In a Good Way: Advancing Funder Collaborations to Promote Health in Indian Country

Funders continue to be challenged by how to best promote work in American Indian communities that builds health equity, addresses community context, and reduces the disproportionate impact of commercial tobacco. In particular, public health programs that address substance abuse and tobacco control promote the use of evidence-based practices that tend to emphasize a one-size-fits-all approach and that are rarely researched among American Indian populations. These practices, therefore, lack cultural validity in those communities. This article examines how three organizations collaborated on work to control commercial tobacco use in Minnesota’s Indian Country, and shares lessons learned on how they came to incorporate tribal culture, respect traditional tobacco practices, and acknowledge historical trauma to inform their grantmaking

Qualitative analysis of the contents of the anterior portion of the oesophagus from adult milkfish, Chanos chanos, captured in Pandan Bay from 10 May-June 1975

Qualitative analysis of food items in the anterior spiral portion of the oesophagus suggests that adult milkfish feed on both benthic and planktonic materials

A correlational study: The relationship of academic self-efficacy and purpose in life in the academic achievement of students living in dormitories

This study is all about the relationship of academic achievement to academic self efficacy and purpose in life of students who are living in dormitories. 300 participants were asked to answer two tests, the college self efficacy test and the purpose in life test. The academic achievement was measured through the GPA that was later on converted to the numerical value by interpolation. Academic achievement was correlated with purpose in life and college self efficacy separately. The results suggest that academic achievement does not have a relationship with purpose in life and it is not directly related to academic self efficacy

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

P-glycoprotein (P-gp) is one of the best-known mediators of drug efflux-based multidrug resistance in many cancers. This validated therapeutic target is a prototypic, plasma membrane resident ATP-Binding Cassette transporter that pumps xenobiotic compounds out of cells. The large, polyspecific drug-binding pocket of P-gp recognizes a variety of structurally unrelated compounds. The transport of these drugs across the membrane is coincident with changes in the size and shape of this pocket during the course of the transport cycle. Here, we present the crystal structures of three inward-facing conformations of mouse P-gp derived from two different crystal forms. One structure has a nanobody bound to the C-terminal side of the first nucleotide-binding domain. This nanobody strongly inhibits the ATP hydrolysis activity of mouse P-gp by hindering the formation of a dimeric complex between the ATP-binding domains, which is essential for nucleotide hydrolysis. Together, these inward-facing conformational snapshots of P-gp demonstrate a range of flexibility exhibited by this transporter, which is likely an essential feature for the binding and transport of large, diverse substrates. The nanobody-bound structure also reveals a unique epitope on P-gp

Meristic variations in milkfish Chanos chanos from Philippine waters

SEAFDEC Contribution No. 218.Variations in meristic characters occur within and between samples of milkfish Chanos chanos (Forsskal) collected on June 1977 from five localities in Philippine waters. The unbranched anal and ventral fin rays are the most plastic, and vertebral number is the most stable of nine meristic characters examined. The number of ventral fin rays is the only meristic feature which differed consistently enough to suggest distinct population groups: South China Sea, comprising samples from Ilocos and Panay Island; Pacific Ocean from Bicol; and Celebes Sea, from Zamboanga and Davao. A discriminant analysis which incorporated generalized distance (Mahanalobis D2) and percent overlap of a reduced set of characters indicated several morphometric subgroups of milkfish in Philippine waters, although geographic subgroups were not clearly demonstrated