Fragmented host distribution and trombiculid parasitic load: Eutrombicula araucanensis and Liolaemus pictus in Chile

International audienceHabitat fragmentation produced by human impacts can generate changes in the distribution and abundance of populations across their geographic ranges. The chigger mites are ectoparasites that are widely distributed on a wide range of species. The distribution depends of the characteristics of the host and of the habitat where said species is found. As the host distribution is highly dependent on environmental factors, chigger mites are good study models to test geographical distribution patterns. The main objective of this study was to determine variation in abundance of Eutrombicula araucanensis, parasite on Liolaemus pictus, by testing three hypotheses: abundant centre hypothesis, abundance optimum hypothesis and latitudinal distribution pattern. For this purpose, mites from 147 individuals from 23 localities along the distribution of L. pictus were extracted. The three distribution models evaluated in the present study were not adequate to represent the geographical structure of parasitic mites on L. pictus. No association between the distance from the area of greatest species abundance and relative intensity, or association with the distance to the mite’s distribution centre was observed. In addition, no latitudinal distribution pattern was observed. Temperate forest fragmentation may influence the population density of mites, with each forest patch having different optimal conditions for development. The heterogeneity makes it difficult to find a clear distribution pattern

Gestational hypothyroxinemia affects its offspring with a reduced suppressive capacity impairing the outcome of the experimental autoimmune encephalomyelitis

Indexación: Scopus.Hypothyroxinemia (Hpx) is a thyroid hormone deficiency (THD) condition highly frequent during pregnancy, which although asymptomatic for the mother, it can impair the cognitive function of the offspring. Previous studies have shown that maternal hypothyroidism increases the severity of experimental autoimmune encephalomyelitis (EAE), an autoimmune disease model for multiple sclerosis (MS). Here, we analyzed the immune response after EAE induction in the adult offspring gestated in Hpx. Mice gestated in Hpx showed an early appearance of EAE symptoms and the increase of all parameters of the disease such as: the pathological score, spinal cord demyelination, and immune cell infiltration in comparison to the adult offspring gestated in euthyroidism. Isolated CD4+CD25+ T cells from spleen of the offspring gestated in Hpx that suffer EAE showed reduced capacity to suppress proliferation of effector T cells (TEff) after being stimulated with anti-CD3 and anti-CD28 antibodies. Moreover, adoptive transfer experiments of CD4+CD25+ T cells from the offspring gestated in Hpx suffering EAE to mice that were induced with EAE showed that the receptor mice suffer more intense EAE pathological score. Even though, no significant differences were detected in the frequency of Treg cells and IL-10 content in the blood, spleen, and brain between mice gestated in Hpx or euthyroidism, T cells CD4+CD25+ from spleen have reduced capacity to differentiate in vitro to Treg and to produce IL-10. Thus, our data support the notion that maternal Hpx can imprint the immune response of the offspring suffering EAE probably due to a reduced capacity to trigger suppression. Such "imprints" on the immune system could contribute to explaining as to why adult offspring gestated in Hpx suffer earlier and more intense EAE. © 2018 Haensgen, Albornoz, Opazo, Bugueño, Jara Fernández, Binzberger, Rivero-Castillo, Venegas Salas, Simon, Cabello-Verrugio, Elorza, Kalergis, Bueno and Riedel.https://www.frontiersin.org/articles/10.3389/fimmu.2018.01257/ful

Effects of non-pharmacological interventions on inflammatory biomarker expression in patients with fibromyalgia: A systematic review

Introduction: Fibromyalgia (FM) is a prevalent disorder. However, few studies have evaluated the effect of treatment interventions on biomarker expression. The aim of this review was to explore the efficacy of non-pharmacological interventions on inflammatory biomarker expression, specifically cytokines, neuropeptides and C-reactive protein (CRP), in FM patients. Method: A literature search using PubMed, EMBASE, PsycINFO and the Cochrane library was performed from January 1990 to March 2015. Randomized controlled trials (RCTs) and non-RCTs published in English, French or Spanish were eligible. Results: Twelve articles with a total of 536 participants were included. After exercise, multidisciplinary, or dietary interventions in FM patients, interleukin (IL) expression appeared reduced, specifically serum IL-8 and IL-6 (spontaneous, lipopolysaccharide (LPS)-induced, or serum). Furthermore, the changes to insulin-like growth factor 1 (IGF-1) levels might indicate a beneficial role for fatigue in obese FM patients. In contrast, evidence of changes in neuropeptide and CRP levels seemed inconsistent. Conclusion: Despite minimal evidence, our findings indicate that exercise interventions might act as an anti-inflammatory treatment in FM patients and ameliorate inflammatory status, especially for pro-inflammatory cytokines. Additional RCTs focused on the changes to inflammatory biomarker expression after non-pharmacological interventions in FM patients are needed

