Seeking counselling for mood disorders in a cardiac centre: a pilot survey of patients’ views

Research suggests a relationship exists between patients with ischemic heart trauma, and mood disorders and that there is therefore a need for psychosocial assessment and, where necessary, treatment for these disorders among heart attack patients [1]. Yet, assessment and treatment for mood disorders is rarely a priority in the cardiologist's office. Thus, counselling therapies for cardiac patients with co-occurring mood disorder are rarely considered or addressed in the cardiologist's office. This study sought to investigate whether cardiac patients would use counselling services if offered in the cardiologist's office. Results suggested mixed sentiments regarding counselling treatment for mood disorders in the cardiologist's office, particularly with regard to sex-differences. Discussion focuses on these sex-differences and the role aspects of ‘gender' and ‘masculinity' may play in accounting for such differences. The paper also discusses the significance of age differences. Implications for interdisciplinary collaboration are presented

Variation in the responses of wild species of duck, gull, and wader to inoculation with a wild-bird-origin H6N2 low pathogenicity avian influenza virus

There is poor understanding of host responses to avian influenza virus (AIV) infection in wild birds, with most experimental studies using captive-bred birds and highly pathogenic AIVs that have an early endpoint. The objective of this study was to experimentally assess antibody responses and patterns of viral excretion in wild birds challenged with a low pathogenicity AIV. Ruddy turnstones (Arenaria interpres), silver gulls (Chroicocephalus novaehollandiae), and wandering whistling ducks (Dendrocygna arcuata) were challenged with a H6N2 virus, and blood, cloacal, and oropharyngeal (OP) swabs were analyzed from each bird over 28 days, with serology conducted on the ducks for a further 7 mo. Nineteen of 22 birds showed evidence of infection, with respiratory infection prevalent in the turnstones and gulls as mostly low titer viral excretion to 4 days postinoculation (DPI) with gastrointestinal replication detected in only one turnstone. In AIV naive ducks, there was gastrointestinal tropism with moderately high titer viral excretion via the cloaca to 6 DPI and low-grade OP viral excretion to 4 DPI. The hemagglutination inhibition antibody response was poor in the ducks, declining from 19 to 56 DPI, with higher titer responses in the gulls and turnstones. All infected birds responded with elevated nucleoprotein antibodies (in competitive enzyme-linked immunosorbent assay) by 7-10 DPI, and in the ducks these waned slowly after 42 DPI and were long-lived to at least 8 mo. The interspecies variability in response was consistent with a subtype that had adapted well in ducks, while the response of the turnstones may have been influenced by preexisting immunity to AIV. These findings provide insight into AIV infection dynamics in wild birds and highlight the need for further research

Influence of regional tectonics and pre-existing structures on the formation of elliptical calderas in the Kenyan Rift

Calderas are formed by the collapse of large magma reservoirs and are commonly elliptical in map view. The orientation of elliptical calderas is often used as an indicator of the local stress regime; but, in some rift settings, pre-existing structural trends may also influence the orientation. We investigated whether either of these two mechanisms controls the orientation of calderas in the Kenyan Rift. Satellite-based mapping was used to identify the rift border faults, intra-rift faults and orientation of the calderas to measure the stress orientations and pre-existing structural trends and to determine the extensional regime at each volcano. We found that extension in northern Kenya is orthogonal, whereas that in southern Kenya is oblique. Elliptical calderas in northern Kenya are orientated NW–SE, aligned with pre-existing structures and perpendicular to recent rift faults. In southern Kenya, the calderas are aligned NE–SW and lie oblique to recent rift faults, but are aligned with pre-existing structures. We conclude that, in oblique continental rifts, pre-existing structures control the development of elongated magma reservoirs. Our results highlight the structural control of magmatism at different crustal levels, where pre-existing structures control the storage and orientation of deeper magma reservoirs and the local stress regime controls intra-rift faulting and shallow magmatism. Supplementary material: Details of the Standard Deviation Ellipse function and statistical methods are available at http://www.geolsoc.org.uk/SUP18849

Cryptococcus neoformans ex vivo capsule size is associated with intracranial pressure and host immune response in HIV-associated cryptococcal meningitis

