Monoxenic culture of the slug parasite Phasmarhabditis hermaphrodita (Nematoda : Rhabditidae) with different bacteria in liquid and solid phase

Seize isolats bactériens, représentant treize espèces, ont été testés pour leur capacité à maintenir la croissance de #Phasmarhabditis hermaphrodita en culture monoxénique sur agar, en boîte de Petri. Tous les isolats permettent la croissance de #P. hermaphrodita, mais la capacité de reproduction varie considérablement suivant les différentes bactéries. Cinq espèces de bactéries ayant permis une croissance vigoureuse de #P. hermaphrodita ont été utilisées pour son élevage en milieu liquide. Toutes permettent la croissance et la reproduction du nématode mais des différences significatives se produisent en ce qui concerne le nombre total de nématodes et celui des #dauer larvae formées. Les différences entre les chiffres totaux ne sont pas significativement différentes de celles observées dans le cas de culture en boîtes de Petri. En milieu liquide, #Providencia rettgeri paraît produire les meilleurs rendements en #dauer larvae. Tant en milieu solide que liquide, la croissance monoxénique de #P. hermaphrodita$ est meilleure sur des milieux à base de rognon de porc que sur des milieux ne comportant que des éléments entièrement solubles. (Résumé d'auteur

Optimising Ferrite-less Pad Reflection Winding with a Multi-Objective Genetic Algorithm

Inductive power transfer is the leading technology for roadway electric vehicle wireless power transfer. A robust magnetic design is desired for magnetic couplers (pads) that are to be buried in a road surface. Ferrite-less designs including a reflection winding have been shown to be a possible way to increase the robustness of pads and reduce leakage magnetic field. This paper presents a methodology to optimise the reflection winding of a ferrite-less pad with a genetic algorithm and presents the results of an example optimisation with an axisymmetric approximation of the wireless power transfer standard SAE J2954 WPT3/Z3 secondary pad, with the results verified in the finite element analysis package FEMM, and in the laboratory. The results verify the reflection coil concept and indicate that improvements in leakage per power can be gained by allowing the reflection winding to be non-planar

H2O2 Enables Convenient Removal of RAFT End-Groups from Block Copolymer Nano-Objects Prepared via Polymerization-Induced Self-Assembly in Water

RAFT-synthesized polymers are typically colored and malodorous due to the presence of the sulfur-based RAFT end-group(s). In principle, RAFT end-groups can be removed by treating molecularly dissolved copolymer chains with excess free radical initiators, amines, or oxidants. Herein we report a convenient method for the removal of RAFT end-groups from aqueous dispersions of diblock copolymer nano-objects using H2O2. This oxidant is relatively cheap, has minimal impact on the copolymer morphology, and produces benign side products that can be readily removed via dialysis. We investigate the efficiency of end-group removal for various diblock copolymer nano-objects prepared with either dithiobenzoate- or trithiocarbonate-based RAFT chain transfer agents. The advantage of using UV GPC rather than UV spectroscopy is demonstrated for assessing both the kinetics and extent of end-group removal

Systematic review of economic evaluations and cost analyses of guideline implementation strategies

Objectives To appraise the quality of economic studies undertaken as part of evaluations of guideline implementation strategies; determine their resources use; and recommend methods to improve future studies. Methods Systematic review of economic studies undertaken alongside robust study designs of clinical guideline implementation strategies published (1966-1998). Studies assessed against the BMJ economic evaluations guidelines for each stage of the guideline process (guideline development, implementation and treatment). Results 235 studies were identified, 63 reported some information on cost. Only 3 studies provided evidence that their guideline was effective and efficient. 38 reported the treatment costs only, 12 implementation and treatment costs, 11 implementation costs alone, and two guideline development, implementation and treatment costs. No study gave reasonably complete information on costs. Conclusions Very few satisfactory economic evaluations of guideline implementation strategies have been performed. Current evaluations have numerous methodological defects and rarely consider all relevant costs and benefits. Future evaluations should focus on evaluating the implementation of evidence based guidelines. Keywords: Cost-effectiveness analysis, physician (or health care professional) behaviour, practice guidelines, quality improvement, systematic review.Peer reviewedAuthor versio

