain. Here we present the clinical and genetic features of 53 patients (42 previously unpublished) with DLG4 variants.METHODS: The clinical and genetic information were collected through GeneMatcher collaboration. All the individuals were investigated by local clinicians and the gene variants were identified by clinical exome/genome sequencing.RESULTS: The clinical picture was predominated by early onset global developmental delay, intellectual disability, autism spectrum disorder, and attention deficit-hyperactivity disorder, all of which point to a brain disorder. Marfanoid habitus, which was previously suggested to be a characteristic feature of DLG4-related phenotypes, was found in only nine individuals and despite some overlapping features, a distinct facial dysmorphism could not be established. Of the 45 different DLG4 variants, 39 were predicted to lead to loss of protein function and the majority occurred de novo (four with unknown origin). The six missense variants identified were suggested to lead to structural or functional changes by protein modeling studies.CONCLUSION: The present study shows that clinical manifestations associated with DLG4 overlap with those found in other neurodevelopmental disorders of synaptic dysfunction; thus, we designate this group of disorders as DLG4-related synaptopathy.Genetics of disease, diagnosis and treatmen
SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids
Kidney failure is frequently observed during and after COVID-19, but it remains elusive whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects kidney cells and is associated with increased tubule-interstitial kidney fibrosis in patient autopsy samples. To study direct effects of the virus on the kidney independent of systemic effects of COVID-19, we infected human-induced pluripotent stem-cell-derived kidney organoids with SARS-CoV-2. Single-cell RNA sequencing indicated injury and dedifferentiation of infected cells with activation of profibrotic signaling pathways. Importantly, SARS-CoV-2 infection also led to increased collagen 1 protein expression in organoids. A SARS-CoV-2 protease inhibitor was able to ameliorate the infection of kidney cells by SARS-CoV-2. Our results suggest that SARS-CoV-2 can directly infect kidney cells and induce cell injury with subsequent fibrosis. These data could explain both acute kidney injury in COVID-19 patients and the development of chronic kidney disease in long COVID
Effect of urea on biomimetic aggregates
The effect of urea on biomimetic aggregates (aqueous and reversed micelles, vesicles and monolayers) was investigated to obtain insights into the effect of the denaturant on structured macromolecules. Direct evidence obtained from light scattering (static and dynamic), monolayer maximum isothermal compression and ionic conductivity measurements, together with indirect evidence from fluorescence photodissociation, fluorescence suppression, and thermal reactions, strongly indicates the direct interaction mechanism of urea with the aggregates. Preferential solvation of the surfactant headgroups by urea results in an increase in the monomer dissociation degree (when applied), which leads to an increase in the area per headgroup and also in the loss of counterion affinitie