<p>Background. The Cryptococcus neoformans polysaccharide capsule is a well-characterised virulence factor with immunomodulatory properties. The organism and/or shed capsule is postulated to raise intracranial pressure(ICP) in cryptococcal meningitis(CM) by mechanical obstruction of cerebrospinal fluid(CSF) outflow. Little is known regarding capsule phenotype in human cryptococcosis. We investigated the relationship of ex vivo CSF capsular phenotype with ICP and CSF immune response, as well as in vitro phenotype.</p> <p>Methods. 134 HIV-infected Ugandan adults with CM had serial lumbar punctures with measurement of CSF opening pressures, quantitative cultures, ex vivo capsule size and shedding, viscosity, and CSF cytokines. 108 had complete data. Induced capsular size and shedding were measured in vitro for 48 C. neoformans isolates.</p> <p>Results. Cryptococcal strains producing larger ex vivo capsules in the baseline(pre-treatment) CSF correlated with higher ICP(P=.02), slower rate of fungal clearance(P=.02), and paucity of CSF inflammation, including decreased CSF white blood cell(WBC) count(P<.001), interleukin(IL)-4(P=.02), IL-6(P=.01), IL-7(P=.04), IL-8(P=.03), and interferon-gamma(P=.03). CSF capsule shedding did not correlate with ICP. On multivariable analysis, capsule size remained independently associated with ICP. Ex vivo capsular size and shedding did not correlate with that of the same isolates grown in vitro.</p> <P>Conclusions. Cryptococcal capsule size ex vivo is an important contributor to virulence in human cryptococcal meningitis.</P&gt

Book Reviews

Book Review 1Book Title: Reproductive Energetics in MammalsBook Authors: A.S.I. Loudon & P.A. Racey (Eds.)Zoological Society of London Symposia 57, 1987 Clarendon. Press, Oxford. 371 pp.Book Review 2Book Title: Classification of Southern African MammalsBook Authors: J.A.J. Meester, I.L. Rautenbach, N.J. Dippenaar & C.M. BakerTransvaal Museum Monograph No.5. 359 pp.Book Review 3Book Title: Pesticide impact on stream fauna with special reference to macroinvertebratesBook Author: R.C. Muirhead-ThomsonCambridge University Press, 1987. 275 pp.Book Review 4Book Title: Evolution of sex determining mechanismsBook Author: James J. BullBenjamin-Cummings Publ. Company / Addison-Wesley Publishing Group, JohannesburgBook Review 5Book Title: The evolutionary ecology of ant-plant mutualismsBook Author: Andrew J. BeattieCambridge University Press 182 pp.Book Review 6Book Title: The Ecology of SexBook Authors: P.J. Greenwood & J. Adams Edward Arnold, London, 1987. 74 pagesBook Review 7Book Title: The Dinosaur Heresies - a revolutionary view of dinosaursBook Author: Robert BakkerPublished by Longman Scientific and Technical, 1987Book Review 8Book Title: Molecular Biology of the GeneBook Authors: Watson, Hopkins, Roberts, Steitz & WeinerVolumes I and II (Fourth Edition) (Benjamin/Cummings. Menlo Park); Addison-Wesley Publishing Group. Johannesburg 1163 pp.Book Review 9Book Title: Evolutionary BiologyBook Author: Eli C. MinkoffAddison-Wesley Publishing Company, Massachussets, 1983. 627pp.Book Review 10Book Title: An ecosystem approach to aquatic ecology. Mirror Lake and its environmentBook Author: Gene E. Likens (Ed.)Springer-Ver1ag, New York. xiv - 516 pages; 197 figuresBook Review 11Book Title: The Physiological Ecology of SeaweedsBook Authors: C.S. Lobban, P.J. Harrison & M.J. Duncan Cambridge University press, Cambridge, 1985. 242 pagesBook Review 12Book Title: Principles of ecologyBook Authors: R.J.Putman & S.D. WrattenCroom Helm, London, 1984. 388 pages

Hospital discharge data is not accurate enough to monitor the incidence of postpartum hemorrhage.

Postpartum hemorrhage remains a leading cause of maternal morbidity and mortality worldwide. Therefore, cumulative incidence of postpartum hemorrhage and severe postpartum hemorrhage are commonly monitored within and compared across maternity hospitals or countries for obstetrical safety improvement. These indicators are usually based on hospital discharge data though their accuracy is seldom assessed. We aimed to measure postpartum hemorrhage and severe postpartum hemorrhage using electronic health records and hospital discharge data separately and compare the detection accuracy of these methods to manual chart review, and to examine the temporal trends in cumulative incidence of these potentially avoidable adverse outcomes. We analyzed routinely collected data of 7904 singleton deliveries from a large Swiss university hospital for a three year period (2014-2016). We identified postpartum hemorrhage and severe postpartum hemorrhage in electronic health records by text mining discharge letters and operative reports and calculating drop in hemoglobin from laboratory tests. Diagnostic and procedure codes were used to identify cases in hospital discharge data. A sample of 334 charts was reviewed manually to provide a reference-standard and evaluate the accuracy of the other detection methods. Sensitivities of detection algorithms based on electronic health records and hospital discharge data were 95.2% (95% CI: 92.6% 97.8%) and 38.2% (33.3% to 43.0%), respectively for postpartum hemorrhage, and 87.5% (85.2% to 89.8%) and 36.2% (26.3% to 46.1%) for severe postpartum hemorrhage. Postpartum hemorrhage cumulative incidence based on electronic health records decreased from 15.6% (13.1% to 18.2%) to 8.5% (6.7% to 10.5%) from the beginning of 2014 to the end of 2016, with an average of 12.5% (11.8% to 13.3%). The cumulative incidence of severe postpartum hemorrhage remained at approximately 4% (3.5% to 4.4%). Hospital discharge data-based algorithms provided significantly underestimated incidences. Hospital discharge data is not accurate enough to assess the incidence of postpartum hemorrhage at hospital or national level. Instead, automated algorithms based on structured and textual data from electronic health records should be considered, as they provide accurate and timely estimates for monitoring and improvement in obstetrical safety. Furthermore, they have the potential to better code for postpartum hemorrhage thus improving hospital reimbursement