On Birthing Dancing Stars: The Need for Bounded Chaos in Information Interaction

While computers causing chaos is acommon social trope, nearly the entirety of the history of computing is dedicated to generating order. Typical interactive information retrieval tasks ask computers to support the traversal and exploration of large, complex information spaces. The implicit assumption is that they are to support users in simplifying the complexity (i.e. in creating order from chaos). But for some types of task, particularly those that involve the creative application or synthesis of knowledge or the creation of new knowledge, this assumption may be incorrect. It is increasingly evident that perfect order—and the systems we create with it—support highly-structured information tasks well, but provide poor support for less-structured tasks.We need digital information environments that help create a little more chaos from order to spark creative thinking and knowledge creation. This paper argues for the need for information systems that offerwhat we term ‘bounded chaos’, and offers research directions that may support the creation of such interface

Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system.

Encounters with neurotropic viruses result in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences to relatively benign infection. One of the principal factors that control the outcome of infection is the localized tissue response and subsequent immune response directed against the invading toxic agent. It is the role of the immune system to contain and control the spread of virus infection in the central nervous system (CNS), and paradoxically, this response may also be pathologic. Chemokines are potent proinflammatory molecules whose expression within virally infected tissues is often associated with protection and/or pathology which correlates with migration and accumulation of immune cells. Indeed, studies with a neurotropic murine coronavirus, mouse hepatitis virus (MHV), have provided important insight into the functional roles of chemokines and chemokine receptors in participating in various aspects of host defense as well as disease development within the CNS. This chapter will highlight recent discoveries that have provided insight into the diverse biologic roles of chemokines and their receptors in coordinating immune responses following viral infection of the CNS

BICCO-Net II. Final report to the Biological Impacts of Climate Change Observation Network (BICCO-Net) Steering Group

• BICCO-Net Phase II presents the most comprehensive single assessment of climate change impacts on UK biodiversity to date. • The results provide a valuable resource for the CCRA 2018, future LWEC report cards, the National Adaptation Programme and other policy-relevant initiatives linked to climate change impacts on biodiversity

Impacts of climate change on national biodiversity population trends

Climate change has had well-documented impacts on the distribution and phenology of species across many taxa, but impacts on species’ abundance, which relates closely to extinction risk and ecosystem function, have not been assessed across taxa. In the most comprehensive multi-taxa comparison to date, we modelled variation in national population indices of 501 mammal, bird, aphid, butterfly and moth species as a function of annual variation in weather variables, which through time allowed us to identify a component of species’ population growth that can be associated with post-1970s climate trends. We found evidence that these climate trends have significantly affected population trends of 15.8% of species, including eight with extreme (> 30% decline per decade) negative trends consistent with detrimental impacts of climate change. The modelled effect of climate change could explain 48% of the significant across-species population decline in moths and 63% of the population increase in winged aphids. The other taxa did not have significant across-species population trends or consistent climate change responses. Population declines in species of conservation concern were linked to both climatic and non-climatic factors respectively accounting for 42 and 58% of the decline. Evident differential impacts of climate change between trophic levels may signal the potential for future ecosystem disruption. Climate change has therefore already driven large-scale population changes of some species, had significant impacts on the overall abundance of some key invertebrate groups and may already have altered biological communities and ecosystems in Great Britain

Homophily in personality enhances group success among real-life friends

Personality affects dyadic relations and teamwork, yet its role among groups of friends has been little explored. We examine for the first time whether similarity in personality enhances the effectiveness of real-life friendship groups. Using data from a longitudinal study of a European fraternity (10 male and 15 female groups), we investigate how individual Big Five personality traits were associated with group formation and whether personality homophily related to how successful the groups were over 1 year (N = 147–196). Group success was measured as group performance/identification (adoption of group markers) and as group bonding (using the inclusion-of-other-in-self scale). Results show that individuals’ similarity in neuroticism and conscientiousness predicted group formation. Furthermore, personality similarity was associated with group success, even after controlling for individual’s own personality. Especially higher group-level similarity in conscientiousness was associated with group performance, and with bonding in male groups.Computer Systems, Imagery and Medi