Derecho a la educación: conocer para defender

En el marco del proyecto de investigación se administró una entrevista voluntaria y anónima a estudiantes de segundo año de las carreras licenciatura en Trabajo Social y Tecnicatura en Acompañamiento Terapéutico con el propósito de conocer y comprender las experiencias educativas transitadas en la universidad en tiempos de educación remota y la educación presencial en este período pos pandemia en el que la universidad habilitó las actividades presenciales.Tales experiencias se interpretaron en clave de garantización o vulneración del derecho a la educación.Universidad Nacional de La Plat

Effects of mindfulness-based interventions on biomarkers in healthy and cancer populations: A systematic review

Background: Only a small number of articles have investigated the relationship between mindfulness-based interventions (MBIs) and biomarkers. The aim of this systematic review was to study the effect of MBIs on specific biomarkers (cytokines, neuropeptides and C-reactive protein (CRP)) in both healthy subjects and cancer patients. Methods: A search was conducted using PubMed, EMBASE, PsycINFO and the Cochrane library between 1980 and September 2016. Results: A total of 13 studies with 1110 participants were included. In the healthy population, MBIs had no effect on cytokines, but were found to increase the levels of the neuropeptide insulin-like growth factor 1 (IGF-1). With respect to neuropeptide Y, despite the absence of post-intervention differences, MBIs may enhance recovery from stress. With regard to CRP, MBIs could be effective in lower Body Mass Index (BMI) individuals. In cancer patients, MBIs seem to have some effect on cytokine levels, although it was not possible to determine which specific cytokines were affected. One possibility is that MBIs might aid recovery of the immune system, increasing the production of interleukin (IL)-4 and decreasing interferon gamma (IFN-¿). Conclusions: MBIs may be involved in changes from a depressive/carcinogenic profile to a more normalized one. However, given the complexity and different contexts of the immune system, and the fact that this investigation is still in its preliminary stage, additional randomized controlled trials are needed to further establish the impact of MBI programmes on biomarkers in both clinical and non-clinical populations

Evidencias de actividad tectónica contemporánea en el sector oriental de la plataforma continental y talud superior del Golfo de Cádiz (SO de la Península Ibérica)

La interpretación de una serie de registros de sísmica de muy alta resolución con ecosonda paramétrica TOPAS obtenidos en las campañas CADHYS0713, INDEMARES/CHICA1011 y ARSA 0313 en el sector oriental de la plataforma continental y talud superior del Golfo de Cádiz entre los 50 y los 400 m de profundidad, ha permitido identificar una serie de estructuras tectónicas que deforman tanto los depósitos de edad Holoceno y Pleistoceno Superior, como la superficie del fondo . Estas unidades estratigráficas se han identificado sobre la Superficie Transgresiva Posglacial, datada en 18 ka. Las principales estructuras identificadas son fallas normales y fallas inversas, cuya actividad se ha relacionado con fases de elevación de estructuras diapíricas de naturaleza salina que se extienden desde zonas emergidas hasta zonas distales del margen continental del Golfo de Cádiz.Very high resolution parametric echosounder (TOPAS) data interpretation obtained during CADHYS0713, INDEMARES/CHICA1011 and ARSA0313 cruises along the middle, external shelf and upper slope of the eastern Gulf of Cadiz between 50 and 400 m depth has allowed us the identification of several active tectonic structures acting since the Holocene. To date this activiy, it have been identified along the study area three postglacial discontinuities, Postglacial Trangressive Surface (TS) of 18 ky BP; the maximum flooding surface (MFS) of 6.5 ky; and the 3.5 ky Mid highstand deposits surface (MHS). Active normal and reverse faults have been identified whose recent activity is closely linked to the uplift episodes of salt diapirs structures from onshore to distal areas of the continental margin.Versión del edito

Tectónica superficial del talud continental medio del margen continental del Golfo de Cádiz nororiental (SO de Iberia)

The northeastern sector of the Gulf of Cadiz continental margin has been deeply studied the last two decades. The seafloor is characterized by the Gulf of Cadiz Contourite Depositional System, strong diapirism and seepage related to the mobility of the frontal units of the Gibraltar Arc. Since 2010 high resolution bathymetric data and high and very high resolution seismic reflection and parametric echosounder profiles have improved the resolution of the previous collected data set. These data allow to analyze the middle continental slope morphology and its shallow structure with the aim to know the active tectonic processes on the seafloor. Two types of structures have been considered: (a) anticline domes and (b) normal faults which produce linear scarps and tectonic depressions. The shallow tectonics in this region is mainly related to the high mobility of geological formations in the subsoil and their ductile mechanical behaviour.Versión del edito

