Indium·113m vir hart-, lewer- en plasentaflikkergrafie

No Abstrac

Adhesion of

111Indium-labelled autologus blood platelets administered to patients preoperatively can be traced in the components of the extracorporeal circuit by gamma camera scintillation imaging. Quantitative assessments can be made of platelet/biomaterial adhesion. It was thus possible to compare the ratio of adherent platelets on the defoaming systems of two types of Bentley BOS-10 oxygenators. The results indicated that more platelets adhered to the areas of the defoamer where gas bubbles burst than to areas such as the gaseous micro-emboli inhibitor sponge through which all the bubbles had to pass in the later types of BOS-10 oxygenator. In both types the pattern of platelet adhesion to the defoamer layers was comparable and was not influenced by bypass time. Gamma camera images of the oxygenators showed that most platelet adhesion took place in areas of blood/gas to biomaterial interfaces. Tubing circuits and cannulae displayed negligible 111 Indium activity on their surfaces, while the oxygenators held a mean of 8.5% of the activity administered to the patients. This technique could be applied to study platelet interaction with various extracorporeal circuits and oxygenators and may help to clarify the role of cardiopulmonary bypass (CPB) in thrombocytopoenia during heart surgery cases