The hydration state of HO−^-(aq)

The HO$^-$(aq) ion participates in myriad aqueous phase chemical processes of biological and chemical interest. A molecularly valid description of its hydration state, currently poorly understood, is a natural prerequisite to modeling chemical transformations involving HO$^-$(aq). Here it is shown that the statistical mechanical quasi-chemical theory of solutions predicts that $\mathrm{HO\cdot[H_2O]_3{}^-}$ is the dominant inner shell coordination structure for HO$^-$(aq) under standard conditions. Experimental observations and other theoretical calculations are adduced to support this conclusion. Hydration free energies of neutral combinations of simple cations with HO$^-$(aq) are evaluated and agree well with experimental values.Comment: 10 pages, 1 figur

Evaluation of the performance of a lateral flow device for quantitative detection of anti-SARS-CoV-2 IgG

Introduction: The AbC-19™ lateral flow immunoassay (LFIA) performance was evaluated on plasma samples from a SARS-CoV-2 vaccination cohort, WHO international standards for anti-SARS-CoV-2 IgG (human), individuals ≥2 weeks from infection of RT-PCR confirmed SARS-CoV-2 genetic variants, as well as microorganism serology. Methods: Pre-vaccination to three weeks post-booster samples were collected from a cohort of 111 patients (including clinically extremely vulnerable patients) from Northern Ireland. All patients received Oxford-AstraZeneca COVID-19 vaccination for the first and second dose, and Pfizer-BioNTech for the third (first booster). WHO international standards, 15 samples from 2 variants of concern (Delta and Omicron) and cross-reactivity with plasma samples from other microorganism infections were also assessed on AbC-19™. Results: All 80 (100%) participants sampled post-booster had high positive IgG responses, compared to 38/95 (40%) participants at 6 months post-first vaccination. WHO standard results correlated with information from corresponding biological data sheets, and antibodies to all genetic variants were detected by LFIA. No cross-reactivity was found with exception of one (of five) Dengue virus samples. Conclusion: These findings suggest BNT162b2 booster vaccination enhanced humoral immunity to SARS-CoV-2 from pre-booster levels, and that this antibody response was detectable by the LFIA. In combination with cross-reactivity, standards and genetic variant results would suggest LFIA may be a cost-effective measure to assess SARS-CoV-2 antibody status

The Genome of the Blind Soil-Dwelling and Ancestrally Wingless Dipluran Campodea augens: A Key Reference Hexapod for Studying the Emergence of Insect Innovations.

The dipluran two-pronged bristletail Campodea augens is a blind ancestrally wingless hexapod with the remarkable capacity to regenerate lost body appendages such as its long antennae. As sister group to Insecta (sensu stricto), Diplura are key to understanding the early evolution of hexapods and the origin and evolution of insects. Here we report the 1.2-Gb draft genome of C. augens and results from comparative genomic analyses with other arthropods. In C. augens, we uncovered the largest chemosensory gene repertoire of ionotropic receptors in the animal kingdom, a massive expansion that might compensate for the loss of vision. We found a paucity of photoreceptor genes mirroring at the genomic level the secondary loss of an ancestral external photoreceptor organ. Expansions of detoxification and carbohydrate metabolism gene families might reflect adaptations for foraging behavior, and duplicated apoptotic genes might underlie its high regenerative potential. The C. augens genome represents one of the key references for studying the emergence of genomic innovations in insects, the most diverse animal group, and opens up novel opportunities to study the under-explored biology of diplurans

An evaluation of the stimulants and impediments to innovation within PFI/PPP projects

This paper identifies the theoretical stimulants and impediments associated with the implementation of PFI/PPP (Private Finance Initiative/Public Private Partnership) projects. A current defect of this procurement approach is the unintentional constraint upon the innovations incorporated into the development of PFI projects. A critical evaluation of the published literature has been utilized to synthesize a theoretical model. The paper proposes a theoretical model for the identification of potential innovation stimulants and impediments within this type of procurement. This theoretical model is then utilised to evaluate four previously completed PFI projects. These project case-studies have been examined in detail. The evaluation demonstrates how ineffective current procedures are. The application of this model before project letting could eliminate unintentional constraints and stimulate improved innovation within the process. The implementation of the model could improve the successful delivery of innovation within the entire PFI/PPP procurement process