Seafloor geomorphology of the Passage of Lanzarote (West Africa Margin): Influences of the oceanographic processes

The seafloor morphology of the Passage of Lanzarote has been analysed with the aim to know the active processes on the bottom surface related to the oceanographic context. Multibeam bathymetric data and high and very high resolution seismic profiles obtained in the SUBVENT2 cruise have been used. Five main morphological groups have been analysed: (a) Volcanic or diapiric submarine hills; (b) Tectonic features on the continental slope (linear scarps and a rhombohedral depression) related to normal faults; (c) Submarine venting at top of diapirs initially triggered circular depressions; (d) Sedimentary instabilities (gullies, canyons, mass transport deposits) are present specially on the Fuerteventura-Lanzarote ridge; and (e) Contouritic bottom features both erosive (central valley, marginal valleys) and depositional (plastered drifts) are on the central part of the passage, and are generated by the interaction of MW and the interface MW-AAIW with seafloor.Versión del edito

Characterization of submarine slides in the upper and middle slope of the Gulf of Cádiz (SW Iberian Peninsula)

The identification and characterization of a series of complex landslides have been carried out using Topographic Parametric Sounder (TOPAS) very high resolution profiles, obtained during the INDEMARES/CHICA1011 and ARSA0313 cruises, along the upper and middle slope of the eastern Gulf of Cádiz continental margin. These landslides constitute a large area of the Upper Quaternary sedimentary deposits in these physiographic domains and are related to active tectonic and diapiric structures along the Upper Quaternary as well as sea-level fall events. The identification of the stratigraphic units has allowed us to obtain the relative age of these gravitational landslides emplacement during the Upper Quaternary.Versión del edito

Seafloor deformation related to Quaternary tectonics in the Majorca Channel, Balearic Promontory (Western Mediterranean)

El análisis morfotectónico del sector central del Promontorio Balear, entre las islas de Ibiza y Mallorca, mediante batimetría multihaz y perfiles sísmicos de muy alta resolución ha permitido diferenciar varios rasgos morfológicos relacionados con la tectónica a dos escalas. Los elementos de gran escala, de dirección NE-SO, son: i) el escarpe Émile Baudot; ii) el monte submarino Émile Baudot, y iii) la alineación de montes submarinos Ausiàs March y Ses Olives. Los elementos de pequeña escala son: i) dos elevaciones longitudinales (ENE-OSO); ii) escarpes rectilíneos (NO-SE a NE-SO); iii) depresiones tectónicas (NNE SSO a NE-SO); y iv) alineaciones rectilíneas de pockmarks (NO-SE a NNE-SSO). Los elementos de mayor tamaño responden a la configuración estructural neógeno-cuaternaria. El escarpe Émile Baudot limita el Promontorio Balear y la cuenca oceánica del Mediterráneo Occidental. La alineación de montes submarinos Ausiàs March y Ses Olives está generada por una fase extensional, y el monte submarino Émile Baudot forma parte de una alineación volcánica NO-SE asociada a la Zona de Fractura de Ibiza. Los elementos de pequeña escala están relacionados con estructuras tectónicas activas que deforman las unidades sedimentarias del Cuaternario y el fondo marino. Las elevaciones longitudinales están generadas por pliegues anticlinales, mientras que el resto de estructuras están asociadas a la actividad de fallas normales de buzamiento alto.A morphotectonic analysis has been carried out between the islands of Ibiza and Majorca in the central sector of the Balearic Promontory using multibeam bathymetry and very high-resolution seismic profiles. Several morphological features related to tectonics at two different scales have been differentiated. The large-scale features have a NE-SW direction, they are: i) the Émile Baudot Escarpment; ii) the Émile Baudot seamount, and iii) the Ausiàs March and Ses Olives seamounts alignment. The differentiated small-scale elements are i) two longitudinal elevations (ENE-WSW); ii) rectilinear scarps (NW-SE to NE-SW); iii) tectonic depressions limited by one or two scarps (NNE-SSW to NE-SW), and iv) rectilinear pockmarks alignments (NW-SE to NNE-SSW). The largest elements respond to the Neogene-Quaternary structural configuration. The Émile Baudot escarpment is the limit between the Balearic Promontory and the Western Mediterranean oceanic basin. The alignment of the Ausiàs March and Ses Olives seamounts respond to the last extensional phase, and the Émile Baudot seamount forms part of a NW-SE volcanic alignment that could be associated with the Ibiza Fracture Zone. The smaller elements are related to active tectonic structures that deform Quaternary sedimentary units and the seafloor. The longitudinal elevations correspond to anticlinal folds, while the rest of the structures are associated to the activity of near vertical normal faults.En prens