The effect of trimming of the frog on the impact accelerations of the equine hoof during walk and trot

Bij conventioneel bekapte hoeven heeft de straal niet tot nauwelijks contact met de grond. Het wordt verondersteld dat de energieabsorberende functie van de straal hierbij gereduceerd is of mogelijk zelfs vrijwel afwezig is. Het valt te verwachten dat een hoef waarvan de straal een goed contact maakt met de ondergrond een geringere impactversnelling zal hebben dan een hoef waarvan de straal niet of nauwelijks de grond raakt.Om deze hypothese te testen ondergingen 10 klinisch gezonde warmbloedpaarden drie achtereenvolgende behandelingen; 1. Onbekapt (controle meting); 2. Bekapte hoefwand + onbekapte straal; 3. Bekapte hoefwand + bekapte straal.het bekappen van de straal lijkt geen invloed te hebben op bovenstaande parameters. Het is echter niet uit te sluiten dat er bij een andere proefopzet(bijvoorbeeld bij lopen op een betonvloer) wel verschillen gevonden kunnen worde

Рівняння електромагнітної механіки пористого насиченого середовища

За двоконтинуумного наближення отримано повну систему співвідношень моделі електромагнітомеханіки статистично однорідного та ізотропного пористого насиченого середовища. Враховано наявність подвійного електричного шару в околі межі контакту твердої і рідкої фаз.Complete set of the model equations for electromagnetic mechanics of the porous saturated medium being statistically homogeneous and isotropic is obtained in two-continuum approximation. The presence of a double electrical layer in an environ of contact boundary of solid and liquid phases is taken into account.В двухконтинуумном приближении получено полную систему соотношений модели электромагнитомеханики статистически однородной и изотропной пористой насыщенной среды. Учтено наличие двойного электрического слоя в окрестности границы контакта твердой и жидкой фаз

[Long-term complications following treatment of testicular cancer and Hodgkin lymphoma].

Patients who were treated in the past with radiotherapy or chemotherapy for testicular cancer or Hodgkin lymphoma are at risk of new malignancies and cardiovascular disease on the long run. Two patient groups who were diagnosed in various hospitals in the Netherlands as having testicular cancer and Hodgkin lymphoma in the period 1965-1995 have survived for a mean period of almost 20 years by now. Both patient groups have higher risks of a new malignancy or cardiovascular disease following radiotherapy and/or chemotherapy than the general population or patients treated without or with less intensive radiotherapy or chemotherapy. As recovery of Hodgkin lymphoma is only achieved by a more intensive treatment approach than the treatment approach for testicular cancer, the risks of a new malignancy or cardiovascular disease are considerably higher among survivors of Hodgkin lymphoma than among survivors of testicular cancer. In both patient groups the long-term risks of new malignancies and cardiovascular disease are still raised in both patient groups up to 25 years after treatment. Because of the relatively high risks of late treatment complications, recommendations for follow-up for survivors of testicular cancer and Hodgkin lymphoma are necessary.</p

The best of both worlds: a hybrid approach for optimal pre- and intraoperative identification of sentinel lymph nodes

Imaging- and therapeutic targets in neoplastic and musculoskeletal inflammatory diseas

Impact of Curcumin (with or without Piperine) on the Pharmacokinetics of Tamoxifen

Tamoxifen is a prodrug that is primarily metabolized into the pharmacologically active metabolite endoxifen and eventually into inactive metabolites. The herb curcumin may increase endoxifen exposure by affecting phase II metabolism. We compared endoxifen and tamoxifen exposure in breast cancer patients with or without curcumin, and with addition of the bio-enhancer piperine. Tamoxifen (20–30mg per day (q.d.)) was either given alone, or combined with curcumin (1200 mg three times daily (t.i.d.)) +/− piperine (10 mg t.i.d.). The primary endpoint of this study was the difference in geometric means for the area under the curve (AUC) of endoxifen. Genotyping was performed to determine CYP2D6 and CYP3A4 phenotypes. The endoxifen AUC0–24h decreased with 7.7% (95%CI: −15.4 to 0.7%; p = 0.07) with curcumin and 12.4% (95%CI: −21.9 to −1.9%; p = 0.02) with curcumin and piperine, compared to tamoxifen alone. Tamoxifen AUC0–24h showed similar results. For patients with an extensive CYP2D6 metabolism phenotype (EM), effects were more pronounced than for intermediate CYP2D6 metabolizers (IMs). In conclusion, the exposure to tamoxifen and endoxifen was significantly decreased by concomitant use of curcumin (+/− piperine). Therefore, co-treatment with curcumin could lower endoxifen concentrations below the threshold for efficacy (potentially 20–40% of the patients), especially in EM patients

Monovision-based vehicle detection, distance and relative speed measurement in urban traffic

This study presents a monovision-based system for on-road vehicle detection and computation of distance and relative speed in urban traffic. Many works have dealt with monovision vehicle detection, but only a few of them provide the distance to the vehicle which is essential for the control of an intelligent transportation system. The system proposed integrates a single camera reducing the monetary cost of stereovision and RADAR-based technologies. The algorithm is divided in three major stages. For vehicle detection, the authors use a combination of two features: the shadow underneath the vehicle and horizontal edges. They propose a new method for shadow thresholding based on the grey-scale histogram assessment of a region of interest on the road. In the second and third stages, the vehicle hypothesis verification and the distance are obtained by means of its number plate whose dimensions and shape are standardised in each country. The analysis of consecutive frames is employed to calculate the relative speed of the vehicle detected. Experimental results showed excellent performance in both vehicle and number plate detections and in the distance measurement, in terms of accuracy and robustness in complex traffic scenarios and under different lighting conditions