Collaterali aortico-polmonari associati a cardiopatie congenite

La presenza di comunicazioni anomale a carico della circolazione sistemica-polmonare \ue8 stata riportata nel cane come diagnosi differenziale del dotto arterioso pervio (PDA), in quanto il reperto caratteristico in letteratura \ue8 un soffio continuo ascellare sinistro. La diagnosi definitiva \ue8 stata effettuata in sede intraoperatoria (angiografia o visualizzazione diretta). I report pubblicati hanno sempre presentato questi difetti congeniti come singoli, a differenza della cardiologia pediatrica, dove sono segnalati in associazione a Tetralogia di Fallot (TdF) e atresia della polmonare

Pre-operative radiochemotherapy with raltitrexed for resectable locally-advanced rectal cancer : a phase II study

Background: The aim of the study was to evaluate the response to and toxicity of pre-operative radiochemotherapy containing raltitrexed (Tomudex) for resectable rectal adenocarcinoma. Patients and Methods: From November 2000 to June 2002, 18 consecutive patients staged T3 N0/N+ were treated with pre-operative chemotherapy (3 mg/m 2 of raltitrexed on days 1, 19, 38) and concurrent radiotherapy (RT) (50.4 Gy) in 6 weeks, followed by radical surgery within 8 weeks. Results: The treatment compliance was high. No major acute toxicity was reported. Concerning late toxicity, genitourinary adverse effects were prevalent. A complete response was observed in one patient (6%), partial response in eight (47%), stable disease in seven (41%) and progression in one case. Three-year actuarial disease-free and overall survival rates were 37% and 87.5%, respectively. Conclusion: Raltitrexed did not increase the pathological response rate compared with the rates obtained with use of preoperative RT alone and reported in the literature. Acute morbidity was low and acceptable, while late toxicity was considerable, prevalently concerning sexual dysfunction and urinary complications

Southern Ocean sea ice and frontal changes during the Late Quaternary and their linkages to Asian summer monsoon

International audienc

Antarctic sea-ice and palaeoproductivity variation over the last 156,000 years in the Indian sector of Southern Ocean

International audienc

Glacial-interglacial flux and size variability of Fragilariopsis kerguelensis and Thalassiosira lentiginosa from the Indian sector of the Southern Ocean

International audienc